Q9NQV6 (PRD10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PR domain zinc finger protein 10

Alternative name(s):
PR domain-containing protein 10
Tristanin

Gene names

Name:	PRDM10
Synonyms:	KIAA1231, PFM7, TRIS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1147 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Domain	The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity.
Sequence similarities	Contains 10 C2H2-type zinc fingers. Contains 1 SET domain.
Sequence caution	The sequence BAA91026.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9NQV6-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     511-514: Missing.
     952-985: Missing.

Isoform 1 (identifier: Q9NQV6-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

Isoform 4 (identifier: Q9NQV6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NQV6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9NQV6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA
     1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9NQV6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1147

1147

PR domain zinc finger protein 10

PRO_0000047767

Regions

Domain

206 – 330

125

SET

Zinc finger

355 – 377

23

C2H2-type 1

Zinc finger

530 – 552

23

C2H2-type 2

Zinc finger

560 – 582

23

C2H2-type 3

Zinc finger

588 – 610

23

C2H2-type 4

Zinc finger

616 – 639

24

C2H2-type 5

Zinc finger

644 – 666

23

C2H2-type 6

Zinc finger

672 – 695

24

C2H2-type 7

Zinc finger

727 – 750

24

C2H2-type 8

Zinc finger

772 – 795

24

C2H2-type 9

Zinc finger

834 – 857

24

C2H2-type 10

Compositional bias

866 – 916

51

Thr-rich

Compositional bias

918 – 1031

114

Gln-rich

Compositional bias

1131 – 1134

4

Poly-Thr

Amino acid modifications

Modified residue

424

1

Phosphoserine Ref.11 Ref.12

Modified residue

428

1

Phosphothreonine Ref.9 Ref.12

Natural variations

Alternative sequence

1 – 97

97

MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5.

VSP_036351

Alternative sequence

511 – 514

4

Missing in isoform 2, isoform 4 and isoform 6.

VSP_035655

Alternative sequence

952 – 985

34

Missing in isoform 2.

VSP_035656

Alternative sequence

984

1

I → IQVSEPTASAPSSA in isoform 4, isoform 5, isoform 6 and isoform 7.

VSP_036352

Alternative sequence

1132 – 1147

16

TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6.

VSP_036353

Natural variant

22

1

A → T.
Corresponds to variant rs11221912 [ dbSNP | Ensembl ].

VAR_054418

Natural variant

573

1

T → A. Ref.4 Ref.7 Ref.8
Corresponds to variant rs2241571 [ dbSNP | Ensembl ].

VAR_019984

Experimental info

Sequence conflict

46

1

P → S in AAI12935. Ref.6

Sequence conflict

387

1

T → A in BAA91026. Ref.8

Sequence conflict

569

1

F → L in BX648944. Ref.4

Sequence conflict

621

1

C → Y in BX648944. Ref.4

Sequence conflict

1112

1

S → N in BX648944. Ref.4

Secondary structure

1

.

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1147

Helix Strand Turn

Details...

Helix

203 – 206

4

Beta strand

212 – 214

3

Turn

216 – 218

3

Beta strand

220 – 225

6

Beta strand

248 – 250

3

Turn

278 – 280

3

Helix

283 – 286

4

Turn

293 – 295

3

Beta strand

298 – 302

5

Beta strand

304 – 313

10

Beta strand

323 – 325

3

Helix

327 – 332

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified January 9, 2013. Version 3. Checksum: E565CA8822CB2934	FASTA	1,147	130,136
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR 550 560 570 580 590 600 EKDKLDQHLR FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL 610 620 630 640 650 660 DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD KAFCRPDKLR 670 680 690 700 710 720 LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE AKKADRISRS KTFKPRITST 730 740 750 760 770 780 DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV 790 800 810 820 830 840 YKSASKRKAH ILKNHPGAEL PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS 850 860 870 880 890 900 KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT 910 920 930 940 950 960 QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA SATSPHQSQQ 970 980 990 1000 1010 1020 STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ GLSPSHIQGS SSTQGQALQQ 1030 1040 1050 1060 1070 1080 QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ MMTLPPGQFV ITDSGVATPV TTGQVKAVTS 1090 1100 1110 1120 1130 1140 GHYVLSESQS ELEEKQTSAL SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP
	Isoform 2 [UniParc]. Checksum: B5680EAEA32A4299	FASTA	1,023	116,444
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR FHGREGNCPL TCDLCNKGFI 490 500 510 520 530 540 SSTSLESHMK LHSDQKTYSC IFCPESFDRL DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ 550 560 570 580 590 600 VKKHVRSFHS EKIYQCTECD KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH 610 620 630 640 650 660 MQRMHNPERE AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH 670 680 690 700 710 720 PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL PPSIRKLRPA 730 740 750 760 770 780 GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP 790 800 810 820 830 840 LTTAVISATP AVLTTDSATG ETVVTTDLLT QAMTELSQTL TTDYRTPQGD YQRIQYIPVS 850 860 870 880 890 900 QSASGLQQPQ HIQLQVVQVA SVSGQPLSPS AQQAQQGLSP SHIQGSSSTQ GQALQQQQQQ 910 920 930 940 950 960 QQNSSVQHTY LPSAWNSFRG YSSEIQMMTL PPGQFVITDS GVATPVTTGQ VKAVTSGHYV 970 980 990 1000 1010 1020 LSESQSELEE KQTSALSGGV QVEPPAHSDS LDPQTNSQQQ TTQYIITTTT NGNGSSEVHI TKP
	Isoform 1 [UniParc]. Checksum: C712D4CDA514D995	FASTA	1,061	120,711
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRLELQNA ALQHLFIRKS FRPFKCLQCG KAFREKDKLD QHLRFHGREG NCPLTCDLCN 490 500 510 520 530 540 KGFISSTSLE SHMKLHSDQK TYSCIFCPES FDRLDLLKDH VAIHINDGYF TCPTCKKRFP 550 560 570 580 590 600 DFIQVKKHVR SFHSEKIYQC TECDKAFCRP DKLRLHMLRH SDRKDFLCST CGKQFKRKDK 610 620 630 640 650 660 LREHMQRMHN PEREAKKADR ISRSKTFKPR ITSTDYDSFT FKCRLCMMGF RRRGMLVNHL 670 680 690 700 710 720 SKRHPDMKIE EVPELTLPII KPNRDYFCQY CDKVYKSASK RKAHILKNHP GAELPPSIRK 730 740 750 760 770 780 LRPAGPGEPD PMLSTHTQLT GTIATPPVCC PHCSKQYSSK TKMVQHIRKK HPEFAQLSNT 790 800 810 820 830 840 IHTPLTTAVI SATPAVLTTD SATGETVVTT DLLTQAMTEL SQTLTTDYRT PQGDYQRIQY 850 860 870 880 890 900 IPVSQSASGL QQPQHIQLQV VQVASATSPH QSQQSTVDVG QLHDPQPYPQ HAIQVQHIQV 910 920 930 940 950 960 SGQPLSPSAQ QAQQGLSPSH IQGSSSTQGQ ALQQQQQQQQ NSSVQHTYLP SAWNSFRGYS 970 980 990 1000 1010 1020 SEIQMMTLPP GQFVITDSGV ATPVTTGQVK AVTSGHYVLS ESQSELEEKQ TSALSGGVQV 1030 1040 1050 1060 EPPAHSDSLD PQTNSQQQTT QYIITTTTNG NGSSEVHITK P
	Isoform 4 [UniParc]. Checksum: 0DF87B79FBAAE62C	FASTA	1,156	130,865
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR NAALQHLFIR KSFRPFKCLQ CGKAFREKDK 550 560 570 580 590 600 LDQHLRFHGR EGNCPLTCDL CNKGFISSTS LESHMKLHSD QKTYSCIFCP ESFDRLDLLK 610 620 630 640 650 660 DHVAIHINDG YFTCPTCKKR FPDFIQVKKH VRSFHSEKIY QCTECDKAFC RPDKLRLHML 670 680 690 700 710 720 RHSDRKDFLC STCGKQFKRK DKLREHMQRM HNPEREAKKA DRISRSKTFK PRITSTDYDS 730 740 750 760 770 780 FTFKCRLCMM GFRRRGMLVN HLSKRHPDMK IEEVPELTLP IIKPNRDYFC QYCDKVYKSA 790 800 810 820 830 840 SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ LTGTIATPPV CCPHCSKQYS 850 860 870 880 890 900 SKTKMVQHIR KKHPEFAQLS NTIHTPLTTA VISATPAVLT TDSATGETVV TTDLLTQAMT 910 920 930 940 950 960 ELSQTLTTDY RTPQGDYQRI QYIPVSQSAS GLQQPQHIQL QVVQVASATS PHQSQQSTVD 970 980 990 1000 1010 1020 VGQLHDPQPY PQHAIQVQHI QVSEPTASAP SSAQVSGQPL SPSAQQAQQG LSPSHIQGSS 1030 1040 1050 1060 1070 1080 STQGQALQQQ QQQQQNSSVQ HTYLPSAWNS FRGYSSEIQM MTLPPGQFVI TDSGVATPVT 1090 1100 1110 1120 1130 1140 TGQVKAVTSG HYVLSESQSE LEEKQTSALS GGVQVEPPAH SDSLDPQTNS QQQTTQYIIT 1150 TTTNGNGSSE VHITKP
	Isoform 5 [UniParc]. Checksum: 7F7B76F86712D167	FASTA	1,074	121,924
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRLELQNA ALQHLFIRKS FRPFKCLQCG KAFREKDKLD QHLRFHGREG NCPLTCDLCN 490 500 510 520 530 540 KGFISSTSLE SHMKLHSDQK TYSCIFCPES FDRLDLLKDH VAIHINDGYF TCPTCKKRFP 550 560 570 580 590 600 DFIQVKKHVR SFHSEKIYQC TECDKAFCRP DKLRLHMLRH SDRKDFLCST CGKQFKRKDK 610 620 630 640 650 660 LREHMQRMHN PEREAKKADR ISRSKTFKPR ITSTDYDSFT FKCRLCMMGF RRRGMLVNHL 670 680 690 700 710 720 SKRHPDMKIE EVPELTLPII KPNRDYFCQY CDKVYKSASK RKAHILKNHP GAELPPSIRK 730 740 750 760 770 780 LRPAGPGEPD PMLSTHTQLT GTIATPPVCC PHCSKQYSSK TKMVQHIRKK HPEFAQLSNT 790 800 810 820 830 840 IHTPLTTAVI SATPAVLTTD SATGETVVTT DLLTQAMTEL SQTLTTDYRT PQGDYQRIQY 850 860 870 880 890 900 IPVSQSASGL QQPQHIQLQV VQVASATSPH QSQQSTVDVG QLHDPQPYPQ HAIQVQHIQV 910 920 930 940 950 960 SEPTASAPSS AQVSGQPLSP SAQQAQQGLS PSHIQGSSST QGQALQQQQQ QQQNSSVQHT 970 980 990 1000 1010 1020 YLPSAWNSFR GYSSEIQMMT LPPGQFVITD SGVATPVTTG QVKAVTSGHY VLSESQSELE 1030 1040 1050 1060 1070 EKQTSALSGG VQVEPPAHSD SLDPQTNSQQ QTTQYIITTT TNGNGSSEVH ITKP
	Isoform 6 [UniParc]. Checksum: 05D1A8B9136B7413	FASTA	1,214	137,427
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR NAALQHLFIR KSFRPFKCLQ CGKAFREKDK 550 560 570 580 590 600 LDQHLRFHGR EGNCPLTCDL CNKGFISSTS LESHMKLHSD QKTYSCIFCP ESFDRLDLLK 610 620 630 640 650 660 DHVAIHINDG YFTCPTCKKR FPDFIQVKKH VRSFHSEKIY QCTECDKAFC RPDKLRLHML 670 680 690 700 710 720 RHSDRKDFLC STCGKQFKRK DKLREHMQRM HNPEREAKKA DRISRSKTFK PRITSTDYDS 730 740 750 760 770 780 FTFKCRLCMM GFRRRGMLVN HLSKRHPDMK IEEVPELTLP IIKPNRDYFC QYCDKVYKSA 790 800 810 820 830 840 SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ LTGTIATPPV CCPHCSKQYS 850 860 870 880 890 900 SKTKMVQHIR KKHPEFAQLS NTIHTPLTTA VISATPAVLT TDSATGETVV TTDLLTQAMT 910 920 930 940 950 960 ELSQTLTTDY RTPQGDYQRI QYIPVSQSAS GLQQPQHIQL QVVQVASATS PHQSQQSTVD 970 980 990 1000 1010 1020 VGQLHDPQPY PQHAIQVQHI QVSEPTASAP SSAQVSGQPL SPSAQQAQQG LSPSHIQGSS 1030 1040 1050 1060 1070 1080 STQGQALQQQ QQQQQNSSVQ HTYLPSAWNS FRGYSSEIQM MTLPPGQFVI TDSGVATPVT 1090 1100 1110 1120 1130 1140 TGQVKAVTSG HYVLSESQSE LEEKQTSALS GGVQVEPPAH SDSLDPQTNS QQQTTQYIIT 1150 1160 1170 1180 1190 1200 AGSKVIQNEF TVGEECELET MTGEKVKTVV QLEGDNKLVT TFKNIKSVTE LNGDIITNTM 1210 TLGDIVFKRI SKRI
	Isoform 7 [UniParc]. Checksum: 1CCEC654DC42F464	FASTA	1,160	131,349
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR 550 560 570 580 590 600 EKDKLDQHLR FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL 610 620 630 640 650 660 DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD KAFCRPDKLR 670 680 690 700 710 720 LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE AKKADRISRS KTFKPRITST 730 740 750 760 770 780 DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV 790 800 810 820 830 840 YKSASKRKAH ILKNHPGAEL PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS 850 860 870 880 890 900 KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT 910 920 930 940 950 960 QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA SATSPHQSQQ 970 980 990 1000 1010 1020 STVDVGQLHD PQPYPQHAIQ VQHIQVSEPT ASAPSSAQVS GQPLSPSAQQ AQQGLSPSHI 1030 1040 1050 1060 1070 1080 QGSSSTQGQA LQQQQQQQQN SSVQHTYLPS AWNSFRGYSS EIQMMTLPPG QFVITDSGVA 1090 1100 1110 1120 1130 1140 TPVTTGQVKA VTSGHYVLSE SQSELEEKQT SALSGGVQVE PPAHSDSLDP QTNSQQQTTQ 1150 1160 YIITTTTNGN GSSEVHITKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development." Siegel D.A., Huang M.K., Becker S.F. Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The yin-yang of PR-domain family genes in tumorigenesis." Jiang G.L., Huang S. Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ALA-573. Tissue: Amygdala.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573. Tissue: Brain and Uterus.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573. Tissue: Colon mucosa.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424 AND THR-428, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF503171 mRNA. Translation: AAP30847.1.
AF275817 mRNA. Translation: AAF87243.1.
AB033057 mRNA. Translation: BAA86545.2.
BX648944 mRNA. No translation available.
AP003041 Genomic DNA. No translation available.
AP003326 Genomic DNA. No translation available.
AP003327 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67761.1.
BC112934 mRNA. Translation: AAI12935.1.
BC117415 mRNA. Translation: AAI17416.1.
BC143612 mRNA. Translation: AAI43613.1.
AK000234 mRNA. Translation: BAA91026.1. Different initiation.

IPI

IPI00299681.
IPI00398772.
IPI00399316.
IPI00411675.
IPI00921029.
IPI00921092.

RefSeq

NP_064613.2. NM_020228.2.
NP_955469.1. NM_199437.1.
NP_955470.1. NM_199438.1.
NP_955471.1. NM_199439.1.

UniGene

Hs.275086.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IHX	X-ray	2.50	A/B/C/D	188-339	[»]

ProteinModelPortal

Q9NQV6.

SMR

Q9NQV6. Positions 192-335, 350-380, 528-860.

ModBase

Search...

PTM databases

PhosphoSite

Q9NQV6.

Polymorphism databases

DMDM

223590132.

Proteomic databases

PaxDb

Q9NQV6.

PRIDE

Q9NQV6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000304538; ENSP00000302669; ENSG00000170325.
ENST00000358825; ENSP00000351686; ENSG00000170325.
ENST00000360871; ENSP00000354118; ENSG00000170325.
ENST00000423662; ENSP00000398431; ENSG00000170325.
ENST00000526082; ENSP00000432237; ENSG00000170325.

GeneID

56980.

KEGG

hsa:56980.

UCSC

uc001qfj.3. human.
uc001qfk.3. human.
uc001qfl.3. human.
uc001qfm.3. human.

Organism-specific databases

CTD

56980.

GeneCards

GC11M129803.

HGNC

HGNC:13995. PRDM10.

HPA

HPA026997.

neXtProt

NX_Q9NQV6.

PharmGKB

PA33708.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOVERGEN

HBG053664.

InParanoid

Q9NQV6.

OrthoDB

EOG4HT8RD.

Gene expression databases

ArrayExpress

Q9NQV6.

Bgee

Q9NQV6.

CleanEx

HS_PRDM10.

Genevestigator

Q9NQV6.

GermOnline

ENSG00000170325. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 5 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR022755. Znf_C2H2_jaz.
[Graphical view]

Pfam

PF00096. zf-C2H2. 3 hits.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 10 hits.
[Graphical view]

PROSITE

PS50280. SET. False negative.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PRDM10. human.

EvolutionaryTrace

Q9NQV6.

GenomeRNAi

56980.

NextBio

35535048.

Entry information

Entry name

PRD10_HUMAN

Accession

Primary (citable) accession number: Q9NQV6
Secondary accession number(s): B7ZL71 , G3XAE5, J3KP23, Q17R90, Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.