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Q9NQX6

- ZN331_HUMAN

UniProt

Q9NQX6 - ZN331_HUMAN

Protein

Zinc finger protein 331

Gene

ZNF331

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation. May play a role in spermatogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri131 – 15323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 331
    Alternative name(s):
    C2H2-like zinc finger protein rearranged in thyroid adenomas
    Zinc finger protein 361
    Zinc finger protein 463
    Gene namesi
    Name:ZNF331
    Synonyms:RITA, ZNF361, ZNF463
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15489. ZNF331.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866703.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Zinc finger protein 331PRO_0000047535Add
    BLAST

    Proteomic databases

    PaxDbiQ9NQX6.
    PRIDEiQ9NQX6.

    PTM databases

    PhosphoSiteiQ9NQX6.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    ArrayExpressiQ9NQX6.
    BgeeiQ9NQX6.
    CleanExiHS_ZNF331.
    GenevestigatoriQ9NQX6.

    Organism-specific databases

    HPAiHPA053616.

    Interactioni

    Protein-protein interaction databases

    BioGridi120663. 11 interactions.
    IntActiQ9NQX6. 9 interactions.
    MINTiMINT-8247397.
    STRINGi9606.ENSP00000253144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQX6.
    SMRiQ9NQX6. Positions 77-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri131 – 15323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri187 – 20923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri215 – 23723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri243 – 26523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri327 – 34923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 37723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9NQX6.
    KOiK09228.
    OMAiKAFSHGH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9NQX6.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NQX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA    50
    YENKSLPTEK NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV 100
    NQMIINYVKR PATREGTPPR THQRHHKENS FECKDCGKAF SRGYQLSQHQ 150
    KIHTGEKPYE CKECKKAFRW GNQLTQHQKI HTGEKPYECK DCGKAFRWGS 200
    SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE KDYECKDCGK 250
    TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE 300
    CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT 350
    GEKPYKCTEC GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK 400
    HERIHTGVKP YGCTECGKSF SHGHQLTQHQ KTHSGAKSYE CKECGKACNH 450
    LNHLREHQRI HNS 463
    Length:463
    Mass (Da):53,739
    Last modified:October 1, 2000 - v1
    Checksum:iA9DB42D0870A7767
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591E → K in AAH09433. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272148 mRNA. Translation: AAF78075.1.
    AF251515 mRNA. Translation: AAF70179.2.
    BC009433 mRNA. Translation: AAH09433.1.
    CCDSiCCDS33102.1.
    RefSeqiNP_001073375.1. NM_001079906.1.
    NP_001073376.1. NM_001079907.1.
    NP_001240727.1. NM_001253798.1.
    NP_001240728.1. NM_001253799.1.
    NP_001240729.1. NM_001253800.1.
    NP_001240730.1. NM_001253801.1.
    NP_061025.5. NM_018555.5.
    XP_005259097.1. XM_005259040.1.
    XP_006723322.1. XM_006723259.1.
    UniGeneiHs.185674.

    Genome annotation databases

    EnsembliENST00000253144; ENSP00000253144; ENSG00000130844.
    ENST00000411977; ENSP00000393336; ENSG00000130844.
    ENST00000449416; ENSP00000393817; ENSG00000130844.
    ENST00000511154; ENSP00000421014; ENSG00000130844.
    ENST00000511593; ENSP00000427439; ENSG00000130844.
    ENST00000512387; ENSP00000421728; ENSG00000130844.
    ENST00000513999; ENSP00000423156; ENSG00000130844.
    GeneIDi55422.
    KEGGihsa:55422.
    UCSCiuc002qbx.1. human.

    Polymorphism databases

    DMDMi34925661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF272148 mRNA. Translation: AAF78075.1 .
    AF251515 mRNA. Translation: AAF70179.2 .
    BC009433 mRNA. Translation: AAH09433.1 .
    CCDSi CCDS33102.1.
    RefSeqi NP_001073375.1. NM_001079906.1.
    NP_001073376.1. NM_001079907.1.
    NP_001240727.1. NM_001253798.1.
    NP_001240728.1. NM_001253799.1.
    NP_001240729.1. NM_001253800.1.
    NP_001240730.1. NM_001253801.1.
    NP_061025.5. NM_018555.5.
    XP_005259097.1. XM_005259040.1.
    XP_006723322.1. XM_006723259.1.
    UniGenei Hs.185674.

    3D structure databases

    ProteinModelPortali Q9NQX6.
    SMRi Q9NQX6. Positions 77-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120663. 11 interactions.
    IntActi Q9NQX6. 9 interactions.
    MINTi MINT-8247397.
    STRINGi 9606.ENSP00000253144.

    PTM databases

    PhosphoSitei Q9NQX6.

    Polymorphism databases

    DMDMi 34925661.

    Proteomic databases

    PaxDbi Q9NQX6.
    PRIDEi Q9NQX6.

    Protocols and materials databases

    DNASUi 55422.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253144 ; ENSP00000253144 ; ENSG00000130844 .
    ENST00000411977 ; ENSP00000393336 ; ENSG00000130844 .
    ENST00000449416 ; ENSP00000393817 ; ENSG00000130844 .
    ENST00000511154 ; ENSP00000421014 ; ENSG00000130844 .
    ENST00000511593 ; ENSP00000427439 ; ENSG00000130844 .
    ENST00000512387 ; ENSP00000421728 ; ENSG00000130844 .
    ENST00000513999 ; ENSP00000423156 ; ENSG00000130844 .
    GeneIDi 55422.
    KEGGi hsa:55422.
    UCSCi uc002qbx.1. human.

    Organism-specific databases

    CTDi 55422.
    GeneCardsi GC19P054024.
    HGNCi HGNC:15489. ZNF331.
    HPAi HPA053616.
    MIMi 606043. gene.
    neXtProti NX_Q9NQX6.
    PharmGKBi PA134866703.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9NQX6.
    KOi K09228.
    OMAi KAFSHGH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9NQX6.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF331. human.
    GeneWikii ZNF331.
    GenomeRNAii 55422.
    NextBioi 59806.
    PROi Q9NQX6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQX6.
    Bgeei Q9NQX6.
    CleanExi HS_ZNF331.
    Genevestigatori Q9NQX6.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors."
      Rippe V., Belge G., Meiboom M., Kazmierczak B., Fusco A., Bullerdiek J.
      Genes Chromosomes Cancer 26:229-236(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463."
      Wu H., Zhang S., Qiu W., Zhang G., Xia Q., Xiao C., Huang X., Huang M., Agen P., Fan T., Yang J., Milunsky A.
      Biochim. Biophys. Acta 1518:190-193(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiZN331_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQX6
    Secondary accession number(s): Q96GJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3