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Protein

Zinc finger protein 331

Gene

ZNF331

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 15323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 331
Alternative name(s):
C2H2-like zinc finger protein rearranged in thyroid adenomas
Zinc finger protein 361
Zinc finger protein 463
Gene namesi
Name:ZNF331
Synonyms:RITA, ZNF361, ZNF463
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15489. ZNF331.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866703.

Polymorphism and mutation databases

BioMutaiZNF331.
DMDMi34925661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Zinc finger protein 331PRO_0000047535Add
BLAST

Proteomic databases

PaxDbiQ9NQX6.
PRIDEiQ9NQX6.

PTM databases

PhosphoSiteiQ9NQX6.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9NQX6.
CleanExiHS_ZNF331.
ExpressionAtlasiQ9NQX6. baseline and differential.
GenevisibleiQ9NQX6. HS.

Interactioni

Protein-protein interaction databases

BioGridi120663. 9 interactions.
IntActiQ9NQX6. 9 interactions.
MINTiMINT-8247397.
STRINGi9606.ENSP00000253144.

Structurei

3D structure databases

ProteinModelPortaliQ9NQX6.
SMRiQ9NQX6. Positions 77-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 15323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124032.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQX6.
KOiK09228.
OMAiKAFSHGH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NQX6.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA
60 70 80 90 100
YENKSLPTEK NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV
110 120 130 140 150
NQMIINYVKR PATREGTPPR THQRHHKENS FECKDCGKAF SRGYQLSQHQ
160 170 180 190 200
KIHTGEKPYE CKECKKAFRW GNQLTQHQKI HTGEKPYECK DCGKAFRWGS
210 220 230 240 250
SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE KDYECKDCGK
260 270 280 290 300
TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE
310 320 330 340 350
CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT
360 370 380 390 400
GEKPYKCTEC GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK
410 420 430 440 450
HERIHTGVKP YGCTECGKSF SHGHQLTQHQ KTHSGAKSYE CKECGKACNH
460
LNHLREHQRI HNS
Length:463
Mass (Da):53,739
Last modified:October 1, 2000 - v1
Checksum:iA9DB42D0870A7767
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591E → K in AAH09433 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272148 mRNA. Translation: AAF78075.1.
AF251515 mRNA. Translation: AAF70179.2.
BC009433 mRNA. Translation: AAH09433.1.
CCDSiCCDS33102.1.
RefSeqiNP_001073375.1. NM_001079906.1.
NP_001073376.1. NM_001079907.1.
NP_001240727.1. NM_001253798.1.
NP_001240728.1. NM_001253799.1.
NP_001240729.1. NM_001253800.1.
NP_001240730.1. NM_001253801.1.
NP_061025.5. NM_018555.5.
XP_005259097.1. XM_005259040.1.
XP_011525376.1. XM_011527074.1.
XP_011525377.1. XM_011527075.1.
XP_011525378.1. XM_011527076.1.
XP_011525379.1. XM_011527077.1.
XP_011525380.1. XM_011527078.1.
XP_011525381.1. XM_011527079.1.
XP_011525382.1. XM_011527080.1.
XP_011525383.1. XM_011527081.1.
XP_011525384.1. XM_011527082.1.
UniGeneiHs.185674.

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844.
ENST00000411977; ENSP00000393336; ENSG00000130844.
ENST00000449416; ENSP00000393817; ENSG00000130844.
ENST00000511154; ENSP00000421014; ENSG00000130844.
ENST00000511593; ENSP00000427439; ENSG00000130844.
ENST00000512387; ENSP00000421728; ENSG00000130844.
ENST00000513999; ENSP00000423156; ENSG00000130844.
GeneIDi55422.
KEGGihsa:55422.
UCSCiuc002qbx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272148 mRNA. Translation: AAF78075.1.
AF251515 mRNA. Translation: AAF70179.2.
BC009433 mRNA. Translation: AAH09433.1.
CCDSiCCDS33102.1.
RefSeqiNP_001073375.1. NM_001079906.1.
NP_001073376.1. NM_001079907.1.
NP_001240727.1. NM_001253798.1.
NP_001240728.1. NM_001253799.1.
NP_001240729.1. NM_001253800.1.
NP_001240730.1. NM_001253801.1.
NP_061025.5. NM_018555.5.
XP_005259097.1. XM_005259040.1.
XP_011525376.1. XM_011527074.1.
XP_011525377.1. XM_011527075.1.
XP_011525378.1. XM_011527076.1.
XP_011525379.1. XM_011527077.1.
XP_011525380.1. XM_011527078.1.
XP_011525381.1. XM_011527079.1.
XP_011525382.1. XM_011527080.1.
XP_011525383.1. XM_011527081.1.
XP_011525384.1. XM_011527082.1.
UniGeneiHs.185674.

3D structure databases

ProteinModelPortaliQ9NQX6.
SMRiQ9NQX6. Positions 77-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120663. 9 interactions.
IntActiQ9NQX6. 9 interactions.
MINTiMINT-8247397.
STRINGi9606.ENSP00000253144.

PTM databases

PhosphoSiteiQ9NQX6.

Polymorphism and mutation databases

BioMutaiZNF331.
DMDMi34925661.

Proteomic databases

PaxDbiQ9NQX6.
PRIDEiQ9NQX6.

Protocols and materials databases

DNASUi55422.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844.
ENST00000411977; ENSP00000393336; ENSG00000130844.
ENST00000449416; ENSP00000393817; ENSG00000130844.
ENST00000511154; ENSP00000421014; ENSG00000130844.
ENST00000511593; ENSP00000427439; ENSG00000130844.
ENST00000512387; ENSP00000421728; ENSG00000130844.
ENST00000513999; ENSP00000423156; ENSG00000130844.
GeneIDi55422.
KEGGihsa:55422.
UCSCiuc002qbx.1. human.

Organism-specific databases

CTDi55422.
GeneCardsiGC19P054024.
HGNCiHGNC:15489. ZNF331.
MIMi606043. gene.
neXtProtiNX_Q9NQX6.
PharmGKBiPA134866703.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124032.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQX6.
KOiK09228.
OMAiKAFSHGH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NQX6.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF331. human.
GeneWikiiZNF331.
GenomeRNAii55422.
NextBioi59806.
PROiQ9NQX6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQX6.
CleanExiHS_ZNF331.
ExpressionAtlasiQ9NQX6. baseline and differential.
GenevisibleiQ9NQX6. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors."
    Rippe V., Belge G., Meiboom M., Kazmierczak B., Fusco A., Bullerdiek J.
    Genes Chromosomes Cancer 26:229-236(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463."
    Wu H., Zhang S., Qiu W., Zhang G., Xia Q., Xiao C., Huang X., Huang M., Agen P., Fan T., Yang J., Milunsky A.
    Biochim. Biophys. Acta 1518:190-193(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiZN331_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX6
Secondary accession number(s): Q96GJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.