Reviewed,
UniProtKB/Swiss-Prot Q9NQX5 (NPDC1_HUMAN)
Last modified
January 19, 2010.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Neural proliferation differentiation and control protein 1 Short name=NPDC-1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 325 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation By similarity. |
| Subcellular location | Membrane; Single-pass membrane protein Potential. |
| Tissue specificity | Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe. |
| Sequence similarities | Belongs to the NPDC1/cab-1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 34 | 34 | Potential | ||||||
| Chain | 35 – 325 | 291 | Neural proliferation differentiation and control protein 1 | PRO_0000021830 | |||||
Regions | |||||||||
| Transmembrane | 182 – 202 | 21 | Potential | ||||||
| Compositional bias | 145 – 167 | 23 | Pro/Ser/Thr-rich | ||||||
| Compositional bias | 227 – 237 | 11 | Pro/Ser/Thr-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 229 | 1 | Phosphoserine Ref.7 | ||||||
Experimental info | |||||||||
| Sequence conflict | 113 | 1 | H → Q in AAF76225. Ref.1 | ||||||
| Sequence conflict | 159 | 1 | L → M in AAK27328. Ref.2 | ||||||
| Sequence conflict | 210 | 1 | Q → H in AAK27328. Ref.2 | ||||||
| Sequence conflict | 218 – 226 | 9 | KADYATAKA → EGRLRHCEG in CAB43321. Ref.6 | ||||||
| Sequence conflict | 289 | 1 | E → D in AAF82603. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Wistow G.J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Iris. |
| [2] | "Characterization and tissue expression of a novel human gene npdc1." Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F. Gene 264:37-44(2001) [PubMed: 11245976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver. |
| [3] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [5] | Evrard C., Apiou F., Dutrillaux B., Rouget P. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-325. Tissue: Brain. |
| [6] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325. Tissue: Uterus. |
| [7] | "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF272357 mRNA. Translation: AAF76225.1. AF285836 mRNA. Translation: AAK27328.1. AL807752 Genomic DNA. Translation: CAI12775.1. BC004217 mRNA. Translation: AAH04217.1. AF283247 mRNA. Translation: AAF82603.1. AL050221 mRNA. Translation: CAB43321.1. |
| IPI | IPI00299699. |
| PIR | T08809. |
| RefSeq | NP_056207.3. |
| UniGene | Hs.457 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NQX5. 4 interactions. |
| STRING | Q9NQX5. |
PTM databases | |
| PhosphoSite | Q9NQX5. |
Proteomic databases | |
| PeptideAtlas | Q9NQX5. |
| PRIDE | Q9NQX5. |
Genome annotation databases | |
| Ensembl | ENST00000371601; ENSP00000360660; ENSG00000107281; Homo sapiens. [Genome view] |
| GeneID | 56654. |
| KEGG | hsa:56654. |
| UCSC | uc004ckr.1. human. |
Organism-specific databases | |
| CTD | 56654. |
| GeneCards | GC09M139053. |
| HGNC | HGNC:7899. NPDC1. |
| HPA | HPA008189. |
| MIM | 605798. gene. |
| PharmGKB | PA31701. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG16812. |
| HOVERGEN | Q9NQX5. |
| OMA | PCLQSFQ. |
| OrthoDB | EOG9NP9P6. |
| PhylomeDB | Q9NQX5. |
Gene expression databases | |
| ArrayExpress | Q9NQX5. |
| Bgee | Q9NQX5. |
| CleanEx | HS_NPDC1. |
| Genevestigator | Q9NQX5. |
| GermOnline | ENSG00000107281. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009635. NPDC1. [Graphical view] |
| PANTHER | PTHR23352. NPDC1. 1 hit. |
| Pfam | PF06809. NPDC1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62117. |
| SOURCE | Search... |
Entry information
| Entry name | NPDC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NQX5 Secondary accession number(s): Q5SPY8 Q9Y434 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


