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Q9NR09

- BIRC6_HUMAN

UniProt

Q9NR09 - BIRC6_HUMAN

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Protein

Baculoviral IAP repeat-containing protein 6

Gene

BIRC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.3 Publications

Enzyme regulationi

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4625 – 46251Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. labyrinthine layer development Source: Ensembl
  3. mitotic nuclear division Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: UniProtKB
  5. negative regulation of endopeptidase activity Source: GOC
  6. negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  7. positive regulation of cell proliferation Source: Ensembl
  8. protein phosphorylation Source: UniProtKB
  9. protein ubiquitination Source: UniProtKB
  10. regulation of cell proliferation Source: UniProtKB
  11. regulation of cytokinesis Source: UniProtKB
  12. spongiotrophoblast layer development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9NR09.

Protein family/group databases

MEROPSiI32.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name:
BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name:
APOLLON
Gene namesi
Name:BIRC6
Synonyms:KIAA1289
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:13516. BIRC6.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane 1 Publication. Midbody 1 Publication. Endosome 1 Publication. Cytoplasmcytoskeletonspindle pole 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. membrane Source: UniProtKB
  3. microtubule organizing center Source: UniProtKB
  4. midbody Source: UniProtKB
  5. spindle pole Source: UniProtKB
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48574857Baculoviral IAP repeat-containing protein 6PRO_0000122361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei480 – 4801Phosphoserine3 Publications

Post-translational modificationi

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NR09.
PaxDbiQ9NR09.
PRIDEiQ9NR09.

PTM databases

PhosphoSiteiQ9NR09.

Expressioni

Tissue specificityi

Expressed in brain cancer cells.

Gene expression databases

BgeeiQ9NR09.
CleanExiHS_BIRC6.
ExpressionAtlasiQ9NR09. baseline and differential.
GenevestigatoriQ9NR09.

Interactioni

Subunit structurei

Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOC4Q96A653EBI-1765160,EBI-355383
KIF23Q022414EBI-1765160,EBI-306852
MAP2K1Q027502EBI-1765160,EBI-492564
PLK1P533503EBI-1765160,EBI-476768

Protein-protein interaction databases

BioGridi121521. 37 interactions.
IntActiQ9NR09. 14 interactions.
STRINGi9606.ENSP00000393596.

Structurei

Secondary structure

1
4857
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4524 – 453310
Beta strandi4536 – 45405
Beta strandi4543 – 45453
Beta strandi4551 – 45555
Helixi4560 – 45645
Helixi4572 – 458817
Beta strandi4597 – 46048
Beta strandi4608 – 46158
Beta strandi4625 – 46317
Turni4634 – 46385
Beta strandi4642 – 46454
Turni4649 – 46524
Helixi4668 – 46703
Helixi4677 – 46793
Turni4683 – 46853
Helixi4688 – 469811
Helixi4704 – 47074
Helixi4711 – 47144
Helixi4718 – 473821
Helixi4741 – 47455
Turni4749 – 47513
Helixi4752 – 477726
Helixi4788 – 481023

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEGX-ray2.01A/B4498-4820[»]
ProteinModelPortaliQ9NR09.
SMRiQ9NR09. Positions 4521-4818.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR09.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati284 – 35875BIRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4576 – 4704129Ubiquitin-conjugatingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 367Poly-Ala
Compositional biasi1660 – 16689Poly-Ala

Domaini

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.1 Publication

Sequence similaritiesi

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000168828.
HOVERGENiHBG050691.
InParanoidiQ9NR09.
KOiK10586.
OMAiGHVDFKF.
OrthoDBiEOG7VTDM2.
PhylomeDBiQ9NR09.
TreeFamiTF105357.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProiIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NR09 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGPG CSSAAGAGAA
60 70 80 90 100
GVSEWLVLRD GCMHCDADGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA
110 120 130 140 150
TLQASALSAK PGGQVKCQYI SAVDKVIFVD DYAVGCRKDL NGILLLDTAL
160 170 180 190 200
QTPVSKQDDV VQLELPVTEA QQLLSACLEK VDISSTEGYD LFITQLKDGL
210 220 230 240 250
KNTSHETAAN HKVAKWATVT FHLPHHVLKS IASAIVNELK KINQNVAALP
260 270 280 290 300
VASSVMDRLS YLLPSARPEL GVGPGRSVDR SLMYSEANRR ETFTSWPHVG
310 320 330 340 350
YRWAQPDPMA QAGFYHQPAS SGDDRAMCFT CSVCLVCWEP TDEPWSEHER
360 370 380 390 400
HSPNCPFVKG EHTQNVPLSV TLATSPAQFP CTDGTDRISC FGSGSCPHFL
410 420 430 440 450
AAATKRGKIC IWDVSKLMKV HLKFEINAYD PAIVQQLILS GDPSSGVDSR
460 470 480 490 500
RPTLAWLEDS SSCSDIPKLE GDSDDLLEDS DSEEHSRSDS VTGHTSQKEA
510 520 530 540 550
MEVSLDITAL SILQQPEKLQ WEIVANVLED TVKDLEELGA NPCLTNSKSE
560 570 580 590 600
KTKEKHQEQH NIPFPCLLAG GLLTYKSPAT SPISSNSHRS LDGLSRTQGE
610 620 630 640 650
SISEQGSTDN ESCTNSELNS PLVRRTLPVL LLYSIKESDE KAGKIFSQMN
660 670 680 690 700
NIMSKSLHDD GFTVPQIIEM ELDSQEQLLL QDPPVTYIQQ FADAAANLTS
710 720 730 740 750
PDSEKWNSVF PKPGTLVQCL RLPKFAEEEN LCIDSITPCA DGIHLLVGLR
760 770 780 790 800
TCPVESLSAI NQVEALNNLN KLNSALCNRR KGELESNLAV VNGANISVIQ
810 820 830 840 850
HESPADVQTP LIIQPEQRNV SGGYLVLYKM NYATRIVTLE EEPIKIQHIK
860 870 880 890 900
DPQDTITSLI LLPPDILDNR EDDCEEPIED MQLTSKNGFE REKTSDISTL
910 920 930 940 950
GHLVITTQGG YVKILDLSNF EILAKVEPPK KEGTEEQDTF VSVIYCSGTD
960 970 980 990 1000
RLCACTKGGE LHFLQIGGTC DDIDEADILV DGSLSKGIEP SSEGSKPLSN
1010 1020 1030 1040 1050
PSSPGISGVD LLVDQPFTLE ILTSLVELTR FETLTPRFSA TVPPCWVEVQ
1060 1070 1080 1090 1100
QEQQQRRHPQ HLHQQHHGDA AQHTRTWKLQ TDSNSWDEHV FELVLPKACM
1110 1120 1130 1140 1150
VGHVDFKFVL NSNITNIPQI QVTLLKNKAP GLGKVNALNI EVEQNGKPSL
1160 1170 1180 1190 1200
VDLNEEMQHM DVEESQCLRL CPFLEDHKED ILCGPVWLAS GLDLSGHAGM
1210 1220 1230 1240 1250
LTLTSPKLVK GMAGGKYRSF LIHVKAVNER GTEEICNGGM RPVVRLPSLK
1260 1270 1280 1290 1300
HQSNKGYSLA SLLAKVAAGK EKSSNVKNEN TSGTRKSENL RGCDLLQEVS
1310 1320 1330 1340 1350
VTIRRFKKTS ISKERVQRCA MLQFSEFHEK LVNTLCRKTD DGQITEHAQS
1360 1370 1380 1390 1400
LVLDTLCWLA GVHSNGPGSS KEGNENLLSK TRKFLSDIVR VCFFEAGRSI
1410 1420 1430 1440 1450
AHKCARFLAL CISNGKCDPC QPAFGPVLLK ALLDNMSFLP AATTGGSVYW
1460 1470 1480 1490 1500
YFVLLNYVKD EDLAGCSTAC ASLLTAVSRQ LQDRLTPMEA LLQTRYGLYS
1510 1520 1530 1540 1550
SPFDPVLFDL EMSGSSCKNV YNSSIGVQSD EIDLSDVLSG NGKVSSCTAA
1560 1570 1580 1590 1600
EGSFTSLTGL LEVEPLHFTC VSTSDGTRIE RDDAMSSFGV TPAVGGLSSG
1610 1620 1630 1640 1650
TVGEASTALS SAAQVALQSL SHAMASAEQQ LQVLQEKQQQ LLKLQQQKAK
1660 1670 1680 1690 1700
LEAKLHQTTA AAAAAASAVG PVHNSVPSNP VAAPGFFIHP SDVIPPTPKT
1710 1720 1730 1740 1750
TPLFMTPPLT PPNEAVSVVI NAELAQLFPG SVIDPPAVNL AAHNKNSNKS
1760 1770 1780 1790 1800
RMNPLGSGLA LAISHASHFL QPPPHQSIII ERMHSGARRF VTLDFGRPIL
1810 1820 1830 1840 1850
LTDVLIPTCG DLASLSIDIW TLGEEVDGRR LVVATDISTH SLILHDLIPP
1860 1870 1880 1890 1900
PVCRFMKITV IGRYGSTNAR AKIPLGFYYG HTYILPWESE LKLMHDPLKG
1910 1920 1930 1940 1950
EGESANQPEI DQHLAMMVAL QEDIQCRYNL ACHRLETLLQ SIDLPPLNSA
1960 1970 1980 1990 2000
NNAQYFLRKP DKAVEEDSRV FSAYQDCIQL QLQLNLAHNA VQRLKVALGA
2010 2020 2030 2040 2050
SRKMLSETSN PEDLIQTSST EQLRTIIRYL LDTLLSLLHA SNGHSVPAVL
2060 2070 2080 2090 2100
QSTFHAQACE ELFKHLCISG TPKIRLHTGL LLVQLCGGER WWGQFLSNVL
2110 2120 2130 2140 2150
QELYNSEQLL IFPQDRVFML LSCIGQRSLS NSGVLESLLN LLDNLLSPLQ
2160 2170 2180 2190 2200
PQLPMHRRTE GVLDIPMISW VVMLVSRLLD YVATVEDEAA AAKKPLNGNQ
2210 2220 2230 2240 2250
WSFINNNLHT QSLNRSSKGS SSLDRLYSRK IRKQLVHHKQ QLNLLKAKQK
2260 2270 2280 2290 2300
ALVEQMEKEK IQSNKGSSYK LLVEQAKLKQ ATSKHFKDLI RLRRTAEWSR
2310 2320 2330 2340 2350
SNLDTEVTTA KESPEIEPLP FTLAHERCIS VVQKLVLFLL SMDFTCHADL
2360 2370 2380 2390 2400
LLFVCKVLAR IANATRPTIH LCEIVNEPQL ERLLLLLVGT DFNRGDISWG
2410 2420 2430 2440 2450
GAWAQYSLTC MLQDILAGEL LAPVAAEAME EGTVGDDVGA TAGDSDDSLQ
2460 2470 2480 2490 2500
QSSVQLLETI DEPLTHDITG APPLSSLEKD KEIDLELLQD LMEVDIDPLD
2510 2520 2530 2540 2550
IDLEKDPLAA KVFKPISSTW YDYWGADYGT YNYNPYIGGL GIPVAKPPAN
2560 2570 2580 2590 2600
TEKNGSQTVS VSVSQALDAR LEVGLEQQAE LMLKMMSTLE ADSILQALTN
2610 2620 2630 2640 2650
TSPTLSQSPT GTDDSLLGGL QAANQTSQLI IQLSSVPMLN VCFNKLFSML
2660 2670 2680 2690 2700
QVHHVQLESL LQLWLTLSLN SSSTGNKENG ADIFLYNANR IPVISLNQAS
2710 2720 2730 2740 2750
ITSFLTVLAW YPNTLLRTWC LVLHSLTLMT NMQLNSGSSS AIGTQESTAH
2760 2770 2780 2790 2800
LLVSDPNLIH VLVKFLSGTS PHGTNQHSPQ VGPTATQAMQ EFLTRLQVHL
2810 2820 2830 2840 2850
SSTCPQIFSE FLLKLIHILS TERGAFQTGQ GPLDAQVKLL EFTLEQNFEV
2860 2870 2880 2890 2900
VSVSTISAVI ESVTFLVHHY ITCSDKVMSR SGSDSSVGAR ACFGGLFANL
2910 2920 2930 2940 2950
IRPGDAKAVC GEMTRDQLMF DLLKLVNILV QLPLSGNREY SARVSVTTNT
2960 2970 2980 2990 3000
TDSVSDEEKV SGGKDGNGSS TSVQGSPAYV ADLVLANQQI MSQILSALGL
3010 3020 3030 3040 3050
CNSSAMAMII GASGLHLTKH ENFHGGLDAI SVGDGLFTIL TTLSKKASTV
3060 3070 3080 3090 3100
HMMLQPILTY MACGYMGRQG SLATCQLSEP LLWFILRVLD TSDALKAFHD
3110 3120 3130 3140 3150
MGGVQLICNN MVTSTRAIVN TARSMVSTIM KFLDSGPNKA VDSTLKTRIL
3160 3170 3180 3190 3200
ASEPDNAEGI HNFAPLGTIT SSSPTAQPAE VLLQATPPHR RARSAAWSYI
3210 3220 3230 3240 3250
FLPEEAWCDL TIHLPAAVLL KEIHIQPHLA SLATCPSSVS VEVSADGVNM
3260 3270 3280 3290 3300
LPLSTPVVTS GLTYIKIQLV KAEVASAVCL RLHRPRDAST LGLSQIKLLG
3310 3320 3330 3340 3350
LTAFGTTSSA TVNNPFLPSE DQVSKTSIGW LRLLHHCLTH ISDLEGMMAS
3360 3370 3380 3390 3400
AAAPTANLLQ TCAALLMSPY CGMHSPNIEV VLVKIGLQST RIGLKLIDIL
3410 3420 3430 3440 3450
LRNCAASGSD PTDLNSPLLF GRLNGLSSDS TIDILYQLGT TQDPGTKDRI
3460 3470 3480 3490 3500
QALLKWVSDS ARVAAMKRSG RMNYMCPNSS TVEYGLLMPS PSHLHCVAAI
3510 3520 3530 3540 3550
LWHSYELLVE YDLPALLDQE LFELLFNWSM SLPCNMVLKK AVDSLLCSMC
3560 3570 3580 3590 3600
HVHPNYFSLL MGWMGITPPP VQCHHRLSMT DDSKKQDLSS SLTDDSKNAQ
3610 3620 3630 3640 3650
APLALTESHL ATLASSSQSP EAIKQLLDSG LPSLLVRSLA SFCFSHISSS
3660 3670 3680 3690 3700
ESIAQSIDIS QDKLRRHHVP QQCNKMPITA DLVAPILRFL TEVGNSHIMK
3710 3720 3730 3740 3750
DWLGGSEVNP LWTALLFLLC HSGSTSGSHN LGAQQTSARS ASLSSAATTG
3760 3770 3780 3790 3800
LTTQQRTAIE NATVAFFLQC ISCHPNNQKL MAQVLCELFQ TSPQRGNLPT
3810 3820 3830 3840 3850
SGNISGFIRR LFLQLMLEDE KVTMFLQSPC PLYKGRINAT SHVIQHPMYG
3860 3870 3880 3890 3900
AGHKFRTLHL PVSTTLSDVL DRVSDTPSIT AKLISEQKDD KEKKNHEEKE
3910 3920 3930 3940 3950
KVKAENGFQD NYSVVVASGL KSQSKRAVSA TPPRPPSRRG RTIPDKIGST
3960 3970 3980 3990 4000
SGAEAANKII TVPVFHLFHK LLAGQPLPAE MTLAQLLTLL YDRKLPQGYR
4010 4020 4030 4040 4050
SIDLTVKLGS RVITDPSLSK TDSYKRLHPE KDHGDLLASC PEDEALTPGD
4060 4070 4080 4090 4100
ECMDGILDES LLETCPIQSP LQVFAGMGGL ALIAERLPML YPEVIQQVSA
4110 4120 4130 4140 4150
PVVTSTTQEK PKDSDQFEWV TIEQSGELVY EAPETVAAEP PPIKSAVQTM
4160 4170 4180 4190 4200
SPIPAHSLAA FGLFLRLPGY AEVLLKERKH AQCLLRLVLG VTDDGEGSHI
4210 4220 4230 4240 4250
LQSPSANVLP TLPFHVLRSL FSTTPLTTDD GVLLRRMALE IGALHLILVC
4260 4270 4280 4290 4300
LSALSHHSPR VPNSSVNQTE PQVSSSHNPT STEEQQLYWA KGTGFGTGST
4310 4320 4330 4340 4350
ASGWDVEQAL TKQRLEEEHV TCLLQVLASY INPVSSAVNG EAQSSHETRG
4360 4370 4380 4390 4400
QNSNALPSVL LELLSQSCLI PAMSSYLRND SVLDMARHVP LYRALLELLR
4410 4420 4430 4440 4450
AIASCAAMVP LLLPLSTENG EEEEEQSECQ TSVGTLLAKM KTCVDTYTNR
4460 4470 4480 4490 4500
LRSKRENVKT GVKPDASDQE PEGLTLLVPD IQKTAEIVYA ATTSLRQANQ
4510 4520 4530 4540 4550
EKKLGEYSKK AAMKPKPLSV LKSLEEKYVA VMKKLQFDTF EMVSEDEDGK
4560 4570 4580 4590 4600
LGFKVNYHYM SQVKNANDAN SAARARRLAQ EAVTLSTSLP LSSSSSVFVR
4610 4620 4630 4640 4650
CDEERLDIMK VLITGPADTP YANGCFEFDV YFPQDYPSSP PLVNLETTGG
4660 4670 4680 4690 4700
HSVRFNPNLY NDGKVCLSIL NTWHGRPEEK WNPQTSSFLQ VLVSVQSLIL
4710 4720 4730 4740 4750
VAEPYFNEPG YERSRGTPSG TQSSREYDGN IRQATVKWAM LEQIRNPSPC
4760 4770 4780 4790 4800
FKEVIHKHFY LKRVEIMAQC EEWIADIQQY SSDKRVGRTM SHHAAALKRH
4810 4820 4830 4840 4850
TAQLREELLK LPCPEGLDPD TDDAPEVCRA TTGAEETLMH DQVKPSSSKE

LPSDFQL
Length:4,857
Mass (Da):530,255
Last modified:November 30, 2010 - v2
Checksum:i0F5939F9C40F4270
GO

Sequence cautioni

The sequence BAA86603.2 differs from that shown. Reason: Frameshift at position 2047.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1332 – 13321V → L in AAF75772. (PubMed:10544019)Curated
Sequence conflicti2319 – 23191L → F in BAA86603. (PubMed:10574462)Curated
Sequence conflicti2674 – 26741T → S in AAF75772. (PubMed:10544019)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079837 Genomic DNA. No translation available.
AL133243 Genomic DNA. No translation available.
AL133245 Genomic DNA. No translation available.
AL133246 Genomic DNA. No translation available.
AF265555 mRNA. Translation: AAF75772.1.
AB033115 mRNA. Translation: BAA86603.2. Frameshift.
CCDSiCCDS33175.2.
RefSeqiNP_057336.3. NM_016252.3.
UniGeneiHs.150107.

Genome annotation databases

EnsembliENST00000421745; ENSP00000393596; ENSG00000115760.
GeneIDi57448.
KEGGihsa:57448.
UCSCiuc010ezu.3. human.

Polymorphism databases

DMDMi313104079.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079837 Genomic DNA. No translation available.
AL133243 Genomic DNA. No translation available.
AL133245 Genomic DNA. No translation available.
AL133246 Genomic DNA. No translation available.
AF265555 mRNA. Translation: AAF75772.1 .
AB033115 mRNA. Translation: BAA86603.2 . Frameshift.
CCDSi CCDS33175.2.
RefSeqi NP_057336.3. NM_016252.3.
UniGenei Hs.150107.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CEG X-ray 2.01 A/B 4498-4820 [» ]
ProteinModelPortali Q9NR09.
SMRi Q9NR09. Positions 4521-4818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121521. 37 interactions.
IntActi Q9NR09. 14 interactions.
STRINGi 9606.ENSP00000393596.

Protein family/group databases

MEROPSi I32.006.

PTM databases

PhosphoSitei Q9NR09.

Polymorphism databases

DMDMi 313104079.

Proteomic databases

MaxQBi Q9NR09.
PaxDbi Q9NR09.
PRIDEi Q9NR09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421745 ; ENSP00000393596 ; ENSG00000115760 .
GeneIDi 57448.
KEGGi hsa:57448.
UCSCi uc010ezu.3. human.

Organism-specific databases

CTDi 57448.
GeneCardsi GC02P032582.
H-InvDB HIX0001957.
HIX0030282.
HGNCi HGNC:13516. BIRC6.
MIMi 605638. gene.
neXtProti NX_Q9NR09.
PharmGKBi PA25363.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000168828.
HOVERGENi HBG050691.
InParanoidi Q9NR09.
KOi K10586.
OMAi GHVDFKF.
OrthoDBi EOG7VTDM2.
PhylomeDBi Q9NR09.
TreeFami TF105357.

Enzyme and pathway databases

SignaLinki Q9NR09.

Miscellaneous databases

ChiTaRSi BIRC6. human.
EvolutionaryTracei Q9NR09.
GeneWikii BIRC6.
GenomeRNAii 57448.
NextBioi 63594.
PROi Q9NR09.
SOURCEi Search...

Gene expression databases

Bgeei Q9NR09.
CleanExi HS_BIRC6.
ExpressionAtlasi Q9NR09. baseline and differential.
Genevestigatori Q9NR09.

Family and domain databases

Gene3Di 1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProi IPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
SMARTi SM00238. BIR. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A human IAP-family gene, apollon, expressed in human brain cancer cells."
    Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.
    Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-4857.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2063-4857.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."
    Qiu X.B., Markant S.L., Yuan J., Goldberg A.L.
    EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF41, UBIQUITINATION, FUNCTION.
  6. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
    Bartke T., Pohl C., Pyrowolakis G., Jentsch S.
    Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION, DOMAIN BIR, INTERACTION WITH HTRA2; CASP3; CASP6; CASP7; CASP9 AND DIABLO/SMAC.
  7. "An Apollon vista of death and destruction."
    Martin S.J.
    Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
    Pohl C., Jentsch S.
    Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH KIF23/MKLP1; USP8/UBPY; BIRC5/SURVIVIN; MAP2K1/MEK1; RAB8A/RAB8; RAB11A/RAB11; PLK1; EXOC3/SEC6 AND EXOC4/SEC8.
  10. "IAPs: more than just inhibitors of apoptosis proteins."
    Dubrez-Daloz L., Dupoux A., Cartier J.
    Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
    Structural genomics consortium (SGC)
    Submitted (APR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 4498-4820.

Entry informationi

Entry nameiBIRC6_HUMAN
AccessioniPrimary (citable) accession number: Q9NR09
Secondary accession number(s): Q9ULD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3