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Reviewed, UniProtKB/Swiss-Prot Q9NR09 (BIRC6_HUMAN)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Baculoviral IAP repeat-containing protein 6
Alternative name(s):
    Ubiquitin-conjugating BIR domain enzyme apollon
Gene names
Name: BIRC6
Synonyms: KIAA1289
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length4829 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May protect cells from undergoing apoptosis.

Tissue specificity

Expressed in brain cancer cells.

Sequence similarities

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.

Contains 1 BIR repeat.

Sequence caution

The sequence BAA86603.2 differs from that shown. Reason: Frameshift at position 2048.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

EXOC4Q96A652EBI-1765160,EBI-355383
KIF23Q022412EBI-1765160,EBI-306852
MAP2K1Q027501EBI-1765160,EBI-492564
PLK1P533501EBI-1765160,EBI-476768
Rab8bP610281EBI-1765160,EBI-911674From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 48294829Baculoviral IAP repeat-containing protein 6
PRO_0000122361

Regions

Repeat256 – 33075BIR
Region4548 – 4676129Ubiquitin-conjugating
Compositional bias2 – 87Poly-Ala
Compositional bias1632 – 16409Poly-Ala

Sites

Active site45971Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue4521Phosphoserine Ref.4

Experimental info

Sequence conflict22911L → F in BAA86603. Ref.2
Sequence conflict26461S → T in BAA86603. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9NR09-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C67126A672CD3653

FASTA4,829527,610
        10         20         30         40         50         60 
MAAAAAAASG PGCSSAAGAG AAGVSEWLVL RDGCMHCDAD GLHSLSYHPA LNAILAVTSR 

        70         80         90        100        110        120 
GTIKVIDGTS GATLQASALS AKPGGQVKCQ YISAVDKVIF VDDYAVGCRK DLNGILLLDT 

       130        140        150        160        170        180 
ALQTPVSKQD DVVQLELPVT EAQQLLSACL EKVDISSTEG YDLFITQLKD GLKNTSHETA 

       190        200        210        220        230        240 
ANHKVAKWAT VTFHLPHHVL KSIASAIVNE LKKINQNVAA LPVASSVMDR LSYLLPSARP 

       250        260        270        280        290        300 
ELGVGPGRSV DRSLMYSEAN RRETFTSWPH VGYRWAQPDP MAQAGFYHQP ASSGDDRAMC 

       310        320        330        340        350        360 
FTCSVCLVCW EPTDEPWSEH ERHSPNCPFV KGEHTQNVPL SVTLATSPAQ FPCTDGTDRI 

       370        380        390        400        410        420 
SCFGSGSCPH FLAAATKRGK ICIWDVSKLM KVHLKFEINA YDPAIVQQLI LSGDPSSGVD 

       430        440        450        460        470        480 
SRRPTLAWLE DSSSCSDIPK LEGDSDDLLE DSDSEEHSRS DSVTGHTSQK EAMEVSLDIT 

       490        500        510        520        530        540 
ALSILQQPEK LQWEIVANVL EDTVKDLEEL GANPCLTNSK SEKTKEKHQE QHNIPFPCLL 

       550        560        570        580        590        600 
AGGLLTYKSP ATSPISSNSH RSLDGLSRTQ GESISEQGST DNESCTNSEL NSPLVRRTLP 

       610        620        630        640        650        660 
VLLLYSIKES DEKAGKIFSQ MNNIMSKSLH DDGFTVPQII EMELDSQEQL LLQDPPVTYI 

       670        680        690        700        710        720 
QQFADAAANL TSPDSEKWNS VFPKPGTLVQ CLRLPKFAEE ENLCIDSITP CADGIHLLVG 

       730        740        750        760        770        780 
LRTCPVESLS AINQVEALNN LNKLNSALCN RRKGELESNL AVVNGANISV IQHESPADVQ 

       790        800        810        820        830        840 
TPLIIQPEQR NVSGGYLVLY KMNYATRIVT LEEEPIKIQH IKDPQDTITS LILLPPDILD 

       850        860        870        880        890        900 
NREDDCEEPI EDMQLTSKNG FEREKTSDIS TLGHLVITTQ GGYVKILDLS NFEILAKVEP 

       910        920        930        940        950        960 
PKKEGTEEQD TFVSVIYCSG TDRLCACTKG GELHFLQIGG TCDDIDEADI LVDGSLSKGI 

       970        980        990       1000       1010       1020 
EPSSEGSKPL SNPSSPGISG VDLLVDQPFT LEILTSLVEL TRFETLTPRF SATVPPCWVE 

      1030       1040       1050       1060       1070       1080 
VQQEQQQRRH PQHLHQQHHG DAAQHTRTWK LQTDSNSWDE HVFELVLPKA CMVGHVDFKF 

