Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NR11

- ZN302_HUMAN

UniProt

Q9NR11 - ZN302_HUMAN

Protein

Zinc finger protein 302

Gene

ZNF302

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri280 – 30223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 302
    Alternative name(s):
    Zinc finger protein 135-like
    Zinc finger protein 140-like
    Zinc finger protein 327
    Gene namesi
    Name:ZNF302
    Synonyms:ZNF135L, ZNF140L, ZNF327
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13848. ZNF302.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37820.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Zinc finger protein 302PRO_0000047522Add
    BLAST

    Proteomic databases

    PaxDbiQ9NR11.
    PRIDEiQ9NR11.

    PTM databases

    PhosphoSiteiQ9NR11.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NR11.
    BgeeiQ9NR11.
    CleanExiHS_ZNF302.
    GenevestigatoriQ9NR11.

    Interactioni

    Protein-protein interaction databases

    BioGridi120987. 6 interactions.
    IntActiQ9NR11. 3 interactions.
    STRINGi9606.ENSP00000391067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR11.
    SMRiQ9NR11. Positions 2-44, 200-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri280 – 30223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9NR11.
    KOiK09228.
    PhylomeDBiQ9NR11.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR11-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP    50
    YVIMLLEDGK EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT 100
    EIFELSELCV FWVLHFLSNS PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF 150
    RLGIKMGKQG IINKEGYLYE DSPQPVTMEK VVKQSYEFSN SNKNLEYTEC 200
    DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV IKSERINGGK 250
    KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR 300
    IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS 350
    LTNHQSTHTG EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA 400
    FIHSSSLIHH QKSHTGEKPY ECRECGKAFC CSSHLTQHQR IHSMKKKYEC 450
    NKCLKVFSSF SFLVQHQSIH TEEKPFEV 478
    Length:478
    Mass (Da):54,814
    Last modified:October 1, 2000 - v1
    Checksum:iC7492069228F55A6
    GO
    Isoform 2 (identifier: Q9NR11-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-169: AYPFPLSHSV...GIINKEGYLY → DWESRWENKELSTKKDIYD

    Show »
    Length:399
    Mass (Da):45,937
    Checksum:iC1C3FE2258423842
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti451 – 4511N → H in AAF67475. 1 PublicationCurated
    Sequence conflicti456 – 4561V → G in AAF67475. 1 PublicationCurated
    Sequence conflicti464 – 4641V → G in AAF67475. 1 PublicationCurated
    Sequence conflicti472 – 4721E → G in AAF67475. 1 PublicationCurated
    Sequence conflicti476 – 4783FEV → LKFRNAGNPSTSLNH in AAF67475. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei72 – 16998AYPFP…EGYLY → DWESRWENKELSTKKDIYD in isoform 2. 4 PublicationsVSP_006914Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF265236 mRNA. Translation: AAF74775.1.
    AF326206 mRNA. Translation: AAK11224.1.
    AF155656 mRNA. Translation: AAF67475.1.
    AL834318 mRNA. Translation: CAD38987.1.
    BC024176 mRNA. Translation: AAH24176.1.
    CCDSiCCDS46042.1. [Q9NR11-2]
    RefSeqiNP_001012320.1. NM_001012320.2. [Q9NR11-2]
    NP_001276110.1. NM_001289181.1.
    NP_001276111.1. NM_001289182.1.
    NP_001276112.1. NM_001289183.1. [Q9NR11-2]
    NP_001276113.1. NM_001289184.1.
    NP_001276114.1. NM_001289185.1.
    NP_001276115.1. NM_001289186.1. [Q9NR11-2]
    NP_001276116.1. NM_001289187.1. [Q9NR11-2]
    NP_001276117.1. NM_001289188.1.
    NP_001276118.1. NM_001289189.1.
    NP_001276119.1. NM_001289190.1.
    NP_001276120.1. NM_001289191.1.
    NP_001276121.1. NM_001289192.1.
    NP_060913.2. NM_018443.3. [Q9NR11-2]
    NP_061145.2. NM_018675.2.
    UniGeneiHs.436350.

    Genome annotation databases

    EnsembliENST00000423823; ENSP00000405219; ENSG00000089335. [Q9NR11-2]
    ENST00000457781; ENSP00000391067; ENSG00000089335. [Q9NR11-2]
    ENST00000505242; ENSP00000421028; ENSG00000089335. [Q9NR11-2]
    GeneIDi55900.
    KEGGihsa:55900.
    UCSCiuc002nvp.1. human. [Q9NR11-2]

    Polymorphism databases

    DMDMi23397010.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF265236 mRNA. Translation: AAF74775.1 .
    AF326206 mRNA. Translation: AAK11224.1 .
    AF155656 mRNA. Translation: AAF67475.1 .
    AL834318 mRNA. Translation: CAD38987.1 .
    BC024176 mRNA. Translation: AAH24176.1 .
    CCDSi CCDS46042.1. [Q9NR11-2 ]
    RefSeqi NP_001012320.1. NM_001012320.2. [Q9NR11-2 ]
    NP_001276110.1. NM_001289181.1.
    NP_001276111.1. NM_001289182.1.
    NP_001276112.1. NM_001289183.1. [Q9NR11-2 ]
    NP_001276113.1. NM_001289184.1.
    NP_001276114.1. NM_001289185.1.
    NP_001276115.1. NM_001289186.1. [Q9NR11-2 ]
    NP_001276116.1. NM_001289187.1. [Q9NR11-2 ]
    NP_001276117.1. NM_001289188.1.
    NP_001276118.1. NM_001289189.1.
    NP_001276119.1. NM_001289190.1.
    NP_001276120.1. NM_001289191.1.
    NP_001276121.1. NM_001289192.1.
    NP_060913.2. NM_018443.3. [Q9NR11-2 ]
    NP_061145.2. NM_018675.2.
    UniGenei Hs.436350.

    3D structure databases

    ProteinModelPortali Q9NR11.
    SMRi Q9NR11. Positions 2-44, 200-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120987. 6 interactions.
    IntActi Q9NR11. 3 interactions.
    STRINGi 9606.ENSP00000391067.

    PTM databases

    PhosphoSitei Q9NR11.

    Polymorphism databases

    DMDMi 23397010.

    Proteomic databases

    PaxDbi Q9NR11.
    PRIDEi Q9NR11.

    Protocols and materials databases

    DNASUi 55900.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423823 ; ENSP00000405219 ; ENSG00000089335 . [Q9NR11-2 ]
    ENST00000457781 ; ENSP00000391067 ; ENSG00000089335 . [Q9NR11-2 ]
    ENST00000505242 ; ENSP00000421028 ; ENSG00000089335 . [Q9NR11-2 ]
    GeneIDi 55900.
    KEGGi hsa:55900.
    UCSCi uc002nvp.1. human. [Q9NR11-2 ]

    Organism-specific databases

    CTDi 55900.
    GeneCardsi GC19P035168.
    HGNCi HGNC:13848. ZNF302.
    neXtProti NX_Q9NR11.
    PharmGKBi PA37820.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9NR11.
    KOi K09228.
    PhylomeDBi Q9NR11.
    TreeFami TF337055.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 55900.
    NextBioi 61259.
    PROi Q9NR11.

    Gene expression databases

    ArrayExpressi Q9NR11.
    Bgeei Q9NR11.
    CleanExi HS_ZNF302.
    Genevestigatori Q9NR11.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a full-length cDNA encoding a novel KRAB type zinc finger protein."
      Mao Y.-M., Xie Y., Zhao W., Kang Y., Lin S.-R., Sun Z.-H., Zhou Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A novel KRAB ZFP gene involved in hepatic cancer."
      Mao Y.-M., Xie Y., Wang Z., Ying K., Lin S.-R., Deng Y.-F., Sun Z.-H.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "A novel gene expressed in human adrenal gland."
      Gu J., Fu S., Ren S., Jin W., Gu Y., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Adrenal gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.

    Entry informationi

    Entry nameiZN302_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR11
    Secondary accession number(s): Q658J3, Q9BZD8, Q9P0J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3