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Q9NR09 (BIRC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Baculoviral IAP repeat-containing protein 6

EC=6.3.2.-
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name=BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name=APOLLON
Gene names
Name:BIRC6
Synonyms:KIAA1289
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4857 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Ref.5 Ref.6 Ref.9

Enzyme regulation

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. Ref.6

Subunit structure

Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Ref.5 Ref.6 Ref.9

Subcellular location

Golgi apparatustrans-Golgi network membrane. Midbody. Endosome. Cytoplasmcytoskeletonspindle pole. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. Ref.9

Tissue specificity

Expressed in brain cancer cells.

Domain

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9. Ref.6

Post-translational modification

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY. Ref.5 Ref.9

Sequence similarities

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.

Contains 1 BIR repeat.

Sequence caution

The sequence BAA86603.2 differs from that shown. Reason: Frameshift at position 2047.

Ontologies

Keywords
   Biological processApoptosis
Cell cycle
Cell division
Mitosis
Ubl conjugation pathway
   Cellular componentCytoplasm
Cytoskeleton
Endosome
Golgi apparatus
Membrane
   Molecular functionLigase
Protease inhibitor
Thiol protease inhibitor
   PTMPhosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

labyrinthine layer development

Inferred from electronic annotation. Source: Ensembl

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of apoptotic process

Inferred from mutant phenotype Ref.6. Source: UniProtKB

negative regulation of endopeptidase activity

Inferred from mutant phenotype Ref.6. Source: GOC

negative regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype Ref.5. Source: UniProtKB

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Traceable author statement Ref.9. Source: UniProtKB

protein ubiquitination

Traceable author statement Ref.9. Source: UniProtKB

regulation of cell proliferation

Traceable author statement Ref.10. Source: UniProtKB

regulation of cytokinesis

Inferred from mutant phenotype Ref.9. Source: UniProtKB

spongiotrophoblast layer development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

endosome

Inferred from direct assay Ref.9. Source: UniProtKB

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from direct assay Ref.9. Source: UniProtKB

midbody

Inferred from direct assay Ref.9. Source: UniProtKB

spindle pole

Inferred from direct assay Ref.9. Source: UniProtKB

trans-Golgi network

Inferred from direct assay Ref.9. Source: UniProtKB

   Molecular_functioncysteine-type endopeptidase inhibitor activity

Inferred from mutant phenotype Ref.6. Source: UniProtKB

ubiquitin-protein ligase activity

Inferred from direct assay Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 48574857Baculoviral IAP repeat-containing protein 6
PRO_0000122361

Regions

Repeat284 – 35875BIR
Region4576 – 4704129Ubiquitin-conjugating
Compositional bias30 – 367Poly-Ala
Compositional bias1660 – 16689Poly-Ala

Sites

Active site46251Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue4801Phosphoserine Ref.11 Ref.13 Ref.15

Experimental info

Sequence conflict13321V → L in AAF75772. Ref.2
Sequence conflict23191L → F in BAA86603. Ref.3
Sequence conflict26741T → S in AAF75772. Ref.2

Secondary structure

.............................................. 4857
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NR09 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 0F5939F9C40F4270

FASTA4,857530,255
        10         20         30         40         50         60 
MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGPG CSSAAGAGAA GVSEWLVLRD 

        70         80         90        100        110        120 
GCMHCDADGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA TLQASALSAK PGGQVKCQYI 

       130        140        150        160        170        180 
SAVDKVIFVD DYAVGCRKDL NGILLLDTAL QTPVSKQDDV VQLELPVTEA QQLLSACLEK 

       190        200        210        220        230        240 
VDISSTEGYD LFITQLKDGL KNTSHETAAN HKVAKWATVT FHLPHHVLKS IASAIVNELK 

       250        260        270        280        290        300 
KINQNVAALP VASSVMDRLS YLLPSARPEL GVGPGRSVDR SLMYSEANRR ETFTSWPHVG 

       310        320        330        340        350        360 
YRWAQPDPMA QAGFYHQPAS SGDDRAMCFT CSVCLVCWEP TDEPWSEHER HSPNCPFVKG 

       370        380        390        400        410        420 
EHTQNVPLSV TLATSPAQFP CTDGTDRISC FGSGSCPHFL AAATKRGKIC IWDVSKLMKV 

       430        440        450        460        470        480 
HLKFEINAYD PAIVQQLILS GDPSSGVDSR RPTLAWLEDS SSCSDIPKLE GDSDDLLEDS 

       490        500        510        520        530        540 
DSEEHSRSDS VTGHTSQKEA MEVSLDITAL SILQQPEKLQ WEIVANVLED TVKDLEELGA 

       550        560        570        580        590        600 
NPCLTNSKSE KTKEKHQEQH NIPFPCLLAG GLLTYKSPAT SPISSNSHRS LDGLSRTQGE 

       610        620        630        640        650        660 
SISEQGSTDN ESCTNSELNS PLVRRTLPVL LLYSIKESDE KAGKIFSQMN NIMSKSLHDD 

       670        680        690        700        710        720 
GFTVPQIIEM ELDSQEQLLL QDPPVTYIQQ FADAAANLTS PDSEKWNSVF PKPGTLVQCL 

       730        740        750        760        770        780 
RLPKFAEEEN LCIDSITPCA DGIHLLVGLR TCPVESLSAI NQVEALNNLN KLNSALCNRR 

       790        800        810        820        830        840 
KGELESNLAV VNGANISVIQ HESPADVQTP LIIQPEQRNV SGGYLVLYKM NYATRIVTLE 

       850        860        870        880        890        900 
EEPIKIQHIK DPQDTITSLI LLPPDILDNR EDDCEEPIED MQLTSKNGFE REKTSDISTL 

       910        920        930        940        950        960 
GHLVITTQGG YVKILDLSNF EILAKVEPPK KEGTEEQDTF VSVIYCSGTD RLCACTKGGE 

       970        980        990       1000       1010       1020 
LHFLQIGGTC DDIDEADILV DGSLSKGIEP SSEGSKPLSN PSSPGISGVD LLVDQPFTLE 

      1030       1040       1050       1060       1070       1080 
ILTSLVELTR FETLTPRFSA TVPPCWVEVQ QEQQQRRHPQ HLHQQHHGDA AQHTRTWKLQ 

      1090       1100       1110       1120       1130       1140 
TDSNSWDEHV FELVLPKACM VGHVDFKFVL NSNITNIPQI QVTLLKNKAP GLGKVNALNI 

      1150       1160       1170       1180       1190       1200 
EVEQNGKPSL VDLNEEMQHM DVEESQCLRL CPFLEDHKED ILCGPVWLAS GLDLSGHAGM 

      1210       1220       1230       1240       1250       1260 
LTLTSPKLVK GMAGGKYRSF LIHVKAVNER GTEEICNGGM RPVVRLPSLK HQSNKGYSLA 

      1270       1280       1290       1300       1310       1320 
SLLAKVAAGK EKSSNVKNEN TSGTRKSENL RGCDLLQEVS VTIRRFKKTS ISKERVQRCA 

      1330       1340       1350       1360       1370       1380 
MLQFSEFHEK LVNTLCRKTD DGQITEHAQS LVLDTLCWLA GVHSNGPGSS KEGNENLLSK 

      1390       1400       1410       1420       1430       1440 
TRKFLSDIVR VCFFEAGRSI AHKCARFLAL CISNGKCDPC QPAFGPVLLK ALLDNMSFLP 

      1450       1460       1470       1480       1490       1500 
AATTGGSVYW YFVLLNYVKD EDLAGCSTAC ASLLTAVSRQ LQDRLTPMEA LLQTRYGLYS 

      1510       1520       1530       1540       1550       1560 
SPFDPVLFDL EMSGSSCKNV YNSSIGVQSD EIDLSDVLSG NGKVSSCTAA EGSFTSLTGL 

      1570       1580       1590       1600       1610       1620 
LEVEPLHFTC VSTSDGTRIE RDDAMSSFGV TPAVGGLSSG TVGEASTALS SAAQVALQSL 

      1630       1640       1650       1660       1670       1680 
SHAMASAEQQ LQVLQEKQQQ LLKLQQQKAK LEAKLHQTTA AAAAAASAVG PVHNSVPSNP 

      1690       1700       1710       1720       1730       1740 
VAAPGFFIHP SDVIPPTPKT TPLFMTPPLT PPNEAVSVVI NAELAQLFPG SVIDPPAVNL 

      1750       1760       1770       1780       1790       1800 
AAHNKNSNKS RMNPLGSGLA LAISHASHFL QPPPHQSIII ERMHSGARRF VTLDFGRPIL 

      1810       1820       1830       1840       1850       1860 
LTDVLIPTCG DLASLSIDIW TLGEEVDGRR LVVATDISTH SLILHDLIPP PVCRFMKITV 

      1870       1880       1890       1900       1910       1920 
IGRYGSTNAR AKIPLGFYYG HTYILPWESE LKLMHDPLKG EGESANQPEI DQHLAMMVAL 

      1930       1940       1950       1960       1970       1980 
QEDIQCRYNL ACHRLETLLQ SIDLPPLNSA NNAQYFLRKP DKAVEEDSRV FSAYQDCIQL 

      1990       2000       2010       2020       2030       2040 
QLQLNLAHNA VQRLKVALGA SRKMLSETSN PEDLIQTSST EQLRTIIRYL LDTLLSLLHA 

      2050       2060       2070       2080       2090       2100 
SNGHSVPAVL QSTFHAQACE ELFKHLCISG TPKIRLHTGL LLVQLCGGER WWGQFLSNVL 

      2110       2120       2130       2140       2150       2160 
QELYNSEQLL IFPQDRVFML LSCIGQRSLS NSGVLESLLN LLDNLLSPLQ PQLPMHRRTE 

      2170       2180       2190       2200       2210       2220 
GVLDIPMISW VVMLVSRLLD YVATVEDEAA AAKKPLNGNQ WSFINNNLHT QSLNRSSKGS 

      2230       2240       2250       2260       2270       2280 
SSLDRLYSRK IRKQLVHHKQ QLNLLKAKQK ALVEQMEKEK IQSNKGSSYK LLVEQAKLKQ 

      2290       2300       2310       2320       2330       2340 
ATSKHFKDLI RLRRTAEWSR SNLDTEVTTA KESPEIEPLP FTLAHERCIS VVQKLVLFLL 

      2350       2360       2370       2380       2390       2400 
SMDFTCHADL LLFVCKVLAR IANATRPTIH LCEIVNEPQL ERLLLLLVGT DFNRGDISWG 

      2410       2420       2430       2440       2450       2460 
GAWAQYSLTC MLQDILAGEL LAPVAAEAME EGTVGDDVGA TAGDSDDSLQ QSSVQLLETI 

      2470       2480       2490       2500       2510       2520 
DEPLTHDITG APPLSSLEKD KEIDLELLQD LMEVDIDPLD IDLEKDPLAA KVFKPISSTW 

      2530       2540       2550       2560       2570       2580 
YDYWGADYGT YNYNPYIGGL GIPVAKPPAN TEKNGSQTVS VSVSQALDAR LEVGLEQQAE 

      2590       2600       2610       2620       2630       2640 
LMLKMMSTLE ADSILQALTN TSPTLSQSPT GTDDSLLGGL QAANQTSQLI IQLSSVPMLN 

      2650       2660       2670       2680       2690       2700 
VCFNKLFSML QVHHVQLESL LQLWLTLSLN SSSTGNKENG ADIFLYNANR IPVISLNQAS 

      2710       2720       2730       2740       2750       2760 
ITSFLTVLAW YPNTLLRTWC LVLHSLTLMT NMQLNSGSSS AIGTQESTAH LLVSDPNLIH 

      2770       2780       2790       2800       2810       2820 
VLVKFLSGTS PHGTNQHSPQ VGPTATQAMQ EFLTRLQVHL SSTCPQIFSE FLLKLIHILS 

      2830       2840       2850       2860       2870       2880 
TERGAFQTGQ GPLDAQVKLL EFTLEQNFEV VSVSTISAVI ESVTFLVHHY ITCSDKVMSR 

      2890       2900       2910       2920       2930       2940 
SGSDSSVGAR ACFGGLFANL IRPGDAKAVC GEMTRDQLMF DLLKLVNILV QLPLSGNREY 

      2950       2960       2970       2980       2990       3000 
SARVSVTTNT TDSVSDEEKV SGGKDGNGSS TSVQGSPAYV ADLVLANQQI MSQILSALGL 

      3010       3020       3030       3040       3050       3060 
CNSSAMAMII GASGLHLTKH ENFHGGLDAI SVGDGLFTIL TTLSKKASTV HMMLQPILTY 

      3070       3080       3090       3100       3110       3120 
MACGYMGRQG SLATCQLSEP LLWFILRVLD TSDALKAFHD MGGVQLICNN MVTSTRAIVN 

      3130       3140       3150       3160       3170       3180 
TARSMVSTIM KFLDSGPNKA VDSTLKTRIL ASEPDNAEGI HNFAPLGTIT SSSPTAQPAE 

      3190       3200       3210       3220       3230       3240 
VLLQATPPHR RARSAAWSYI FLPEEAWCDL TIHLPAAVLL KEIHIQPHLA SLATCPSSVS 

