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Protein

Unconventional myosin-Vc

Gene

MYO5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vc
Gene namesi
Name:MYO5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:7604. MYO5C.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55930.
OpenTargetsiENSG00000128833.
PharmGKBiPA31409.

Polymorphism and mutation databases

BioMutaiMYO5C.
DMDMi294862453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001234632 – 1742Unconventional myosin-VcAdd BLAST1741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NQX4.
MaxQBiQ9NQX4.
PaxDbiQ9NQX4.
PeptideAtlasiQ9NQX4.
PRIDEiQ9NQX4.

PTM databases

iPTMnetiQ9NQX4.
PhosphoSitePlusiQ9NQX4.
SwissPalmiQ9NQX4.

Expressioni

Tissue specificityi

Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.1 Publication

Gene expression databases

BgeeiENSG00000128833.
CleanExiHS_MYO5C.
ExpressionAtlasiQ9NQX4. baseline and differential.
GenevisibleiQ9NQX4. HS.

Organism-specific databases

HPAiCAB020790.
HPA032116.

Interactioni

Protein-protein interaction databases

BioGridi121005. 107 interactors.
IntActiQ9NQX4. 86 interactors.
STRINGi9606.ENSP00000261839.

Structurei

Secondary structure

11742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Beta strandi12 – 17Combined sources6
Turni18 – 20Combined sources3
Beta strandi21 – 29Combined sources9
Beta strandi37 – 42Combined sources6
Beta strandi47 – 51Combined sources5
Beta strandi54 – 56Combined sources3
Turni64 – 68Combined sources5
Helixi72 – 74Combined sources3
Helixi80 – 92Combined sources13
Beta strandi98 – 101Combined sources4
Beta strandi104 – 108Combined sources5
Helixi119 – 125Combined sources7
Turni130 – 132Combined sources3
Helixi137 – 151Combined sources15
Beta strandi155 – 160Combined sources6
Helixi167 – 182Combined sources16
Helixi190 – 205Combined sources16
Beta strandi218 – 226Combined sources9
Beta strandi232 – 240Combined sources9
Helixi245 – 247Combined sources3
Helixi258 – 264Combined sources7
Turni265 – 268Combined sources4
Helixi270 – 275Combined sources6
Turni280 – 282Combined sources3
Helixi284 – 287Combined sources4
Helixi299 – 312Combined sources14
Helixi317 – 333Combined sources17
Beta strandi339 – 341Combined sources3
Turni342 – 344Combined sources3
Beta strandi345 – 347Combined sources3
Helixi353 – 362Combined sources10
Helixi366 – 373Combined sources8
Beta strandi374 – 379Combined sources6
Beta strandi384 – 388Combined sources5
Helixi391 – 420Combined sources30
Beta strandi429 – 435Combined sources7
Beta strandi443 – 445Combined sources3
Helixi447 – 467Combined sources21
Helixi469 – 477Combined sources9
Helixi491 – 498Combined sources8
Helixi503 – 512Combined sources10
Helixi518 – 529Combined sources12
Turni530 – 532Combined sources3
Beta strandi543 – 549Combined sources7
Beta strandi554 – 558Combined sources5
Helixi562 – 567Combined sources6
Helixi572 – 579Combined sources8
Helixi584 – 589Combined sources6
Helixi624 – 640Combined sources17
Beta strandi642 – 650Combined sources9
Helixi663 – 672Combined sources10
Helixi675 – 684Combined sources10
Beta strandi688 – 691Combined sources4
Helixi693 – 698Combined sources6
Turni706 – 708Combined sources3
Helixi714 – 722Combined sources9
Beta strandi728 – 733Combined sources6
Beta strandi738 – 740Combined sources3
Helixi744 – 751Combined sources8
Helixi1371 – 1378Combined sources8
Helixi1388 – 1391Combined sources4
Helixi1395 – 1408Combined sources14
Helixi1413 – 1433Combined sources21
Helixi1438 – 1457Combined sources20
Helixi1462 – 1464Combined sources3
Turni1470 – 1474Combined sources5
Helixi1483 – 1516Combined sources34
Helixi1548 – 1563Combined sources16
Turni1564 – 1566Combined sources3
Helixi1569 – 1593Combined sources25
Helixi1595 – 1597Combined sources3
Helixi1600 – 1619Combined sources20
Helixi1625 – 1642Combined sources18
Helixi1650 – 1657Combined sources8
Helixi1663 – 1672Combined sources10
Beta strandi1677 – 1680Combined sources4
Helixi1685 – 1694Combined sources10
Helixi1695 – 1697Combined sources3
Helixi1725 – 1727Combined sources3
Helixi1732 – 1734Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
5HMPX-ray2.40A/B5-754[»]
ProteinModelPortaliQ9NQX4.
SMRiQ9NQX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 753Myosin motorAdd BLAST687
Domaini756 – 779IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini780 – 806IQ 2PROSITE-ProRule annotationAdd BLAST27
Domaini807 – 829IQ 3PROSITE-ProRule annotationAdd BLAST23
Domaini830 – 854IQ 4PROSITE-ProRule annotationAdd BLAST25
Domaini855 – 884IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1421 – 1697DilutePROSITE-ProRule annotationAdd BLAST277

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili884 – 1351Sequence analysisAdd BLAST468

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 5 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ9NQX4.
KOiK10357.
OMAiEDFQMDI.
OrthoDBiEOG091G0G93.
PhylomeDBiQ9NQX4.
TreeFamiTF328771.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY
60 70 80 90 100
SVNPESLPPL RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY
110 120 130 140 150
SGIILVAMNP YKQLPIYGDA IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR
160 170 180 190 200
NNRNQSIIVS GESGAGKTVS ARYAMRYFAT VSKSGSNAHV EDKVLASNPI
210 220 230 240 250
TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY LLEKSRVVFQ
260 270 280 290 300
SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
310 320 330 340 350
AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE
360 370 380 390 400
DDSHLKVFCE LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA
410 420 430 440 450
LAKKIYAHLF DFIVERINQA LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF
460 470 480 490 500
CINYANEKLQ QQFNMHVFKL EQEEYMKEDI PWTLIDFYDN QPVIDLIEAK
510 520 530 540 550
MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR MSNTSFVIQH
560 570 580 590 600
FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF
610 620 630 640 650
GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI
660 670 680 690 700
KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG
710 720 730 740 750
ILMTKQELSF SDKKEVCKVV LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK
760 770 780 790 800
LRLDKLRQSC VMVQKHMRGW LQRKKFLRER RAALIIQQYF RGQQTVRKAI
810 820 830 840 850
TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY SRGFLARRRY
860 870 880 890 900
RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED
910 920 930 940 950
QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY
960 970 980 990 1000
RDAVEEKLAK LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD
1010 1020 1030 1040 1050
VQKEERQRML LEKSFELKTQ DYEKQIQSLK EEIKALKDEK MQLQHLVEGE
1060 1070 1080 1090 1100
HVTSDGLKAE VARLSKQVKT ISEFEKEIEL LQAQKIDVEK HVQSQKREMR
1110 1120 1130 1140 1150
EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV
1160 1170 1180 1190 1200
LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
1210 1220 1230 1240 1250
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL
1260 1270 1280 1290 1300
HRSQEEEGTQ RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES
1310 1320 1330 1340 1350
EVKCNFRQEA SRLTLENRDL EEELDMKDRV IKKLQDQVKT LSKTIGKAND
1360 1370 1380 1390 1400
VHSSSGPKEY LGMLQYKRED EAKLIQNLIL DLKPRGVVVN MIPGLPAHIL
1410 1420 1430 1440 1450
FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM LSFWLSNTCH
1460 1470 1480 1490 1500
FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF
1510 1520 1530 1540 1550
IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS
1560 1570 1580 1590 1600
VLQQLSYFYT TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC
1610 1620 1630 1640 1650
RKGMQIRCNI SYLEEWLKDK NLQNSLAKET LEPLSQAAWL LQVKKTTDSD
1660 1670 1680 1690 1700
AKEIYERCTS LSAVQIIKIL NSYTPIDDFE KRVTPSFVRK VQALLNSRED
1710 1720 1730 1740
SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN RL
Length:1,742
Mass (Da):202,810
Last modified:April 20, 2010 - v2
Checksum:i790B1518098B9054
GO
Isoform 2 (identifier: Q9NQX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     425-430: GKQHTF → VLKPLM
     431-1742: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):48,392
Checksum:i5EC9C554382216F1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061365172R → C.Corresponds to variant rs55686434dbSNPEnsembl.1
Natural variantiVAR_010646522L → P.1 Publication1
Natural variantiVAR_010647634L → S.1
Natural variantiVAR_0245441075E → K.Corresponds to variant rs3825801dbSNPEnsembl.1
Natural variantiVAR_0561861396P → L.Corresponds to variant rs17650440dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056592425 – 430GKQHTF → VLKPLM in isoform 2. 1 Publication6
Alternative sequenceiVSP_056593431 – 1742Missing in isoform 2. 1 PublicationAdd BLAST1312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA. Translation: AAF78783.1.
AC010674 Genomic DNA. No translation available.
BC064841 mRNA. Translation: AAH64841.1.
CCDSiCCDS42036.1. [Q9NQX4-1]
RefSeqiNP_061198.2. NM_018728.3. [Q9NQX4-1]
UniGeneiHs.487036.

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833. [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833. [Q9NQX4-2]
GeneIDi55930.
KEGGihsa:55930.
UCSCiuc010bff.4. human. [Q9NQX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA. Translation: AAF78783.1.
AC010674 Genomic DNA. No translation available.
BC064841 mRNA. Translation: AAH64841.1.
CCDSiCCDS42036.1. [Q9NQX4-1]
RefSeqiNP_061198.2. NM_018728.3. [Q9NQX4-1]
UniGeneiHs.487036.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
5HMPX-ray2.40A/B5-754[»]
ProteinModelPortaliQ9NQX4.
SMRiQ9NQX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121005. 107 interactors.
IntActiQ9NQX4. 86 interactors.
STRINGi9606.ENSP00000261839.

PTM databases

iPTMnetiQ9NQX4.
PhosphoSitePlusiQ9NQX4.
SwissPalmiQ9NQX4.

Polymorphism and mutation databases

BioMutaiMYO5C.
DMDMi294862453.

Proteomic databases

EPDiQ9NQX4.
MaxQBiQ9NQX4.
PaxDbiQ9NQX4.
PeptideAtlasiQ9NQX4.
PRIDEiQ9NQX4.

Protocols and materials databases

DNASUi55930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833. [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833. [Q9NQX4-2]
GeneIDi55930.
KEGGihsa:55930.
UCSCiuc010bff.4. human. [Q9NQX4-1]

Organism-specific databases

CTDi55930.
DisGeNETi55930.
GeneCardsiMYO5C.
H-InvDBHIX0038194.
HIX0202185.
HGNCiHGNC:7604. MYO5C.
HPAiCAB020790.
HPA032116.
MIMi610022. gene.
neXtProtiNX_Q9NQX4.
OpenTargetsiENSG00000128833.
PharmGKBiPA31409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ9NQX4.
KOiK10357.
OMAiEDFQMDI.
OrthoDBiEOG091G0G93.
PhylomeDBiQ9NQX4.
TreeFamiTF328771.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128833-MONOMER.

Miscellaneous databases

ChiTaRSiMYO5C. human.
GenomeRNAii55930.
PROiQ9NQX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128833.
CleanExiHS_MYO5C.
ExpressionAtlasiQ9NQX4. baseline and differential.
GenevisibleiQ9NQX4. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5C_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX4
Secondary accession number(s): Q6P1W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.