Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein C8orf4

Gene

C8orf4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May decrease apoptosis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf4
Alternative name(s):
Thyroid cancer protein 1
Short name:
TC-1
Gene namesi
Name:C8orf4
Synonyms:TC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:1357. C8orf4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25962.

Polymorphism and mutation databases

BioMutaiC8orf4.
DMDMi296434443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Uncharacterized protein C8orf4PRO_0000089605Add
BLAST

Proteomic databases

PRIDEiQ9NR00.

PTM databases

PhosphoSiteiQ9NR00.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in thyroid papillary carcinoma.1 Publication

Gene expression databases

BgeeiQ9NR00.
CleanExiHS_C8orf4.
GenevisibleiQ9NR00. HS.

Organism-specific databases

HPAiHPA027188.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi121222. 2 interactions.
IntActiQ9NR00. 1 interaction.
STRINGi9606.ENSP00000319914.

Structurei

3D structure databases

DisProtiDP00372.
ProteinModelPortaliQ9NR00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41380.
GeneTreeiENSGT00390000003458.
HOGENOMiHOG000111608.
HOVERGENiHBG054954.
InParanoidiQ9NR00.
OMAiDQDLEEK.
OrthoDBiEOG7ZGX5C.
PhylomeDBiQ9NR00.
TreeFamiTF338287.

Family and domain databases

InterProiIPR020282. Arg_vasopressin-induced_prot_1.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9NR00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER
60 70 80 90 100
LFRNSGDKKA EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK

YSIKVH
Length:106
Mass (Da):12,337
Last modified:May 18, 2010 - v2
Checksum:i2D5C93B7E1E7AE09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101V → I.2 Publications
Corresponds to variant rs6474226 [ dbSNP | Ensembl ].
VAR_050819

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268037 mRNA. Translation: AAF78961.1.
AC022733 Genomic DNA. No translation available.
BC020623 mRNA. Translation: AAH20623.1.
BC021672 mRNA. Translation: AAH21672.1.
CCDSiCCDS6115.1.
RefSeqiNP_064515.1. NM_020130.4.
UniGeneiHs.591849.
Hs.745031.

Genome annotation databases

EnsembliENST00000315792; ENSP00000319914; ENSG00000176907.
GeneIDi56892.
KEGGihsa:56892.
UCSCiuc003xnq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268037 mRNA. Translation: AAF78961.1.
AC022733 Genomic DNA. No translation available.
BC020623 mRNA. Translation: AAH20623.1.
BC021672 mRNA. Translation: AAH21672.1.
CCDSiCCDS6115.1.
RefSeqiNP_064515.1. NM_020130.4.
UniGeneiHs.591849.
Hs.745031.

3D structure databases

DisProtiDP00372.
ProteinModelPortaliQ9NR00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121222. 2 interactions.
IntActiQ9NR00. 1 interaction.
STRINGi9606.ENSP00000319914.

PTM databases

PhosphoSiteiQ9NR00.

Polymorphism and mutation databases

BioMutaiC8orf4.
DMDMi296434443.

Proteomic databases

PRIDEiQ9NR00.

Protocols and materials databases

DNASUi56892.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315792; ENSP00000319914; ENSG00000176907.
GeneIDi56892.
KEGGihsa:56892.
UCSCiuc003xnq.2. human.

Organism-specific databases

CTDi56892.
GeneCardsiGC08P040010.
HGNCiHGNC:1357. C8orf4.
HPAiHPA027188.
MIMi607702. gene.
neXtProtiNX_Q9NR00.
PharmGKBiPA25962.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41380.
GeneTreeiENSGT00390000003458.
HOGENOMiHOG000111608.
HOVERGENiHBG054954.
InParanoidiQ9NR00.
OMAiDQDLEEK.
OrthoDBiEOG7ZGX5C.
PhylomeDBiQ9NR00.
TreeFamiTF338287.

Miscellaneous databases

ChiTaRSiC8orf4. human.
GeneWikiiC8orf4.
GenomeRNAii56892.
NextBioi62311.
PROiQ9NR00.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NR00.
CleanExiHS_C8orf4.
GenevisibleiQ9NR00. HS.

Family and domain databases

InterProiIPR020282. Arg_vasopressin-induced_prot_1.
[Graphical view]
PfamiPF15063. TC1. 1 hit.
[Graphical view]
ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer."
    Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q.
    Genomics 69:342-347(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-10.
    Tissue: Thyroid papillary carcinoma.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-10.
    Tissue: Lung and Urinary bladder.
  4. "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer."
    Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K.
    Cancer Res. 64:2766-2773(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.

Entry informationi

Entry nameiCH004_HUMAN
AccessioniPrimary (citable) accession number: Q9NR00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.