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Q9NR00

- CH004_HUMAN

UniProt

Q9NR00 - CH004_HUMAN

Protein

Uncharacterized protein C8orf4

Gene

C8orf4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May decrease apoptosis.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C8orf4
    Alternative name(s):
    Thyroid cancer protein 1
    Short name:
    TC-1
    Gene namesi
    Name:C8orf4
    Synonyms:TC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1357. C8orf4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25962.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 106106Uncharacterized protein C8orf4PRO_0000089605Add
    BLAST

    Proteomic databases

    PRIDEiQ9NR00.

    PTM databases

    PhosphoSiteiQ9NR00.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in thyroid papillary carcinoma.1 Publication

    Gene expression databases

    BgeeiQ9NR00.
    CleanExiHS_C8orf4.
    GenevestigatoriQ9NR00.

    Organism-specific databases

    HPAiHPA027188.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi121222. 2 interactions.
    IntActiQ9NR00. 1 interaction.
    STRINGi9606.ENSP00000319914.

    Structurei

    3D structure databases

    DisProtiDP00372.
    ProteinModelPortaliQ9NR00.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG41380.
    HOGENOMiHOG000111608.
    HOVERGENiHBG054954.
    InParanoidiQ9NR00.
    OMAiDQDLEEK.
    OrthoDBiEOG7ZGX5C.
    PhylomeDBiQ9NR00.
    TreeFamiTF338287.

    Family and domain databases

    InterProiIPR020282. Arg_vasopressin-induced_prot_1.
    [Graphical view]
    PfamiPF15063. TC1. 1 hit.
    [Graphical view]
    ProDomiPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q9NR00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER    50
    LFRNSGDKKA EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK 100
    YSIKVH 106
    Length:106
    Mass (Da):12,337
    Last modified:May 18, 2010 - v2
    Checksum:i2D5C93B7E1E7AE09
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101V → I.2 Publications
    Corresponds to variant rs6474226 [ dbSNP | Ensembl ].
    VAR_050819

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268037 mRNA. Translation: AAF78961.1.
    AC022733 Genomic DNA. No translation available.
    BC020623 mRNA. Translation: AAH20623.1.
    BC021672 mRNA. Translation: AAH21672.1.
    CCDSiCCDS6115.1.
    RefSeqiNP_064515.1. NM_020130.4.
    UniGeneiHs.591849.
    Hs.745031.

    Genome annotation databases

    EnsembliENST00000315792; ENSP00000319914; ENSG00000176907.
    GeneIDi56892.
    KEGGihsa:56892.
    UCSCiuc003xnq.2. human.

    Polymorphism databases

    DMDMi296434443.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268037 mRNA. Translation: AAF78961.1 .
    AC022733 Genomic DNA. No translation available.
    BC020623 mRNA. Translation: AAH20623.1 .
    BC021672 mRNA. Translation: AAH21672.1 .
    CCDSi CCDS6115.1.
    RefSeqi NP_064515.1. NM_020130.4.
    UniGenei Hs.591849.
    Hs.745031.

    3D structure databases

    DisProti DP00372.
    ProteinModelPortali Q9NR00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121222. 2 interactions.
    IntActi Q9NR00. 1 interaction.
    STRINGi 9606.ENSP00000319914.

    PTM databases

    PhosphoSitei Q9NR00.

    Polymorphism databases

    DMDMi 296434443.

    Proteomic databases

    PRIDEi Q9NR00.

    Protocols and materials databases

    DNASUi 56892.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315792 ; ENSP00000319914 ; ENSG00000176907 .
    GeneIDi 56892.
    KEGGi hsa:56892.
    UCSCi uc003xnq.2. human.

    Organism-specific databases

    CTDi 56892.
    GeneCardsi GC08P040010.
    HGNCi HGNC:1357. C8orf4.
    HPAi HPA027188.
    MIMi 607702. gene.
    neXtProti NX_Q9NR00.
    PharmGKBi PA25962.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41380.
    HOGENOMi HOG000111608.
    HOVERGENi HBG054954.
    InParanoidi Q9NR00.
    OMAi DQDLEEK.
    OrthoDBi EOG7ZGX5C.
    PhylomeDBi Q9NR00.
    TreeFami TF338287.

    Miscellaneous databases

    ChiTaRSi C8orf4. human.
    GeneWikii C8orf4.
    GenomeRNAii 56892.
    NextBioi 62311.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NR00.
    CleanExi HS_C8orf4.
    Genevestigatori Q9NR00.

    Family and domain databases

    InterProi IPR020282. Arg_vasopressin-induced_prot_1.
    [Graphical view ]
    Pfami PF15063. TC1. 1 hit.
    [Graphical view ]
    ProDomi PD287216. Arg_vasopressin-induced_prot_1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer."
      Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q.
      Genomics 69:342-347(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-10.
      Tissue: Thyroid papillary carcinoma.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-10.
      Tissue: Lung and Urinary bladder.
    4. "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer."
      Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K.
      Cancer Res. 64:2766-2773(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiCH004_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3