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Q9NQV7

- PRDM9_HUMAN

UniProt

Q9NQV7 - PRDM9_HUMAN

Protein

Histone-lysine N-methyltransferase PRDM9

Gene

PRDM9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri388 – 41124C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri552 – 57423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri580 – 60223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri608 – 63023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 65823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri664 – 68623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri776 – 79823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri832 – 85423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri860 – 88223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. recombination hotspot binding Source: Ensembl
    4. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. meiotic gene conversion Source: MGI
    2. positive regulation of meiosis I Source: Ensembl
    3. positive regulation of reciprocal meiotic recombination Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. spermatogenesis Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Meiosis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_27271. Meiotic recombination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase PRDM9 (EC:2.1.1.43)
    Alternative name(s):
    PR domain zinc finger protein 9
    PR domain-containing protein 9
    Gene namesi
    Name:PRDM9
    Synonyms:PFM6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:13994. PRDM9.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33721.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 894894Histone-lysine N-methyltransferase PRDM9PRO_0000047766Add
    BLAST

    Proteomic databases

    PaxDbiQ9NQV7.
    PRIDEiQ9NQV7.

    PTM databases

    PhosphoSiteiQ9NQV7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NQV7.
    BgeeiQ9NQV7.
    CleanExiHS_PRDM9.
    GenevestigatoriQ9NQV7.

    Organism-specific databases

    HPAiHPA059555.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296682.

    Structurei

    Secondary structure

    1
    894
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi199 – 2013
    Beta strandi203 – 2053
    Turni206 – 2094
    Beta strandi210 – 2167
    Turni217 – 2193
    Helixi237 – 2404
    Beta strandi246 – 2505
    Beta strandi258 – 2625
    Beta strandi278 – 2814
    Helixi284 – 2863
    Beta strandi289 – 29810
    Beta strandi301 – 3066
    Turni310 – 3123
    Helixi315 – 3184
    Turni325 – 3273
    Beta strandi330 – 3356
    Beta strandi338 – 3458
    Beta strandi354 – 3563
    Helixi362 – 3676
    Turni368 – 3703
    Helixi373 – 3775
    Beta strandi391 – 3944
    Beta strandi396 – 3994
    Helixi400 – 41011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IJDX-ray2.15A/B195-415[»]
    ProteinModelPortaliQ9NQV7.
    SMRiQ9NQV7. Positions 195-411, 528-892.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 8664KRAB-relatedPROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 358115SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB-related domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri388 – 41124C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri524 – 54623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri552 – 57423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri580 – 60223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri608 – 63023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 65823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri664 – 68623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri776 – 79823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri804 – 82623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri832 – 85423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri860 – 88223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG108291.
    InParanoidiQ9NQV7.
    OMAiRECGWGF.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9NQV7.
    TreeFamiTF338096.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR001214. SET_dom.
    IPR019041. SSXRD_motif.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF09514. SSXRD. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50806. KRAB_RELATED. 1 hit.
    PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NQV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPEKSQEES PEEDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR    50
    YRNVKRNYNA LITIGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ 100
    VKPPWMALRV EQRKHQKGMP KASFSNESSL KELSRTANLL NASGSEQAQK 150
    PVSPSGEAST SGQHSRLKLE LRKKETERKM YSLRERKGHA YKEVSEPQDD 200
    DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL SLPPGLRIGP 250
    SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANNG YSWLITKGRN 300
    CYEYVDGKDK SWANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG 350
    CELLVWYGDE YGQELGIKWG SKWKKELMAG REPKPEIHPC PSCCLAFSSQ 400
    KFLSQHVERN HSSQNFPGPS ARKLLQPENP CPGDQNQEQQ YPDPHSRNDK 450
    TKGQEIKERS KLLNKRTWQR EISRAFSSPP KGQMGSCRVG KRIMEEESRT 500
    GQKVNPGNTG KLFVGVGISR IAKVKYGECG QGFSVKSDVI THQRTHTGEK 550
    LYVCRECGRG FSWKSHLLIH QRIHTGEKPY VCRECGRGFS WQSVLLTHQR 600
    THTGEKPYVC RECGRGFSRQ SVLLTHQRRH TGEKPYVCRE CGRGFSRQSV 650
    LLTHQRRHTG EKPYVCRECG RGFSWQSVLL THQRTHTGEK PYVCRECGRG 700
    FSWQSVLLTH QRTHTGEKPY VCRECGRGFS NKSHLLRHQR THTGEKPYVC 750
    RECGRGFRDK SHLLRHQRTH TGEKPYVCRE CGRGFRDKSN LLSHQRTHTG 800
    EKPYVCRECG RGFSNKSHLL RHQRTHTGEK PYVCRECGRG FRNKSHLLRH 850
    QRTHTGEKPY VCRECGRGFS DRSSLCYHQR THTGEKPYVC REDE 894
    Length:894
    Mass (Da):103,376
    Last modified:November 4, 2008 - v2
    Checksum:iDE53094C32EFF83B
    GO

    Sequence cautioni

    The sequence AAF87242.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951I → VRRACHF in AAF87242. (PubMed:10668202)Curated
    Sequence conflicti377 – 3815Missing in AAF87242. (PubMed:10668202)Curated
    Sequence conflicti681 – 6811T → S in BAG63234. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti335 – 3351Y → H Common polymorphism; may be a genetic risk for patients with azoospermia caused by meiotic arrest. 1 Publication
    VAR_054417

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ388610 mRNA. Translation: ABD47939.1.
    AK301776 mRNA. Translation: BAG63234.1.
    AC025451 Genomic DNA. No translation available.
    AF275816 mRNA. Translation: AAF87242.1. Different initiation.
    CCDSiCCDS43307.1.
    RefSeqiNP_064612.2. NM_020227.2.
    UniGeneiHs.283096.

    Genome annotation databases

    EnsembliENST00000296682; ENSP00000296682; ENSG00000164256.
    GeneIDi56979.
    KEGGihsa:56979.
    UCSCiuc003jgo.3. human.

    Polymorphism databases

    DMDMi212276459.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ388610 mRNA. Translation: ABD47939.1 .
    AK301776 mRNA. Translation: BAG63234.1 .
    AC025451 Genomic DNA. No translation available.
    AF275816 mRNA. Translation: AAF87242.1 . Different initiation.
    CCDSi CCDS43307.1.
    RefSeqi NP_064612.2. NM_020227.2.
    UniGenei Hs.283096.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IJD X-ray 2.15 A/B 195-415 [» ]
    ProteinModelPortali Q9NQV7.
    SMRi Q9NQV7. Positions 195-411, 528-892.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296682.

    PTM databases

    PhosphoSitei Q9NQV7.

    Polymorphism databases

    DMDMi 212276459.

    Proteomic databases

    PaxDbi Q9NQV7.
    PRIDEi Q9NQV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296682 ; ENSP00000296682 ; ENSG00000164256 .
    GeneIDi 56979.
    KEGGi hsa:56979.
    UCSCi uc003jgo.3. human.

    Organism-specific databases

    CTDi 56979.
    GeneCardsi GC05P023558.
    HGNCi HGNC:13994. PRDM9.
    HPAi HPA059555.
    MIMi 609760. gene.
    neXtProti NX_Q9NQV7.
    PharmGKBi PA33721.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG108291.
    InParanoidi Q9NQV7.
    OMAi RECGWGF.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9NQV7.
    TreeFami TF338096.

    Enzyme and pathway databases

    Reactomei REACT_27271. Meiotic recombination.

    Miscellaneous databases

    GeneWikii PRDM9.
    GenomeRNAii 56979.
    NextBioi 62639.
    PROi Q9NQV7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQV7.
    Bgeei Q9NQV7.
    CleanExi HS_PRDM9.
    Genevestigatori Q9NQV7.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR003655. Krueppel-associated_box-rel.
    IPR001214. SET_dom.
    IPR019041. SSXRD_motif.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF09514. SSXRD. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50806. KRAB_RELATED. 1 hit.
    PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of PR domain-containing 9 (PRDM9)."
      Ying J., Wong A.H.Y., Li H., Wang Y., Tao Q.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The yin-yang of PR-domain family genes in tumorigenesis."
      Jiang G.L., Huang S.
      Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-894.
    5. "Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest."
      Miyamoto T., Koh E., Sakugawa N., Sato H., Hayashi H., Namiki M., Sengoku K.
      J. Assist. Reprod. Genet. 25:553-557(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-335.

    Entry informationi

    Entry nameiPRDM9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQV7
    Secondary accession number(s): B4DX22, Q27Q50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3