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Protein

StAR-related lipid transfer protein 7, mitochondrial

Gene

STARD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a protective role in mucosal tissues by preventing exaggerated allergic responses.By similarity

GO - Molecular functioni

GO - Biological processi

  • phospholipid transport Source: GO_Central
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084090-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 7, mitochondrial
Alternative name(s):
Gestational trophoblastic tumor protein 1
START domain-containing protein 7
Short name:
StARD7
Gene namesi
Name:STARD7
Synonyms:GTT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18063. STARD7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi56910.
OpenTargetsiENSG00000084090.
PharmGKBiPA38285.

Chemistry databases

ChEMBLiCHEMBL3399912.

Polymorphism and mutation databases

BioMutaiSTARD7.
DMDMi215273945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 58MitochondrionSequence analysisAdd BLAST58
ChainiPRO_000022067459 – 370StAR-related lipid transfer protein 7, mitochondrialAdd BLAST312

Proteomic databases

EPDiQ9NQZ5.
MaxQBiQ9NQZ5.
PaxDbiQ9NQZ5.
PeptideAtlasiQ9NQZ5.
PRIDEiQ9NQZ5.

PTM databases

iPTMnetiQ9NQZ5.
PhosphoSitePlusiQ9NQZ5.

Expressioni

Tissue specificityi

Expressed in nasal epithelial cells. Down-regulated in nasal epithelial cells in patients experiencing an asthma exacerbation as compared to stable asthmatics and healthy controls.1 Publication

Gene expression databases

BgeeiENSG00000084090.
CleanExiHS_STARD7.
ExpressionAtlasiQ9NQZ5. baseline and differential.
GenevisibleiQ9NQZ5. HS.

Organism-specific databases

HPAiCAB033965.
HPA064978.

Interactioni

Protein-protein interaction databases

BioGridi121238. 20 interactors.
STRINGi9606.ENSP00000338030.

Structurei

3D structure databases

ProteinModelPortaliQ9NQZ5.
SMRiQ9NQZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 327STARTPROSITE-ProRule annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 111Sequence analysisAdd BLAST26

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2761. Eukaryota.
ENOG4111HC0. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000231824.
HOVERGENiHBG054150.
InParanoidiQ9NQZ5.
OMAiLYEYRVL.
OrthoDBiEOG091G0CQ5.
PhylomeDBiQ9NQZ5.
TreeFamiTF320705.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRRLLAAW LAGTRGGGLL ALLANQCRFV TGLRVRRAQQ IAQLYGRLYS
60 70 80 90 100
ESSRRVLLGR LWRRLHGRPG HASALMAALA GVFVWDEERI QEEELQRSIN
110 120 130 140 150
EMKRLEEMSN MFQSSGVQHH PPEPKAQTEG NEDSEGKEQR WEMVMDKKHF
160 170 180 190 200
KLWRRPITGT HLYQYRVFGT YTDVTPRQFF NVQLDTEYRK KWDALVIKLE
210 220 230 240 250
VIERDVVSGS EVLHWVTHFP YPMYSRDYVY VRRYSVDQEN NMMVLVSRAV
260 270 280 290 300
EHPSVPESPE FVRVRSYESQ MVIRPHKSFD ENGFDYLLTY SDNPQTVFPR
310 320 330 340 350
YCVSWMVSSG MPDFLEKLHM ATLKAKNMEI KVKDYISAKP LEMSSEAKAT
360 370
SQSSERKNEG SCGPARIEYA
Length:370
Mass (Da):43,113
Last modified:November 25, 2008 - v2
Checksum:i2E7CDD6CC504D86C
GO

Sequence cautioni

The sequence AAF81750 differs from that shown. Reason: Frameshift at position 53.Curated
The sequence AAH07894 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH08894 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH09998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12774 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12793 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH13279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14076 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14274 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72 – 73Missing in AAF81750 (PubMed:15013637).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020345140R → P.1 PublicationCorresponds to variant rs2276650dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270647 mRNA. Translation: AAF81750.1. Frameshift.
AC012307 Genomic DNA. Translation: AAY24223.1.
CH471207 Genomic DNA. Translation: EAW71382.1.
CH471207 Genomic DNA. Translation: EAW71383.1.
BC007894 mRNA. Translation: AAH07894.1. Different initiation.
BC008894 mRNA. Translation: AAH08894.1. Different initiation.
BC009998 mRNA. Translation: AAH09998.1. Different initiation.
BC012774 mRNA. Translation: AAH12774.1. Different initiation.
BC012793 mRNA. Translation: AAH12793.1. Different initiation.
BC013279 mRNA. Translation: AAH13279.1. Different initiation.
BC014076 mRNA. Translation: AAH14076.1. Different initiation.
BC014274 mRNA. Translation: AAH14274.3. Different initiation.
BC032106 mRNA. Translation: AAH32106.1. Different initiation.
CCDSiCCDS2017.2.
RefSeqiNP_064536.2. NM_020151.3.
UniGeneiHs.469331.

Genome annotation databases

EnsembliENST00000337288; ENSP00000338030; ENSG00000084090.
GeneIDi56910.
KEGGihsa:56910.
UCSCiuc002svm.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270647 mRNA. Translation: AAF81750.1. Frameshift.
AC012307 Genomic DNA. Translation: AAY24223.1.
CH471207 Genomic DNA. Translation: EAW71382.1.
CH471207 Genomic DNA. Translation: EAW71383.1.
BC007894 mRNA. Translation: AAH07894.1. Different initiation.
BC008894 mRNA. Translation: AAH08894.1. Different initiation.
BC009998 mRNA. Translation: AAH09998.1. Different initiation.
BC012774 mRNA. Translation: AAH12774.1. Different initiation.
BC012793 mRNA. Translation: AAH12793.1. Different initiation.
BC013279 mRNA. Translation: AAH13279.1. Different initiation.
BC014076 mRNA. Translation: AAH14076.1. Different initiation.
BC014274 mRNA. Translation: AAH14274.3. Different initiation.
BC032106 mRNA. Translation: AAH32106.1. Different initiation.
CCDSiCCDS2017.2.
RefSeqiNP_064536.2. NM_020151.3.
UniGeneiHs.469331.

3D structure databases

ProteinModelPortaliQ9NQZ5.
SMRiQ9NQZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121238. 20 interactors.
STRINGi9606.ENSP00000338030.

Chemistry databases

ChEMBLiCHEMBL3399912.

PTM databases

iPTMnetiQ9NQZ5.
PhosphoSitePlusiQ9NQZ5.

Polymorphism and mutation databases

BioMutaiSTARD7.
DMDMi215273945.

Proteomic databases

EPDiQ9NQZ5.
MaxQBiQ9NQZ5.
PaxDbiQ9NQZ5.
PeptideAtlasiQ9NQZ5.
PRIDEiQ9NQZ5.

Protocols and materials databases

DNASUi56910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337288; ENSP00000338030; ENSG00000084090.
GeneIDi56910.
KEGGihsa:56910.
UCSCiuc002svm.6. human.

Organism-specific databases

CTDi56910.
DisGeNETi56910.
GeneCardsiSTARD7.
HGNCiHGNC:18063. STARD7.
HPAiCAB033965.
HPA064978.
MIMi616712. gene.
neXtProtiNX_Q9NQZ5.
OpenTargetsiENSG00000084090.
PharmGKBiPA38285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2761. Eukaryota.
ENOG4111HC0. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000231824.
HOVERGENiHBG054150.
InParanoidiQ9NQZ5.
OMAiLYEYRVL.
OrthoDBiEOG091G0CQ5.
PhylomeDBiQ9NQZ5.
TreeFamiTF320705.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084090-MONOMER.
ReactomeiR-HSA-1483191. Synthesis of PC.

Miscellaneous databases

ChiTaRSiSTARD7. human.
GeneWikiiSTARD7.
GenomeRNAii56910.
PROiQ9NQZ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084090.
CleanExiHS_STARD7.
ExpressionAtlasiQ9NQZ5. baseline and differential.
GenevisibleiQ9NQZ5. HS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAR7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQZ5
Secondary accession number(s): D3DXG9
, Q53T44, Q6GU43, Q969M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.