Q9NR00 (CH004_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C8orf4

Alternative name(s):
Thyroid cancer protein 1
Short name=TC-1

Gene names

Name:	C8orf4
Synonyms:	TC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May decrease apoptosis. Ref.4
Subunit structure	Monomer. Ref.4
Tissue specificity	Ubiquitous. Expressed in thyroid papillary carcinoma. Ref.1

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Uncharacterized protein C8orf4		PRO_0000089605
Natural variations
	Natural variant	10	1	V → I. Ref.1 Ref.3 Corresponds to variant rs6474226 [ dbSNP | Ensembl ].		VAR_050819

Sequences

	Sequence		Length	Mass (Da)
	Q9NR00 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 2D5C93B7E1E7AE09	FASTA	106	12,337
	10 20 30 40 50 60 MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA 70 80 90 100 EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer." Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q. Genomics 69:342-347(2000) [PubMed: 11056052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ILE-10. Tissue: Thyroid papillary carcinoma.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-10. Tissue: Lung and Urinary bladder.
[4]	"TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer." Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K. Cancer Res. 64:2766-2773(2004) [PubMed: 15087392] [Abstract] Cited for: FUNCTION, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF268037 mRNA. Translation: AAF78961.1. AC022733 Genomic DNA. No translation available. BC020623 mRNA. Translation: AAH20623.1. BC021672 mRNA. Translation: AAH21672.1.
IPI	IPI00024500.
RefSeq	NP_064515.1. NM_020130.4.
UniGene	Hs.591849.
3D structure databases
ProteinModelPortal	Q9NR00.
DisProt	DP00372.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NR00. 1 interaction.
STRING	Q9NR00.
Polymorphism databases
DMDM	296434443.
Proteomic databases
PRIDE	Q9NR00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315792; ENSP00000319914; ENSG00000176907.
GeneID	56892.
KEGG	hsa:56892.
UCSC	uc003xnq.1. human.
Organism-specific databases
CTD	56892.
GeneCards	GC08P040010.
HGNC	HGNC:1357. C8orf4.
HPA	HPA027188.
MIM	607702. gene.
neXtProt	NX_Q9NR00.
PharmGKB	PA25962.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20688.
GeneTree	ENSGT00390000003458.
HOGENOM	HBG443562.
HOVERGEN	HBG054954.
InParanoid	Q9NR00.
OMA	DQDLEEK.
OrthoDB	EOG4D26RG.
PhylomeDB	Q9NR00.
Gene expression databases
ArrayExpress	Q9NR00.
Bgee	Q9NR00.
CleanEx	HS_C8orf4.
Genevestigator	Q9NR00.
GermOnline	ENSG00000176907. Homo sapiens.
Family and domain databases
InterPro	IPR020282. Arg_vasopressin-induced_prot_1. [Graphical view]
ProDom	PD287216. Arg_vasopressin-induced_prot_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	62311.
SOURCE	Search...

Entry information

Entry name

CH004_HUMAN

Accession

Primary (citable) accession number: Q9NR00

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.