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Protein

Unconventional myosin-Vc

Gene

MYO5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vc
Gene namesi
Name:MYO5C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:7604. MYO5C.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31409.

Polymorphism and mutation databases

BioMutaiMYO5C.
DMDMi294862453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 17421741Unconventional myosin-VcPRO_0000123463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NQX4.
MaxQBiQ9NQX4.
PaxDbiQ9NQX4.
PeptideAtlasiQ9NQX4.
PRIDEiQ9NQX4.

PTM databases

iPTMnetiQ9NQX4.
PhosphoSiteiQ9NQX4.
SwissPalmiQ9NQX4.

Expressioni

Tissue specificityi

Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.1 Publication

Gene expression databases

BgeeiQ9NQX4.
CleanExiHS_MYO5C.
ExpressionAtlasiQ9NQX4. baseline and differential.
GenevisibleiQ9NQX4. HS.

Organism-specific databases

HPAiCAB020790.
HPA032116.

Interactioni

Protein-protein interaction databases

BioGridi121005. 107 interactions.
IntActiQ9NQX4. 86 interactions.
STRINGi9606.ENSP00000261839.

Structurei

Secondary structure

1
1742
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 64Combined sources
Beta strandi12 – 176Combined sources
Turni18 – 203Combined sources
Beta strandi21 – 299Combined sources
Beta strandi37 – 426Combined sources
Beta strandi47 – 515Combined sources
Beta strandi54 – 563Combined sources
Helixi72 – 743Combined sources
Helixi80 – 9213Combined sources
Beta strandi98 – 1014Combined sources
Beta strandi104 – 1085Combined sources
Helixi119 – 1257Combined sources
Turni130 – 1323Combined sources
Helixi137 – 15115Combined sources
Beta strandi155 – 1606Combined sources
Helixi167 – 18216Combined sources
Helixi190 – 20516Combined sources
Beta strandi218 – 2269Combined sources
Beta strandi232 – 2409Combined sources
Helixi245 – 2473Combined sources
Helixi258 – 2647Combined sources
Turni265 – 2684Combined sources
Helixi270 – 2756Combined sources
Turni280 – 2823Combined sources
Helixi284 – 2874Combined sources
Helixi299 – 31214Combined sources
Helixi317 – 33317Combined sources
Beta strandi339 – 3413Combined sources
Turni342 – 3443Combined sources
Beta strandi345 – 3473Combined sources
Helixi353 – 36210Combined sources
Helixi366 – 3738Combined sources
Beta strandi374 – 3796Combined sources
Beta strandi384 – 3885Combined sources
Helixi391 – 42030Combined sources
Beta strandi429 – 4357Combined sources
Beta strandi443 – 4453Combined sources
Helixi447 – 46721Combined sources
Helixi469 – 4779Combined sources
Helixi491 – 4988Combined sources
Helixi503 – 51210Combined sources
Helixi518 – 52912Combined sources
Turni530 – 5323Combined sources
Beta strandi543 – 5497Combined sources
Beta strandi554 – 5585Combined sources
Helixi562 – 5676Combined sources
Helixi572 – 5798Combined sources
Helixi584 – 5896Combined sources
Helixi624 – 64017Combined sources
Beta strandi642 – 6509Combined sources
Helixi663 – 67210Combined sources
Helixi675 – 68410Combined sources
Helixi693 – 6986Combined sources
Turni706 – 7083Combined sources
Helixi714 – 7229Combined sources
Beta strandi728 – 7336Combined sources
Beta strandi738 – 7403Combined sources
Helixi744 – 7518Combined sources
Helixi1371 – 13788Combined sources
Helixi1388 – 13914Combined sources
Helixi1395 – 140814Combined sources
Helixi1413 – 143321Combined sources
Helixi1438 – 145720Combined sources
Helixi1462 – 14643Combined sources
Turni1470 – 14745Combined sources
Helixi1483 – 151634Combined sources
Helixi1548 – 156316Combined sources
Turni1564 – 15663Combined sources
Helixi1569 – 159325Combined sources
Helixi1595 – 15973Combined sources
Helixi1600 – 161920Combined sources
Helixi1625 – 164218Combined sources
Helixi1650 – 16578Combined sources
Helixi1663 – 167210Combined sources
Beta strandi1677 – 16804Combined sources
Helixi1685 – 169410Combined sources
Helixi1695 – 16973Combined sources
Helixi1725 – 17273Combined sources
Helixi1732 – 17343Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
ProteinModelPortaliQ9NQX4.
SMRiQ9NQX4. Positions 2-781, 1359-1742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 753687Myosin motorAdd
BLAST
Domaini756 – 77924IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini780 – 80627IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini807 – 82923IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini830 – 85425IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini855 – 88430IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini1421 – 1697277DilutePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili884 – 1351468Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 5 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ9NQX4.
KOiK10357.
OMAiEDFQMDI.
OrthoDBiEOG7PK8XT.
PhylomeDBiQ9NQX4.
TreeFamiTF328771.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY
60 70 80 90 100
SVNPESLPPL RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY
110 120 130 140 150
SGIILVAMNP YKQLPIYGDA IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR
160 170 180 190 200
NNRNQSIIVS GESGAGKTVS ARYAMRYFAT VSKSGSNAHV EDKVLASNPI
210 220 230 240 250
TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY LLEKSRVVFQ
260 270 280 290 300
SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
310 320 330 340 350
AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE
360 370 380 390 400
DDSHLKVFCE LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA
410 420 430 440 450
LAKKIYAHLF DFIVERINQA LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF
460 470 480 490 500
CINYANEKLQ QQFNMHVFKL EQEEYMKEDI PWTLIDFYDN QPVIDLIEAK
510 520 530 540 550
MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR MSNTSFVIQH
560 570 580 590 600
FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF
610 620 630 640 650
GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI
660 670 680 690 700
KPNDEKLPFE FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG
710 720 730 740 750
ILMTKQELSF SDKKEVCKVV LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK
760 770 780 790 800
LRLDKLRQSC VMVQKHMRGW LQRKKFLRER RAALIIQQYF RGQQTVRKAI
810 820 830 840 850
TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY SRGFLARRRY
860 870 880 890 900
RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED
910 920 930 940 950
QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY
960 970 980 990 1000
RDAVEEKLAK LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD
1010 1020 1030 1040 1050
VQKEERQRML LEKSFELKTQ DYEKQIQSLK EEIKALKDEK MQLQHLVEGE
1060 1070 1080 1090 1100
HVTSDGLKAE VARLSKQVKT ISEFEKEIEL LQAQKIDVEK HVQSQKREMR
1110 1120 1130 1140 1150
EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA YEGLKKATRV
1160 1170 1180 1190 1200
LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
1210 1220 1230 1240 1250
VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL
1260 1270 1280 1290 1300
HRSQEEEGTQ RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES
1310 1320 1330 1340 1350
EVKCNFRQEA SRLTLENRDL EEELDMKDRV IKKLQDQVKT LSKTIGKAND
1360 1370 1380 1390 1400
VHSSSGPKEY LGMLQYKRED EAKLIQNLIL DLKPRGVVVN MIPGLPAHIL
1410 1420 1430 1440 1450
FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM LSFWLSNTCH
1460 1470 1480 1490 1500
FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF
1510 1520 1530 1540 1550
IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS
1560 1570 1580 1590 1600
VLQQLSYFYT TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC
1610 1620 1630 1640 1650
RKGMQIRCNI SYLEEWLKDK NLQNSLAKET LEPLSQAAWL LQVKKTTDSD
1660 1670 1680 1690 1700
AKEIYERCTS LSAVQIIKIL NSYTPIDDFE KRVTPSFVRK VQALLNSRED
1710 1720 1730 1740
SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN RL
Length:1,742
Mass (Da):202,810
Last modified:April 20, 2010 - v2
Checksum:i790B1518098B9054
GO
Isoform 2 (identifier: Q9NQX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     425-430: GKQHTF → VLKPLM
     431-1742: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):48,392
Checksum:i5EC9C554382216F1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721R → C.
Corresponds to variant rs55686434 [ dbSNP | Ensembl ].
VAR_061365
Natural varianti522 – 5221L → P.1 Publication
VAR_010646
Natural varianti634 – 6341L → S.
VAR_010647
Natural varianti1075 – 10751E → K.
Corresponds to variant rs3825801 [ dbSNP | Ensembl ].
VAR_024544
Natural varianti1396 – 13961P → L.
Corresponds to variant rs17650440 [ dbSNP | Ensembl ].
VAR_056186

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei425 – 4306GKQHTF → VLKPLM in isoform 2. 1 PublicationVSP_056592
Alternative sequencei431 – 17421312Missing in isoform 2. 1 PublicationVSP_056593Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA. Translation: AAF78783.1.
AC010674 Genomic DNA. No translation available.
BC064841 mRNA. Translation: AAH64841.1.
CCDSiCCDS42036.1. [Q9NQX4-1]
RefSeqiNP_061198.2. NM_018728.3. [Q9NQX4-1]
UniGeneiHs.487036.

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833. [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833. [Q9NQX4-2]
GeneIDi55930.
KEGGihsa:55930.
UCSCiuc010bff.4. human. [Q9NQX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272390 mRNA. Translation: AAF78783.1.
AC010674 Genomic DNA. No translation available.
BC064841 mRNA. Translation: AAH64841.1.
CCDSiCCDS42036.1. [Q9NQX4-1]
RefSeqiNP_061198.2. NM_018728.3. [Q9NQX4-1]
UniGeneiHs.487036.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4L8TX-ray2.95A1319-1742[»]
4ZG4X-ray2.36B/E1-755[»]
ProteinModelPortaliQ9NQX4.
SMRiQ9NQX4. Positions 2-781, 1359-1742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121005. 107 interactions.
IntActiQ9NQX4. 86 interactions.
STRINGi9606.ENSP00000261839.

PTM databases

iPTMnetiQ9NQX4.
PhosphoSiteiQ9NQX4.
SwissPalmiQ9NQX4.

Polymorphism and mutation databases

BioMutaiMYO5C.
DMDMi294862453.

Proteomic databases

EPDiQ9NQX4.
MaxQBiQ9NQX4.
PaxDbiQ9NQX4.
PeptideAtlasiQ9NQX4.
PRIDEiQ9NQX4.

Protocols and materials databases

DNASUi55930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261839; ENSP00000261839; ENSG00000128833. [Q9NQX4-1]
ENST00000559459; ENSP00000454064; ENSG00000128833. [Q9NQX4-2]
GeneIDi55930.
KEGGihsa:55930.
UCSCiuc010bff.4. human. [Q9NQX4-1]

Organism-specific databases

CTDi55930.
GeneCardsiMYO5C.
H-InvDBHIX0038194.
HIX0202185.
HGNCiHGNC:7604. MYO5C.
HPAiCAB020790.
HPA032116.
MIMi610022. gene.
neXtProtiNX_Q9NQX4.
PharmGKBiPA31409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160. Eukaryota.
KOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000171839.
HOVERGENiHBG052556.
InParanoidiQ9NQX4.
KOiK10357.
OMAiEDFQMDI.
OrthoDBiEOG7PK8XT.
PhylomeDBiQ9NQX4.
TreeFamiTF328771.

Miscellaneous databases

ChiTaRSiMYO5C. human.
GenomeRNAii55930.
PROiQ9NQX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQX4.
CleanExiHS_MYO5C.
ExpressionAtlasiQ9NQX4. baseline and differential.
GenevisibleiQ9NQX4. HS.

Family and domain databases

InterProiIPR002710. Dilute_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM01132. DIL. 1 hit.
SM00015. IQ. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51126. DILUTE. 1 hit.
PS50096. IQ. 4 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human myosin-Vc is a novel class V myosin expressed in epithelial cells."
    Rodriguez O.C., Cheney R.E.
    J. Cell Sci. 115:991-1004(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-522, TISSUE SPECIFICITY.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: PNS.
  4. Bienvenut W.V., Dhillon A.S., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.

Entry informationi

Entry nameiMYO5C_HUMAN
AccessioniPrimary (citable) accession number: Q9NQX4
Secondary accession number(s): Q6P1W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.