SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NQX6

- ZN331_HUMAN

UniProt

Q9NQX6 - ZN331_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Zinc finger protein 331
Gene
ZNF331, RITA, ZNF361, ZNF463
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. May play a role in spermatogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 15323C2H2-type 1
Add
BLAST
Zinc fingeri159 – 18123C2H2-type 2
Add
BLAST
Zinc fingeri187 – 20923C2H2-type 3
Add
BLAST
Zinc fingeri215 – 23723C2H2-type 4
Add
BLAST
Zinc fingeri243 – 26523C2H2-type 5
Add
BLAST
Zinc fingeri271 – 29323C2H2-type 6
Add
BLAST
Zinc fingeri299 – 32123C2H2-type 7
Add
BLAST
Zinc fingeri327 – 34923C2H2-type 8
Add
BLAST
Zinc fingeri355 – 37723C2H2-type 9
Add
BLAST
Zinc fingeri383 – 40523C2H2-type 10
Add
BLAST
Zinc fingeri411 – 43323C2H2-type 11
Add
BLAST
Zinc fingeri439 – 46123C2H2-type 12
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 331
Alternative name(s):
C2H2-like zinc finger protein rearranged in thyroid adenomas
Zinc finger protein 361
Zinc finger protein 463
Gene namesi
Name:ZNF331
Synonyms:RITA, ZNF361, ZNF463
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15489. ZNF331.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Zinc finger protein 331
PRO_0000047535Add
BLAST

Proteomic databases

PaxDbiQ9NQX6.
PRIDEiQ9NQX6.

PTM databases

PhosphoSiteiQ9NQX6.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

ArrayExpressiQ9NQX6.
BgeeiQ9NQX6.
CleanExiHS_ZNF331.
GenevestigatoriQ9NQX6.

Organism-specific databases

HPAiHPA053616.

Interactioni

Protein-protein interaction databases

BioGridi120663. 11 interactions.
IntActiQ9NQX6. 9 interactions.
MINTiMINT-8247397.
STRINGi9606.ENSP00000253144.

Structurei

3D structure databases

ProteinModelPortaliQ9NQX6.
SMRiQ9NQX6. Positions 77-461.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRAB
Add
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NQX6.
KOiK09228.
OMAiKAFSHGH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9NQX6.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQX6-1 [UniParc]FASTAAdd to Basket

« Hide

MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA    50
YENKSLPTEK NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV 100
NQMIINYVKR PATREGTPPR THQRHHKENS FECKDCGKAF SRGYQLSQHQ 150
KIHTGEKPYE CKECKKAFRW GNQLTQHQKI HTGEKPYECK DCGKAFRWGS 200
SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE KDYECKDCGK 250
TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE 300
CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT 350
GEKPYKCTEC GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK 400
HERIHTGVKP YGCTECGKSF SHGHQLTQHQ KTHSGAKSYE CKECGKACNH 450
LNHLREHQRI HNS 463
Length:463
Mass (Da):53,739
Last modified:October 1, 2000 - v1
Checksum:iA9DB42D0870A7767
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591E → K in AAH09433. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272148 mRNA. Translation: AAF78075.1.
AF251515 mRNA. Translation: AAF70179.2.
BC009433 mRNA. Translation: AAH09433.1.
CCDSiCCDS33102.1.
RefSeqiNP_001073375.1. NM_001079906.1.
NP_001073376.1. NM_001079907.1.
NP_001240727.1. NM_001253798.1.
NP_001240728.1. NM_001253799.1.
NP_001240729.1. NM_001253800.1.
NP_001240730.1. NM_001253801.1.
NP_061025.5. NM_018555.5.
XP_005259097.1. XM_005259040.1.
XP_006723322.1. XM_006723259.1.
UniGeneiHs.185674.

Genome annotation databases

EnsembliENST00000253144; ENSP00000253144; ENSG00000130844.
ENST00000411977; ENSP00000393336; ENSG00000130844.
ENST00000449416; ENSP00000393817; ENSG00000130844.
ENST00000511154; ENSP00000421014; ENSG00000130844.
ENST00000511593; ENSP00000427439; ENSG00000130844.
ENST00000512387; ENSP00000421728; ENSG00000130844.
ENST00000513999; ENSP00000423156; ENSG00000130844.
GeneIDi55422.
KEGGihsa:55422.
UCSCiuc002qbx.1. human.

Polymorphism databases

DMDMi34925661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272148 mRNA. Translation: AAF78075.1 .
AF251515 mRNA. Translation: AAF70179.2 .
BC009433 mRNA. Translation: AAH09433.1 .
CCDSi CCDS33102.1.
RefSeqi NP_001073375.1. NM_001079906.1.
NP_001073376.1. NM_001079907.1.
NP_001240727.1. NM_001253798.1.
NP_001240728.1. NM_001253799.1.
NP_001240729.1. NM_001253800.1.
NP_001240730.1. NM_001253801.1.
NP_061025.5. NM_018555.5.
XP_005259097.1. XM_005259040.1.
XP_006723322.1. XM_006723259.1.
UniGenei Hs.185674.

3D structure databases

ProteinModelPortali Q9NQX6.
SMRi Q9NQX6. Positions 77-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120663. 11 interactions.
IntActi Q9NQX6. 9 interactions.
MINTi MINT-8247397.
STRINGi 9606.ENSP00000253144.

PTM databases

PhosphoSitei Q9NQX6.

Polymorphism databases

DMDMi 34925661.

Proteomic databases

PaxDbi Q9NQX6.
PRIDEi Q9NQX6.

Protocols and materials databases

DNASUi 55422.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253144 ; ENSP00000253144 ; ENSG00000130844 .
ENST00000411977 ; ENSP00000393336 ; ENSG00000130844 .
ENST00000449416 ; ENSP00000393817 ; ENSG00000130844 .
ENST00000511154 ; ENSP00000421014 ; ENSG00000130844 .
ENST00000511593 ; ENSP00000427439 ; ENSG00000130844 .
ENST00000512387 ; ENSP00000421728 ; ENSG00000130844 .
ENST00000513999 ; ENSP00000423156 ; ENSG00000130844 .
GeneIDi 55422.
KEGGi hsa:55422.
UCSCi uc002qbx.1. human.

Organism-specific databases

CTDi 55422.
GeneCardsi GC19P054024.
HGNCi HGNC:15489. ZNF331.
HPAi HPA053616.
MIMi 606043. gene.
neXtProti NX_Q9NQX6.
PharmGKBi PA134866703.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9NQX6.
KOi K09228.
OMAi KAFSHGH.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9NQX6.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF331. human.
GeneWikii ZNF331.
GenomeRNAii 55422.
NextBioi 59806.
PROi Q9NQX6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQX6.
Bgeei Q9NQX6.
CleanExi HS_ZNF331.
Genevestigatori Q9NQX6.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors."
    Rippe V., Belge G., Meiboom M., Kazmierczak B., Fusco A., Bullerdiek J.
    Genes Chromosomes Cancer 26:229-236(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463."
    Wu H., Zhang S., Qiu W., Zhang G., Xia Q., Xiao C., Huang X., Huang M., Agen P., Fan T., Yang J., Milunsky A.
    Biochim. Biophys. Acta 1518:190-193(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiZN331_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX6
Secondary accession number(s): Q96GJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi