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Q9NQX5 (NPDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neural proliferation differentiation and control protein 1
Short name=NPDC-1
Gene names
Name:NPDC1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.

Sequence similarities

Belongs to the NPDC1/cab-1 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 325291Neural proliferation differentiation and control protein 1
PRO_0000021830

Regions

Transmembrane182 – 20221Helical; Potential
Compositional bias145 – 16723Pro/Ser/Thr-rich
Compositional bias227 – 23711Pro/Ser/Thr-rich

Amino acid modifications

Modified residue2291Phosphoserine Ref.7

Experimental info

Sequence conflict1131H → Q in AAF76225. Ref.1
Sequence conflict1591L → M in AAK27328. Ref.2
Sequence conflict2101Q → H in AAK27328. Ref.2
Sequence conflict218 – 2269KADYATAKA → EGRLRHCEG in CAB43321. Ref.6
Sequence conflict2891E → D in AAF82603. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9NQX5 [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: 21D6512AD345A575

FASTA32534,516
        10         20         30         40         50         60 
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA 

        70         80         90        100        110        120 
HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK 

       130        140        150        160        170        180 
DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG 

       190        200        210        220        230        240 
DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ 

       250        260        270        280        290        300 
RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME 

       310        320 
VRNPLFDHAA LSAPLPAPSS PPALP

« Hide

References

« Hide 'large scale' references
[1]Wistow G.J.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Iris.
[2]"Characterization and tissue expression of a novel human gene npdc1."
Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F.
Gene 264:37-44(2001) [PubMed: 11245976] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[5]Evrard C., Apiou F., Dutrillaux B., Rouget P.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-325.
Tissue: Brain.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325.
Tissue: Uterus.
[7]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF272357 mRNA. Translation: AAF76225.1.
AF285836 mRNA. Translation: AAK27328.1.
AL807752 Genomic DNA. Translation: CAI12775.1.
BC004217 mRNA. Translation: AAH04217.1.
AF283247 mRNA. Translation: AAF82603.1.
AL050221 mRNA. Translation: CAB43321.1.
IPIIPI00299699.
PIRT08809.
RefSeqNP_056207.3. NM_015392.3.
UniGeneHs.719906.

3D structure databases

ProteinModelPortalQ9NQX5.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9NQX5. 6 interactions.
STRINGQ9NQX5.

PTM databases

PhosphoSiteQ9NQX5.

Polymorphism databases

DMDM22261810.

Proteomic databases

PeptideAtlasQ9NQX5.
PRIDEQ9NQX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371601; ENSP00000360660; ENSG00000107281.
GeneID56654.
KEGGhsa:56654.
UCSCuc004ckr.1. human.

Organism-specific databases

CTD56654.
GeneCardsGC09M139933.
H-InvDBHIX0008564.
HGNCHGNC:7899. NPDC1.
HPAHPA008189.
MIM605798. gene.
neXtProtNX_Q9NQX5.
PharmGKBPA31701.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16812.
GeneTreeENSGT00440000038604.
HOVERGENHBG052657.
OMAPCLQSFQ.
OrthoDBEOG46DM3G.
PhylomeDBQ9NQX5.

Gene expression databases

ArrayExpressQ9NQX5.
BgeeQ9NQX5.
CleanExHS_NPDC1.
GenevestigatorQ9NQX5.
GermOnlineENSG00000107281. Homo sapiens.

Family and domain databases

InterProIPR009635. NPDC1.
[Graphical view]
PANTHERPTHR23352. NPDC1. 1 hit.
PfamPF06809. NPDC1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio62117.
SOURCESearch...

Entry information

Entry nameNPDC1_HUMAN
AccessionPrimary (citable) accession number: Q9NQX5
Secondary accession number(s): Q5SPY8 expand/collapse secondary AC list , Q9BTD6, Q9BXT3, Q9NQS2, Q9Y434
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 13, 2002
Last modified: January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents