ID   NPDC1_HUMAN             Reviewed;         325 AA.
AC   Q9NQX5; Q5SPY8; Q9BTD6; Q9BXT3; Q9NQS2; Q9Y434;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-2002, sequence version 2.
DT   25-JAN-2012, entry version 91.
DE   RecName: Full=Neural proliferation differentiation and control protein 1;
DE            Short=NPDC-1;
DE   Flags: Precursor;
GN   Name=NPDC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Iris;
RA   Wistow G.J.;
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal liver;
RX   MEDLINE=21142391; PubMed=11245976; DOI=10.1016/S0378-1119(01)00324-9;
RA   Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F.;
RT   "Characterization and tissue expression of a novel human gene npdc1.";
RL   Gene 264:37-44(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 39-325.
RC   TISSUE=Brain;
RA   Evrard C., Apiou F., Dutrillaux B., Rouget P.;
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325.
RC   TISSUE=Uterus;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=19007248; DOI=10.1021/ac801708p;
RA   Wang B., Malik R., Nigg E.A., Korner R.;
RT   "Evaluation of the low-specificity protease elastase for large-scale
RT   phosphoproteome analysis.";
RL   Anal. Chem. 80:9526-9533(2008).
CC   -!- FUNCTION: Suppresses oncogenic transformation in neural and non-
CC       neural cells and down-regulates neural cell proliferation. Might
CC       be involved in transcriptional regulation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- TISSUE SPECIFICITY: Strongly expressed in adult brain; especially
CC       in hippocampus, frontal lobe and temporal lobe.
CC   -!- SIMILARITY: Belongs to the NPDC1/cab-1 family.
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DR   EMBL; AF272357; AAF76225.1; -; mRNA.
DR   EMBL; AF285836; AAK27328.1; -; mRNA.
DR   EMBL; AL807752; CAI12775.1; -; Genomic_DNA.
DR   EMBL; BC004217; AAH04217.1; -; mRNA.
DR   EMBL; AF283247; AAF82603.1; -; mRNA.
DR   EMBL; AL050221; CAB43321.1; -; mRNA.
DR   IPI; IPI00299699; -.
DR   PIR; T08809; T08809.
DR   RefSeq; NP_056207.3; NM_015392.3.
DR   UniGene; Hs.719906; -.
DR   ProteinModelPortal; Q9NQX5; -.
DR   IntAct; Q9NQX5; 6.
DR   STRING; Q9NQX5; -.
DR   PhosphoSite; Q9NQX5; -.
DR   DMDM; 22261810; -.
DR   PeptideAtlas; Q9NQX5; -.
DR   PRIDE; Q9NQX5; -.
DR   Ensembl; ENST00000371601; ENSP00000360660; ENSG00000107281.
DR   GeneID; 56654; -.
DR   KEGG; hsa:56654; -.
DR   UCSC; uc004ckr.1; human.
DR   CTD; 56654; -.
DR   GeneCards; GC09M139933; -.
DR   H-InvDB; HIX0008564; -.
DR   HGNC; HGNC:7899; NPDC1.
DR   HPA; HPA008189; -.
DR   MIM; 605798; gene.
DR   neXtProt; NX_Q9NQX5; -.
DR   PharmGKB; PA31701; -.
DR   eggNOG; prNOG16812; -.
DR   GeneTree; ENSGT00440000038604; -.
DR   HOVERGEN; HBG052657; -.
DR   OMA; PCLQSFQ; -.
DR   OrthoDB; EOG46DM3G; -.
DR   PhylomeDB; Q9NQX5; -.
DR   NextBio; 62117; -.
DR   ArrayExpress; Q9NQX5; -.
DR   Bgee; Q9NQX5; -.
DR   CleanEx; HS_NPDC1; -.
DR   Genevestigator; Q9NQX5; -.
DR   GermOnline; ENSG00000107281; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009635; NPDC1.
DR   PANTHER; PTHR23352; NPDC1; 1.
DR   Pfam; PF06809; NPDC1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Membrane; Phosphoprotein; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     34       Potential.
FT   CHAIN        35    325       Neural proliferation differentiation and
FT                                control protein 1.
FT                                /FTId=PRO_0000021830.
FT   TRANSMEM    182    202       Helical; (Potential).
FT   COMPBIAS    145    167       Pro/Ser/Thr-rich.
FT   COMPBIAS    227    237       Pro/Ser/Thr-rich.
FT   MOD_RES     229    229       Phosphoserine.
FT   CONFLICT    113    113       H -> Q (in Ref. 1; AAF76225).
FT   CONFLICT    159    159       L -> M (in Ref. 2; AAK27328).
FT   CONFLICT    210    210       Q -> H (in Ref. 2; AAK27328).
FT   CONFLICT    218    226       KADYATAKA -> EGRLRHCEG (in Ref. 6;
FT                                CAB43321).
FT   CONFLICT    289    289       E -> D (in Ref. 5; AAF82603).
SQ   SEQUENCE   325 AA;  34516 MW;  21D6512AD345A575 CRC64;
     MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA
     HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK
     DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG
     DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ
     RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME
     VRNPLFDHAA LSAPLPAPSS PPALP
//