Reviewed, UniProtKB/Swiss-Prot Q9NQX5 (NPDC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Neural proliferation differentiation and control protein 1
      Short name=NPDC-1

Gene names

Name:

NPDC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.
Sequence similarities	Belongs to the NPDC1/cab-1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 325	291	Neural proliferation differentiation and control protein 1		PRO_0000021830
Regions
	Transmembrane	182 – 202	21	Potential
	Compositional bias	145 – 167	23	Pro/Ser/Thr-rich
	Compositional bias	227 – 237	11	Pro/Ser/Thr-rich
Amino acid modifications
	Modified residue	229	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	113	1	H → Q in AAF76225. Ref.1
	Sequence conflict	159	1	L → M in AAK27328. Ref.2
	Sequence conflict	210	1	Q → H in AAK27328. Ref.2
	Sequence conflict	218 – 226	9	KADYATAKA → EGRLRHCEG in CAB43321. Ref.6
	Sequence conflict	289	1	E → D in AAF82603. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9NQX5-1 [UniParc]. Last modified August 13, 2002. Version 2. Checksum: 21D6512AD345A575	FASTA	325	34,516
	10 20 30 40 50 60 MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA 70 80 90 100 110 120 HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK 130 140 150 160 170 180 DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG 190 200 210 220 230 240 DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ 250 260 270 280 290 300 RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME 310 320 VRNPLFDHAA LSAPLPAPSS PPALP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wistow G.J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Iris.
[2]	"Characterization and tissue expression of a novel human gene npdc1." Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F. Gene 264:37-44(2001) [PubMed: 11245976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[5]	Evrard C., Apiou F., Dutrillaux B., Rouget P. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-325. Tissue: Brain.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325. Tissue: Uterus.
[7]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF272357 mRNA. Translation: AAF76225.1. AF285836 mRNA. Translation: AAK27328.1. AL807752 Genomic DNA. Translation: CAI12775.1. BC004217 mRNA. Translation: AAH04217.1. AF283247 mRNA. Translation: AAF82603.1. AL050221 mRNA. Translation: CAB43321.1.
IPI	IPI00299699.
PIR	T08809.
RefSeq	NP_056207.3.
UniGene	Hs.457
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NQX5. 4 interactions.
STRING	Q9NQX5.
PTM databases
PhosphoSite	Q9NQX5.
Proteomic databases
PeptideAtlas	Q9NQX5.
PRIDE	Q9NQX5.
Genome annotation databases
Ensembl	ENST00000371601; ENSP00000360660; ENSG00000107281; Homo sapiens. [Genome view]
GeneID	56654.
KEGG	hsa:56654.
UCSC	uc004ckr.1. human.
Organism-specific databases
CTD	56654.
GeneCards	GC09M139053.
HGNC	HGNC:7899. NPDC1.
HPA	HPA008189.
MIM	605798. gene.
PharmGKB	PA31701.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16812.
HOVERGEN	Q9NQX5.
OMA	PCLQSFQ.
OrthoDB	EOG9NP9P6.
PhylomeDB	Q9NQX5.
Gene expression databases
ArrayExpress	Q9NQX5.
Bgee	Q9NQX5.
CleanEx	HS_NPDC1.
Genevestigator	Q9NQX5.
GermOnline	ENSG00000107281. Homo sapiens.
Family and domain databases
InterPro	IPR009635. NPDC1. [Graphical view]
PANTHER	PTHR23352. NPDC1. 1 hit.
Pfam	PF06809. NPDC1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62117.
SOURCE	Search...

Entry information

Entry name

NPDC1_HUMAN

Accession

Primary (citable) accession number: Q9NQX5
Secondary accession number(s): Q5SPY8 , Q9BTD6, Q9BXT3, Q9NQS2, Q9Y434

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	August 13, 2002
Last modified:	January 19, 2010
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.