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Q9NQX7

- ITM2C_HUMAN

UniProt

Q9NQX7 - ITM2C_HUMAN

Protein

Integral membrane protein 2C

Gene

ITM2C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei242 – 2432Cleavage; by furin

    GO - Molecular functioni

    1. ATP binding Source: Ensembl
    2. beta-amyloid binding Source: BHF-UCL
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of neuron projection development Source: UniProtKB
    2. neuron differentiation Source: UniProtKB
    3. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integral membrane protein 2C
    Alternative name(s):
    Cerebral protein 14
    Transmembrane protein BRI3
    Cleaved into the following chain:
    Gene namesi
    Name:ITM2C
    Synonyms:BRI3
    ORF Names:hucep-14, NPD018, PSEC0047
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6175. ITM2C.

    Subcellular locationi

    Lysosome membrane By similarity; Single-pass type II membrane protein By similarity. Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: LIFEdb
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosomal membrane Source: UniProtKB-SubCell
    5. lysosome Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Lysosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi241 – 2422KR → AA: Completely abrogates proteolytic processing. 1 Publication

    Organism-specific databases

    PharmGKBiPA29972.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Integral membrane protein 2CPRO_0000154826Add
    BLAST
    Peptidei243 – 26725CT-BRI3PRO_0000232645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi163 ↔ 222By similarity
    Glycosylationi169 – 1691N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9NQX7.
    PaxDbiQ9NQX7.
    PRIDEiQ9NQX7.

    PTM databases

    PhosphoSiteiQ9NQX7.

    Expressioni

    Tissue specificityi

    High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.2 Publications

    Gene expression databases

    ArrayExpressiQ9NQX7.
    BgeeiQ9NQX7.
    CleanExiHS_BRI3.
    HS_ITM2C.
    GenevestigatoriQ9NQX7.

    Interactioni

    Subunit structurei

    Interacts with BACE1. Interacts with APP. Interacts with STMN2.3 Publications

    Protein-protein interaction databases

    BioGridi123553. 4 interactions.
    IntActiQ9NQX7. 4 interactions.
    MINTiMINT-4724210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 23095BRICHOSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ITM2 family.Curated
    Contains 1 BRICHOS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283703.
    HOVERGENiHBG059373.
    InParanoidiQ9NQX7.
    KOiK18265.
    OMAiCSGKETY.
    PhylomeDBiQ9NQX7.
    TreeFamiTF317770.

    Family and domain databases

    InterProiIPR007084. BRICHOS_dom.
    [Graphical view]
    PfamiPF04089. BRICHOS. 1 hit.
    [Graphical view]
    SMARTiSM01039. BRICHOS. 1 hit.
    [Graphical view]
    PROSITEiPS50869. BRICHOS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK    50
    RGGSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY 100
    EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR 150
    GLTAYHDISL DKCYVIELNT TIVLPPRNFW ELLMNVKRGT YLPQTYIIQE 200
    EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN KRGAKNCNAI 250
    RHFENTFVVE TLICGVV 267
    Length:267
    Mass (Da):30,224
    Last modified:October 1, 2000 - v1
    Checksum:i234DDB91B4F282E7
    GO
    Isoform 2 (identifier: Q9NQX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-87: Missing.

    Show »
    Length:220
    Mass (Da):24,956
    Checksum:i9C16C85BD37BA9CC
    GO
    Isoform 3 (identifier: Q9NQX7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-187: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:230
    Mass (Da):25,921
    Checksum:i6C8BF583B61C58D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 3918Missing in BAC03562. (PubMed:14702039)CuratedAdd
    BLAST
    Sequence conflicti133 – 1331V → A in BAD96417. 1 PublicationCurated
    Sequence conflicti205 – 2051T → A in CAG33489. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531G → S.5 Publications
    Corresponds to variant rs2289235 [ dbSNP | Ensembl ].
    VAR_022111

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei41 – 8747Missing in isoform 2. 2 PublicationsVSP_013471Add
    BLAST
    Alternative sequencei151 – 18737Missing in isoform 3. 1 PublicationVSP_013472Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003629 mRNA. Translation: BAB46927.1.
    AF272043 mRNA. Translation: AAF89492.1.
    AY049777 mRNA. Translation: AAL15434.1.
    AF271781 mRNA. Translation: AAG44792.1.
    AL136603 mRNA. Translation: CAB66538.1.
    AK056321 mRNA. Translation: BAG51676.1.
    AK090975 mRNA. Translation: BAC03562.1.
    CR457208 mRNA. Translation: CAG33489.1.
    AK222697 mRNA. Translation: BAD96417.1.
    AK075361 mRNA. Translation: BAC11570.1.
    AL713651 mRNA. Translation: CAD28460.1.
    CH471063 Genomic DNA. Translation: EAW70936.1.
    BC002424 mRNA. Translation: AAH02424.1.
    BC025742 mRNA. Translation: AAH25742.1.
    BC050668 mRNA. Translation: AAH50668.1.
    BC098563 mRNA. Translation: AAH98563.1.
    CCDSiCCDS2479.1. [Q9NQX7-1]
    CCDS33395.1. [Q9NQX7-3]
    CCDS33396.1. [Q9NQX7-2]
    RefSeqiNP_001012532.1. NM_001012514.2. [Q9NQX7-2]
    NP_001012534.1. NM_001012516.2. [Q9NQX7-3]
    NP_001274169.1. NM_001287240.1.
    NP_001274170.1. NM_001287241.1. [Q9NQX7-1]
    NP_112188.1. NM_030926.5. [Q9NQX7-1]
    UniGeneiHs.111577.

    Genome annotation databases

    EnsembliENST00000326407; ENSP00000322100; ENSG00000135916. [Q9NQX7-3]
    ENST00000326427; ENSP00000322730; ENSG00000135916. [Q9NQX7-1]
    ENST00000335005; ENSP00000335121; ENSG00000135916. [Q9NQX7-2]
    GeneIDi81618.
    KEGGihsa:81618.
    UCSCiuc002vqz.3. human. [Q9NQX7-1]
    uc002vra.3. human. [Q9NQX7-2]
    uc002vrb.3. human. [Q9NQX7-3]

    Polymorphism databases

    DMDMi12585259.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003629 mRNA. Translation: BAB46927.1 .
    AF272043 mRNA. Translation: AAF89492.1 .
    AY049777 mRNA. Translation: AAL15434.1 .
    AF271781 mRNA. Translation: AAG44792.1 .
    AL136603 mRNA. Translation: CAB66538.1 .
    AK056321 mRNA. Translation: BAG51676.1 .
    AK090975 mRNA. Translation: BAC03562.1 .
    CR457208 mRNA. Translation: CAG33489.1 .
    AK222697 mRNA. Translation: BAD96417.1 .
    AK075361 mRNA. Translation: BAC11570.1 .
    AL713651 mRNA. Translation: CAD28460.1 .
    CH471063 Genomic DNA. Translation: EAW70936.1 .
    BC002424 mRNA. Translation: AAH02424.1 .
    BC025742 mRNA. Translation: AAH25742.1 .
    BC050668 mRNA. Translation: AAH50668.1 .
    BC098563 mRNA. Translation: AAH98563.1 .
    CCDSi CCDS2479.1. [Q9NQX7-1 ]
    CCDS33395.1. [Q9NQX7-3 ]
    CCDS33396.1. [Q9NQX7-2 ]
    RefSeqi NP_001012532.1. NM_001012514.2. [Q9NQX7-2 ]
    NP_001012534.1. NM_001012516.2. [Q9NQX7-3 ]
    NP_001274169.1. NM_001287240.1.
    NP_001274170.1. NM_001287241.1. [Q9NQX7-1 ]
    NP_112188.1. NM_030926.5. [Q9NQX7-1 ]
    UniGenei Hs.111577.

    3D structure databases

    ProteinModelPortali Q9NQX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123553. 4 interactions.
    IntActi Q9NQX7. 4 interactions.
    MINTi MINT-4724210.

    PTM databases

    PhosphoSitei Q9NQX7.

    Polymorphism databases

    DMDMi 12585259.

    Proteomic databases

    MaxQBi Q9NQX7.
    PaxDbi Q9NQX7.
    PRIDEi Q9NQX7.

    Protocols and materials databases

    DNASUi 81618.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326407 ; ENSP00000322100 ; ENSG00000135916 . [Q9NQX7-3 ]
    ENST00000326427 ; ENSP00000322730 ; ENSG00000135916 . [Q9NQX7-1 ]
    ENST00000335005 ; ENSP00000335121 ; ENSG00000135916 . [Q9NQX7-2 ]
    GeneIDi 81618.
    KEGGi hsa:81618.
    UCSCi uc002vqz.3. human. [Q9NQX7-1 ]
    uc002vra.3. human. [Q9NQX7-2 ]
    uc002vrb.3. human. [Q9NQX7-3 ]

    Organism-specific databases

    CTDi 81618.
    GeneCardsi GC02P231729.
    HGNCi HGNC:6175. ITM2C.
    MIMi 609554. gene.
    neXtProti NX_Q9NQX7.
    PharmGKBi PA29972.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283703.
    HOVERGENi HBG059373.
    InParanoidi Q9NQX7.
    KOi K18265.
    OMAi CSGKETY.
    PhylomeDBi Q9NQX7.
    TreeFami TF317770.

    Miscellaneous databases

    ChiTaRSi ITM2C. human.
    GeneWikii ITM2C.
    GenomeRNAii 81618.
    NextBioi 71968.
    PROi Q9NQX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQX7.
    Bgeei Q9NQX7.
    CleanExi HS_BRI3.
    HS_ITM2C.
    Genevestigatori Q9NQX7.

    Family and domain databases

    InterProi IPR007084. BRICHOS_dom.
    [Graphical view ]
    Pfami PF04089. BRICHOS. 1 hit.
    [Graphical view ]
    SMARTi SM01039. BRICHOS. 1 hit.
    [Graphical view ]
    PROSITEi PS50869. BRICHOS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a gene specifically expressed in human brain."
      Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-53.
      Tissue: Brain.
    2. "Sequence, genomic structure and tissue expression of human BRI3, a member of the BRI gene family."
      Vidal R., Calero M., Revesz T., Plant G., Ghiso J., Frangione B.
      Gene 266:95-102(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. Wu J., Zhang B., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-53.
      Tissue: Amygdala.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-53.
    8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-53.
      Tissue: Uterus.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT SER-53.
      Tissue: Brain, Chondrosarcoma and Colon.
    13. "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin."
      Wickham L., Benjannet S., Marcinkiewicz E., Chretien M., Seidah N.G.
      J. Neurochem. 92:93-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BACE1, GLYCOSYLATION, CLEAVAGE, TISSUE SPECIFICITY, MUTAGENESIS OF 241-LYS-ARG-242.
    14. "BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells."
      Gong Y., Wu J., Qiang H., Liu B., Chi Z., Chen T., Yin B., Peng X., Yuan J.
      BMB Rep. 41:287-293(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STMN2.
    15. "Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis."
      Martin L., Fluhrer R., Haass C.
      J. Biol. Chem. 284:5662-5670(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF CLEAVAGE BY ADAM10 AND SPPL2B, SUBCELLULAR LOCATION.
    16. "BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2."
      Matsuda S., Matsuda Y., D'Adamio L.
      J. Biol. Chem. 284:15815-15825(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH APP.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiITM2C_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQX7
    Secondary accession number(s): B3KPG4
    , Q4G0A8, Q53H84, Q6IAE7, Q86VK5, Q8N288, Q8TAW0, Q9BUP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3