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Protein

Endothelial zinc finger protein induced by tumor necrosis factor alpha

Gene

ZNF71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial zinc finger protein induced by tumor necrosis factor alpha
Alternative name(s):
Zinc finger protein 71
Gene namesi
Name:ZNF71
Synonyms:EZFIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13141. ZNF71.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58491.
OpenTargetsiENSG00000197951.
PharmGKBiPA37715.

Polymorphism and mutation databases

BioMutaiZNF71.
DMDMi21263627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473811 – 489Endothelial zinc finger protein induced by tumor necrosis factor alphaAdd BLAST489

Proteomic databases

MaxQBiQ9NQZ8.
PaxDbiQ9NQZ8.
PeptideAtlasiQ9NQZ8.
PRIDEiQ9NQZ8.

PTM databases

iPTMnetiQ9NQZ8.
PhosphoSitePlusiQ9NQZ8.

Expressioni

Tissue specificityi

Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.

Inductioni

By TNF.

Gene expression databases

BgeeiENSG00000197951.
CleanExiHS_ZNF71.
ExpressionAtlasiQ9NQZ8. baseline and differential.
GenevisibleiQ9NQZ8. HS.

Organism-specific databases

HPAiHPA018124.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM41Q8WV444EBI-7138235,EBI-725997

Protein-protein interaction databases

BioGridi121821. 42 interactors.
IntActiQ9NQZ8. 13 interactors.
MINTiMINT-8247445.
STRINGi9606.ENSP00000328245.

Structurei

3D structure databases

ProteinModelPortaliQ9NQZ8.
SMRiQ9NQZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 152C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri158 – 180C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139326.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQZ8.
OMAiCHELKAF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NQZ8.
TreeFamiTF350858.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q9NQZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG
60 70 80 90 100
DAGAEWEPLG IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG
110 120 130 140 150
ACPPVRRGKN FSSTSDLSKP PMPCEEKKTY DCSECGKAFS RSSSLIKHQR
160 170 180 190 200
IHTGEKPFEC DTCGKHFIER SSLTIHQRVH TGEKPYACGD CGKAFSQRMN
210 220 230 240 250
LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK PYACGDCGKA
260 270 280 290 300
FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC
310 320 330 340 350
KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG
360 370 380 390 400
VKPFECSECG KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH
410 420 430 440 450
QIVHTGEKPY VCGECGKAFS QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN
460 470 480
SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN LTRHLRIHT
Length:489
Mass (Da):54,498
Last modified:October 1, 2000 - v1
Checksum:i6B1156D21FF9295C
GO

Sequence cautioni

The sequence AAD23608 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05276227R → G. Corresponds to variant dbSNP:rs10405299Ensembl.1
Natural variantiVAR_024196105V → I. Corresponds to variant dbSNP:rs2072501Ensembl.1
Natural variantiVAR_052763121P → L. Corresponds to variant dbSNP:rs35392779Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269249 mRNA. Translation: AAF88036.1.
AC007228 Genomic DNA. Translation: AAD23608.1. Different initiation.
BC014280 mRNA. Translation: AAH14280.1.
X60074 Genomic DNA. Translation: CAC16174.1.
M88357 Genomic DNA. Translation: AAA61315.1.
CCDSiCCDS12947.1.
PIRiA42825.
A43284.
RefSeqiNP_067039.1. NM_021216.4.
XP_016882569.1. XM_017027080.1.
UniGeneiHs.301431.
Hs.600391.

Genome annotation databases

EnsembliENST00000328070; ENSP00000328245; ENSG00000197951.
GeneIDi58491.
KEGGihsa:58491.
UCSCiuc002qnm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF71_HUMAN
AccessioniPrimary (citable) accession number: Q9NQZ8
Secondary accession number(s): Q15919, Q9UC09, Q9UQD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families