Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelial zinc finger protein induced by tumor necrosis factor alpha

Gene

ZNF71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial zinc finger protein induced by tumor necrosis factor alpha
Alternative name(s):
Zinc finger protein 71
Gene namesi
Name:ZNF71
Synonyms:EZFIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13141. ZNF71.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37715.

Polymorphism and mutation databases

BioMutaiZNF71.
DMDMi21263627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Endothelial zinc finger protein induced by tumor necrosis factor alphaPRO_0000047381Add
BLAST

Proteomic databases

PaxDbiQ9NQZ8.
PeptideAtlasiQ9NQZ8.
PRIDEiQ9NQZ8.

PTM databases

iPTMnetiQ9NQZ8.
PhosphoSiteiQ9NQZ8.

Expressioni

Tissue specificityi

Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.

Inductioni

By TNF.

Gene expression databases

BgeeiENSG00000197951.
CleanExiHS_ZNF71.
ExpressionAtlasiQ9NQZ8. baseline and differential.
GenevisibleiQ9NQZ8. HS.

Organism-specific databases

HPAiHPA018124.

Interactioni

Protein-protein interaction databases

BioGridi121821. 39 interactions.
IntActiQ9NQZ8. 5 interactions.
MINTiMINT-8247445.
STRINGi9606.ENSP00000328245.

Structurei

3D structure databases

ProteinModelPortaliQ9NQZ8.
SMRiQ9NQZ8. Positions 90-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 15223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri158 – 18023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri186 – 20823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQZ8.
OMAiCHELKAF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NQZ8.
TreeFamiTF350858.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG
60 70 80 90 100
DAGAEWEPLG IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG
110 120 130 140 150
ACPPVRRGKN FSSTSDLSKP PMPCEEKKTY DCSECGKAFS RSSSLIKHQR
160 170 180 190 200
IHTGEKPFEC DTCGKHFIER SSLTIHQRVH TGEKPYACGD CGKAFSQRMN
210 220 230 240 250
LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK PYACGDCGKA
260 270 280 290 300
FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC
310 320 330 340 350
KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG
360 370 380 390 400
VKPFECSECG KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH
410 420 430 440 450
QIVHTGEKPY VCGECGKAFS QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN
460 470 480
SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN LTRHLRIHT
Length:489
Mass (Da):54,498
Last modified:October 1, 2000 - v1
Checksum:i6B1156D21FF9295C
GO

Sequence cautioni

The sequence AAD23608 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271R → G.
Corresponds to variant rs10405299 [ dbSNP | Ensembl ].
VAR_052762
Natural varianti105 – 1051V → I.
Corresponds to variant rs2072501 [ dbSNP | Ensembl ].
VAR_024196
Natural varianti121 – 1211P → L.
Corresponds to variant rs35392779 [ dbSNP | Ensembl ].
VAR_052763

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269249 mRNA. Translation: AAF88036.1.
AC007228 Genomic DNA. Translation: AAD23608.1. Different initiation.
BC014280 mRNA. Translation: AAH14280.1.
X60074 Genomic DNA. Translation: CAC16174.1.
M88357 Genomic DNA. Translation: AAA61315.1.
CCDSiCCDS12947.1.
PIRiA42825.
A43284.
RefSeqiNP_067039.1. NM_021216.4.
UniGeneiHs.301431.
Hs.600391.

Genome annotation databases

EnsembliENST00000328070; ENSP00000328245; ENSG00000197951.
GeneIDi58491.
KEGGihsa:58491.
UCSCiuc002qnm.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269249 mRNA. Translation: AAF88036.1.
AC007228 Genomic DNA. Translation: AAD23608.1. Different initiation.
BC014280 mRNA. Translation: AAH14280.1.
X60074 Genomic DNA. Translation: CAC16174.1.
M88357 Genomic DNA. Translation: AAA61315.1.
CCDSiCCDS12947.1.
PIRiA42825.
A43284.
RefSeqiNP_067039.1. NM_021216.4.
UniGeneiHs.301431.
Hs.600391.

3D structure databases

ProteinModelPortaliQ9NQZ8.
SMRiQ9NQZ8. Positions 90-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121821. 39 interactions.
IntActiQ9NQZ8. 5 interactions.
MINTiMINT-8247445.
STRINGi9606.ENSP00000328245.

PTM databases

iPTMnetiQ9NQZ8.
PhosphoSiteiQ9NQZ8.

Polymorphism and mutation databases

BioMutaiZNF71.
DMDMi21263627.

Proteomic databases

PaxDbiQ9NQZ8.
PeptideAtlasiQ9NQZ8.
PRIDEiQ9NQZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328070; ENSP00000328245; ENSG00000197951.
GeneIDi58491.
KEGGihsa:58491.
UCSCiuc002qnm.5. human.

Organism-specific databases

CTDi58491.
GeneCardsiZNF71.
HGNCiHGNC:13141. ZNF71.
HPAiHPA018124.
MIMi194545. gene.
neXtProtiNX_Q9NQZ8.
PharmGKBiPA37715.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQZ8.
OMAiCHELKAF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NQZ8.
TreeFamiTF350858.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF71.
GenomeRNAii58491.
PROiQ9NQZ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197951.
CleanExiHS_ZNF71.
ExpressionAtlasiQ9NQZ8. baseline and differential.
GenevisibleiQ9NQZ8. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF71_HUMAN
AccessioniPrimary (citable) accession number: Q9NQZ8
Secondary accession number(s): Q15919, Q9UC09, Q9UQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.