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Q9NQY0

- BIN3_HUMAN

UniProt

Q9NQY0 - BIN3_HUMAN

Protein

Bridging integrator 3

Gene

BIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in cytokinesis and septation where it has a role in the localization of F-actin.

    GO - Molecular functioni

    1. cytoskeletal adaptor activity Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. actin filament organization Source: UniProtKB
    2. barrier septum assembly Source: UniProtKB-KW
    3. cytokinesis Source: UniProtKB
    4. protein localization Source: UniProtKB
    5. unidimensional cell growth Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Septation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bridging integrator 3
    Gene namesi
    Name:BIN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1054. BIN3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25357.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Bridging integrator 3PRO_0000192955Add
    BLAST

    Proteomic databases

    MaxQBiQ9NQY0.
    PaxDbiQ9NQY0.
    PRIDEiQ9NQY0.

    PTM databases

    PhosphoSiteiQ9NQY0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed except in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9NQY0.
    BgeeiQ9NQY0.
    CleanExiHS_BIN3.
    GenevestigatoriQ9NQY0.

    Organism-specific databases

    HPAiHPA023769.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DNMBPQ6XZF72EBI-2653038,EBI-2483419

    Protein-protein interaction databases

    BioGridi120995. 3 interactions.
    IntActiQ9NQY0. 1 interaction.
    STRINGi9606.ENSP00000276416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQY0.
    SMRiQ9NQY0. Positions 24-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 232224BARPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili18 – 5134Sequence AnalysisAdd
    BLAST
    Coiled coili120 – 15233Sequence AnalysisAdd
    BLAST
    Coiled coili231 – 24717Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG264615.
    HOGENOMiHOG000007254.
    HOVERGENiHBG001358.
    InParanoidiQ9NQY0.
    OMAiKFAEEGY.
    OrthoDBiEOG78WKSG.
    PhylomeDBiQ9NQY0.
    TreeFamiTF331711.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    [Graphical view]
    PfamiPF03114. BAR. 1 hit.
    [Graphical view]
    SMARTiSM00721. BAR. 1 hit.
    [Graphical view]
    PROSITEiPS51021. BAR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQY0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD    50
    ADLAMSKSAV KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV 100
    NQIQKTVIEP LKKFGSVFPS LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK 150
    TGPVLAKLHQ AREELRPVRE DFEAKNRQLL EEMPRFYGSR LDYFQPSFES 200
    LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK LSELRALSIV 250
    ADD 253
    Length:253
    Mass (Da):29,665
    Last modified:October 1, 2000 - v1
    Checksum:i254CC7113749C584
    GO
    Isoform 2 (identifier: Q9NQY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-54: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:199
    Mass (Da):23,218
    Checksum:iF3DE198DC4AB1EF0
    GO

    Sequence cautioni

    The sequence AAH01223.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221N → I in BAA91603. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_013465Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271732 mRNA. Translation: AAF76218.1.
    AK001289 mRNA. Translation: BAA91603.1.
    AK023980 mRNA. Translation: BAB14751.1.
    BC001223 mRNA. Translation: AAH01223.1. Different initiation.
    BC009824 mRNA. Translation: AAH09824.1.
    CCDSiCCDS47825.1. [Q9NQY0-1]
    RefSeqiNP_061158.1. NM_018688.4. [Q9NQY0-1]
    UniGeneiHs.433722.

    Genome annotation databases

    EnsembliENST00000276416; ENSP00000276416; ENSG00000147439. [Q9NQY0-1]
    ENST00000519513; ENSP00000430423; ENSG00000147439. [Q9NQY0-2]
    GeneIDi55909.
    KEGGihsa:55909.
    UCSCiuc003xcl.3. human. [Q9NQY0-1]

    Polymorphism databases

    DMDMi30912742.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271732 mRNA. Translation: AAF76218.1 .
    AK001289 mRNA. Translation: BAA91603.1 .
    AK023980 mRNA. Translation: BAB14751.1 .
    BC001223 mRNA. Translation: AAH01223.1 . Different initiation.
    BC009824 mRNA. Translation: AAH09824.1 .
    CCDSi CCDS47825.1. [Q9NQY0-1 ]
    RefSeqi NP_061158.1. NM_018688.4. [Q9NQY0-1 ]
    UniGenei Hs.433722.

    3D structure databases

    ProteinModelPortali Q9NQY0.
    SMRi Q9NQY0. Positions 24-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120995. 3 interactions.
    IntActi Q9NQY0. 1 interaction.
    STRINGi 9606.ENSP00000276416.

    PTM databases

    PhosphoSitei Q9NQY0.

    Polymorphism databases

    DMDMi 30912742.

    Proteomic databases

    MaxQBi Q9NQY0.
    PaxDbi Q9NQY0.
    PRIDEi Q9NQY0.

    Protocols and materials databases

    DNASUi 55909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276416 ; ENSP00000276416 ; ENSG00000147439 . [Q9NQY0-1 ]
    ENST00000519513 ; ENSP00000430423 ; ENSG00000147439 . [Q9NQY0-2 ]
    GeneIDi 55909.
    KEGGi hsa:55909.
    UCSCi uc003xcl.3. human. [Q9NQY0-1 ]

    Organism-specific databases

    CTDi 55909.
    GeneCardsi GC08M022477.
    HGNCi HGNC:1054. BIN3.
    HPAi HPA023769.
    MIMi 606396. gene.
    neXtProti NX_Q9NQY0.
    PharmGKBi PA25357.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264615.
    HOGENOMi HOG000007254.
    HOVERGENi HBG001358.
    InParanoidi Q9NQY0.
    OMAi KFAEEGY.
    OrthoDBi EOG78WKSG.
    PhylomeDBi Q9NQY0.
    TreeFami TF331711.

    Miscellaneous databases

    GeneWikii BIN3.
    GenomeRNAii 55909.
    NextBioi 61298.
    PROi Q9NQY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQY0.
    Bgeei Q9NQY0.
    CleanExi HS_BIN3.
    Genevestigatori Q9NQY0.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    [Graphical view ]
    Pfami PF03114. BAR. 1 hit.
    [Graphical view ]
    SMARTi SM00721. BAR. 1 hit.
    [Graphical view ]
    PROSITEi PS51021. BAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p."
      Routhier E.L., Burn T.C., Abbaszade I., Summers M., Albright C.F., Prendergast G.C.
      J. Biol. Chem. 276:21670-21677(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Skin.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBIN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQY0
    Secondary accession number(s): Q9BVG2, Q9NVY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3