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Protein

PR domain zinc finger protein 10

Gene

PRDM10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri672 – 69524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri727 – 75024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri772 – 79524C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri834 – 85724C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

SignaLinkiQ9NQV6.

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 10 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 10
Tristanin
Gene namesi
Name:PRDM10
Synonyms:KIAA1231, PFM7, TRIS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13995. PRDM10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11471147PR domain zinc finger protein 10PRO_0000047767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei424 – 4241Phosphoserine2 Publications
Modified residuei428 – 4281Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NQV6.
PaxDbiQ9NQV6.
PRIDEiQ9NQV6.

PTM databases

PhosphoSiteiQ9NQV6.

Expressioni

Gene expression databases

BgeeiQ9NQV6.
CleanExiHS_PRDM10.
ExpressionAtlasiQ9NQV6. baseline and differential.
GenevestigatoriQ9NQV6.

Organism-specific databases

HPAiHPA026997.

Interactioni

Protein-protein interaction databases

BioGridi121298. 5 interactions.

Structurei

Secondary structure

1
1147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi203 – 2064Combined sources
Beta strandi212 – 2143Combined sources
Turni216 – 2183Combined sources
Beta strandi220 – 2256Combined sources
Beta strandi248 – 2503Combined sources
Turni278 – 2803Combined sources
Helixi283 – 2864Combined sources
Turni293 – 2953Combined sources
Beta strandi298 – 3025Combined sources
Beta strandi304 – 31310Combined sources
Beta strandi323 – 3253Combined sources
Helixi327 – 3326Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IHXX-ray2.50A/B/C/D188-339[»]
ProteinModelPortaliQ9NQV6.
SMRiQ9NQV6. Positions 167-385, 523-702, 724-750, 770-797.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQV6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 326119SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi866 – 91651Thr-richAdd
BLAST
Compositional biasi918 – 1031114Gln-richAdd
BLAST
Compositional biasi1131 – 11344Poly-Thr

Domaini

The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri588 – 61023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 63924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri644 – 66623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri672 – 69524C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri727 – 75024C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri772 – 79524C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri834 – 85724C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120578.
HOVERGENiHBG053664.
InParanoidiQ9NQV6.
OMAiHDPQTYT.
OrthoDBiEOG70GMFD.
TreeFamiTF350894.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q9NQV6-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV
60 70 80 90 100
YTADGASYTS VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS
110 120 130 140 150
LPVHNQVLPS IESVDGSDPL ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE
160 170 180 190 200
DGEDTDLDDW EPDPPRPFDP HDLWCEECNN AHASVCPKHG PLHPIPNRPV
210 220 230 240 250
LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL VRGSELKDCY
260 270 280 290 300
IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA
310 320 330 340 350
YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE
360 370 380 390 400
QEKNWPCYEC NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG
410 420 430 440 450
PGRRPGRPPK FIRLEITSEN GEKSDDGTQD LLHFPTKEQF DEAEPATLNG
460 470 480 490 500
LDQPEQTTIP IPQLPQETQS SLEHEPETHT LHLQPQHEES VVPTQSTLTA
510 520 530 540 550
DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR
560 570 580 590 600
FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL
610 620 630 640 650
DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD
660 670 680 690 700
KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE
710 720 730 740 750
AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH
760 770 780 790 800
PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL
810 820 830 840 850
PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV
860 870 880 890 900
QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT
910 920 930 940 950
QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA
960 970 980 990 1000
SATSPHQSQQ STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ
1010 1020 1030 1040 1050
GLSPSHIQGS SSTQGQALQQ QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ
1060 1070 1080 1090 1100
MMTLPPGQFV ITDSGVATPV TTGQVKAVTS GHYVLSESQS ELEEKQTSAL
1110 1120 1130 1140
SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP
Length:1,147
Mass (Da):130,136
Last modified:January 9, 2013 - v3
Checksum:iE565CA8822CB2934
GO
Isoform 2 (identifier: Q9NQV6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     511-514: Missing.
     952-985: Missing.

Show »
Length:1,023
Mass (Da):116,444
Checksum:iB5680EAEA32A4299
GO
Isoform 1 (identifier: Q9NQV6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

Show »
Length:1,061
Mass (Da):120,711
Checksum:iC712D4CDA514D995
GO
Isoform 4 (identifier: Q9NQV6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,156
Mass (Da):130,865
Checksum:i0DF87B79FBAAE62C
GO
Isoform 5 (identifier: Q9NQV6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,074
Mass (Da):121,924
Checksum:i7F7B76F86712D167
GO
Isoform 6 (identifier: Q9NQV6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA
     1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

Note: No experimental confirmation available.

Show »
Length:1,214
Mass (Da):137,427
Checksum:i05D1A8B9136B7413
GO
Isoform 7 (identifier: Q9NQV6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,160
Mass (Da):131,349
Checksum:i1CCEC654DC42F464
GO

Sequence cautioni

The sequence BAA91026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461P → S in AAI12935. 1 PublicationCurated
Sequence conflicti387 – 3871T → A in BAA91026. (PubMed:14702039)Curated
Sequence conflicti569 – 5691F → L in BX648944. (PubMed:17974005)Curated
Sequence conflicti621 – 6211C → Y in BX648944. (PubMed:17974005)Curated
Sequence conflicti1112 – 11121S → N in BX648944. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221A → T.
Corresponds to variant rs11221912 [ dbSNP | Ensembl ].
VAR_054418
Natural varianti573 – 5731T → A.3 Publications
Corresponds to variant rs2241571 [ dbSNP | Ensembl ].
VAR_019984

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5. 4 PublicationsVSP_036351Add
BLAST
Alternative sequencei511 – 5144Missing in isoform 2, isoform 4 and isoform 6. 3 PublicationsVSP_035655
Alternative sequencei952 – 98534Missing in isoform 2. 1 PublicationVSP_035656Add
BLAST
Alternative sequencei984 – 9841I → IQVSEPTASAPSSA in isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_036352
Alternative sequencei1132 – 114716TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6. 1 PublicationVSP_036353Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503171 mRNA. Translation: AAP30847.1.
AF275817 mRNA. Translation: AAF87243.1.
AB033057 mRNA. Translation: BAA86545.2.
BX648944 mRNA. No translation available.
AP003041 Genomic DNA. No translation available.
AP003326 Genomic DNA. No translation available.
AP003327 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67761.1.
BC112934 mRNA. Translation: AAI12935.1.
BC117415 mRNA. Translation: AAI17416.1.
BC143612 mRNA. Translation: AAI43613.1.
AK000234 mRNA. Translation: BAA91026.1. Different initiation.
CCDSiCCDS44771.1. [Q9NQV6-7]
CCDS44772.1. [Q9NQV6-1]
CCDS8484.1. [Q9NQV6-4]
CCDS8485.1. [Q9NQV6-2]
RefSeqiNP_064613.2. NM_020228.2. [Q9NQV6-7]
NP_955469.1. NM_199437.1. [Q9NQV6-4]
NP_955470.1. NM_199438.1. [Q9NQV6-1]
NP_955471.1. NM_199439.1. [Q9NQV6-2]
UniGeneiHs.275086.

Genome annotation databases

EnsembliENST00000304538; ENSP00000302669; ENSG00000170325. [Q9NQV6-2]
ENST00000358825; ENSP00000351686; ENSG00000170325. [Q9NQV6-7]
ENST00000360871; ENSP00000354118; ENSG00000170325. [Q9NQV6-4]
ENST00000423662; ENSP00000398431; ENSG00000170325. [Q9NQV6-1]
ENST00000526082; ENSP00000432237; ENSG00000170325. [Q9NQV6-5]
GeneIDi56980.
KEGGihsa:56980.
UCSCiuc001qfj.3. human. [Q9NQV6-1]
uc001qfk.3. human. [Q9NQV6-2]
uc001qfl.3. human. [Q9NQV6-5]
uc001qfn.3. human.

Polymorphism databases

DMDMi442570289.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503171 mRNA. Translation: AAP30847.1.
AF275817 mRNA. Translation: AAF87243.1.
AB033057 mRNA. Translation: BAA86545.2.
BX648944 mRNA. No translation available.
AP003041 Genomic DNA. No translation available.
AP003326 Genomic DNA. No translation available.
AP003327 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67761.1.
BC112934 mRNA. Translation: AAI12935.1.
BC117415 mRNA. Translation: AAI17416.1.
BC143612 mRNA. Translation: AAI43613.1.
AK000234 mRNA. Translation: BAA91026.1. Different initiation.
CCDSiCCDS44771.1. [Q9NQV6-7]
CCDS44772.1. [Q9NQV6-1]
CCDS8484.1. [Q9NQV6-4]
CCDS8485.1. [Q9NQV6-2]
RefSeqiNP_064613.2. NM_020228.2. [Q9NQV6-7]
NP_955469.1. NM_199437.1. [Q9NQV6-4]
NP_955470.1. NM_199438.1. [Q9NQV6-1]
NP_955471.1. NM_199439.1. [Q9NQV6-2]
UniGeneiHs.275086.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IHXX-ray2.50A/B/C/D188-339[»]
ProteinModelPortaliQ9NQV6.
SMRiQ9NQV6. Positions 167-385, 523-702, 724-750, 770-797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121298. 5 interactions.

PTM databases

PhosphoSiteiQ9NQV6.

Polymorphism databases

DMDMi442570289.

Proteomic databases

MaxQBiQ9NQV6.
PaxDbiQ9NQV6.
PRIDEiQ9NQV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304538; ENSP00000302669; ENSG00000170325. [Q9NQV6-2]
ENST00000358825; ENSP00000351686; ENSG00000170325. [Q9NQV6-7]
ENST00000360871; ENSP00000354118; ENSG00000170325. [Q9NQV6-4]
ENST00000423662; ENSP00000398431; ENSG00000170325. [Q9NQV6-1]
ENST00000526082; ENSP00000432237; ENSG00000170325. [Q9NQV6-5]
GeneIDi56980.
KEGGihsa:56980.
UCSCiuc001qfj.3. human. [Q9NQV6-1]
uc001qfk.3. human. [Q9NQV6-2]
uc001qfl.3. human. [Q9NQV6-5]
uc001qfn.3. human.

Organism-specific databases

CTDi56980.
GeneCardsiGC11M129769.
HGNCiHGNC:13995. PRDM10.
HPAiHPA026997.
neXtProtiNX_Q9NQV6.
PharmGKBiPA33708.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120578.
HOVERGENiHBG053664.
InParanoidiQ9NQV6.
OMAiHDPQTYT.
OrthoDBiEOG70GMFD.
TreeFamiTF350894.

Enzyme and pathway databases

SignaLinkiQ9NQV6.

Miscellaneous databases

ChiTaRSiPRDM10. human.
EvolutionaryTraceiQ9NQV6.
GenomeRNAii56980.
NextBioi35535048.
PROiQ9NQV6.

Gene expression databases

BgeeiQ9NQV6.
CleanExiHS_PRDM10.
ExpressionAtlasiQ9NQV6. baseline and differential.
GenevestigatoriQ9NQV6.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development."
    Siegel D.A., Huang M.K., Becker S.F.
    Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The yin-yang of PR-domain family genes in tumorigenesis."
    Jiang G.L., Huang S.
    Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ALA-573.
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573.
    Tissue: Brain and Uterus.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573.
    Tissue: Colon mucosa.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424 AND THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Methyltransferase domain of human PR domain-containing protein 10."
    Structural genomics consortium (SGC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 188-339.

Entry informationi

Entry nameiPRD10_HUMAN
AccessioniPrimary (citable) accession number: Q9NQV6
Secondary accession number(s): B7ZL71
, G3XAE5, J3KP23, Q17R90, Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 9, 2013
Last modified: February 4, 2015
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.