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Protein

Zinc finger protein 302

Gene

ZNF302

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri280 – 30223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 302
Alternative name(s):
Zinc finger protein 135-like
Zinc finger protein 140-like
Zinc finger protein 327
Gene namesi
Name:ZNF302
Synonyms:ZNF135L, ZNF140L, ZNF327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13848. ZNF302.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37820.

Polymorphism and mutation databases

BioMutaiZNF302.
DMDMi23397010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Zinc finger protein 302PRO_0000047522Add
BLAST

Proteomic databases

MaxQBiQ9NR11.
PaxDbiQ9NR11.
PRIDEiQ9NR11.

PTM databases

PhosphoSiteiQ9NR11.

Expressioni

Gene expression databases

BgeeiQ9NR11.
CleanExiHS_ZNF302.
ExpressionAtlasiQ9NR11. baseline and differential.
GenevisibleiQ9NR11. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-3916142,EBI-739624

Protein-protein interaction databases

BioGridi120987. 10 interactions.
IntActiQ9NR11. 4 interactions.
STRINGi9606.ENSP00000391067.

Structurei

3D structure databases

ProteinModelPortaliQ9NR11.
SMRiQ9NR11. Positions 2-44, 200-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri280 – 30223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000122945.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NR11.
KOiK09228.
PhylomeDBiQ9NR11.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP
60 70 80 90 100
YVIMLLEDGK EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT
110 120 130 140 150
EIFELSELCV FWVLHFLSNS PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF
160 170 180 190 200
RLGIKMGKQG IINKEGYLYE DSPQPVTMEK VVKQSYEFSN SNKNLEYTEC
210 220 230 240 250
DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV IKSERINGGK
260 270 280 290 300
KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR
310 320 330 340 350
IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS
360 370 380 390 400
LTNHQSTHTG EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA
410 420 430 440 450
FIHSSSLIHH QKSHTGEKPY ECRECGKAFC CSSHLTQHQR IHSMKKKYEC
460 470
NKCLKVFSSF SFLVQHQSIH TEEKPFEV
Length:478
Mass (Da):54,814
Last modified:October 1, 2000 - v1
Checksum:iC7492069228F55A6
GO
Isoform 2 (identifier: Q9NR11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-169: AYPFPLSHSV...GIINKEGYLY → DWESRWENKELSTKKDIYD

Show »
Length:399
Mass (Da):45,937
Checksum:iC1C3FE2258423842
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti451 – 4511N → H in AAF67475 (Ref. 3) Curated
Sequence conflicti456 – 4561V → G in AAF67475 (Ref. 3) Curated
Sequence conflicti464 – 4641V → G in AAF67475 (Ref. 3) Curated
Sequence conflicti472 – 4721E → G in AAF67475 (Ref. 3) Curated
Sequence conflicti476 – 4783FEV → LKFRNAGNPSTSLNH in AAF67475 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 16998AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2. 4 PublicationsVSP_006914Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265236 mRNA. Translation: AAF74775.1.
AF326206 mRNA. Translation: AAK11224.1.
AF155656 mRNA. Translation: AAF67475.1.
AL834318 mRNA. Translation: CAD38987.1.
BC024176 mRNA. Translation: AAH24176.1.
CCDSiCCDS46042.1. [Q9NR11-2]
RefSeqiNP_001012320.1. NM_001012320.2. [Q9NR11-2]
NP_001276110.1. NM_001289181.1.
NP_001276111.1. NM_001289182.1.
NP_001276112.1. NM_001289183.1. [Q9NR11-2]
NP_001276113.1. NM_001289184.1.
NP_001276114.1. NM_001289185.1.
NP_001276115.1. NM_001289186.1. [Q9NR11-2]
NP_001276116.1. NM_001289187.1. [Q9NR11-2]
NP_001276117.1. NM_001289188.1.
NP_001276118.1. NM_001289189.1.
NP_001276119.1. NM_001289190.1.
NP_001276120.1. NM_001289191.1.
NP_001276121.1. NM_001289192.1.
NP_060913.2. NM_018443.3. [Q9NR11-2]
NP_061145.2. NM_018675.2.
UniGeneiHs.436350.

Genome annotation databases

EnsembliENST00000423823; ENSP00000405219; ENSG00000089335. [Q9NR11-2]
ENST00000457781; ENSP00000391067; ENSG00000089335. [Q9NR11-2]
ENST00000505242; ENSP00000421028; ENSG00000089335. [Q9NR11-2]
GeneIDi55900.
KEGGihsa:55900.
UCSCiuc002nvp.1. human. [Q9NR11-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265236 mRNA. Translation: AAF74775.1.
AF326206 mRNA. Translation: AAK11224.1.
AF155656 mRNA. Translation: AAF67475.1.
AL834318 mRNA. Translation: CAD38987.1.
BC024176 mRNA. Translation: AAH24176.1.
CCDSiCCDS46042.1. [Q9NR11-2]
RefSeqiNP_001012320.1. NM_001012320.2. [Q9NR11-2]
NP_001276110.1. NM_001289181.1.
NP_001276111.1. NM_001289182.1.
NP_001276112.1. NM_001289183.1. [Q9NR11-2]
NP_001276113.1. NM_001289184.1.
NP_001276114.1. NM_001289185.1.
NP_001276115.1. NM_001289186.1. [Q9NR11-2]
NP_001276116.1. NM_001289187.1. [Q9NR11-2]
NP_001276117.1. NM_001289188.1.
NP_001276118.1. NM_001289189.1.
NP_001276119.1. NM_001289190.1.
NP_001276120.1. NM_001289191.1.
NP_001276121.1. NM_001289192.1.
NP_060913.2. NM_018443.3. [Q9NR11-2]
NP_061145.2. NM_018675.2.
UniGeneiHs.436350.

3D structure databases

ProteinModelPortaliQ9NR11.
SMRiQ9NR11. Positions 2-44, 200-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120987. 10 interactions.
IntActiQ9NR11. 4 interactions.
STRINGi9606.ENSP00000391067.

PTM databases

PhosphoSiteiQ9NR11.

Polymorphism and mutation databases

BioMutaiZNF302.
DMDMi23397010.

Proteomic databases

MaxQBiQ9NR11.
PaxDbiQ9NR11.
PRIDEiQ9NR11.

Protocols and materials databases

DNASUi55900.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423823; ENSP00000405219; ENSG00000089335. [Q9NR11-2]
ENST00000457781; ENSP00000391067; ENSG00000089335. [Q9NR11-2]
ENST00000505242; ENSP00000421028; ENSG00000089335. [Q9NR11-2]
GeneIDi55900.
KEGGihsa:55900.
UCSCiuc002nvp.1. human. [Q9NR11-2]

Organism-specific databases

CTDi55900.
GeneCardsiGC19P035168.
HGNCiHGNC:13848. ZNF302.
neXtProtiNX_Q9NR11.
PharmGKBiPA37820.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00790000122945.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NR11.
KOiK09228.
PhylomeDBiQ9NR11.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF302. human.
GenomeRNAii55900.
NextBioi61259.
PROiQ9NR11.

Gene expression databases

BgeeiQ9NR11.
CleanExiHS_ZNF302.
ExpressionAtlasiQ9NR11. baseline and differential.
GenevisibleiQ9NR11. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a full-length cDNA encoding a novel KRAB type zinc finger protein."
    Mao Y.-M., Xie Y., Zhao W., Kang Y., Lin S.-R., Sun Z.-H., Zhou Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel KRAB ZFP gene involved in hepatic cancer."
    Mao Y.-M., Xie Y., Wang Z., Ying K., Lin S.-R., Deng Y.-F., Sun Z.-H.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "A novel gene expressed in human adrenal gland."
    Gu J., Fu S., Ren S., Jin W., Gu Y., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Adrenal gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiZN302_HUMAN
AccessioniPrimary (citable) accession number: Q9NR11
Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.