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Protein

Bridging integrator 3

Gene

BIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and septation where it has a role in the localization of F-actin.

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB

GO - Biological processi

  • actin filament organization Source: UniProtKB
  • barrier septum assembly Source: UniProtKB-KW
  • cytokinesis Source: UniProtKB
  • myoblast migration involved in skeletal muscle regeneration Source: Ensembl
  • protein localization Source: UniProtKB
  • regulation of lamellipodium assembly Source: Ensembl
  • skeletal muscle fiber development Source: Ensembl
  • unidimensional cell growth Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Bridging integrator 3
Gene namesi
Name:BIN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147439.11.
HGNCiHGNC:1054. BIN3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147439.
PharmGKBiPA25357.

Polymorphism and mutation databases

BioMutaiBIN3.
DMDMi30912742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929551 – 253Bridging integrator 3Add BLAST253

Proteomic databases

EPDiQ9NQY0.
MaxQBiQ9NQY0.
PaxDbiQ9NQY0.
PeptideAtlasiQ9NQY0.
PRIDEiQ9NQY0.

PTM databases

iPTMnetiQ9NQY0.
PhosphoSitePlusiQ9NQY0.

Expressioni

Tissue specificityi

Ubiquitously expressed except in brain.1 Publication

Gene expression databases

BgeeiENSG00000147439.
CleanExiHS_BIN3.
ExpressionAtlasiQ9NQY0. baseline and differential.
GenevisibleiQ9NQY0. HS.

Organism-specific databases

HPAiHPA023769.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi120995. 26 interactors.
IntActiQ9NQY0. 10 interactors.
STRINGi9606.ENSP00000276416.

Structurei

3D structure databases

ProteinModelPortaliQ9NQY0.
SMRiQ9NQY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 232BARPROSITE-ProRule annotationAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili18 – 51Sequence analysisAdd BLAST34
Coiled coili120 – 152Sequence analysisAdd BLAST33
Coiled coili231 – 247Sequence analysisAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KDSE. Eukaryota.
ENOG4111K64. LUCA.
GeneTreeiENSGT00510000048076.
HOGENOMiHOG000007254.
HOVERGENiHBG001358.
InParanoidiQ9NQY0.
KOiK20120.
OMAiNDRDYEV.
OrthoDBiEOG091G0I81.
PhylomeDBiQ9NQY0.
TreeFamiTF331711.

Family and domain databases

InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
PfamiView protein in Pfam
PF03114. BAR. 1 hit.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD
60 70 80 90 100
ADLAMSKSAV KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV
110 120 130 140 150
NQIQKTVIEP LKKFGSVFPS LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK
160 170 180 190 200
TGPVLAKLHQ AREELRPVRE DFEAKNRQLL EEMPRFYGSR LDYFQPSFES
210 220 230 240 250
LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK LSELRALSIV

ADD
Length:253
Mass (Da):29,665
Last modified:October 1, 2000 - v1
Checksum:i254CC7113749C584
GO
Isoform 2 (identifier: Q9NQY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):23,218
Checksum:iF3DE198DC4AB1EF0
GO

Sequence cautioni

The sequence AAH01223 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122N → I in BAA91603 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0134651 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271732 mRNA. Translation: AAF76218.1.
AK001289 mRNA. Translation: BAA91603.1.
AK023980 mRNA. Translation: BAB14751.1.
BC001223 mRNA. Translation: AAH01223.1. Different initiation.
BC009824 mRNA. Translation: AAH09824.1.
CCDSiCCDS47825.1. [Q9NQY0-1]
RefSeqiNP_061158.1. NM_018688.4. [Q9NQY0-1]
XP_011542888.1. XM_011544586.2. [Q9NQY0-2]
UniGeneiHs.433722.

Genome annotation databases

EnsembliENST00000276416; ENSP00000276416; ENSG00000147439. [Q9NQY0-1]
ENST00000519513; ENSP00000430423; ENSG00000147439. [Q9NQY0-2]
GeneIDi55909.
KEGGihsa:55909.
UCSCiuc003xcl.5. human. [Q9NQY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBIN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQY0
Secondary accession number(s): Q9BVG2, Q9NVY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot