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Q9NQY0 (BIN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bridging integrator 3
Gene names
Name:BIN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Subcellular location

Cytoplasmcytoskeleton.

Tissue specificity

Ubiquitously expressed except in brain. Ref.1

Sequence similarities

Contains 1 BAR domain.

Sequence caution

The sequence AAH01223.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DNMBPQ6XZF72EBI-2653038,EBI-2483419

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NQY0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NQY0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Bridging integrator 3
PRO_0000192955

Regions

Domain9 – 232224BAR
Coiled coil18 – 5134 Potential
Coiled coil120 – 15233 Potential
Coiled coil231 – 24717 Potential

Natural variations

Alternative sequence1 – 5454Missing in isoform 2.
VSP_013465

Experimental info

Sequence conflict1221N → I in BAA91603. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 254CC7113749C584

FASTA25329,665
        10         20         30         40         50         60 
MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD ADLAMSKSAV 

        70         80         90        100        110        120 
KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV NQIQKTVIEP LKKFGSVFPS 

       130        140        150        160        170        180 
LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK TGPVLAKLHQ AREELRPVRE DFEAKNRQLL 

       190        200        210        220        230        240 
EEMPRFYGSR LDYFQPSFES LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK 

       250 
LSELRALSIV ADD 

« Hide

Isoform 2 [UniParc].

Checksum: F3DE198DC4AB1EF0
Show »

FASTA19923,218

References

« Hide 'large scale' references
[1]"Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p."
Routhier E.L., Burn T.C., Abbaszade I., Summers M., Albright C.F., Prendergast G.C.
J. Biol. Chem. 276:21670-21677(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung and Skin.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF271732 mRNA. Translation: AAF76218.1.
AK001289 mRNA. Translation: BAA91603.1.
AK023980 mRNA. Translation: BAB14751.1.
BC001223 mRNA. Translation: AAH01223.1. Different initiation.
BC009824 mRNA. Translation: AAH09824.1.
CCDSCCDS47825.1. [Q9NQY0-1]
RefSeqNP_061158.1. NM_018688.4. [Q9NQY0-1]
UniGeneHs.433722.

3D structure databases

ProteinModelPortalQ9NQY0.
SMRQ9NQY0. Positions 24-219.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120995. 3 interactions.
IntActQ9NQY0. 1 interaction.
STRING9606.ENSP00000276416.

PTM databases

PhosphoSiteQ9NQY0.

Polymorphism databases

DMDM30912742.

Proteomic databases

MaxQBQ9NQY0.
PaxDbQ9NQY0.
PRIDEQ9NQY0.

Protocols and materials databases

DNASU55909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276416; ENSP00000276416; ENSG00000147439. [Q9NQY0-1]
ENST00000519513; ENSP00000430423; ENSG00000147439. [Q9NQY0-2]
GeneID55909.
KEGGhsa:55909.
UCSCuc003xcl.3. human. [Q9NQY0-1]

Organism-specific databases

CTD55909.
GeneCardsGC08M022477.
HGNCHGNC:1054. BIN3.
HPAHPA023769.
MIM606396. gene.
neXtProtNX_Q9NQY0.
PharmGKBPA25357.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264615.
HOGENOMHOG000007254.
HOVERGENHBG001358.
InParanoidQ9NQY0.
OMAKFAEEGY.
OrthoDBEOG78WKSG.
PhylomeDBQ9NQY0.
TreeFamTF331711.

Gene expression databases

ArrayExpressQ9NQY0.
BgeeQ9NQY0.
CleanExHS_BIN3.
GenevestigatorQ9NQY0.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
[Graphical view]
PfamPF03114. BAR. 1 hit.
[Graphical view]
SMARTSM00721. BAR. 1 hit.
[Graphical view]
PROSITEPS51021. BAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBIN3.
GenomeRNAi55909.
NextBio61298.
PROQ9NQY0.
SOURCESearch...

Entry information

Entry nameBIN3_HUMAN
AccessionPrimary (citable) accession number: Q9NQY0
Secondary accession number(s): Q9BVG2, Q9NVY9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM