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Q9NQX6 (ZN331_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 331
Alternative name(s):
C2H2-like zinc finger protein rearranged in thyroid adenomas
Zinc finger protein 361
Zinc finger protein 463
Gene names
Name:ZNF331
Synonyms:RITA, ZNF361, ZNF463
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Subcellular location

Nucleus Potential.

Tissue specificity

Testis specific.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Zinc finger protein 331
PRO_0000047535

Regions

Domain6 – 7873KRAB
Zinc finger131 – 15323C2H2-type 1
Zinc finger159 – 18123C2H2-type 2
Zinc finger187 – 20923C2H2-type 3
Zinc finger215 – 23723C2H2-type 4
Zinc finger243 – 26523C2H2-type 5
Zinc finger271 – 29323C2H2-type 6
Zinc finger299 – 32123C2H2-type 7
Zinc finger327 – 34923C2H2-type 8
Zinc finger355 – 37723C2H2-type 9
Zinc finger383 – 40523C2H2-type 10
Zinc finger411 – 43323C2H2-type 11
Zinc finger439 – 46123C2H2-type 12

Experimental info

Sequence conflict591E → K in AAH09433. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NQX6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A9DB42D0870A7767

FASTA46353,739
        10         20         30         40         50         60 
MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA YENKSLPTEK 

        70         80         90        100        110        120 
NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV NQMIINYVKR PATREGTPPR 

       130        140        150        160        170        180 
THQRHHKENS FECKDCGKAF SRGYQLSQHQ KIHTGEKPYE CKECKKAFRW GNQLTQHQKI 

       190        200        210        220        230        240 
HTGEKPYECK DCGKAFRWGS SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE 

       250        260        270        280        290        300 
KDYECKDCGK TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE 

       310        320        330        340        350        360 
CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT GEKPYKCTEC 

       370        380        390        400        410        420 
GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK HERIHTGVKP YGCTECGKSF 

       430        440        450        460 
SHGHQLTQHQ KTHSGAKSYE CKECGKACNH LNHLREHQRI HNS 

« Hide

References

« Hide 'large scale' references
[1]"A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors."
Rippe V., Belge G., Meiboom M., Kazmierczak B., Fusco A., Bullerdiek J.
Genes Chromosomes Cancer 26:229-236(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463."
Wu H., Zhang S., Qiu W., Zhang G., Xia Q., Xiao C., Huang X., Huang M., Agen P., Fan T., Yang J., Milunsky A.
Biochim. Biophys. Acta 1518:190-193(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF272148 mRNA. Translation: AAF78075.1.
AF251515 mRNA. Translation: AAF70179.2.
BC009433 mRNA. Translation: AAH09433.1.
CCDSCCDS33102.1.
RefSeqNP_001073375.1. NM_001079906.1.
NP_001073376.1. NM_001079907.1.
NP_001240727.1. NM_001253798.1.
NP_001240728.1. NM_001253799.1.
NP_001240729.1. NM_001253800.1.
NP_001240730.1. NM_001253801.1.
NP_061025.5. NM_018555.5.
XP_005259097.1. XM_005259040.1.
XP_006723322.1. XM_006723259.1.
UniGeneHs.185674.

3D structure databases

ProteinModelPortalQ9NQX6.
SMRQ9NQX6. Positions 77-461.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120663. 11 interactions.
IntActQ9NQX6. 9 interactions.
MINTMINT-8247397.
STRING9606.ENSP00000253144.

PTM databases

PhosphoSiteQ9NQX6.

Polymorphism databases

DMDM34925661.

Proteomic databases

PaxDbQ9NQX6.
PRIDEQ9NQX6.

Protocols and materials databases

DNASU55422.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253144; ENSP00000253144; ENSG00000130844.
ENST00000411977; ENSP00000393336; ENSG00000130844.
ENST00000449416; ENSP00000393817; ENSG00000130844.
ENST00000511154; ENSP00000421014; ENSG00000130844.
ENST00000511593; ENSP00000427439; ENSG00000130844.
ENST00000512387; ENSP00000421728; ENSG00000130844.
ENST00000513999; ENSP00000423156; ENSG00000130844.
GeneID55422.
KEGGhsa:55422.
UCSCuc002qbx.1. human.

Organism-specific databases

CTD55422.
GeneCardsGC19P054024.
HGNCHGNC:15489. ZNF331.
HPAHPA053616.
MIM606043. gene.
neXtProtNX_Q9NQX6.
PharmGKBPA134866703.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9NQX6.
KOK09228.
OMAKAFSHGH.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9NQX6.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9NQX6.
BgeeQ9NQX6.
CleanExHS_ZNF331.
GenevestigatorQ9NQX6.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF331. human.
GeneWikiZNF331.
GenomeRNAi55422.
NextBio59806.
PROQ9NQX6.
SOURCESearch...

Entry information

Entry nameZN331_HUMAN
AccessionPrimary (citable) accession number: Q9NQX6
Secondary accession number(s): Q96GJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM