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Protein

Neural proliferation differentiation and control protein 1

Gene

NPDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neural proliferation differentiation and control protein 1
Short name:
NPDC-1
Gene namesi
Name:NPDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:7899. NPDC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56654.
OpenTargetsiENSG00000107281.
PharmGKBiPA31701.

Polymorphism and mutation databases

BioMutaiNPDC1.
DMDMi22261810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002183035 – 325Neural proliferation differentiation and control protein 1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQX5.
MaxQBiQ9NQX5.
PaxDbiQ9NQX5.
PeptideAtlasiQ9NQX5.
PRIDEiQ9NQX5.

PTM databases

iPTMnetiQ9NQX5.
PhosphoSitePlusiQ9NQX5.

Expressioni

Tissue specificityi

Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.

Gene expression databases

BgeeiENSG00000107281.
CleanExiHS_NPDC1.
ExpressionAtlasiQ9NQX5. baseline and differential.
GenevisibleiQ9NQX5. HS.

Organism-specific databases

HPAiHPA008189.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KHDRBS2Q5VWX15EBI-748927,EBI-742808
KRTAP10-5P603703EBI-748927,EBI-10172150
KRTAP10-7P604093EBI-748927,EBI-10172290
KRTAP10-9P604113EBI-748927,EBI-10172052
KRTAP5-9P263715EBI-748927,EBI-3958099
MDFIQ997507EBI-748927,EBI-724076
NOTCH2NLQ7Z3S95EBI-748927,EBI-945833

Protein-protein interaction databases

BioGridi121167. 29 interactors.
IntActiQ9NQX5. 22 interactors.
STRINGi9606.ENSP00000360660.

Structurei

3D structure databases

ProteinModelPortaliQ9NQX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 167Pro/Ser/Thr-richAdd BLAST23
Compositional biasi227 – 237Pro/Ser/Thr-richAdd BLAST11

Sequence similaritiesi

Belongs to the NPDC1/cab-1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3884. Eukaryota.
ENOG4111QDP. LUCA.
GeneTreeiENSGT00440000038604.
HOGENOMiHOG000231546.
HOVERGENiHBG052657.
InParanoidiQ9NQX5.
OMAiEPVHMSP.
PhylomeDBiQ9NQX5.
TreeFamiTF318443.

Family and domain databases

InterProiIPR009635. NPDC1.
[Graphical view]
PANTHERiPTHR23352. PTHR23352. 1 hit.
PfamiPF06809. NPDC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL
60 70 80 90 100
KRRARCPPGA HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID
110 120 130 140 150
FLAQELARKE SGHSTPPLPK DRQRLPEPAT LGFSARGQGL ELGLPSTPGT
160 170 180 190 200
PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG DGLALVLILA FCVAGAAALS
210 220 230 240 250
VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ RLAQSAEMYH
260 270 280 290 300
YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME
310 320
VRNPLFDHAA LSAPLPAPSS PPALP
Length:325
Mass (Da):34,516
Last modified:August 13, 2002 - v2
Checksum:i21D6512AD345A575
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113H → Q in AAF76225 (Ref. 1) Curated1
Sequence conflicti159L → M in AAK27328 (PubMed:11245976).Curated1
Sequence conflicti210Q → H in AAK27328 (PubMed:11245976).Curated1
Sequence conflicti218 – 226KADYATAKA → EGRLRHCEG in CAB43321 (PubMed:17974005).Curated9
Sequence conflicti289E → D in AAF82603 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272357 mRNA. Translation: AAF76225.1.
AF285836 mRNA. Translation: AAK27328.1.
AL807752 Genomic DNA. Translation: CAI12775.1.
BC004217 mRNA. Translation: AAH04217.1.
AF283247 mRNA. Translation: AAF82603.1.
AL050221 mRNA. Translation: CAB43321.1.
CCDSiCCDS7024.1.
PIRiT08809.
RefSeqiNP_056207.3. NM_015392.3.
UniGeneiHs.719906.

Genome annotation databases

EnsembliENST00000371601; ENSP00000360660; ENSG00000107281.
GeneIDi56654.
KEGGihsa:56654.
UCSCiuc004ckt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272357 mRNA. Translation: AAF76225.1.
AF285836 mRNA. Translation: AAK27328.1.
AL807752 Genomic DNA. Translation: CAI12775.1.
BC004217 mRNA. Translation: AAH04217.1.
AF283247 mRNA. Translation: AAF82603.1.
AL050221 mRNA. Translation: CAB43321.1.
CCDSiCCDS7024.1.
PIRiT08809.
RefSeqiNP_056207.3. NM_015392.3.
UniGeneiHs.719906.

3D structure databases

ProteinModelPortaliQ9NQX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121167. 29 interactors.
IntActiQ9NQX5. 22 interactors.
STRINGi9606.ENSP00000360660.

PTM databases

iPTMnetiQ9NQX5.
PhosphoSitePlusiQ9NQX5.

Polymorphism and mutation databases

BioMutaiNPDC1.
DMDMi22261810.

Proteomic databases

EPDiQ9NQX5.
MaxQBiQ9NQX5.
PaxDbiQ9NQX5.
PeptideAtlasiQ9NQX5.
PRIDEiQ9NQX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371601; ENSP00000360660; ENSG00000107281.
GeneIDi56654.
KEGGihsa:56654.
UCSCiuc004ckt.3. human.

Organism-specific databases

CTDi56654.
DisGeNETi56654.
GeneCardsiNPDC1.
HGNCiHGNC:7899. NPDC1.
HPAiHPA008189.
MIMi605798. gene.
neXtProtiNX_Q9NQX5.
OpenTargetsiENSG00000107281.
PharmGKBiPA31701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3884. Eukaryota.
ENOG4111QDP. LUCA.
GeneTreeiENSGT00440000038604.
HOGENOMiHOG000231546.
HOVERGENiHBG052657.
InParanoidiQ9NQX5.
OMAiEPVHMSP.
PhylomeDBiQ9NQX5.
TreeFamiTF318443.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107281-MONOMER.

Miscellaneous databases

ChiTaRSiNPDC1. human.
GeneWikiiNPDC1.
GenomeRNAii56654.
PROiQ9NQX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107281.
CleanExiHS_NPDC1.
ExpressionAtlasiQ9NQX5. baseline and differential.
GenevisibleiQ9NQX5. HS.

Family and domain databases

InterProiIPR009635. NPDC1.
[Graphical view]
PANTHERiPTHR23352. PTHR23352. 1 hit.
PfamiPF06809. NPDC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX5
Secondary accession number(s): Q5SPY8
, Q9BTD6, Q9BXT3, Q9NQS2, Q9Y434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 13, 2002
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.