      1090       1100       1110       1120       1130       1140 
VLNSNITNIP QIQVTLLKNK APGLGKVNAL NIEVEQNGKP SLVDLNEEMQ HMDVEESQCL 

      1150       1160       1170       1180       1190       1200 
RLCPFLEDHK EDILCGPVWL ASGLDLSGHA GMLTLTSPKL VKGMAGGKYR SFLIHVKAVN 

      1210       1220       1230       1240       1250       1260 
ERGTEEICNG GMRPVVRLPS LKHQSNKGYS LASLLAKVAA GKEKSSNVKN ENTSGTRKSE 

      1270       1280       1290       1300       1310       1320 
NLRGCDLLQE VSVTIRRFKK TSISKERVQR CAMLQFSEFH EKLLNTLCRK TDDGQITEHA 

      1330       1340       1350       1360       1370       1380 
QSLVLDTLCW LAGVHSNGPG SSKEGNENLL SKTRKFLSDI VRVCFFEAGR SIAHKCARFL 

      1390       1400       1410       1420       1430       1440 
ALCISNGKCD PCQPAFGPVL LKALLDNMSF LPAATTGGSV YWYFVLLNYV KDEDLAGCST 

      1450       1460       1470       1480       1490       1500 
ACASLLTAVS RQLQDRLTPM EALLQTRYGL YSSPFDPVLF DLEMSGSSCK NVYNSSIGVQ 

      1510       1520       1530       1540       1550       1560 
SDEIDLSDVL SGNGKVSSCT AAEGSFTSLT GLLEVEPLHF TCVSTSDGTR IERDDAMSSF 

      1570       1580       1590       1600       1610       1620 
GVTPAVGGLS SGTVGEASTA LSSAAQVALQ SLSHAMASAE QQLQVLQEKQ QQLLKLQQQK 

      1630       1640       1650       1660       1670       1680 
AKLEAKLHQT TAAAAAAASA VGPVHNSVPS NPVAAPGFFI HPSDVIPPTP KTTPLFMTPP 

      1690       1700       1710       1720       1730       1740 
LTPPNEAVSV VINAELAQLF PGSVIDPPAV NLAAHNKNSN KSRMNPLGSG LALAISHASH 

      1750       1760       1770       1780       1790       1800 
FLQPPPHQSI IIERMHSGAR RFVTLDFGRP ILLTDVLIPT CGDLASLSID IWTLGEEVDG 

      1810       1820       1830       1840       1850       1860 
RRLVVATDIS THSLILHDLI PPPVCRFMKI TVIGRYGSTN ARAKIPLGFY YGHTYILPWE 

      1870       1880       1890       1900       1910       1920 
SELKLMHDPL KGEGESANQP EIDQHLAMMV ALQEDIQCRY NLACHRLETL LQSIDLPPLN 

      1930       1940       1950       1960       1970       1980 
SANNAQYFLR KPDKAVEEDS RVFSAYQDCI QLQLQLNLAH NAVQRLKVAL GASRKMLSET 

      1990       2000       2010       2020       2030       2040 
SNPEDLIQTS STEQLRTIIR YLLDTLLSLL HASNGHSVPA VLQSTFHAQA CEELFKHLCI 

      2050       2060       2070       2080       2090       2100 
SGTPKIRLHT GLLLVQLCGG ERWWGQFLSN VLQELYNSEQ LLIFPQDRVF MLLSCIGQRS 

      2110       2120       2130       2140       2150       2160 
LSNSGVLESL LNLLDNLLSP LQPQLPMHRR TEGVLDIPMI SWVVMLVSRL LDYVATVEDE 

      2170       2180       2190       2200       2210       2220 
AAAAKKPLNG NQWSFINNNL HTQSLNRSSK GSSSLDRLYS RKIRKQLVHH KQQLNLLKAK 

      2230       2240       2250       2260       2270       2280 
QKALVEQMEK EKIQSNKGSS YKLLVEQAKL KQATSKHFKD LIRLRRTAEW SRSNLDTEVT 

      2290       2300       2310       2320       2330       2340 
TAKESPEIEP LPFTLAHERC ISVVQKLVLF LLSMDFTCHA DLLLFVCKVL ARIANATRPT 

      2350       2360       2370       2380       2390       2400 
IHLCEIVNEP QLERLLLLLV GTDFNRGDIS WGGAWAQYSL TCMLQDILAG ELLAPVAAEA 

      2410       2420       2430       2440       2450       2460 
MEEGTVGDDV GATAGDSDDS LQQSSVQLLE TIDEPLTHDI TGAPPLSSLE KDKEIDLELL 

      2470       2480       2490       2500       2510       2520 
QDLMEVDIDP LDIDLEKDPL AAKVFKPISS TWYDYWGADY GTYNYNPYIG GLGIPVAKPP 

      2530       2540       2550       2560       2570       2580 
ANTEKNGSQT VSVSVSQALD ARLEVGLEQQ AELMLKMMST LEADSILQAL TNTSPTLSQS 

      2590       2600       2610       2620       2630       2640 
PTGTDDSLLG GLQAANQTSQ LIIQLSSVPM LNVCFNKLFS MLQVHHVQLE SLLQLWLTLS 

      2650       2660       2670       2680       2690       2700 
LNSSSSGNKE NGADIFLYNA NRIPVISLNQ ASITSFLTVL AWYPNTLLRT WCLVLHSLTL 

      2710       2720       2730       2740       2750       2760 
MTNMQLNSGS SSAIGTQEST AHLLVSDPNL IHVLVKFLSG TSPHGTNQHS PQVGPTATQA 

      2770       2780       2790       2800       2810       2820 
MQEFLTRLQV HLSSTCPQIF SEFLLKLIHI LSTERGAFQT GQGPLDAQVK LLEFTLEQNF 

      2830       2840       2850       2860       2870       2880 
EVVSVSTISA VIESVTFLVH HYITCSDKVM SRSGSDSSVG ARACFGGLFA NLIRPGDAKA 

      2890       2900       2910       2920       2930       2940 
VCGEMTRDQL MFDLLKLVNI LVQLPLSGNR EYSARVSVTT NTTDSVSDEE KVSGGKDGNG 

      2950       2960       2970       2980       2990       3000 
SSTSVQGSPA YVADLVLANQ QIMSQILSAL GLCNSSAMAM IIGASGLHLT KHENFHGGLD 

      3010       3020       3030       3040       3050       3060 
AISVGDGLFT ILTTLSKKAS TVHMMLQPIL TYMACGYMGR QGSLATCQLS EPLLWFILRV 

      3070       3080       3090       3100       3110       3120 
LDTSDALKAF HDMGGVQLIC NNMVTSTRAI VNTARSMVST IMKFLDSGPN KAVDSTLKTR 

      3130       3140       3150       3160       3170       3180 
ILASEPDNAE GIHNFAPLGT ITSSSPTAQP AEVLLQATPP HRRARSAAWS YIFLPEEAWC 

      3190       3200       3210       3220       3230       3240 
DLTIHLPAAV LLKEIHIQPH LASLATCPSS VSVEVSADGV NMLPLSTPVV TSGLTYIKIQ 

      3250       3260       3270       3280       3290       3300 
LVKAEVASAV CLRLHRPRDA STLGLSQIKL LGLTAFGTTS SATVNNPFLP SEDQVSKTSI 

      3310       3320       3330       3340       3350       3360 
GWLRLLHHCL THISDLEGMM ASAAAPTANL LQTCAALLMS PYCGMHSPNI EVVLVKIGLQ 

      3370       3380       3390       3400       3410       3420 
STRIGLKLID ILLRNCAASG SDPTDLNSPL LFGRLNGLSS DSTIDILYQL GTTQDPGTKD 

      3430       3440       3450       3460       3470       3480 
RIQALLKWVS DSARVAAMKR SGRMNYMCPN SSTVEYGLLM PSPSHLHCVA AILWHSYELL 

      3490       3500       3510       3520       3530       3540 
VEYDLPALLD QELFELLFNW SMSLPCNMVL KKAVDSLLCS MCHVHPNYFS LLMGWMGITP 

      3550       3560       3570       3580       3590       3600 
PPVQCHHRLS MTDDSKKQDL SSSLTDDSKN AQAPLALTES HLATLASSSQ SPEAIKQLLD 

      3610       3620       3630       3640       3650       3660 
SGLPSLLVRS LASFCFSHIS SSESIAQSID ISQDKLRRHH VPQQCNKMPI TADLVAPILR 

      3670       3680       3690       3700       3710       3720 
FLTEVGNSHI MKDWLGGSEV NPLWTALLFL LCHSGSTSGS HNLGAQQTSA RSASLSSAAT 

      3730       3740       3750       3760       3770       3780 
TGLTTQQRTA IENATVAFFL QCISCHPNNQ KLMAQVLCEL FQTSPQRGNL PTSGNISGFI 

      3790       3800       3810       3820       3830       3840 
RRLFLQLMLE DEKVTMFLQS PCPLYKGRIN ATSHVIQHPM YGAGHKFRTL HLPVSTTLSD 

      3850       3860       3870       3880       3890       3900 
VLDRVSDTPS ITAKLISEQK DDKEKKNHEE KEKVKAENGF QDNYSVVVAS GLKSQSKRAV 

      3910       3920       3930       3940       3950       3960 
SATPPRPPSR RGRTIPDKIG STSGAEAANK IITVPVFHLF HKLLAGQPLP AEMTLAQLLT 

