Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 302

Gene

ZNF302

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri280 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 302
Alternative name(s):
Zinc finger protein 135-like
Zinc finger protein 140-like
Zinc finger protein 327
Gene namesi
Name:ZNF302
Synonyms:ZNF135L, ZNF140L, ZNF327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000089335.20
HGNCiHGNC:13848 ZNF302
neXtProtiNX_Q9NR11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089335
PharmGKBiPA37820

Polymorphism and mutation databases

BioMutaiZNF302
DMDMi23397010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475221 – 478Zinc finger protein 302Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9NR11
PaxDbiQ9NR11
PeptideAtlasiQ9NR11
PRIDEiQ9NR11
ProteomicsDBi82242
82243 [Q9NR11-2]

PTM databases

iPTMnetiQ9NR11
PhosphoSitePlusiQ9NR11

Expressioni

Gene expression databases

BgeeiENSG00000089335
CleanExiHS_ZNF302
ExpressionAtlasiQ9NR11 baseline and differential
GenevisibleiQ9NR11 HS

Organism-specific databases

HPAiHPA059503

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-3916142,EBI-739624

Protein-protein interaction databases

BioGridi120987, 13 interactors
IntActiQ9NR11, 5 interactors
STRINGi9606.ENSP00000391067

Structurei

3D structure databases

ProteinModelPortaliQ9NR11
SMRiQ9NR11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri280 – 302C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144389
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9NR11
KOiK09228
PhylomeDBiQ9NR11
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP
60 70 80 90 100
YVIMLLEDGK EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT
110 120 130 140 150
EIFELSELCV FWVLHFLSNS PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF
160 170 180 190 200
RLGIKMGKQG IINKEGYLYE DSPQPVTMEK VVKQSYEFSN SNKNLEYTEC
210 220 230 240 250
DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV IKSERINGGK
260 270 280 290 300
KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR
310 320 330 340 350
IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS
360 370 380 390 400
LTNHQSTHTG EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA
410 420 430 440 450
FIHSSSLIHH QKSHTGEKPY ECRECGKAFC CSSHLTQHQR IHSMKKKYEC
460 470
NKCLKVFSSF SFLVQHQSIH TEEKPFEV
Length:478
Mass (Da):54,814
Last modified:October 1, 2000 - v1
Checksum:iC7492069228F55A6
GO
Isoform 2 (identifier: Q9NR11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-169: AYPFPLSHSV...GIINKEGYLY → DWESRWENKELSTKKDIYD

Show »
Length:399
Mass (Da):45,937
Checksum:iC1C3FE2258423842
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti451N → H in AAF67475 (Ref. 3) Curated1
Sequence conflicti456V → G in AAF67475 (Ref. 3) Curated1
Sequence conflicti464V → G in AAF67475 (Ref. 3) Curated1
Sequence conflicti472E → G in AAF67475 (Ref. 3) Curated1
Sequence conflicti476 – 478FEV → LKFRNAGNPSTSLNH in AAF67475 (Ref. 3) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00691472 – 169AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2. 4 PublicationsAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265236 mRNA Translation: AAF74775.1
AF326206 mRNA Translation: AAK11224.1
AF155656 mRNA Translation: AAF67475.1
AL834318 mRNA Translation: CAD38987.1
BC024176 mRNA Translation: AAH24176.1
CCDSiCCDS46042.1 [Q9NR11-2]
RefSeqiNP_001012320.1, NM_001012320.2 [Q9NR11-2]
NP_001276110.1, NM_001289181.1
NP_001276111.1, NM_001289182.1
NP_001276112.1, NM_001289183.1 [Q9NR11-2]
NP_001276113.1, NM_001289184.1
NP_001276114.1, NM_001289185.1
NP_001276115.1, NM_001289186.1 [Q9NR11-2]
NP_001276116.1, NM_001289187.1 [Q9NR11-2]
NP_001276117.1, NM_001289188.1
NP_001276118.1, NM_001289189.1
NP_001276119.1, NM_001289190.1
NP_001276120.1, NM_001289191.1
NP_001276121.1, NM_001289192.1
NP_060913.2, NM_018443.3 [Q9NR11-2]
NP_061145.2, NM_018675.2
UniGeneiHs.436350

Genome annotation databases

EnsembliENST00000423823; ENSP00000405219; ENSG00000089335 [Q9NR11-2]
ENST00000457781; ENSP00000391067; ENSG00000089335 [Q9NR11-2]
ENST00000505242; ENSP00000421028; ENSG00000089335 [Q9NR11-2]
GeneIDi55900
KEGGihsa:55900
UCSCiuc002nvp.3 human [Q9NR11-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN302_HUMAN
AccessioniPrimary (citable) accession number: Q9NR11
Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health