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Q9NR11

- ZN302_HUMAN

UniProt

Q9NR11 - ZN302_HUMAN

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Protein
Zinc finger protein 302
Gene
ZNF302, ZNF135L, ZNF140L, ZNF327
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri280 – 30223C2H2-type 1
Add
BLAST
Zinc fingeri308 – 33023C2H2-type 2
Add
BLAST
Zinc fingeri336 – 35823C2H2-type 3
Add
BLAST
Zinc fingeri364 – 38623C2H2-type 4
Add
BLAST
Zinc fingeri392 – 41423C2H2-type 5
Add
BLAST
Zinc fingeri420 – 44223C2H2-type 6
Add
BLAST
Zinc fingeri448 – 47023C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 302
Alternative name(s):
Zinc finger protein 135-like
Zinc finger protein 140-like
Zinc finger protein 327
Gene namesi
Name:ZNF302
Synonyms:ZNF135L, ZNF140L, ZNF327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13848. ZNF302.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Zinc finger protein 302
PRO_0000047522Add
BLAST

Proteomic databases

PaxDbiQ9NR11.
PRIDEiQ9NR11.

PTM databases

PhosphoSiteiQ9NR11.

Expressioni

Gene expression databases

ArrayExpressiQ9NR11.
BgeeiQ9NR11.
CleanExiHS_ZNF302.
GenevestigatoriQ9NR11.

Interactioni

Protein-protein interaction databases

BioGridi120987. 6 interactions.
IntActiQ9NR11. 3 interactions.
STRINGi9606.ENSP00000391067.

Structurei

3D structure databases

ProteinModelPortaliQ9NR11.
SMRiQ9NR11. Positions 2-44, 200-471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRAB
Add
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NR11.
KOiK09228.
PhylomeDBiQ9NR11.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NR11-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP    50
YVIMLLEDGK EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT 100
EIFELSELCV FWVLHFLSNS PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF 150
RLGIKMGKQG IINKEGYLYE DSPQPVTMEK VVKQSYEFSN SNKNLEYTEC 200
DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV IKSERINGGK 250
KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR 300
IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS 350
LTNHQSTHTG EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA 400
FIHSSSLIHH QKSHTGEKPY ECRECGKAFC CSSHLTQHQR IHSMKKKYEC 450
NKCLKVFSSF SFLVQHQSIH TEEKPFEV 478
Length:478
Mass (Da):54,814
Last modified:October 1, 2000 - v1
Checksum:iC7492069228F55A6
GO
Isoform 2 (identifier: Q9NR11-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-169: AYPFPLSHSV...GIINKEGYLY → DWESRWENKELSTKKDIYD

Show »
Length:399
Mass (Da):45,937
Checksum:iC1C3FE2258423842
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 16998AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2.
VSP_006914Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti451 – 4511N → H in AAF67475. 1 Publication
Sequence conflicti456 – 4561V → G in AAF67475. 1 Publication
Sequence conflicti464 – 4641V → G in AAF67475. 1 Publication
Sequence conflicti472 – 4721E → G in AAF67475. 1 Publication
Sequence conflicti476 – 4783FEV → LKFRNAGNPSTSLNH in AAF67475. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF265236 mRNA. Translation: AAF74775.1.
AF326206 mRNA. Translation: AAK11224.1.
AF155656 mRNA. Translation: AAF67475.1.
AL834318 mRNA. Translation: CAD38987.1.
BC024176 mRNA. Translation: AAH24176.1.
CCDSiCCDS46042.1. [Q9NR11-2]
RefSeqiNP_001012320.1. NM_001012320.2. [Q9NR11-2]
NP_001276110.1. NM_001289181.1.
NP_001276111.1. NM_001289182.1.
NP_001276112.1. NM_001289183.1. [Q9NR11-2]
NP_001276113.1. NM_001289184.1.
NP_001276114.1. NM_001289185.1.
NP_001276115.1. NM_001289186.1. [Q9NR11-2]
NP_001276116.1. NM_001289187.1. [Q9NR11-2]
NP_001276117.1. NM_001289188.1.
NP_001276118.1. NM_001289189.1.
NP_001276119.1. NM_001289190.1.
NP_001276120.1. NM_001289191.1.
NP_001276121.1. NM_001289192.1.
NP_060913.2. NM_018443.3. [Q9NR11-2]
NP_061145.2. NM_018675.2.
UniGeneiHs.436350.

Genome annotation databases

EnsembliENST00000423823; ENSP00000405219; ENSG00000089335. [Q9NR11-2]
ENST00000457781; ENSP00000391067; ENSG00000089335. [Q9NR11-2]
ENST00000505242; ENSP00000421028; ENSG00000089335. [Q9NR11-2]
GeneIDi55900.
KEGGihsa:55900.
UCSCiuc002nvp.1. human. [Q9NR11-2]

Polymorphism databases

DMDMi23397010.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF265236 mRNA. Translation: AAF74775.1 .
AF326206 mRNA. Translation: AAK11224.1 .
AF155656 mRNA. Translation: AAF67475.1 .
AL834318 mRNA. Translation: CAD38987.1 .
BC024176 mRNA. Translation: AAH24176.1 .
CCDSi CCDS46042.1. [Q9NR11-2 ]
RefSeqi NP_001012320.1. NM_001012320.2. [Q9NR11-2 ]
NP_001276110.1. NM_001289181.1.
NP_001276111.1. NM_001289182.1.
NP_001276112.1. NM_001289183.1. [Q9NR11-2 ]
NP_001276113.1. NM_001289184.1.
NP_001276114.1. NM_001289185.1.
NP_001276115.1. NM_001289186.1. [Q9NR11-2 ]
NP_001276116.1. NM_001289187.1. [Q9NR11-2 ]
NP_001276117.1. NM_001289188.1.
NP_001276118.1. NM_001289189.1.
NP_001276119.1. NM_001289190.1.
NP_001276120.1. NM_001289191.1.
NP_001276121.1. NM_001289192.1.
NP_060913.2. NM_018443.3. [Q9NR11-2 ]
NP_061145.2. NM_018675.2.
UniGenei Hs.436350.

3D structure databases

ProteinModelPortali Q9NR11.
SMRi Q9NR11. Positions 2-44, 200-471.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120987. 6 interactions.
IntActi Q9NR11. 3 interactions.
STRINGi 9606.ENSP00000391067.

PTM databases

PhosphoSitei Q9NR11.

Polymorphism databases

DMDMi 23397010.

Proteomic databases

PaxDbi Q9NR11.
PRIDEi Q9NR11.

Protocols and materials databases

DNASUi 55900.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000423823 ; ENSP00000405219 ; ENSG00000089335 . [Q9NR11-2 ]
ENST00000457781 ; ENSP00000391067 ; ENSG00000089335 . [Q9NR11-2 ]
ENST00000505242 ; ENSP00000421028 ; ENSG00000089335 . [Q9NR11-2 ]
GeneIDi 55900.
KEGGi hsa:55900.
UCSCi uc002nvp.1. human. [Q9NR11-2 ]

Organism-specific databases

CTDi 55900.
GeneCardsi GC19P035168.
HGNCi HGNC:13848. ZNF302.
neXtProti NX_Q9NR11.
PharmGKBi PA37820.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9NR11.
KOi K09228.
PhylomeDBi Q9NR11.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 55900.
NextBioi 61259.
PROi Q9NR11.

Gene expression databases

ArrayExpressi Q9NR11.
Bgeei Q9NR11.
CleanExi HS_ZNF302.
Genevestigatori Q9NR11.

Family and domain databases

Gene3Di 3.30.160.60. 7 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a full-length cDNA encoding a novel KRAB type zinc finger protein."
    Mao Y.-M., Xie Y., Zhao W., Kang Y., Lin S.-R., Sun Z.-H., Zhou Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel KRAB ZFP gene involved in hepatic cancer."
    Mao Y.-M., Xie Y., Wang Z., Ying K., Lin S.-R., Deng Y.-F., Sun Z.-H.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "A novel gene expressed in human adrenal gland."
    Gu J., Fu S., Ren S., Jin W., Gu Y., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Adrenal gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiZN302_HUMAN
AccessioniPrimary (citable) accession number: Q9NR11
Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi