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Q9NR09

- BIRC6_HUMAN

UniProt

Q9NR09 - BIRC6_HUMAN

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Protein
Baculoviral IAP repeat-containing protein 6
Gene
BIRC6, KIAA1289
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.3 Publications

Enzyme regulationi

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4625 – 46251Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. labyrinthine layer development Source: Ensembl
  3. mitotic nuclear division Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: UniProtKB
  5. negative regulation of endopeptidase activity Source: GOC
  6. negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  7. positive regulation of cell proliferation Source: Ensembl
  8. protein phosphorylation Source: UniProtKB
  9. protein ubiquitination Source: UniProtKB
  10. regulation of cell proliferation Source: UniProtKB
  11. regulation of cytokinesis Source: UniProtKB
  12. spongiotrophoblast layer development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9NR09.

Protein family/group databases

MEROPSiI32.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name:
BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name:
APOLLON
Gene namesi
Name:BIRC6
Synonyms:KIAA1289
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:13516. BIRC6.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane. Midbody. Endosome. Cytoplasmcytoskeletonspindle pole. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.1 Publication

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. membrane Source: UniProtKB-KW
  3. microtubule organizing center Source: UniProtKB
  4. midbody Source: UniProtKB
  5. spindle pole Source: UniProtKB
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48574857Baculoviral IAP repeat-containing protein 6
PRO_0000122361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei480 – 4801Phosphoserine3 Publications

Post-translational modificationi

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NR09.
PaxDbiQ9NR09.
PRIDEiQ9NR09.

PTM databases

PhosphoSiteiQ9NR09.

Expressioni

Tissue specificityi

Expressed in brain cancer cells.

Gene expression databases

ArrayExpressiQ9NR09.
BgeeiQ9NR09.
CleanExiHS_BIRC6.
GenevestigatoriQ9NR09.

Interactioni

Subunit structurei

Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOC4Q96A653EBI-1765160,EBI-355383
KIF23Q022414EBI-1765160,EBI-306852
MAP2K1Q027502EBI-1765160,EBI-492564
PLK1P533503EBI-1765160,EBI-476768

Protein-protein interaction databases

BioGridi121521. 18 interactions.
IntActiQ9NR09. 14 interactions.
STRINGi9606.ENSP00000393596.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4524 – 453310
Beta strandi4536 – 45405
Beta strandi4543 – 45453
Beta strandi4551 – 45555
Helixi4560 – 45645
Helixi4572 – 458817
Beta strandi4597 – 46048
Beta strandi4608 – 46158
Beta strandi4625 – 46317
Turni4634 – 46385
Beta strandi4642 – 46454
Turni4649 – 46524
Helixi4668 – 46703
Helixi4677 – 46793
Turni4683 – 46853
Helixi4688 – 469811
Helixi4704 – 47074
Helixi4711 – 47144
Helixi4718 – 473821
Helixi4741 – 47455
Turni4749 – 47513
Helixi4752 – 477726
Helixi4788 – 481023

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEGX-ray2.01A/B4498-4820[»]
ProteinModelPortaliQ9NR09.
SMRiQ9NR09. Positions 4521-4818.

Miscellaneous databases

EvolutionaryTraceiQ9NR09.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati284 – 35875BIR
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4576 – 4704129Ubiquitin-conjugating
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 367Poly-Ala
Compositional biasi1660 – 16689Poly-Ala

Domaini

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.1 Publication

Sequence similaritiesi

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Contains 1 BIR repeat.

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000168828.
HOVERGENiHBG050691.
InParanoidiQ9NR09.
KOiK10586.
OMAiGHVDFKF.
OrthoDBiEOG7VTDM2.
PhylomeDBiQ9NR09.
TreeFamiTF105357.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProiIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NR09-1 [UniParc]FASTAAdd to Basket

« Hide

MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGPG CSSAAGAGAA     50
GVSEWLVLRD GCMHCDADGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA 100
TLQASALSAK PGGQVKCQYI SAVDKVIFVD DYAVGCRKDL NGILLLDTAL 150
QTPVSKQDDV VQLELPVTEA QQLLSACLEK VDISSTEGYD LFITQLKDGL 200
KNTSHETAAN HKVAKWATVT FHLPHHVLKS IASAIVNELK KINQNVAALP 250
VASSVMDRLS YLLPSARPEL GVGPGRSVDR SLMYSEANRR ETFTSWPHVG 300
YRWAQPDPMA QAGFYHQPAS SGDDRAMCFT CSVCLVCWEP TDEPWSEHER 350
HSPNCPFVKG EHTQNVPLSV TLATSPAQFP CTDGTDRISC FGSGSCPHFL 400
AAATKRGKIC IWDVSKLMKV HLKFEINAYD PAIVQQLILS GDPSSGVDSR 450
RPTLAWLEDS SSCSDIPKLE GDSDDLLEDS DSEEHSRSDS VTGHTSQKEA 500
MEVSLDITAL SILQQPEKLQ WEIVANVLED TVKDLEELGA NPCLTNSKSE 550
KTKEKHQEQH NIPFPCLLAG GLLTYKSPAT SPISSNSHRS LDGLSRTQGE 600
SISEQGSTDN ESCTNSELNS PLVRRTLPVL LLYSIKESDE KAGKIFSQMN 650
NIMSKSLHDD GFTVPQIIEM ELDSQEQLLL QDPPVTYIQQ FADAAANLTS 700
PDSEKWNSVF PKPGTLVQCL RLPKFAEEEN LCIDSITPCA DGIHLLVGLR 750
TCPVESLSAI NQVEALNNLN KLNSALCNRR KGELESNLAV VNGANISVIQ 800
HESPADVQTP LIIQPEQRNV SGGYLVLYKM NYATRIVTLE EEPIKIQHIK 850
DPQDTITSLI LLPPDILDNR EDDCEEPIED MQLTSKNGFE REKTSDISTL 900
GHLVITTQGG YVKILDLSNF EILAKVEPPK KEGTEEQDTF VSVIYCSGTD 950
RLCACTKGGE LHFLQIGGTC DDIDEADILV DGSLSKGIEP SSEGSKPLSN 1000
PSSPGISGVD LLVDQPFTLE ILTSLVELTR FETLTPRFSA TVPPCWVEVQ 1050
QEQQQRRHPQ HLHQQHHGDA AQHTRTWKLQ TDSNSWDEHV FELVLPKACM 1100
VGHVDFKFVL NSNITNIPQI QVTLLKNKAP GLGKVNALNI EVEQNGKPSL 1150
VDLNEEMQHM DVEESQCLRL CPFLEDHKED ILCGPVWLAS GLDLSGHAGM 1200
LTLTSPKLVK GMAGGKYRSF LIHVKAVNER GTEEICNGGM RPVVRLPSLK 1250
HQSNKGYSLA SLLAKVAAGK EKSSNVKNEN TSGTRKSENL RGCDLLQEVS 1300
VTIRRFKKTS ISKERVQRCA MLQFSEFHEK LVNTLCRKTD DGQITEHAQS 1350
LVLDTLCWLA GVHSNGPGSS KEGNENLLSK TRKFLSDIVR VCFFEAGRSI 1400
AHKCARFLAL CISNGKCDPC QPAFGPVLLK ALLDNMSFLP AATTGGSVYW 1450
YFVLLNYVKD EDLAGCSTAC ASLLTAVSRQ LQDRLTPMEA LLQTRYGLYS 1500
SPFDPVLFDL EMSGSSCKNV YNSSIGVQSD EIDLSDVLSG NGKVSSCTAA 1550
EGSFTSLTGL LEVEPLHFTC VSTSDGTRIE RDDAMSSFGV TPAVGGLSSG 1600
TVGEASTALS SAAQVALQSL SHAMASAEQQ LQVLQEKQQQ LLKLQQQKAK 1650
LEAKLHQTTA AAAAAASAVG PVHNSVPSNP VAAPGFFIHP SDVIPPTPKT 1700
TPLFMTPPLT PPNEAVSVVI NAELAQLFPG SVIDPPAVNL AAHNKNSNKS 1750
RMNPLGSGLA LAISHASHFL QPPPHQSIII ERMHSGARRF VTLDFGRPIL 1800
LTDVLIPTCG DLASLSIDIW TLGEEVDGRR LVVATDISTH SLILHDLIPP 1850
PVCRFMKITV IGRYGSTNAR AKIPLGFYYG HTYILPWESE LKLMHDPLKG 1900
EGESANQPEI DQHLAMMVAL QEDIQCRYNL ACHRLETLLQ SIDLPPLNSA 1950
NNAQYFLRKP DKAVEEDSRV FSAYQDCIQL QLQLNLAHNA VQRLKVALGA 2000
SRKMLSETSN PEDLIQTSST EQLRTIIRYL LDTLLSLLHA SNGHSVPAVL 2050
QSTFHAQACE ELFKHLCISG TPKIRLHTGL LLVQLCGGER WWGQFLSNVL 2100
QELYNSEQLL IFPQDRVFML LSCIGQRSLS NSGVLESLLN LLDNLLSPLQ 2150
PQLPMHRRTE GVLDIPMISW VVMLVSRLLD YVATVEDEAA AAKKPLNGNQ 2200
WSFINNNLHT QSLNRSSKGS SSLDRLYSRK IRKQLVHHKQ QLNLLKAKQK 2250
ALVEQMEKEK IQSNKGSSYK LLVEQAKLKQ ATSKHFKDLI RLRRTAEWSR 2300
SNLDTEVTTA KESPEIEPLP FTLAHERCIS VVQKLVLFLL SMDFTCHADL 2350
LLFVCKVLAR IANATRPTIH LCEIVNEPQL ERLLLLLVGT DFNRGDISWG 2400
GAWAQYSLTC MLQDILAGEL LAPVAAEAME EGTVGDDVGA TAGDSDDSLQ 2450
QSSVQLLETI DEPLTHDITG APPLSSLEKD KEIDLELLQD LMEVDIDPLD 2500
IDLEKDPLAA KVFKPISSTW YDYWGADYGT YNYNPYIGGL GIPVAKPPAN 2550
TEKNGSQTVS VSVSQALDAR LEVGLEQQAE LMLKMMSTLE ADSILQALTN 2600
TSPTLSQSPT GTDDSLLGGL QAANQTSQLI IQLSSVPMLN VCFNKLFSML 2650
QVHHVQLESL LQLWLTLSLN SSSTGNKENG ADIFLYNANR IPVISLNQAS 2700
ITSFLTVLAW YPNTLLRTWC LVLHSLTLMT NMQLNSGSSS AIGTQESTAH 2750
LLVSDPNLIH VLVKFLSGTS PHGTNQHSPQ VGPTATQAMQ EFLTRLQVHL 2800
SSTCPQIFSE FLLKLIHILS TERGAFQTGQ GPLDAQVKLL EFTLEQNFEV 2850
VSVSTISAVI ESVTFLVHHY ITCSDKVMSR SGSDSSVGAR ACFGGLFANL 2900
IRPGDAKAVC GEMTRDQLMF DLLKLVNILV QLPLSGNREY SARVSVTTNT 2950
TDSVSDEEKV SGGKDGNGSS TSVQGSPAYV ADLVLANQQI MSQILSALGL 3000
CNSSAMAMII GASGLHLTKH ENFHGGLDAI SVGDGLFTIL TTLSKKASTV 3050
HMMLQPILTY MACGYMGRQG SLATCQLSEP LLWFILRVLD TSDALKAFHD 3100
MGGVQLICNN MVTSTRAIVN TARSMVSTIM KFLDSGPNKA VDSTLKTRIL 3150
ASEPDNAEGI HNFAPLGTIT SSSPTAQPAE VLLQATPPHR RARSAAWSYI 3200
FLPEEAWCDL TIHLPAAVLL KEIHIQPHLA SLATCPSSVS VEVSADGVNM 3250
LPLSTPVVTS GLTYIKIQLV KAEVASAVCL RLHRPRDAST LGLSQIKLLG 3300
LTAFGTTSSA TVNNPFLPSE DQVSKTSIGW LRLLHHCLTH ISDLEGMMAS 3350
AAAPTANLLQ TCAALLMSPY CGMHSPNIEV VLVKIGLQST RIGLKLIDIL 3400
LRNCAASGSD PTDLNSPLLF GRLNGLSSDS TIDILYQLGT TQDPGTKDRI 3450
QALLKWVSDS ARVAAMKRSG RMNYMCPNSS TVEYGLLMPS PSHLHCVAAI 3500
LWHSYELLVE YDLPALLDQE LFELLFNWSM SLPCNMVLKK AVDSLLCSMC 3550
HVHPNYFSLL MGWMGITPPP VQCHHRLSMT DDSKKQDLSS SLTDDSKNAQ 3600
APLALTESHL ATLASSSQSP EAIKQLLDSG LPSLLVRSLA SFCFSHISSS 3650
ESIAQSIDIS QDKLRRHHVP QQCNKMPITA DLVAPILRFL TEVGNSHIMK 3700
DWLGGSEVNP LWTALLFLLC HSGSTSGSHN LGAQQTSARS ASLSSAATTG 3750
LTTQQRTAIE NATVAFFLQC ISCHPNNQKL MAQVLCELFQ TSPQRGNLPT 3800
SGNISGFIRR LFLQLMLEDE KVTMFLQSPC PLYKGRINAT SHVIQHPMYG 3850
AGHKFRTLHL PVSTTLSDVL DRVSDTPSIT AKLISEQKDD KEKKNHEEKE 3900
KVKAENGFQD NYSVVVASGL KSQSKRAVSA TPPRPPSRRG RTIPDKIGST 3950
SGAEAANKII TVPVFHLFHK LLAGQPLPAE MTLAQLLTLL YDRKLPQGYR 4000
SIDLTVKLGS RVITDPSLSK TDSYKRLHPE KDHGDLLASC PEDEALTPGD 4050
ECMDGILDES LLETCPIQSP LQVFAGMGGL ALIAERLPML YPEVIQQVSA 4100
PVVTSTTQEK PKDSDQFEWV TIEQSGELVY EAPETVAAEP PPIKSAVQTM 4150
SPIPAHSLAA FGLFLRLPGY AEVLLKERKH AQCLLRLVLG VTDDGEGSHI 4200
LQSPSANVLP TLPFHVLRSL FSTTPLTTDD GVLLRRMALE IGALHLILVC 4250
LSALSHHSPR VPNSSVNQTE PQVSSSHNPT STEEQQLYWA KGTGFGTGST 4300
ASGWDVEQAL TKQRLEEEHV TCLLQVLASY INPVSSAVNG EAQSSHETRG 4350
QNSNALPSVL LELLSQSCLI PAMSSYLRND SVLDMARHVP LYRALLELLR 4400
AIASCAAMVP LLLPLSTENG EEEEEQSECQ TSVGTLLAKM KTCVDTYTNR 4450
LRSKRENVKT GVKPDASDQE PEGLTLLVPD IQKTAEIVYA ATTSLRQANQ 4500
EKKLGEYSKK AAMKPKPLSV LKSLEEKYVA VMKKLQFDTF EMVSEDEDGK 4550
LGFKVNYHYM SQVKNANDAN SAARARRLAQ EAVTLSTSLP LSSSSSVFVR 4600
CDEERLDIMK VLITGPADTP YANGCFEFDV YFPQDYPSSP PLVNLETTGG 4650
HSVRFNPNLY NDGKVCLSIL NTWHGRPEEK WNPQTSSFLQ VLVSVQSLIL 4700
VAEPYFNEPG YERSRGTPSG TQSSREYDGN IRQATVKWAM LEQIRNPSPC 4750
FKEVIHKHFY LKRVEIMAQC EEWIADIQQY SSDKRVGRTM SHHAAALKRH 4800
TAQLREELLK LPCPEGLDPD TDDAPEVCRA TTGAEETLMH DQVKPSSSKE 4850
LPSDFQL 4857
Length:4,857
Mass (Da):530,255
Last modified:November 30, 2010 - v2
Checksum:i0F5939F9C40F4270
GO

Sequence cautioni

The sequence BAA86603.2 differs from that shown. Reason: Frameshift at position 2047.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1332 – 13321V → L in AAF75772. 1 Publication
Sequence conflicti2319 – 23191L → F in BAA86603. 1 Publication
Sequence conflicti2674 – 26741T → S in AAF75772. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079837 Genomic DNA. No translation available.
AL133243 Genomic DNA. No translation available.
AL133245 Genomic DNA. No translation available.
AL133246 Genomic DNA. No translation available.
AF265555 mRNA. Translation: AAF75772.1.
AB033115 mRNA. Translation: BAA86603.2. Frameshift.
CCDSiCCDS33175.2.
RefSeqiNP_057336.3. NM_016252.3.
UniGeneiHs.150107.

Genome annotation databases

EnsembliENST00000421745; ENSP00000393596; ENSG00000115760.
GeneIDi57448.
KEGGihsa:57448.
UCSCiuc010ezu.3. human.

Polymorphism databases

DMDMi313104079.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079837 Genomic DNA. No translation available.
AL133243 Genomic DNA. No translation available.
AL133245 Genomic DNA. No translation available.
AL133246 Genomic DNA. No translation available.
AF265555 mRNA. Translation: AAF75772.1 .
AB033115 mRNA. Translation: BAA86603.2 . Frameshift.
CCDSi CCDS33175.2.
RefSeqi NP_057336.3. NM_016252.3.
UniGenei Hs.150107.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CEG X-ray 2.01 A/B 4498-4820 [» ]
ProteinModelPortali Q9NR09.
SMRi Q9NR09. Positions 4521-4818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121521. 18 interactions.
IntActi Q9NR09. 14 interactions.
STRINGi 9606.ENSP00000393596.

Protein family/group databases

MEROPSi I32.006.

PTM databases

PhosphoSitei Q9NR09.

Polymorphism databases

DMDMi 313104079.

Proteomic databases

MaxQBi Q9NR09.
PaxDbi Q9NR09.
PRIDEi Q9NR09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421745 ; ENSP00000393596 ; ENSG00000115760 .
GeneIDi 57448.
KEGGi hsa:57448.
UCSCi uc010ezu.3. human.

Organism-specific databases

CTDi 57448.
GeneCardsi GC02P032582.
H-InvDB HIX0001957.
HIX0030282.
HGNCi HGNC:13516. BIRC6.
MIMi 605638. gene.
neXtProti NX_Q9NR09.
PharmGKBi PA25363.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000168828.
HOVERGENi HBG050691.
InParanoidi Q9NR09.
KOi K10586.
OMAi GHVDFKF.
OrthoDBi EOG7VTDM2.
PhylomeDBi Q9NR09.
TreeFami TF105357.

Enzyme and pathway databases

SignaLinki Q9NR09.

Miscellaneous databases

ChiTaRSi BIRC6. human.
EvolutionaryTracei Q9NR09.
GeneWikii BIRC6.
GenomeRNAii 57448.
NextBioi 63594.
PROi Q9NR09.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NR09.
Bgeei Q9NR09.
CleanExi HS_BIRC6.
Genevestigatori Q9NR09.

Family and domain databases

Gene3Di 1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProi IPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
SMARTi SM00238. BIR. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A human IAP-family gene, apollon, expressed in human brain cancer cells."
    Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.
    Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-4857.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2063-4857.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."
    Qiu X.B., Markant S.L., Yuan J., Goldberg A.L.
    EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF41, UBIQUITINATION, FUNCTION.
  6. "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
    Bartke T., Pohl C., Pyrowolakis G., Jentsch S.
    Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION, DOMAIN BIR, INTERACTION WITH HTRA2; CASP3; CASP6; CASP7; CASP9 AND DIABLO/SMAC.
  7. "An Apollon vista of death and destruction."
    Martin S.J.
    Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
    Pohl C., Jentsch S.
    Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH KIF23/MKLP1; USP8/UBPY; BIRC5/SURVIVIN; MAP2K1/MEK1; RAB8A/RAB8; RAB11A/RAB11; PLK1; EXOC3/SEC6 AND EXOC4/SEC8.
  10. "IAPs: more than just inhibitors of apoptosis proteins."
    Dubrez-Daloz L., Dupoux A., Cartier J.
    Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
    Structural genomics consortium (SGC)
    Submitted (APR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 4498-4820.

Entry informationi

Entry nameiBIRC6_HUMAN
AccessioniPrimary (citable) accession number: Q9NR09
Secondary accession number(s): Q9ULD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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