      3250       3260       3270       3280       3290       3300 
VEVSADGVNM LPLSTPVVTS GLTYIKIQLV KAEVASAVCL RLHRPRDAST LGLSQIKLLG 

      3310       3320       3330       3340       3350       3360 
LTAFGTTSSA TVNNPFLPSE DQVSKTSIGW LRLLHHCLTH ISDLEGMMAS AAAPTANLLQ 

      3370       3380       3390       3400       3410       3420 
TCAALLMSPY CGMHSPNIEV VLVKIGLQST RIGLKLIDIL LRNCAASGSD PTDLNSPLLF 

      3430       3440       3450       3460       3470       3480 
GRLNGLSSDS TIDILYQLGT TQDPGTKDRI QALLKWVSDS ARVAAMKRSG RMNYMCPNSS 

      3490       3500       3510       3520       3530       3540 
TVEYGLLMPS PSHLHCVAAI LWHSYELLVE YDLPALLDQE LFELLFNWSM SLPCNMVLKK 

      3550       3560       3570       3580       3590       3600 
AVDSLLCSMC HVHPNYFSLL MGWMGITPPP VQCHHRLSMT DDSKKQDLSS SLTDDSKNAQ 

      3610       3620       3630       3640       3650       3660 
APLALTESHL ATLASSSQSP EAIKQLLDSG LPSLLVRSLA SFCFSHISSS ESIAQSIDIS 

      3670       3680       3690       3700       3710       3720 
QDKLRRHHVP QQCNKMPITA DLVAPILRFL TEVGNSHIMK DWLGGSEVNP LWTALLFLLC 

      3730       3740       3750       3760       3770       3780 
HSGSTSGSHN LGAQQTSARS ASLSSAATTG LTTQQRTAIE NATVAFFLQC ISCHPNNQKL 

      3790       3800       3810       3820       3830       3840 
MAQVLCELFQ TSPQRGNLPT SGNISGFIRR LFLQLMLEDE KVTMFLQSPC PLYKGRINAT 

      3850       3860       3870       3880       3890       3900 
SHVIQHPMYG AGHKFRTLHL PVSTTLSDVL DRVSDTPSIT AKLISEQKDD KEKKNHEEKE 

      3910       3920       3930       3940       3950       3960 
KVKAENGFQD NYSVVVASGL KSQSKRAVSA TPPRPPSRRG RTIPDKIGST SGAEAANKII 

      3970       3980       3990       4000       4010       4020 
TVPVFHLFHK LLAGQPLPAE MTLAQLLTLL YDRKLPQGYR SIDLTVKLGS RVITDPSLSK 

      4030       4040       4050       4060       4070       4080 
TDSYKRLHPE KDHGDLLASC PEDEALTPGD ECMDGILDES LLETCPIQSP LQVFAGMGGL 

      4090       4100       4110       4120       4130       4140 
ALIAERLPML YPEVIQQVSA PVVTSTTQEK PKDSDQFEWV TIEQSGELVY EAPETVAAEP 

      4150       4160       4170       4180       4190       4200 
PPIKSAVQTM SPIPAHSLAA FGLFLRLPGY AEVLLKERKH AQCLLRLVLG VTDDGEGSHI 

      4210       4220       4230       4240       4250       4260 
LQSPSANVLP TLPFHVLRSL FSTTPLTTDD GVLLRRMALE IGALHLILVC LSALSHHSPR 

      4270       4280       4290       4300       4310       4320 
VPNSSVNQTE PQVSSSHNPT STEEQQLYWA KGTGFGTGST ASGWDVEQAL TKQRLEEEHV 

      4330       4340       4350       4360       4370       4380 
TCLLQVLASY INPVSSAVNG EAQSSHETRG QNSNALPSVL LELLSQSCLI PAMSSYLRND 

      4390       4400       4410       4420       4430       4440 
SVLDMARHVP LYRALLELLR AIASCAAMVP LLLPLSTENG EEEEEQSECQ TSVGTLLAKM 

      4450       4460       4470       4480       4490       4500 
KTCVDTYTNR LRSKRENVKT GVKPDASDQE PEGLTLLVPD IQKTAEIVYA ATTSLRQANQ 

      4510       4520       4530       4540       4550       4560 
EKKLGEYSKK AAMKPKPLSV LKSLEEKYVA VMKKLQFDTF EMVSEDEDGK LGFKVNYHYM 

      4570       4580       4590       4600       4610       4620 
SQVKNANDAN SAARARRLAQ EAVTLSTSLP LSSSSSVFVR CDEERLDIMK VLITGPADTP 

      4630       4640       4650       4660       4670       4680 
YANGCFEFDV YFPQDYPSSP PLVNLETTGG HSVRFNPNLY NDGKVCLSIL NTWHGRPEEK 

      4690       4700       4710       4720       4730       4740 
WNPQTSSFLQ VLVSVQSLIL VAEPYFNEPG YERSRGTPSG TQSSREYDGN IRQATVKWAM 

      4750       4760       4770       4780       4790       4800 
LEQIRNPSPC FKEVIHKHFY LKRVEIMAQC EEWIADIQQY SSDKRVGRTM SHHAAALKRH 

      4810       4820       4830       4840       4850 
TAQLREELLK LPCPEGLDPD TDDAPEVCRA TTGAEETLMH DQVKPSSSKE LPSDFQL 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"A human IAP-family gene, apollon, expressed in human brain cancer cells."
Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.
Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-4857.
Tissue: Brain.
[3]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2063-4857.
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."
Qiu X.B., Markant S.L., Yuan J., Goldberg A.L.
EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RNF41, UBIQUITINATION, FUNCTION.
[6]"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
Bartke T., Pohl C., Pyrowolakis G., Jentsch S.
Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION, DOMAIN BIR, INTERACTION WITH HTRA2; CASP3; CASP6; CASP7; CASP9 AND DIABLO/SMAC.
[7]"An Apollon vista of death and destruction."
Martin S.J.
Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
Pohl C., Jentsch S.
Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, UBIQUITINATION, DEUBIQUITINATION, INTERACTION WITH KIF23/MKLP1; USP8/UBPY; BIRC5/SURVIVIN; MAP2K1/MEK1; RAB8A/RAB8; RAB11A/RAB11; PLK1; EXOC3/SEC6 AND EXOC4/SEC8.
[10]"IAPs: more than just inhibitors of apoptosis proteins."
Dubrez-Daloz L., Dupoux A., Cartier J.
Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON FUNCTION.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
Structural genomics consortium (SGC)
Submitted (APR-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 4498-4820.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC079837 Genomic DNA. No translation available.
AL133243 Genomic DNA. No translation available.
AL133245 Genomic DNA. No translation available.
AL133246 Genomic DNA. No translation available.
AF265555 mRNA. Translation: AAF75772.1.
AB033115 mRNA. Translation: BAA86603.2. Frameshift.
RefSeqNP_057336.3. NM_016252.3.
UniGeneHs.150107.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEGX-ray2.01A/B4498-4820[»]
ProteinModelPortalQ9NR09.
SMRQ9NR09. Positions 4521-4818.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121521. 18 interactions.
IntActQ9NR09. 14 interactions.
STRING9606.ENSP00000393596.

Protein family/group databases

MEROPSI32.006.

PTM databases

PhosphoSiteQ9NR09.

Polymorphism databases

DMDM313104079.

Proteomic databases

PaxDbQ9NR09.
PRIDEQ9NR09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000421745; ENSP00000393596; ENSG00000115760.
GeneID57448.
KEGGhsa:57448.
UCSCuc010ezu.3. human.

Organism-specific databases

CTD57448.
GeneCardsGC02P032582.
H-InvDBHIX0001957.
HIX0030282.
HGNCHGNC:13516. BIRC6.
MIM605638. gene.
neXtProtNX_Q9NR09.
PharmGKBPA25363.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5078.
HOGENOMHOG000168828.
HOVERGENHBG050691.
InParanoidQ9NR09.
KOK10586.
OMAGHVDFKF.
OrthoDBEOG7VTDM2.
PhylomeDBQ9NR09.
TreeFamTF105357.

Enzyme and pathway databases

SignaLinkQ9NR09.

Gene expression databases

ArrayExpressQ9NR09.
BgeeQ9NR09.
CleanExHS_BIRC6.
GenevestigatorQ9NR09.

Family and domain databases

Gene3D1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERPTHR10044:SF77. PTHR10044:SF77. 1 hit.
PfamPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBIRC6. human.
EvolutionaryTraceQ9NR09.
GeneWikiBIRC6.
GenomeRNAi57448.
NextBio63594.
PROQ9NR09.
SOURCESearch...

Entry information

Entry nameBIRC6_HUMAN
AccessionPrimary (citable) accession number: Q9NR09
Secondary accession number(s): Q9ULD1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM