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Protein

Ectonucleoside triphosphate diphosphohydrolase 7

Gene

ENTPD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

Cofactori

Ca2+1 Publication, Mg2+1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.5. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 7 (EC:3.6.1.-)
Short name:
NTPDase 7
Alternative name(s):
Lysosomal apyrase-like protein 1
Gene namesi
Name:ENTPD7
Synonyms:LALP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19745. ENTPD7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence analysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 546497VesicularSequence analysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST
Topological domaini568 – 60437CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993462.

Polymorphism and mutation databases

BioMutaiENTPD7.
DMDMi74752912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Ectonucleoside triphosphate diphosphohydrolase 7PRO_0000274419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi448 ↔ 477By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NQZ7.
MaxQBiQ9NQZ7.
PaxDbiQ9NQZ7.
PeptideAtlasiQ9NQZ7.
PRIDEiQ9NQZ7.

PTM databases

iPTMnetiQ9NQZ7.
PhosphoSiteiQ9NQZ7.

Expressioni

Gene expression databases

BgeeiENSG00000198018.
CleanExiHS_ENTPD7.
ExpressionAtlasiQ9NQZ7. baseline and differential.
GenevisibleiQ9NQZ7. HS.

Organism-specific databases

HPAiCAB008667.
HPA014351.

Interactioni

Protein-protein interaction databases

BioGridi121358. 24 interactions.
STRINGi9606.ENSP00000359520.

Structurei

3D structure databases

ProteinModelPortaliQ9NQZ7.
SMRiQ9NQZ7. Positions 82-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000090205.
HOVERGENiHBG006789.
InParanoidiQ9NQZ7.
KOiK14643.
OMAiIHHRQTR.
OrthoDBiEOG091G04IV.
PhylomeDBiQ9NQZ7.
TreeFamiTF354343.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARISFSYLC PASWYFTVPT VSPFLRQRVA FLGLFFISCL LLLMLIIDFR
60 70 80 90 100
HWSASLPRDR QYERYLARVG ELEATDTEDP NLNYGLVVDC GSSGSRIFVY
110 120 130 140 150
FWPRHNGNPH DLLDIKQMRD RNSQPVVKKI KPGISAMADT PEHASDYLRP
160 170 180 190 200
LLSFAAAHVP VKKHKETPLY ILCTAGMRLL PERKQLAILA DLVKDLPLEF
210 220 230 240 250
DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDESDA EATQELAAGR
260 270 280 290 300
RRTVGILDMG GASLQIAYEV PTSTSVLPAK QEEAAKILLA EFNLGCDVQH
310 320 330 340 350
TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLNKNRLLG QKTGLSPDNP
360 370 380 390 400
FLDPCLPVGL TDVVERNSQV LHVRGRGDWV SCGAMLSPLL ARSNTSQASL
410 420 430 440 450
NGIYQSPIDF NNSEFYGFSE FFYCTEDVLR IGGRYHGPTF AKAAQDYCGM
460 470 480 490 500
AWSVLTQRFK NGLFSSHADE HRLKYQCFKS AWMYQVLHEG FHFPYDYPNL
510 520 530 540 550
RTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQEGVRQAHG SWFRLSFVYN
560 570 580 590 600
HYLFFACILV VLLAIFLYLL RLRRIHHRQT RASAPLDLLW LEEVVPMMGV

QVGP
Length:604
Mass (Da):68,960
Last modified:October 1, 2000 - v1
Checksum:i6B73997A8AB318D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti276 – 2761V → A.1 Publication
Corresponds to variant rs11190245 [ dbSNP | Ensembl ].
VAR_030287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269255 mRNA. Translation: AAF90135.1.
AK055540 mRNA. Translation: BAG51533.1.
AK314542 mRNA. Translation: BAG37130.1.
AL133353 Genomic DNA. Translation: CAI14498.1.
CH471066 Genomic DNA. Translation: EAW49861.1.
BC119008 mRNA. Translation: AAI19009.1.
BC122857 mRNA. Translation: AAI22858.1.
CCDSiCCDS7480.1.
RefSeqiNP_065087.1. NM_020354.3.
UniGeneiHs.28326.
Hs.744948.

Genome annotation databases

EnsembliENST00000370489; ENSP00000359520; ENSG00000198018.
GeneIDi57089.
KEGGihsa:57089.
UCSCiuc001kqa.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269255 mRNA. Translation: AAF90135.1.
AK055540 mRNA. Translation: BAG51533.1.
AK314542 mRNA. Translation: BAG37130.1.
AL133353 Genomic DNA. Translation: CAI14498.1.
CH471066 Genomic DNA. Translation: EAW49861.1.
BC119008 mRNA. Translation: AAI19009.1.
BC122857 mRNA. Translation: AAI22858.1.
CCDSiCCDS7480.1.
RefSeqiNP_065087.1. NM_020354.3.
UniGeneiHs.28326.
Hs.744948.

3D structure databases

ProteinModelPortaliQ9NQZ7.
SMRiQ9NQZ7. Positions 82-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121358. 24 interactions.
STRINGi9606.ENSP00000359520.

PTM databases

iPTMnetiQ9NQZ7.
PhosphoSiteiQ9NQZ7.

Polymorphism and mutation databases

BioMutaiENTPD7.
DMDMi74752912.

Proteomic databases

EPDiQ9NQZ7.
MaxQBiQ9NQZ7.
PaxDbiQ9NQZ7.
PeptideAtlasiQ9NQZ7.
PRIDEiQ9NQZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370489; ENSP00000359520; ENSG00000198018.
GeneIDi57089.
KEGGihsa:57089.
UCSCiuc001kqa.5. human.

Organism-specific databases

CTDi57089.
GeneCardsiENTPD7.
HGNCiHGNC:19745. ENTPD7.
HPAiCAB008667.
HPA014351.
MIMi616753. gene.
neXtProtiNX_Q9NQZ7.
PharmGKBiPA134993462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000090205.
HOVERGENiHBG006789.
InParanoidiQ9NQZ7.
KOiK14643.
OMAiIHHRQTR.
OrthoDBiEOG091G04IV.
PhylomeDBiQ9NQZ7.
TreeFamiTF354343.

Enzyme and pathway databases

BRENDAi3.6.1.5. 2681.

Miscellaneous databases

ChiTaRSiENTPD7. human.
GenomeRNAii57089.
PROiQ9NQZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198018.
CleanExiHS_ENTPD7.
ExpressionAtlasiQ9NQZ7. baseline and differential.
GenevisibleiQ9NQZ7. HS.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTP7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQZ7
Secondary accession number(s): B2RB83, B3KP21, D3DR64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.