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Q9NR00 (CH004_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C8orf4
Alternative name(s):
Thyroid cancer protein 1
Short name=TC-1
Gene names
Name:C8orf4
Synonyms:TC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May decrease apoptosis. Ref.4

Subunit structure

Monomer. Ref.4

Tissue specificity

Ubiquitous. Expressed in thyroid papillary carcinoma. Ref.1

Ontologies

Keywords
   Biological processApoptosis
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Uncharacterized protein C8orf4
PRO_0000089605

Natural variations

Natural variant101V → I. Ref.1 Ref.3
Corresponds to variant rs6474226 [ dbSNP | Ensembl ].
VAR_050819

Sequences

Sequence LengthMass (Da)Tools
Q9NR00 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 2D5C93B7E1E7AE09

FASTA10612,337
        10         20         30         40         50         60 
MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA 

        70         80         90        100 
EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer."
Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q.
Genomics 69:342-347(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-10.
Tissue: Thyroid papillary carcinoma.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-10.
Tissue: Lung and Urinary bladder.
[4]"TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer."
Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K.
Cancer Res. 64:2766-2773(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF268037 mRNA. Translation: AAF78961.1.
AC022733 Genomic DNA. No translation available.
BC020623 mRNA. Translation: AAH20623.1.
BC021672 mRNA. Translation: AAH21672.1.
RefSeqNP_064515.1. NM_020130.4.
UniGeneHs.591849.
Hs.745031.

3D structure databases

DisProtDP00372.
ProteinModelPortalQ9NR00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121222. 2 interactions.
IntActQ9NR00. 1 interaction.
STRING9606.ENSP00000319914.

PTM databases

PhosphoSiteQ9NR00.

Polymorphism databases

DMDM296434443.

Proteomic databases

PRIDEQ9NR00.

Protocols and materials databases

DNASU56892.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315792; ENSP00000319914; ENSG00000176907.
GeneID56892.
KEGGhsa:56892.
UCSCuc003xnq.2. human.

Organism-specific databases

CTD56892.
GeneCardsGC08P040010.
HGNCHGNC:1357. C8orf4.
HPAHPA027188.
MIM607702. gene.
neXtProtNX_Q9NR00.
PharmGKBPA25962.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41380.
HOGENOMHOG000111608.
HOVERGENHBG054954.
InParanoidQ9NR00.
OMADQDLEEK.
OrthoDBEOG7ZGX5C.
PhylomeDBQ9NR00.
TreeFamTF338287.

Gene expression databases

BgeeQ9NR00.
CleanExHS_C8orf4.
GenevestigatorQ9NR00.

Family and domain databases

InterProIPR020282. Arg_vasopressin-induced_prot_1.
[Graphical view]
ProDomPD287216. Arg_vasopressin-induced_prot_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSC8orf4. human.
GeneWikiC8orf4.
GenomeRNAi56892.
NextBio62311.
SOURCESearch...

Entry information

Entry nameCH004_HUMAN
AccessionPrimary (citable) accession number: Q9NR00
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM