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Q9NQY0

- BIN3_HUMAN

UniProt

Q9NQY0 - BIN3_HUMAN

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Protein

Bridging integrator 3

Gene

BIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and septation where it has a role in the localization of F-actin.

GO - Molecular functioni

  1. cytoskeletal adaptor activity Source: UniProtKB

GO - Biological processi

  1. actin filament organization Source: UniProtKB
  2. barrier septum assembly Source: UniProtKB-KW
  3. cytokinesis Source: UniProtKB
  4. myoblast migration involved in skeletal muscle regeneration Source: Ensembl
  5. protein localization Source: UniProtKB
  6. regulation of lamellipodium assembly Source: Ensembl
  7. skeletal muscle fiber development Source: Ensembl
  8. unidimensional cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Bridging integrator 3
Gene namesi
Name:BIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1054. BIN3.

Subcellular locationi

GO - Cellular componenti

  1. actin filament Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Bridging integrator 3PRO_0000192955Add
BLAST

Proteomic databases

MaxQBiQ9NQY0.
PaxDbiQ9NQY0.
PRIDEiQ9NQY0.

PTM databases

PhosphoSiteiQ9NQY0.

Expressioni

Tissue specificityi

Ubiquitously expressed except in brain.1 Publication

Gene expression databases

BgeeiQ9NQY0.
CleanExiHS_BIN3.
ExpressionAtlasiQ9NQY0. baseline and differential.
GenevestigatoriQ9NQY0.

Organism-specific databases

HPAiHPA023769.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DNMBPQ6XZF72EBI-2653038,EBI-2483419

Protein-protein interaction databases

BioGridi120995. 9 interactions.
IntActiQ9NQY0. 1 interaction.
STRINGi9606.ENSP00000276416.

Structurei

3D structure databases

ProteinModelPortaliQ9NQY0.
SMRiQ9NQY0. Positions 24-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 232224BARPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili18 – 5134Sequence AnalysisAdd
BLAST
Coiled coili120 – 15233Sequence AnalysisAdd
BLAST
Coiled coili231 – 24717Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG264615.
GeneTreeiENSGT00510000048076.
HOGENOMiHOG000007254.
HOVERGENiHBG001358.
InParanoidiQ9NQY0.
OMAiKFAEEGY.
OrthoDBiEOG78WKSG.
PhylomeDBiQ9NQY0.
TreeFamiTF331711.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
[Graphical view]
PROSITEiPS51021. BAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQY0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD
60 70 80 90 100
ADLAMSKSAV KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV
110 120 130 140 150
NQIQKTVIEP LKKFGSVFPS LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK
160 170 180 190 200
TGPVLAKLHQ AREELRPVRE DFEAKNRQLL EEMPRFYGSR LDYFQPSFES
210 220 230 240 250
LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK LSELRALSIV

ADD
Length:253
Mass (Da):29,665
Last modified:October 1, 2000 - v1
Checksum:i254CC7113749C584
GO
Isoform 2 (identifier: Q9NQY0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: No experimental confirmation available.

Show »
Length:199
Mass (Da):23,218
Checksum:iF3DE198DC4AB1EF0
GO

Sequence cautioni

The sequence AAH01223.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221N → I in BAA91603. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5454Missing in isoform 2. 1 PublicationVSP_013465Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271732 mRNA. Translation: AAF76218.1.
AK001289 mRNA. Translation: BAA91603.1.
AK023980 mRNA. Translation: BAB14751.1.
BC001223 mRNA. Translation: AAH01223.1. Different initiation.
BC009824 mRNA. Translation: AAH09824.1.
CCDSiCCDS47825.1. [Q9NQY0-1]
RefSeqiNP_061158.1. NM_018688.4. [Q9NQY0-1]
UniGeneiHs.433722.

Genome annotation databases

EnsembliENST00000276416; ENSP00000276416; ENSG00000147439. [Q9NQY0-1]
ENST00000519513; ENSP00000430423; ENSG00000147439. [Q9NQY0-2]
GeneIDi55909.
KEGGihsa:55909.
UCSCiuc003xcl.3. human. [Q9NQY0-1]

Polymorphism databases

DMDMi30912742.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF271732 mRNA. Translation: AAF76218.1 .
AK001289 mRNA. Translation: BAA91603.1 .
AK023980 mRNA. Translation: BAB14751.1 .
BC001223 mRNA. Translation: AAH01223.1 . Different initiation.
BC009824 mRNA. Translation: AAH09824.1 .
CCDSi CCDS47825.1. [Q9NQY0-1 ]
RefSeqi NP_061158.1. NM_018688.4. [Q9NQY0-1 ]
UniGenei Hs.433722.

3D structure databases

ProteinModelPortali Q9NQY0.
SMRi Q9NQY0. Positions 24-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120995. 9 interactions.
IntActi Q9NQY0. 1 interaction.
STRINGi 9606.ENSP00000276416.

PTM databases

PhosphoSitei Q9NQY0.

Polymorphism databases

DMDMi 30912742.

Proteomic databases

MaxQBi Q9NQY0.
PaxDbi Q9NQY0.
PRIDEi Q9NQY0.

Protocols and materials databases

DNASUi 55909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276416 ; ENSP00000276416 ; ENSG00000147439 . [Q9NQY0-1 ]
ENST00000519513 ; ENSP00000430423 ; ENSG00000147439 . [Q9NQY0-2 ]
GeneIDi 55909.
KEGGi hsa:55909.
UCSCi uc003xcl.3. human. [Q9NQY0-1 ]

Organism-specific databases

CTDi 55909.
GeneCardsi GC08M022477.
HGNCi HGNC:1054. BIN3.
HPAi HPA023769.
MIMi 606396. gene.
neXtProti NX_Q9NQY0.
PharmGKBi PA25357.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264615.
GeneTreei ENSGT00510000048076.
HOGENOMi HOG000007254.
HOVERGENi HBG001358.
InParanoidi Q9NQY0.
OMAi KFAEEGY.
OrthoDBi EOG78WKSG.
PhylomeDBi Q9NQY0.
TreeFami TF331711.

Miscellaneous databases

GeneWikii BIN3.
GenomeRNAii 55909.
NextBioi 61298.
PROi Q9NQY0.
SOURCEi Search...

Gene expression databases

Bgeei Q9NQY0.
CleanExi HS_BIN3.
ExpressionAtlasi Q9NQY0. baseline and differential.
Genevestigatori Q9NQY0.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
[Graphical view ]
Pfami PF03114. BAR. 1 hit.
[Graphical view ]
SMARTi SM00721. BAR. 1 hit.
[Graphical view ]
PROSITEi PS51021. BAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p."
    Routhier E.L., Burn T.C., Abbaszade I., Summers M., Albright C.F., Prendergast G.C.
    J. Biol. Chem. 276:21670-21677(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBIN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQY0
Secondary accession number(s): Q9BVG2, Q9NVY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3