      3970       3980       3990       4000       4010       4020 
LLYDRKLPQG YRSIDLTVKL GSRVITDPSL SKTDSYKRLH PEKDHGDLLA SCPEDEALTP 

      4030       4040       4050       4060       4070       4080 
GDECMDGILD ESLLETCPIQ SPLQVFAGMG GLALIAERLP MLYPEVIQQV SAPVVTSTTQ 

      4090       4100       4110       4120       4130       4140 
EKPKDSDQFE WVTIEQSGEL VYEAPETVAA EPPPIKSAVQ TMSPIPAHSL AAFGLFLRLP 

      4150       4160       4170       4180       4190       4200 
GYAEVLLKER KHAQCLLRLV LGVTDDGEGS HILQSPSANV LPTLPFHVLR SLFSTTPLTT 

      4210       4220       4230       4240       4250       4260 
DDGVLLRRMA LEIGALHLIL VCLSALSHHS PRVPNSSVNQ TEPQVSSSHN PTSTEEQQLY 

      4270       4280       4290       4300       4310       4320 
WAKGTGFGTG STASGWDVEQ ALTKQRLEEE HVTCLLQVLA SYINPVSSAV NGEAQSSHET 

      4330       4340       4350       4360       4370       4380 
RGQNSNALPS VLLELLSQSC LIPAMSSYLR NDSVLDMARH VPLYRALLEL LRAIASCAAM 

      4390       4400       4410       4420       4430       4440 
VPLLLPLSTE NGEEEEEQSE CQTSVGTLLA KMKTCVDTYT NRLRSKRENV KTGVKPDASD 

      4450       4460       4470       4480       4490       4500 
QEPEGLTLLV PDIQKTAEIV YAATTSLRQA NQEKKLGEYS KKAAMKPKPL SVLKSLEEKY 

      4510       4520       4530       4540       4550       4560 
VAVMKKLQFD TFEMVSEDED GKLGFKVNYH YMSQVKNAND ANSAARARRL AQEAVTLSTS 

      4570       4580       4590       4600       4610       4620 
LPLSSSSSVF VRCDEERLDI MKVLITGPAD TPYANGCFEF DVYFPQDYPS SPPLVNLETT 

      4630       4640       4650       4660       4670       4680 
GGHSVRFNPN LYNDGKVCLS ILNTWHGRPE EKWNPQTSSF LQVLVSVQSL ILVAEPYFNE 

      4690       4700       4710       4720       4730       4740 
PGYERSRGTP SGTQSSREYD GNIRQATVKW AMLEQIRNPS PCFKEVIHKH FYLKRVEIMA 

      4750       4760       4770       4780       4790       4800 
QCEEWIADIQ QYSSDKRVGR TMSHHAAALK RHTAQLREEL LKLPCPEGLD PDTDDAPEVC 

      4810       4820 
RATTGAEETL MHDQVKPSSS KELPSDFQL

« Hide

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References

« Hide 'large scale' references
[1]"A human IAP-family gene, apollon, expressed in human brain cancer cells."
Chen Z., Naito M., Hori S., Mashima T., Yamori T., Tsuruo T.
Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed: 10544019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2035-4829.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, MASS SPECTROMETRY.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]"Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
Structural genomics consortium (SGC)
Submitted (APR-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 4470-4792.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF265555 mRNA. Translation: AAF75772.1.
AB033115 mRNA. Translation: BAA86603.2. Frameshift.
IPIIPI00299635.
RefSeqNP_057336.3.
UniGeneHs.150107

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3CEGX-ray2.01A/B4470-4792[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ9NR09. 8 interactions.

Protein family/group databases

MEROPSI32.006.

PTM databases

PhosphoSiteQ9NR09.

Proteomic databases

PRIDEQ9NR09.

Genome annotation databases

EnsemblENSG00000115760. Homo sapiens. [Contig view]
GeneID57448.
KEGGhsa:57448.

Organism-specific databases

GeneCardsGC02P032435.
H-InvDBHIX0001957.
HIX0030282.
HGNCHGNC:13516. BIRC6.
MIM605638. gene.
PharmGKBPA25363.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9NR09.

Gene expression databases

ArrayExpressQ9NR09.
BgeeQ9NR09.
CleanExHS_BIRC6.

Family and domain databases

InterProIPR001370. Prot_inh_I32_IAP.
IPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PfamPF00653. BIR. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00238. BIR. 1 hit.
SM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS01282. BIR_REPEAT_1. False negative.
PS50143. BIR_REPEAT_2. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. False negative.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio63594.
SOURCESearch...

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Entry information

Entry nameBIRC6_HUMAN
AccessionPrimary (citable) accession number: Q9NR09
Secondary accession number(s): Q9ULD1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents