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Q9NR09

- BIRC6_HUMAN

UniProt

Q9NR09 - BIRC6_HUMAN

Protein

Baculoviral IAP repeat-containing protein 6

Gene

BIRC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.3 Publications

    Enzyme regulationi

    Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei4625 – 46251Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. labyrinthine layer development Source: Ensembl
    3. mitotic nuclear division Source: UniProtKB-KW
    4. negative regulation of apoptotic process Source: UniProtKB
    5. negative regulation of endopeptidase activity Source: GOC
    6. negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
    7. positive regulation of cell proliferation Source: Ensembl
    8. protein phosphorylation Source: UniProtKB
    9. protein ubiquitination Source: UniProtKB
    10. regulation of cell proliferation Source: UniProtKB
    11. regulation of cytokinesis Source: UniProtKB
    12. spongiotrophoblast layer development Source: Ensembl

    Keywords - Molecular functioni

    Ligase, Protease inhibitor, Thiol protease inhibitor

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ9NR09.

    Protein family/group databases

    MEROPSiI32.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
    Alternative name(s):
    BIR repeat-containing ubiquitin-conjugating enzyme
    Short name:
    BRUCE
    Ubiquitin-conjugating BIR domain enzyme apollon
    Short name:
    APOLLON
    Gene namesi
    Name:BIRC6
    Synonyms:KIAA1289
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13516. BIRC6.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication. Midbody 1 Publication. Endosome 1 Publication. Cytoplasmcytoskeletonspindle pole 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
    Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.

    GO - Cellular componenti

    1. endosome Source: UniProtKB
    2. membrane Source: UniProtKB
    3. microtubule organizing center Source: UniProtKB
    4. midbody Source: UniProtKB
    5. spindle pole Source: UniProtKB
    6. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 48574857Baculoviral IAP repeat-containing protein 6PRO_0000122361Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei480 – 4801Phosphoserine4 Publications

    Post-translational modificationi

    Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.2 Publications

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9NR09.
    PaxDbiQ9NR09.
    PRIDEiQ9NR09.

    PTM databases

    PhosphoSiteiQ9NR09.

    Expressioni

    Tissue specificityi

    Expressed in brain cancer cells.

    Gene expression databases

    ArrayExpressiQ9NR09.
    BgeeiQ9NR09.
    CleanExiHS_BIRC6.
    GenevestigatoriQ9NR09.

    Interactioni

    Subunit structurei

    Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EXOC4Q96A653EBI-1765160,EBI-355383
    KIF23Q022414EBI-1765160,EBI-306852
    MAP2K1Q027502EBI-1765160,EBI-492564
    PLK1P533503EBI-1765160,EBI-476768

    Protein-protein interaction databases

    BioGridi121521. 18 interactions.
    IntActiQ9NR09. 14 interactions.
    STRINGi9606.ENSP00000393596.

    Structurei

    Secondary structure

    1
    4857
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4524 – 453310
    Beta strandi4536 – 45405
    Beta strandi4543 – 45453
    Beta strandi4551 – 45555
    Helixi4560 – 45645
    Helixi4572 – 458817
    Beta strandi4597 – 46048
    Beta strandi4608 – 46158
    Beta strandi4625 – 46317
    Turni4634 – 46385
    Beta strandi4642 – 46454
    Turni4649 – 46524
    Helixi4668 – 46703
    Helixi4677 – 46793
    Turni4683 – 46853
    Helixi4688 – 469811
    Helixi4704 – 47074
    Helixi4711 – 47144
    Helixi4718 – 473821
    Helixi4741 – 47455
    Turni4749 – 47513
    Helixi4752 – 477726
    Helixi4788 – 481023

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CEGX-ray2.01A/B4498-4820[»]
    ProteinModelPortaliQ9NR09.
    SMRiQ9NR09. Positions 4521-4818.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NR09.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati284 – 35875BIRAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4576 – 4704129Ubiquitin-conjugatingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 367Poly-Ala
    Compositional biasi1660 – 16689Poly-Ala

    Domaini

    The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.1 Publication

    Sequence similaritiesi

    In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated
    Contains 1 BIR repeat.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000168828.
    HOVERGENiHBG050691.
    InParanoidiQ9NR09.
    KOiK10586.
    OMAiGHVDFKF.
    OrthoDBiEOG7VTDM2.
    PhylomeDBiQ9NR09.
    TreeFamiTF105357.

    Family and domain databases

    Gene3Di1.10.1170.10. 1 hit.
    2.130.10.10. 4 hits.
    3.10.110.10. 1 hit.
    InterProiIPR001370. BIR.
    IPR022103. BIRC6.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF00653. BIR. 1 hit.
    PF12356. DUF3643. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view]
    SMARTiSM00238. BIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NR09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGPG CSSAAGAGAA     50
    GVSEWLVLRD GCMHCDADGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA 100
    TLQASALSAK PGGQVKCQYI SAVDKVIFVD DYAVGCRKDL NGILLLDTAL 150
    QTPVSKQDDV VQLELPVTEA QQLLSACLEK VDISSTEGYD LFITQLKDGL 200
    KNTSHETAAN HKVAKWATVT FHLPHHVLKS IASAIVNELK KINQNVAALP 250
    VASSVMDRLS YLLPSARPEL GVGPGRSVDR SLMYSEANRR ETFTSWPHVG 300
    YRWAQPDPMA QAGFYHQPAS SGDDRAMCFT CSVCLVCWEP TDEPWSEHER 350
    HSPNCPFVKG EHTQNVPLSV TLATSPAQFP CTDGTDRISC FGSGSCPHFL 400
    AAATKRGKIC IWDVSKLMKV HLKFEINAYD PAIVQQLILS GDPSSGVDSR 450
    RPTLAWLEDS SSCSDIPKLE GDSDDLLEDS DSEEHSRSDS VTGHTSQKEA 500
    MEVSLDITAL SILQQPEKLQ WEIVANVLED TVKDLEELGA NPCLTNSKSE 550
    KTKEKHQEQH NIPFPCLLAG GLLTYKSPAT SPISSNSHRS LDGLSRTQGE 600
    SISEQGSTDN ESCTNSELNS PLVRRTLPVL LLYSIKESDE KAGKIFSQMN 650
    NIMSKSLHDD GFTVPQIIEM ELDSQEQLLL QDPPVTYIQQ FADAAANLTS 700
    PDSEKWNSVF PKPGTLVQCL RLPKFAEEEN LCIDSITPCA DGIHLLVGLR 750
    TCPVESLSAI NQVEALNNLN KLNSALCNRR KGELESNLAV VNGANISVIQ 800
    HESPADVQTP LIIQPEQRNV SGGYLVLYKM NYATRIVTLE EEPIKIQHIK 850
    DPQDTITSLI LLPPDILDNR EDDCEEPIED MQLTSKNGFE REKTSDISTL 900
    GHLVITTQGG YVKILDLSNF EILAKVEPPK KEGTEEQDTF VSVIYCSGTD 950
    RLCACTKGGE LHFLQIGGTC DDIDEADILV DGSLSKGIEP SSEGSKPLSN 1000
    PSSPGISGVD LLVDQPFTLE ILTSLVELTR FETLTPRFSA TVPPCWVEVQ 1050
    QEQQQRRHPQ HLHQQHHGDA AQHTRTWKLQ TDSNSWDEHV FELVLPKACM 1100
    VGHVDFKFVL NSNITNIPQI QVTLLKNKAP GLGKVNALNI EVEQNGKPSL 1150
    VDLNEEMQHM DVEESQCLRL CPFLEDHKED ILCGPVWLAS GLDLSGHAGM 1200
    LTLTSPKLVK GMAGGKYRSF LIHVKAVNER GTEEICNGGM RPVVRLPSLK 1250
    HQSNKGYSLA SLLAKVAAGK EKSSNVKNEN TSGTRKSENL RGCDLLQEVS 1300
    VTIRRFKKTS ISKERVQRCA MLQFSEFHEK LVNTLCRKTD DGQITEHAQS 1350
    LVLDTLCWLA GVHSNGPGSS KEGNENLLSK TRKFLSDIVR VCFFEAGRSI 1400
    AHKCARFLAL CISNGKCDPC QPAFGPVLLK ALLDNMSFLP AATTGGSVYW 1450
    YFVLLNYVKD EDLAGCSTAC ASLLTAVSRQ LQDRLTPMEA LLQTRYGLYS 1500
    SPFDPVLFDL EMSGSSCKNV YNSSIGVQSD EIDLSDVLSG NGKVSSCTAA 1550
    EGSFTSLTGL LEVEPLHFTC VSTSDGTRIE RDDAMSSFGV TPAVGGLSSG 1600
    TVGEASTALS SAAQVALQSL SHAMASAEQQ LQVLQEKQQQ LLKLQQQKAK 1650
    LEAKLHQTTA AAAAAASAVG PVHNSVPSNP VAAPGFFIHP SDVIPPTPKT 1700
    TPLFMTPPLT PPNEAVSVVI NAELAQLFPG SVIDPPAVNL AAHNKNSNKS 1750
    RMNPLGSGLA LAISHASHFL QPPPHQSIII ERMHSGARRF VTLDFGRPIL 1800
    LTDVLIPTCG DLASLSIDIW TLGEEVDGRR LVVATDISTH SLILHDLIPP 1850
    PVCRFMKITV IGRYGSTNAR AKIPLGFYYG HTYILPWESE LKLMHDPLKG 1900
    EGESANQPEI DQHLAMMVAL QEDIQCRYNL ACHRLETLLQ SIDLPPLNSA 1950
    NNAQYFLRKP DKAVEEDSRV FSAYQDCIQL QLQLNLAHNA VQRLKVALGA 2000
    SRKMLSETSN PEDLIQTSST EQLRTIIRYL LDTLLSLLHA SNGHSVPAVL 2050
    QSTFHAQACE ELFKHLCISG TPKIRLHTGL LLVQLCGGER WWGQFLSNVL 2100
    QELYNSEQLL IFPQDRVFML LSCIGQRSLS NSGVLESLLN LLDNLLSPLQ 2150
    PQLPMHRRTE GVLDIPMISW VVMLVSRLLD YVATVEDEAA AAKKPLNGNQ 2200
    WSFINNNLHT QSLNRSSKGS SSLDRLYSRK IRKQLVHHKQ QLNLLKAKQK 2250
    ALVEQMEKEK IQSNKGSSYK LLVEQAKLKQ ATSKHFKDLI RLRRTAEWSR 2300
    SNLDTEVTTA KESPEIEPLP FTLAHERCIS VVQKLVLFLL SMDFTCHADL 2350
    LLFVCKVLAR IANATRPTIH LCEIVNEPQL ERLLLLLVGT DFNRGDISWG 2400
    GAWAQYSLTC MLQDILAGEL LAPVAAEAME EGTVGDDVGA TAGDSDDSLQ 2450
    QSSVQLLETI DEPLTHDITG APPLSSLEKD KEIDLELLQD LMEVDIDPLD 2500
    IDLEKDPLAA KVFKPISSTW YDYWGADYGT YNYNPYIGGL GIPVAKPPAN 2550
    TEKNGSQTVS VSVSQALDAR LEVGLEQQAE LMLKMMSTLE ADSILQALTN 2600
    TSPTLSQSPT GTDDSLLGGL QAANQTSQLI IQLSSVPMLN VCFNKLFSML 2650
    QVHHVQLESL LQLWLTLSLN SSSTGNKENG ADIFLYNANR IPVISLNQAS 2700
    ITSFLTVLAW YPNTLLRTWC LVLHSLTLMT NMQLNSGSSS AIGTQESTAH 2750
    LLVSDPNLIH VLVKFLSGTS PHGTNQHSPQ VGPTATQAMQ EFLTRLQVHL 2800
    SSTCPQIFSE FLLKLIHILS TERGAFQTGQ GPLDAQVKLL EFTLEQNFEV 2850
    VSVSTISAVI ESVTFLVHHY ITCSDKVMSR SGSDSSVGAR ACFGGLFANL 2900
    IRPGDAKAVC GEMTRDQLMF DLLKLVNILV QLPLSGNREY SARVSVTTNT 2950
    TDSVSDEEKV SGGKDGNGSS TSVQGSPAYV ADLVLANQQI MSQILSALGL 3000
    CNSSAMAMII GASGLHLTKH ENFHGGLDAI SVGDGLFTIL TTLSKKASTV 3050
    HMMLQPILTY MACGYMGRQG SLATCQLSEP LLWFILRVLD TSDALKAFHD 3100
    MGGVQLICNN MVTSTRAIVN TARSMVSTIM KFLDSGPNKA VDSTLKTRIL 3150
    ASEPDNAEGI HNFAPLGTIT SSSPTAQPAE VLLQATPPHR RARSAAWSYI 3200
    FLPEEAWCDL TIHLPAAVLL KEIHIQPHLA SLATCPSSVS VEVSADGVNM 3250
    LPLSTPVVTS GLTYIKIQLV KAEVASAVCL RLHRPRDAST LGLSQIKLLG 3300
    LTAFGTTSSA TVNNPFLPSE DQVSKTSIGW LRLLHHCLTH ISDLEGMMAS 3350
    AAAPTANLLQ TCAALLMSPY CGMHSPNIEV VLVKIGLQST RIGLKLIDIL 3400
    LRNCAASGSD PTDLNSPLLF GRLNGLSSDS TIDILYQLGT TQDPGTKDRI 3450
    QALLKWVSDS ARVAAMKRSG RMNYMCPNSS TVEYGLLMPS PSHLHCVAAI 3500
    LWHSYELLVE YDLPALLDQE LFELLFNWSM SLPCNMVLKK AVDSLLCSMC 3550
    HVHPNYFSLL MGWMGITPPP VQCHHRLSMT DDSKKQDLSS SLTDDSKNAQ 3600
    APLALTESHL ATLASSSQSP EAIKQLLDSG LPSLLVRSLA SFCFSHISSS 3650
    ESIAQSIDIS QDKLRRHHVP QQCNKMPITA DLVAPILRFL TEVGNSHIMK 3700
    DWLGGSEVNP LWTALLFLLC HSGSTSGSHN LGAQQTSARS ASLSSAATTG 3750
    LTTQQRTAIE NATVAFFLQC ISCHPNNQKL MAQVLCELFQ TSPQRGNLPT 3800
    SGNISGFIRR LFLQLMLEDE KVTMFLQSPC PLYKGRINAT SHVIQHPMYG 3850
    AGHKFRTLHL PVSTTLSDVL DRVSDTPSIT AKLISEQKDD KEKKNHEEKE 3900
    KVKAENGFQD NYSVVVASGL KSQSKRAVSA TPPRPPSRRG RTIPDKIGST 3950
    SGAEAANKII TVPVFHLFHK LLAGQPLPAE MTLAQLLTLL YDRKLPQGYR 4000
    SIDLTVKLGS RVITDPSLSK TDSYKRLHPE KDHGDLLASC PEDEALTPGD 4050
    ECMDGILDES LLETCPIQSP LQVFAGMGGL ALIAERLPML YPEVIQQVSA 4100
    PVVTSTTQEK PKDSDQFEWV TIEQSGELVY EAPETVAAEP PPIKSAVQTM 4150
    SPIPAHSLAA FGLFLRLPGY AEVLLKERKH AQCLLRLVLG VTDDGEGSHI 4200
    LQSPSANVLP TLPFHVLRSL FSTTPLTTDD GVLLRRMALE IGALHLILVC 4250
    LSALSHHSPR VPNSSVNQTE PQVSSSHNPT STEEQQLYWA KGTGFGTGST 4300
    ASGWDVEQAL TKQRLEEEHV TCLLQVLASY INPVSSAVNG EAQSSHETRG 4350
    QNSNALPSVL LELLSQSCLI PAMSSYLRND SVLDMARHVP LYRALLELLR 4400
    AIASCAAMVP LLLPLSTENG EEEEEQSECQ TSVGTLLAKM KTCVDTYTNR 4450
    LRSKRENVKT GVKPDASDQE PEGLTLLVPD IQKTAEIVYA ATTSLRQANQ 4500
    EKKLGEYSKK AAMKPKPLSV LKSLEEKYVA VMKKLQFDTF EMVSEDEDGK 4550
    LGFKVNYHYM SQVKNANDAN SAARARRLAQ EAVTLSTSLP LSSSSSVFVR 4600
    CDEERLDIMK VLITGPADTP YANGCFEFDV YFPQDYPSSP PLVNLETTGG 4650
    HSVRFNPNLY NDGKVCLSIL NTWHGRPEEK WNPQTSSFLQ VLVSVQSLIL 4700
    VAEPYFNEPG YERSRGTPSG TQSSREYDGN IRQATVKWAM LEQIRNPSPC 4750
    FKEVIHKHFY LKRVEIMAQC EEWIADIQQY SSDKRVGRTM SHHAAALKRH 4800
    TAQLREELLK LPCPEGLDPD TDDAPEVCRA TTGAEETLMH DQVKPSSSKE 4850
    LPSDFQL 4857
    Length:4,857
    Mass (Da):530,255
    Last modified:November 30, 2010 - v2
    Checksum:i0F5939F9C40F4270
    GO

    Sequence cautioni

    The sequence BAA86603.2 differs from that shown. Reason: Frameshift at position 2047.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1332 – 13321V → L in AAF75772. (PubMed:10544019)Curated
    Sequence conflicti2319 – 23191L → F in BAA86603. (PubMed:10574462)Curated
    Sequence conflicti2674 – 26741T → S in AAF75772. (PubMed:10544019)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079837 Genomic DNA. No translation available.
    AL133243 Genomic DNA. No translation available.
    AL133245 Genomic DNA. No translation available.
    AL133246 Genomic DNA. No translation available.
    AF265555 mRNA. Translation: AAF75772.1.
    AB033115 mRNA. Translation: BAA86603.2. Frameshift.
    CCDSiCCDS33175.2.
    RefSeqiNP_057336.3. NM_016252.3.
    UniGeneiHs.150107.

    Genome annotation databases

    EnsembliENST00000421745; ENSP00000393596; ENSG00000115760.
    GeneIDi57448.
    KEGGihsa:57448.
    UCSCiuc010ezu.3. human.

    Polymorphism databases

    DMDMi313104079.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079837 Genomic DNA. No translation available.
    AL133243 Genomic DNA. No translation available.
    AL133245 Genomic DNA. No translation available.
    AL133246 Genomic DNA. No translation available.
    AF265555 mRNA. Translation: AAF75772.1 .
    AB033115 mRNA. Translation: BAA86603.2 . Frameshift.
    CCDSi CCDS33175.2.
    RefSeqi NP_057336.3. NM_016252.3.
    UniGenei Hs.150107.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CEG X-ray 2.01 A/B 4498-4820 [» ]
    ProteinModelPortali Q9NR09.
    SMRi Q9NR09. Positions 4521-4818.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121521. 18 interactions.
    IntActi Q9NR09. 14 interactions.
    STRINGi 9606.ENSP00000393596.

    Protein family/group databases

    MEROPSi I32.006.

    PTM databases

    PhosphoSitei Q9NR09.

    Polymorphism databases

    DMDMi 313104079.

    Proteomic databases

    MaxQBi Q9NR09.
    PaxDbi Q9NR09.
    PRIDEi Q9NR09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421745 ; ENSP00000393596 ; ENSG00000115760 .
    GeneIDi 57448.
    KEGGi hsa:57448.
    UCSCi uc010ezu.3. human.

    Organism-specific databases

    CTDi 57448.
    GeneCardsi GC02P032582.
    H-InvDB HIX0001957.
    HIX0030282.
    HGNCi HGNC:13516. BIRC6.
    MIMi 605638. gene.
    neXtProti NX_Q9NR09.
    PharmGKBi PA25363.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000168828.
    HOVERGENi HBG050691.
    InParanoidi Q9NR09.
    KOi K10586.
    OMAi GHVDFKF.
    OrthoDBi EOG7VTDM2.
    PhylomeDBi Q9NR09.
    TreeFami TF105357.

    Enzyme and pathway databases

    SignaLinki Q9NR09.

    Miscellaneous databases

    ChiTaRSi BIRC6. human.
    EvolutionaryTracei Q9NR09.
    GeneWikii BIRC6.
    GenomeRNAii 57448.
    NextBioi 63594.
    PROi Q9NR09.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR09.
    Bgeei Q9NR09.
    CleanExi HS_BIRC6.
    Genevestigatori Q9NR09.

    Family and domain databases

    Gene3Di 1.10.1170.10. 1 hit.
    2.130.10.10. 4 hits.
    3.10.110.10. 1 hit.
    InterProi IPR001370. BIR.
    IPR022103. BIRC6.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF00653. BIR. 1 hit.
    PF12356. DUF3643. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SMARTi SM00238. BIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "A human IAP-family gene, apollon, expressed in human brain cancer cells."
      Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.
      Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-4857.
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2063-4857.
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."
      Qiu X.B., Markant S.L., Yuan J., Goldberg A.L.
      EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF41, UBIQUITINATION, FUNCTION.
    6. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
      Bartke T., Pohl C., Pyrowolakis G., Jentsch S.
      Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION, DOMAIN BIR, INTERACTION WITH HTRA2; CASP3; CASP6; CASP7; CASP9 AND DIABLO/SMAC.
    7. "An Apollon vista of death and destruction."
      Martin S.J.
      Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
      Pohl C., Jentsch S.
      Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH KIF23/MKLP1; USP8/UBPY; BIRC5/SURVIVIN; MAP2K1/MEK1; RAB8A/RAB8; RAB11A/RAB11; PLK1; EXOC3/SEC6 AND EXOC4/SEC8.
    10. "IAPs: more than just inhibitors of apoptosis proteins."
      Dubrez-Daloz L., Dupoux A., Cartier J.
      Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
      Structural genomics consortium (SGC)
      Submitted (APR-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 4498-4820.

    Entry informationi

    Entry nameiBIRC6_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR09
    Secondary accession number(s): Q9ULD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3