Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein transport protein Sec31B

Gene

SEC31B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075826-MONOMER.
SignaLinkiQ9NQW1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec31B
Alternative name(s):
SEC31-like protein 2
SEC31-related protein B
SEC31B-1
Gene namesi
Name:SEC31B
Synonyms:SEC31L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23197. SEC31B.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmic vesicleCOPII-coated vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
  • vesicle coat Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075826.
PharmGKBiPA162402792.

Polymorphism and mutation databases

BioMutaiSEC31B.
DMDMi74762753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951531 – 1179Protein transport protein Sec31BAdd BLAST1179

Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NQW1.
PeptideAtlasiQ9NQW1.
PRIDEiQ9NQW1.

PTM databases

iPTMnetiQ9NQW1.
PhosphoSitePlusiQ9NQW1.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000075826.
CleanExiHS_SEC31B.
ExpressionAtlasiQ9NQW1. baseline and differential.
GenevisibleiQ9NQW1. HS.

Organism-specific databases

HPAiHPA035882.
HPA040819.
HPA060052.

Interactioni

Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with SEC31A.By similarity1 Publication

Protein-protein interaction databases

BioGridi117447. 13 interactors.
IntActiQ9NQW1. 4 interactors.
STRINGi9606.ENSP00000359370.

Structurei

3D structure databases

ProteinModelPortaliQ9NQW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati67 – 110WD 2Add BLAST44
Repeati119 – 159WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 341WD 7Add BLAST41
Repeati391 – 422WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi821 – 1073Pro-richAdd BLAST253

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ9NQW1.
KOiK14005.
OMAiHAVELCL.
OrthoDBiEOG091G01VB.
PhylomeDBiQ9NQW1.
TreeFamiTF313842.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQW1-1) [UniParc]FASTAAdd to basket
Also known as: SEC31B-F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKELERPA VQAWSPASQY PLYLATGTSA QQLDSSFSTN GTLEIFEVDF
60 70 80 90 100
RDPSLDLKHR GVLSALSRFH KLVWGSFGSG LLESSGVIVG GGDNGMLILY
110 120 130 140 150
NVTHILSSGK EPVIAQKQKH TGAVRALDLN PFQGNLLASG ASDSEIFIWD
160 170 180 190 200
LNNLNVPMTL GSKSQQPPED IKALSWNRQA QHILSSAHPS GKAVVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDIATQLV LCSEDDRLPV IQLWDLRFAS
260 270 280 290 300
SPLKVLESHS RGILSVSWSQ ADAELLLTSA KDSQILCRNL GSSEVVYKLP
310 320 330 340 350
TQSSWCFDVQ WCPRDPSVFS AASFNGWISL YSVMGRSWEV QHMRQADKIS
360 370 380 390 400
SSFSKGQPLP PLQVPEQVAQ APLIPPLKKP PKWIRRPTGV SFAFGGKLVT
410 420 430 440 450
FGLPSTPAHL VPQPCPRLVF ISQVTTESEF LMRSAELQEA LGSGNLLNYC
460 470 480 490 500
QNKSQQALLQ SEKMLWQFLK VTLEQDSRMK FLKLLGYSKD ELQKKVATWL
510 520 530 540 550
KSDVGLGESP QPKGNDLNSD RQQAFCSQAS KHTTKEASAS SAFFDELVPQ
560 570 580 590 600
NMTPWEIPIT KDIDGLLSQA LLLGELGPAV ELCLKEERFA DAIILAQAGG
610 620 630 640 650
TDLLKQTQER YLAKKKTKIS SLLACVVQKN WKDVVCTCSL KNWREALALL
660 670 680 690 700
LTYSGTEKFP ELCDMLGTRM EQEGSRALTS EARLCYVCSG SVERLVECWA
710 720 730 740 750
KCHQALSPMA LQDLMEKVMV LNRSLEQLRG PHGVSPGPAT TYRVTQYANL
760 770 780 790 800
LAAQGSLATA MSFLPRDCAQ PPVQQLRDRL FHAQGSAVLG QQSPPFPFPR
810 820 830 840 850
IVVGATLHSK ETSSYRLGSQ PSHQVPTPSP RPRVFTPQSS PAMPLAPSHP
860 870 880 890 900
SPYQGPRTQN ISDYRAPGPQ AIQPLPLSPG VRPASSQPQL LGGQRVQVPN
910 920 930 940 950
PVGFPGTWPL PGSPLPMACP GIMRPGSTSL PETPRLFPLL PLRPLGPGRM
960 970 980 990 1000
VSHTPAPPAS FPVPYLPGDP GAPCSSVLPT TGILTPHPGP QDSWKEAPAP
1010 1020 1030 1040 1050
RGNLQRNKLP ETFMPPAPIT APVMSLTPEL QGILPSQPPV SSVSHAPPGV
1060 1070 1080 1090 1100
PGELSLQLQH LPPEKMERKE LPPEHQSLKS SFEALLQRCS LSATDLKTKR
1110 1120 1130 1140 1150
KLEEAAQRLE YLYEKLCEGT LSPHVVAGLH EVARCVDAGS FEQGLAVHAQ
1160 1170
VAGCSSFSEV SSFMPILKAV LIIAHKLLV
Length:1,179
Mass (Da):128,697
Last modified:October 1, 2000 - v1
Checksum:i88C591B060643A5D
GO
Isoform 2 (identifier: Q9NQW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.
     349-349: I → V
     350-1179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:348
Mass (Da):38,450
Checksum:iBD8A60259743B860
GO
Isoform 3 (identifier: Q9NQW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: FHKLVWGSFGSGLLESS → ATSWLQGPAILKSSLGI
     86-1179: Missing.

Show »
Length:85
Mass (Da):9,294
Checksum:i1CA9C2A4C9F56411
GO
Isoform 4 (identifier: Q9NQW1-4) [UniParc]FASTAAdd to basket
Also known as: SEC31B-t

The sequence of this isoform differs from the canonical sequence as follows:
     470-482: KVTLEQDSRMKFL → KPARDSSGARR
     483-1179: Missing.

Show »
Length:480
Mass (Da):52,984
Checksum:iA91F37DAA6824103
GO
Isoform 5 (identifier: Q9NQW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.

Note: No experimental confirmation available.
Show »
Length:1,178
Mass (Da):128,569
Checksum:i102AA849D41A1D65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti805A → V in CAB45735 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03322889V → A.1 PublicationCorresponds to variant rs3763695dbSNPEnsembl.1
Natural variantiVAR_033229100Y → C.Corresponds to variant rs7074707dbSNPEnsembl.1
Natural variantiVAR_033230129L → F.1 PublicationCorresponds to variant rs3793706dbSNPEnsembl.1
Natural variantiVAR_033231332S → A.1 PublicationCorresponds to variant rs2295774dbSNPEnsembl.1
Natural variantiVAR_033232372P → S.Corresponds to variant rs2295772dbSNPEnsembl.1
Natural variantiVAR_053415433R → Q.Corresponds to variant rs2295771dbSNPEnsembl.1
Natural variantiVAR_053416478R → T.Corresponds to variant rs11819496dbSNPEnsembl.1
Natural variantiVAR_033233527S → R.Corresponds to variant rs17113157dbSNPEnsembl.1
Natural variantiVAR_0332341169A → S.Corresponds to variant rs2298075dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02675769 – 85FHKLV…LLESS → ATSWLQGPAILKSSLGI in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_02675886 – 1179Missing in isoform 3. 1 PublicationAdd BLAST1094
Alternative sequenceiVSP_026759165Missing in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_026760349I → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_026761350 – 1179Missing in isoform 2. 1 PublicationAdd BLAST830
Alternative sequenceiVSP_026762470 – 482KVTLE…RMKFL → KPARDSSGARR in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_026763483 – 1179Missing in isoform 4. CuratedAdd BLAST697

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA. Translation: AAF78243.1.
AL080141 mRNA. Translation: CAB45735.1.
BX640914 mRNA. Translation: CAE45955.1.
AL133352 Genomic DNA. Translation: CAH73561.1.
BC034946 mRNA. Translation: AAH34946.1.
BC044569 mRNA. No translation available.
BC144313 mRNA. Translation: AAI44314.1.
CCDSiCCDS7495.1. [Q9NQW1-1]
PIRiT12526.
RefSeqiNP_056305.1. NM_015490.3. [Q9NQW1-1]
UniGeneiHs.18889.

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826. [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826. [Q9NQW1-2]
GeneIDi25956.
KEGGihsa:25956.
UCSCiuc001krc.2. human. [Q9NQW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA. Translation: AAF78243.1.
AL080141 mRNA. Translation: CAB45735.1.
BX640914 mRNA. Translation: CAE45955.1.
AL133352 Genomic DNA. Translation: CAH73561.1.
BC034946 mRNA. Translation: AAH34946.1.
BC044569 mRNA. No translation available.
BC144313 mRNA. Translation: AAI44314.1.
CCDSiCCDS7495.1. [Q9NQW1-1]
PIRiT12526.
RefSeqiNP_056305.1. NM_015490.3. [Q9NQW1-1]
UniGeneiHs.18889.

3D structure databases

ProteinModelPortaliQ9NQW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117447. 13 interactors.
IntActiQ9NQW1. 4 interactors.
STRINGi9606.ENSP00000359370.

PTM databases

iPTMnetiQ9NQW1.
PhosphoSitePlusiQ9NQW1.

Polymorphism and mutation databases

BioMutaiSEC31B.
DMDMi74762753.

Proteomic databases

PaxDbiQ9NQW1.
PeptideAtlasiQ9NQW1.
PRIDEiQ9NQW1.

Protocols and materials databases

DNASUi25956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826. [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826. [Q9NQW1-2]
GeneIDi25956.
KEGGihsa:25956.
UCSCiuc001krc.2. human. [Q9NQW1-1]

Organism-specific databases

CTDi25956.
GeneCardsiSEC31B.
HGNCiHGNC:23197. SEC31B.
HPAiHPA035882.
HPA040819.
HPA060052.
MIMi610258. gene.
neXtProtiNX_Q9NQW1.
OpenTargetsiENSG00000075826.
PharmGKBiPA162402792.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ9NQW1.
KOiK14005.
OMAiHAVELCL.
OrthoDBiEOG091G01VB.
PhylomeDBiQ9NQW1.
TreeFamiTF313842.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075826-MONOMER.
SignaLinkiQ9NQW1.

Miscellaneous databases

ChiTaRSiSEC31B. human.
GenomeRNAii25956.
PROiQ9NQW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075826.
CleanExiHS_SEC31B.
ExpressionAtlasiQ9NQW1. baseline and differential.
GenevisibleiQ9NQW1. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC31B_HUMAN
AccessioniPrimary (citable) accession number: Q9NQW1
Secondary accession number(s): B7ZM75
, Q6MZS3, Q86UF0, Q9Y4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.