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Q9NR11 (ZN302_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 302
Alternative name(s):
Zinc finger protein 135-like
Zinc finger protein 140-like
Zinc finger protein 327
Gene names
Name:ZNF302
Synonyms:ZNF135L, ZNF140L, ZNF327
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NR11-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NR11-2)

The sequence of this isoform differs from the canonical sequence as follows:
     72-169: AYPFPLSHSV...GIINKEGYLY → DWESRWENKELSTKKDIYD

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Zinc finger protein 302
PRO_0000047522

Regions

Domain4 – 7572KRAB
Zinc finger280 – 30223C2H2-type 1
Zinc finger308 – 33023C2H2-type 2
Zinc finger336 – 35823C2H2-type 3
Zinc finger364 – 38623C2H2-type 4
Zinc finger392 – 41423C2H2-type 5
Zinc finger420 – 44223C2H2-type 6
Zinc finger448 – 47023C2H2-type 7

Natural variations

Alternative sequence72 – 16998AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2.
VSP_006914

Experimental info

Sequence conflict4511N → H in AAF67475. Ref.3
Sequence conflict4561V → G in AAF67475. Ref.3
Sequence conflict4641V → G in AAF67475. Ref.3
Sequence conflict4721E → G in AAF67475. Ref.3
Sequence conflict476 – 4783FEV → LKFRNAGNPSTSLNH in AAF67475. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C7492069228F55A6

FASTA47854,814
        10         20         30         40         50         60 
MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP YVIMLLEDGK 

        70         80         90        100        110        120 
EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT EIFELSELCV FWVLHFLSNS 

       130        140        150        160        170        180 
PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF RLGIKMGKQG IINKEGYLYE DSPQPVTMEK 

       190        200        210        220        230        240 
VVKQSYEFSN SNKNLEYTEC DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV 

       250        260        270        280        290        300 
IKSERINGGK KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR 

       310        320        330        340        350        360 
IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS LTNHQSTHTG 

       370        380        390        400        410        420 
EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA FIHSSSLIHH QKSHTGEKPY 

       430        440        450        460        470 
ECRECGKAFC CSSHLTQHQR IHSMKKKYEC NKCLKVFSSF SFLVQHQSIH TEEKPFEV 

« Hide

Isoform 2 [UniParc].

Checksum: C1C3FE2258423842
Show »

FASTA39945,937

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a full-length cDNA encoding a novel KRAB type zinc finger protein."
Mao Y.-M., Xie Y., Zhao W., Kang Y., Lin S.-R., Sun Z.-H., Zhou Z.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A novel KRAB ZFP gene involved in hepatic cancer."
Mao Y.-M., Xie Y., Wang Z., Ying K., Lin S.-R., Deng Y.-F., Sun Z.-H.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"A novel gene expressed in human adrenal gland."
Gu J., Fu S., Ren S., Jin W., Gu Y., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Adrenal gland.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF265236 mRNA. Translation: AAF74775.1.
AF326206 mRNA. Translation: AAK11224.1.
AF155656 mRNA. Translation: AAF67475.1.
AL834318 mRNA. Translation: CAD38987.1.
BC024176 mRNA. Translation: AAH24176.1.
RefSeqNP_001012320.1. NM_001012320.2.
NP_060913.2. NM_018443.3.
UniGeneHs.436350.

3D structure databases

ProteinModelPortalQ9NR11.
SMRQ9NR11. Positions 2-44, 176-476.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120987. 6 interactions.
IntActQ9NR11. 3 interactions.
STRING9606.ENSP00000391067.

PTM databases

PhosphoSiteQ9NR11.

Polymorphism databases

DMDM23397010.

Proteomic databases

PaxDbQ9NR11.
PRIDEQ9NR11.

Protocols and materials databases

DNASU55900.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000423823; ENSP00000405219; ENSG00000089335. [Q9NR11-2]
ENST00000457781; ENSP00000391067; ENSG00000089335. [Q9NR11-2]
ENST00000505242; ENSP00000421028; ENSG00000089335. [Q9NR11-2]
GeneID55900.
KEGGhsa:55900.
UCSCuc002nvp.1. human. [Q9NR11-2]

Organism-specific databases

CTD55900.
GeneCardsGC19P035168.
HGNCHGNC:13848. ZNF302.
neXtProtNX_Q9NR11.
PharmGKBPA37820.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9NR11.
KOK09228.
PhylomeDBQ9NR11.
TreeFamTF337055.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9NR11.
BgeeQ9NR11.
CleanExHS_ZNF302.
GenevestigatorQ9NR11.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55900.
NextBio61259.
PROQ9NR11.

Entry information

Entry nameZN302_HUMAN
AccessionPrimary (citable) accession number: Q9NR11
Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM