Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable histone-lysine N-methyltransferase PRDM7

Gene

PRDM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable histone methyltransferase.By similarity

Miscellaneous

The mouse orthologous protein seems not to exist. According to PubMed:17916234, human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone-lysine N-methyltransferase PRDM7 (EC:2.1.1.43)
Alternative name(s):
PR domain zinc finger protein 7
PR domain-containing protein 7
Gene namesi
Name:PRDM7
Synonyms:PFM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000126856.13.
HGNCiHGNC:9351. PRDM7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126856.
PharmGKBiPA33719.

Polymorphism and mutation databases

BioMutaiPRDM7.
DMDMi223590134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477631 – 492Probable histone-lysine N-methyltransferase PRDM7Add BLAST492

Proteomic databases

EPDiQ9NQW5.
PaxDbiQ9NQW5.
PeptideAtlasiQ9NQW5.
PRIDEiQ9NQW5.

PTM databases

iPTMnetiQ9NQW5.
PhosphoSitePlusiQ9NQW5.

Expressioni

Gene expression databases

BgeeiENSG00000126856.
CleanExiHS_PRDM7.
ExpressionAtlasiQ9NQW5. baseline and differential.

Organism-specific databases

HPAiHPA059555.
HPA059944.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF1Q130773EBI-10312471,EBI-359224

Protein-protein interaction databases

BioGridi116286. 1 interactor.
IntActiQ9NQW5. 2 interactors.
STRINGi9606.ENSP00000396732.

Structurei

3D structure databases

ProteinModelPortaliQ9NQW5.
SMRiQ9NQW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86KRAB-relatedPROSITE-ProRule annotationAdd BLAST64
Domaini244 – 358SETPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

eggNOGiKOG2461. Eukaryota.
ENOG410ZFVU. LUCA.
GeneTreeiENSGT00830000128341.
HOGENOMiHOG000115687.
InParanoidiQ9NQW5.
KOiK20796.
OMAiVWNEASH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NQW5.
TreeFamiTF337915.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR003655. Krueppel-associated_box-rel.
IPR001214. SET_dom.
IPR019041. SSXRD_motif.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF09514. SSXRD. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50806. KRAB_RELATED. 1 hit.
PS50280. SET. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQW5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPERSQEES PEGDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR
60 70 80 90 100
YRNVKMNYNA LITVGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ
110 120 130 140 150
VKPPWMAFRG EQSKHQKGMP KASFNNESSL RELSGTPNLL NTSDSEQAQK
160 170 180 190 200
PVSPPGEAST SGQHSRLKLE LRRKETEGKM YSLRERKGHA YKEISEPQDD
210 220 230 240 250
DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL SLPPGLRIGP
260 270 280 290 300
SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANSG YSWLITKGRN
310 320 330 340 350
CYEYVDGKDK SSANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG
360 370 380 390 400
CELLVWSGDE YGQELGIRSS IEPAESLGQA VNCWSGMGMS MARNWASSGA
410 420 430 440 450
ASGRKSSWQG ENQSQRSIHV PHAVWPFQVK NFSVNMWNAI TPLRTSQDHL
460 470 480 490
QENFSNQRIP AQGIRIRSGN ILIHAAVMTK PKVKRSKKGP NS
Length:492
Mass (Da):55,777
Last modified:February 10, 2009 - v2
Checksum:i0C80D8DE8BA65DC5
GO
Isoform 2 (identifier: Q9NQW5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     318-377: YVNCARDDEE...RSSIEPAESL → TKARDPSMSL...RGSESGAAIF
     378-492: Missing.

Show »
Length:171
Mass (Da):18,442
Checksum:iF4F63783520C0072
GO
Isoform 3 (identifier: Q9NQW5-1) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     368-492: RSSIEPAESL...VKRSKKGPNS → KWGSKWKKEL...GEAPVCRKDE

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:407
Mass (Da):45,890
Checksum:iD09E7D983CFA4426
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357S → Y in AAF78084 (PubMed:10668202).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05746190D → E1 PublicationCorresponds to variant dbSNP:rs12925933Ensembl.1
Natural variantiVAR_057462131R → K. Corresponds to variant dbSNP:rs2078478Ensembl.1
Natural variantiVAR_057463435N → K. Corresponds to variant dbSNP:rs7206111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0363491 – 206Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST206
Alternative sequenceiVSP_006930318 – 377YVNCA…PAESL → TKARDPSMSLMLSGLFKSKI SQSTCGTQSLLSELPRTICK KTSPTRESLPRGSESGAAIF in isoform 2. 2 PublicationsAdd BLAST60
Alternative sequenceiVSP_036350368 – 492RSSIE…KGPNS → KWGSKWKKELMAGREPKPEI HPCPSCCLAFSSQKFLSQHV ERNHSSQNFPGPSARKLLQP ENPCPGDQNQERQYSDPRCC NDKTKGQEIKERSKLLNKRT WQREISRAFSSPPKGQMGSS RVGERMMEEESRTGQKVNPG NTGKLFVGVGISRIAKVKYG ECGQGFSDKSDVITHQRTHT GGKPYVCRECGEGFSRKSDL LSHQRTHTGEKPYVCRECER GFSRKSVLLIHQRTHRGEAP VCRKDE in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_006931378 – 492Missing in isoform 2. 2 PublicationsAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM690991 mRNA. Translation: CAM84449.1.
AF274347 mRNA. Translation: AAF78084.1.
AF274348 mRNA. Translation: AAF78085.1.
CH471184 Genomic DNA. Translation: EAW66654.1.
BC107033 mRNA. Translation: AAI07034.1.
CCDSiCCDS45557.1. [Q9NQW5-3]
RefSeqiNP_001091643.1. NM_001098173.1. [Q9NQW5-3]
XP_005256331.1. XM_005256274.3. [Q9NQW5-3]
UniGeneiHs.406695.

Genome annotation databases

EnsembliENST00000449207; ENSP00000396732; ENSG00000126856. [Q9NQW5-3]
GeneIDi11105.
KEGGihsa:11105.
UCSCiuc010cje.4. human. [Q9NQW5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRDM7_HUMAN
AccessioniPrimary (citable) accession number: Q9NQW5
Secondary accession number(s): A4Q9G8, Q08EM4, Q9NQW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot