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Protein

Protein transport protein Sec31B

Gene

SEC31B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9NQW1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec31B
Alternative name(s):
SEC31-like protein 2
SEC31-related protein B
SEC31B-1
Gene namesi
Name:SEC31B
Synonyms:SEC31L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23197. SEC31B.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmic vesicleCOPII-coated vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
  • vesicle coat Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402792.

Polymorphism and mutation databases

BioMutaiSEC31B.
DMDMi74762753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11791179Protein transport protein Sec31BPRO_0000295153Add
BLAST

Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NQW1.
PRIDEiQ9NQW1.

PTM databases

PhosphoSiteiQ9NQW1.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).2 Publications

Gene expression databases

BgeeiQ9NQW1.
CleanExiHS_SEC31B.
ExpressionAtlasiQ9NQW1. baseline and differential.
GenevestigatoriQ9NQW1.

Organism-specific databases

HPAiHPA035882.
HPA040819.

Interactioni

Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with SEC31A.By similarity1 Publication

Protein-protein interaction databases

BioGridi117447. 10 interactions.
IntActiQ9NQW1. 4 interactions.
STRINGi9606.ENSP00000359370.

Structurei

3D structure databases

ProteinModelPortaliQ9NQW1.
SMRiQ9NQW1. Positions 5-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati67 – 11044WD 2Add
BLAST
Repeati119 – 15941WD 3Add
BLAST
Repeati166 – 20641WD 4Add
BLAST
Repeati209 – 25446WD 5Add
BLAST
Repeati258 – 29841WD 6Add
BLAST
Repeati301 – 34141WD 7Add
BLAST
Repeati391 – 42232WD 8; interaction with SEC13PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi821 – 1073253Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG248389.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ9NQW1.
KOiK14005.
OMAiPSEKMLW.
OrthoDBiEOG7B31M1.
PhylomeDBiQ9NQW1.
TreeFamiTF313842.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQW1-1) [UniParc]FASTAAdd to basket

Also known as: SEC31B-F

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKELERPA VQAWSPASQY PLYLATGTSA QQLDSSFSTN GTLEIFEVDF
60 70 80 90 100
RDPSLDLKHR GVLSALSRFH KLVWGSFGSG LLESSGVIVG GGDNGMLILY
110 120 130 140 150
NVTHILSSGK EPVIAQKQKH TGAVRALDLN PFQGNLLASG ASDSEIFIWD
160 170 180 190 200
LNNLNVPMTL GSKSQQPPED IKALSWNRQA QHILSSAHPS GKAVVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDIATQLV LCSEDDRLPV IQLWDLRFAS
260 270 280 290 300
SPLKVLESHS RGILSVSWSQ ADAELLLTSA KDSQILCRNL GSSEVVYKLP
310 320 330 340 350
TQSSWCFDVQ WCPRDPSVFS AASFNGWISL YSVMGRSWEV QHMRQADKIS
360 370 380 390 400
SSFSKGQPLP PLQVPEQVAQ APLIPPLKKP PKWIRRPTGV SFAFGGKLVT
410 420 430 440 450
FGLPSTPAHL VPQPCPRLVF ISQVTTESEF LMRSAELQEA LGSGNLLNYC
460 470 480 490 500
QNKSQQALLQ SEKMLWQFLK VTLEQDSRMK FLKLLGYSKD ELQKKVATWL
510 520 530 540 550
KSDVGLGESP QPKGNDLNSD RQQAFCSQAS KHTTKEASAS SAFFDELVPQ
560 570 580 590 600
NMTPWEIPIT KDIDGLLSQA LLLGELGPAV ELCLKEERFA DAIILAQAGG
610 620 630 640 650
TDLLKQTQER YLAKKKTKIS SLLACVVQKN WKDVVCTCSL KNWREALALL
660 670 680 690 700
LTYSGTEKFP ELCDMLGTRM EQEGSRALTS EARLCYVCSG SVERLVECWA
710 720 730 740 750
KCHQALSPMA LQDLMEKVMV LNRSLEQLRG PHGVSPGPAT TYRVTQYANL
760 770 780 790 800
LAAQGSLATA MSFLPRDCAQ PPVQQLRDRL FHAQGSAVLG QQSPPFPFPR
810 820 830 840 850
IVVGATLHSK ETSSYRLGSQ PSHQVPTPSP RPRVFTPQSS PAMPLAPSHP
860 870 880 890 900
SPYQGPRTQN ISDYRAPGPQ AIQPLPLSPG VRPASSQPQL LGGQRVQVPN
910 920 930 940 950
PVGFPGTWPL PGSPLPMACP GIMRPGSTSL PETPRLFPLL PLRPLGPGRM
960 970 980 990 1000
VSHTPAPPAS FPVPYLPGDP GAPCSSVLPT TGILTPHPGP QDSWKEAPAP
1010 1020 1030 1040 1050
RGNLQRNKLP ETFMPPAPIT APVMSLTPEL QGILPSQPPV SSVSHAPPGV
1060 1070 1080 1090 1100
PGELSLQLQH LPPEKMERKE LPPEHQSLKS SFEALLQRCS LSATDLKTKR
1110 1120 1130 1140 1150
KLEEAAQRLE YLYEKLCEGT LSPHVVAGLH EVARCVDAGS FEQGLAVHAQ
1160 1170
VAGCSSFSEV SSFMPILKAV LIIAHKLLV
Length:1,179
Mass (Da):128,697
Last modified:October 1, 2000 - v1
Checksum:i88C591B060643A5D
GO
Isoform 2 (identifier: Q9NQW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.
     349-349: I → V
     350-1179: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:348
Mass (Da):38,450
Checksum:iBD8A60259743B860
GO
Isoform 3 (identifier: Q9NQW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-85: FHKLVWGSFGSGLLESS → ATSWLQGPAILKSSLGI
     86-1179: Missing.

Show »
Length:85
Mass (Da):9,294
Checksum:i1CA9C2A4C9F56411
GO
Isoform 4 (identifier: Q9NQW1-4) [UniParc]FASTAAdd to basket

Also known as: SEC31B-t

The sequence of this isoform differs from the canonical sequence as follows:
     470-482: KVTLEQDSRMKFL → KPARDSSGARR
     483-1179: Missing.

Show »
Length:480
Mass (Da):52,984
Checksum:iA91F37DAA6824103
GO
Isoform 5 (identifier: Q9NQW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-165: Missing.

Note: No experimental confirmation available.

Show »
Length:1,178
Mass (Da):128,569
Checksum:i102AA849D41A1D65
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti805 – 8051A → V in CAB45735 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891V → A.1 Publication
Corresponds to variant rs3763695 [ dbSNP | Ensembl ].
VAR_033228
Natural varianti100 – 1001Y → C.
Corresponds to variant rs7074707 [ dbSNP | Ensembl ].
VAR_033229
Natural varianti129 – 1291L → F.1 Publication
Corresponds to variant rs3793706 [ dbSNP | Ensembl ].
VAR_033230
Natural varianti332 – 3321S → A.1 Publication
Corresponds to variant rs2295774 [ dbSNP | Ensembl ].
VAR_033231
Natural varianti372 – 3721P → S.
Corresponds to variant rs2295772 [ dbSNP | Ensembl ].
VAR_033232
Natural varianti433 – 4331R → Q.
Corresponds to variant rs2295771 [ dbSNP | Ensembl ].
VAR_053415
Natural varianti478 – 4781R → T.
Corresponds to variant rs11819496 [ dbSNP | Ensembl ].
VAR_053416
Natural varianti527 – 5271S → R.
Corresponds to variant rs17113157 [ dbSNP | Ensembl ].
VAR_033233
Natural varianti1169 – 11691A → S.
Corresponds to variant rs2298075 [ dbSNP | Ensembl ].
VAR_033234

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 8517FHKLV…LLESS → ATSWLQGPAILKSSLGI in isoform 3. 1 PublicationVSP_026757Add
BLAST
Alternative sequencei86 – 11791094Missing in isoform 3. 1 PublicationVSP_026758Add
BLAST
Alternative sequencei165 – 1651Missing in isoform 2 and isoform 5. 1 PublicationVSP_026759
Alternative sequencei349 – 3491I → V in isoform 2. 1 PublicationVSP_026760
Alternative sequencei350 – 1179830Missing in isoform 2. 1 PublicationVSP_026761Add
BLAST
Alternative sequencei470 – 48213KVTLE…RMKFL → KPARDSSGARR in isoform 4. CuratedVSP_026762Add
BLAST
Alternative sequencei483 – 1179697Missing in isoform 4. CuratedVSP_026763Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA. Translation: AAF78243.1.
AL080141 mRNA. Translation: CAB45735.1.
BX640914 mRNA. Translation: CAE45955.1.
AL133352 Genomic DNA. Translation: CAH73561.1.
BC034946 mRNA. Translation: AAH34946.1.
BC044569 mRNA. No translation available.
BC144313 mRNA. Translation: AAI44314.1.
CCDSiCCDS7495.1. [Q9NQW1-1]
PIRiT12526.
RefSeqiNP_056305.1. NM_015490.3. [Q9NQW1-1]
UniGeneiHs.18889.

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826. [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826. [Q9NQW1-2]
GeneIDi25956.
KEGGihsa:25956.
UCSCiuc001krc.1. human. [Q9NQW1-1]
uc010qpo.1. human. [Q9NQW1-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274863 mRNA. Translation: AAF78243.1.
AL080141 mRNA. Translation: CAB45735.1.
BX640914 mRNA. Translation: CAE45955.1.
AL133352 Genomic DNA. Translation: CAH73561.1.
BC034946 mRNA. Translation: AAH34946.1.
BC044569 mRNA. No translation available.
BC144313 mRNA. Translation: AAI44314.1.
CCDSiCCDS7495.1. [Q9NQW1-1]
PIRiT12526.
RefSeqiNP_056305.1. NM_015490.3. [Q9NQW1-1]
UniGeneiHs.18889.

3D structure databases

ProteinModelPortaliQ9NQW1.
SMRiQ9NQW1. Positions 5-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117447. 10 interactions.
IntActiQ9NQW1. 4 interactions.
STRINGi9606.ENSP00000359370.

PTM databases

PhosphoSiteiQ9NQW1.

Polymorphism and mutation databases

BioMutaiSEC31B.
DMDMi74762753.

Proteomic databases

PaxDbiQ9NQW1.
PRIDEiQ9NQW1.

Protocols and materials databases

DNASUi25956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370345; ENSP00000359370; ENSG00000075826. [Q9NQW1-1]
ENST00000462434; ENSP00000474124; ENSG00000075826. [Q9NQW1-2]
GeneIDi25956.
KEGGihsa:25956.
UCSCiuc001krc.1. human. [Q9NQW1-1]
uc010qpo.1. human. [Q9NQW1-5]

Organism-specific databases

CTDi25956.
GeneCardsiGC10M102237.
HGNCiHGNC:23197. SEC31B.
HPAiHPA035882.
HPA040819.
MIMi610258. gene.
neXtProtiNX_Q9NQW1.
PharmGKBiPA162402792.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG248389.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiQ9NQW1.
KOiK14005.
OMAiPSEKMLW.
OrthoDBiEOG7B31M1.
PhylomeDBiQ9NQW1.
TreeFamiTF313842.

Enzyme and pathway databases

SignaLinkiQ9NQW1.

Miscellaneous databases

ChiTaRSiSEC31B. human.
GenomeRNAii25956.
NextBioi47564.
PROiQ9NQW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQW1.
CleanExiHS_SEC31B.
ExpressionAtlasiQ9NQW1. baseline and differential.
GenevestigatoriQ9NQW1.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human Sec31B: a family of new mammalian orthologues of yeast Sec31p that associate with the COPII coat."
    Stankewich M.C., Stabach P.R., Morrow J.S.
    J. Cell Sci. 119:958-969(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH SEC13 AND SEC31A.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-1179 (ISOFORM 1).
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANTS ALA-89; PHE-129 AND ALA-332.
    Tissue: Testis.
  5. "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport."
    Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W.
    J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Ubiquitin-dependent regulation of COPII coat size and function."
    Jin L., Pahuja K.B., Wickliffe K.E., Gorur A., Baumgartel C., Schekman R., Rape M.
    Nature 482:495-500(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.

Entry informationi

Entry nameiSC31B_HUMAN
AccessioniPrimary (citable) accession number: Q9NQW1
Secondary accession number(s): B7ZM75
, Q6MZS3, Q86UF0, Q9Y4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.