Reviewed, UniProtKB/Swiss-Prot Q9NR00 (CH004_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C8orf4
Alternative name(s):
    Thyroid cancer protein 1
      Short name=TC-1

Gene names

Name:	C8orf4
Synonyms:	TC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May decrease apoptosis. Ref.3
Subunit structure	Monomer. Ref.3
Tissue specificity	Ubiquitous. Expressed in thyroid papillary carcinoma. Ref.1

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Uncharacterized protein C8orf4		PRO_0000089605
Natural variations
	Natural variant	10	1	I → V: dbSNP rs6474226.		VAR_050819

Sequences

	Sequence		Length	Mass (Da)
	Q9NR00-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3EF7100FDA640599	FASTA	106	12,351
	10 20 30 40 50 60 MKAKRSHQAI IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA 70 80 90 100 EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer." Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q. Genomics 69:342-347(2000) [PubMed: 11056052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Thyroid papillary carcinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Urinary bladder.
[3]	"TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer." Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K. Cancer Res. 64:2766-2773(2004) [PubMed: 15087392] [Abstract] Cited for: FUNCTION, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF268037 mRNA. Translation: AAF78961.1. BC020623 mRNA. Translation: AAH20623.1. BC021672 mRNA. Translation: AAH21672.1.
IPI	IPI00024500.
RefSeq	NP_064515.1.
UniGene	Hs.591849
3D structure databases
DisProt	DP00372.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NR00.
Proteomic databases
PRIDE	Q9NR00.
Genome annotation databases
Ensembl	ENST00000315792; ENSP00000319914; ENSG00000176907; Homo sapiens. [Genome view]
GeneID	56892.
KEGG	hsa:56892.
UCSC	uc003xnq.1. human.
Organism-specific databases
CTD	56892.
GeneCards	GC08P040130.
HGNC	HGNC:1357. C8orf4.
MIM	607702. gene.
PharmGKB	PA25962.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG443562.
HOVERGEN	Q9NR00.
InParanoid	Q9NR00.
Gene expression databases
ArrayExpress	Q9NR00.
Bgee	Q9NR00.
CleanEx	HS_C8orf4.
Genevestigator	Q9NR00.
GermOnline	ENSG00000176907. Homo sapiens.
Family and domain databases
InterPro	IPR020282. Arg_vasopressin-induced_prot_1. [Graphical view]
ProDom	PD287216. Arg_vasopressin-induced_prot_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	62311.
SOURCE	Search...

Entry information

Entry name

CH004_HUMAN

Accession

Primary (citable) accession number: Q9NR00

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2000
Last modified:	December 15, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.