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Q9NQV6

- PRD10_HUMAN

UniProt

Q9NQV6 - PRD10_HUMAN

Protein

PR domain zinc finger protein 10

Gene

PRDM10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri530 – 55223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63924C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri644 – 66623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri672 – 69524C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri727 – 75024C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri772 – 79524C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri834 – 85724C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    SignaLinkiQ9NQV6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PR domain zinc finger protein 10 (EC:2.1.1.-)
    Alternative name(s):
    PR domain-containing protein 10
    Tristanin
    Gene namesi
    Name:PRDM10
    Synonyms:KIAA1231, PFM7, TRIS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13995. PRDM10.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33708.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11471147PR domain zinc finger protein 10PRO_0000047767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei424 – 4241Phosphoserine2 Publications
    Modified residuei428 – 4281Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NQV6.
    PaxDbiQ9NQV6.
    PRIDEiQ9NQV6.

    PTM databases

    PhosphoSiteiQ9NQV6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NQV6.
    BgeeiQ9NQV6.
    CleanExiHS_PRDM10.
    GenevestigatoriQ9NQV6.

    Organism-specific databases

    HPAiHPA026997.

    Interactioni

    Protein-protein interaction databases

    BioGridi121298. 2 interactions.

    Structurei

    Secondary structure

    1
    1147
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi203 – 2064
    Beta strandi212 – 2143
    Turni216 – 2183
    Beta strandi220 – 2256
    Beta strandi248 – 2503
    Turni278 – 2803
    Helixi283 – 2864
    Turni293 – 2953
    Beta strandi298 – 3025
    Beta strandi304 – 31310
    Beta strandi323 – 3253
    Helixi327 – 3326

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IHXX-ray2.50A/B/C/D188-339[»]
    ProteinModelPortaliQ9NQV6.
    SMRiQ9NQV6. Positions 167-374, 523-825.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NQV6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini208 – 326119SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi866 – 91651Thr-richAdd
    BLAST
    Compositional biasi918 – 1031114Gln-richAdd
    BLAST
    Compositional biasi1131 – 11344Poly-Thr

    Domaini

    The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri530 – 55223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri588 – 61023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 63924C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri644 – 66623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri672 – 69524C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri727 – 75024C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri772 – 79524C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri834 – 85724C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG053664.
    InParanoidiQ9NQV6.
    OMAiHDPQTYT.
    OrthoDBiEOG70GMFD.
    TreeFamiTF350894.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR022755. Znf_C2H2_jaz.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 4 hits.
    PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: Q9NQV6-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV     50
    YTADGASYTS VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS 100
    LPVHNQVLPS IESVDGSDPL ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE 150
    DGEDTDLDDW EPDPPRPFDP HDLWCEECNN AHASVCPKHG PLHPIPNRPV 200
    LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL VRGSELKDCY 250
    IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 300
    YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE 350
    QEKNWPCYEC NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG 400
    PGRRPGRPPK FIRLEITSEN GEKSDDGTQD LLHFPTKEQF DEAEPATLNG 450
    LDQPEQTTIP IPQLPQETQS SLEHEPETHT LHLQPQHEES VVPTQSTLTA 500
    DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR 550
    FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL 600
    DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD 650
    KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE 700
    AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH 750
    PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL 800
    PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV 850
    QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT 900
    QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA 950
    SATSPHQSQQ STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ 1000
    GLSPSHIQGS SSTQGQALQQ QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ 1050
    MMTLPPGQFV ITDSGVATPV TTGQVKAVTS GHYVLSESQS ELEEKQTSAL 1100
    SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP 1147
    Length:1,147
    Mass (Da):130,136
    Last modified:January 9, 2013 - v3
    Checksum:iE565CA8822CB2934
    GO
    Isoform 2 (identifier: Q9NQV6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
         511-514: Missing.
         952-985: Missing.

    Show »
    Length:1,023
    Mass (Da):116,444
    Checksum:iB5680EAEA32A4299
    GO
    Isoform 1 (identifier: Q9NQV6-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

    Show »
    Length:1,061
    Mass (Da):120,711
    Checksum:iC712D4CDA514D995
    GO
    Isoform 4 (identifier: Q9NQV6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         511-514: Missing.
         984-984: I → IQVSEPTASAPSSA

    Note: No experimental confirmation available.

    Show »
    Length:1,156
    Mass (Da):130,865
    Checksum:i0DF87B79FBAAE62C
    GO
    Isoform 5 (identifier: Q9NQV6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
         984-984: I → IQVSEPTASAPSSA

    Note: No experimental confirmation available.

    Show »
    Length:1,074
    Mass (Da):121,924
    Checksum:i7F7B76F86712D167
    GO
    Isoform 6 (identifier: Q9NQV6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         511-514: Missing.
         984-984: I → IQVSEPTASAPSSA
         1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

    Note: No experimental confirmation available.

    Show »
    Length:1,214
    Mass (Da):137,427
    Checksum:i05D1A8B9136B7413
    GO
    Isoform 7 (identifier: Q9NQV6-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         984-984: I → IQVSEPTASAPSSA

    Note: No experimental confirmation available.

    Show »
    Length:1,160
    Mass (Da):131,349
    Checksum:i1CCEC654DC42F464
    GO

    Sequence cautioni

    The sequence BAA91026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461P → S in AAI12935. 1 PublicationCurated
    Sequence conflicti387 – 3871T → A in BAA91026. (PubMed:14702039)Curated
    Sequence conflicti569 – 5691F → L in BX648944. (PubMed:17974005)Curated
    Sequence conflicti621 – 6211C → Y in BX648944. (PubMed:17974005)Curated
    Sequence conflicti1112 – 11121S → N in BX648944. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221A → T.
    Corresponds to variant rs11221912 [ dbSNP | Ensembl ].
    VAR_054418
    Natural varianti573 – 5731T → A.3 Publications
    Corresponds to variant rs2241571 [ dbSNP | Ensembl ].
    VAR_019984

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9797MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5. 4 PublicationsVSP_036351Add
    BLAST
    Alternative sequencei511 – 5144Missing in isoform 2, isoform 4 and isoform 6. 3 PublicationsVSP_035655
    Alternative sequencei952 – 98534Missing in isoform 2. 1 PublicationVSP_035656Add
    BLAST
    Alternative sequencei984 – 9841I → IQVSEPTASAPSSA in isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_036352
    Alternative sequencei1132 – 114716TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6. 1 PublicationVSP_036353Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503171 mRNA. Translation: AAP30847.1.
    AF275817 mRNA. Translation: AAF87243.1.
    AB033057 mRNA. Translation: BAA86545.2.
    BX648944 mRNA. No translation available.
    AP003041 Genomic DNA. No translation available.
    AP003326 Genomic DNA. No translation available.
    AP003327 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67761.1.
    BC112934 mRNA. Translation: AAI12935.1.
    BC117415 mRNA. Translation: AAI17416.1.
    BC143612 mRNA. Translation: AAI43613.1.
    AK000234 mRNA. Translation: BAA91026.1. Different initiation.
    CCDSiCCDS44771.1. [Q9NQV6-7]
    CCDS44772.1. [Q9NQV6-1]
    CCDS8484.1. [Q9NQV6-4]
    CCDS8485.1. [Q9NQV6-2]
    RefSeqiNP_064613.2. NM_020228.2. [Q9NQV6-7]
    NP_955469.1. NM_199437.1. [Q9NQV6-4]
    NP_955470.1. NM_199438.1. [Q9NQV6-1]
    NP_955471.1. NM_199439.1. [Q9NQV6-2]
    UniGeneiHs.275086.

    Genome annotation databases

    EnsembliENST00000304538; ENSP00000302669; ENSG00000170325. [Q9NQV6-2]
    ENST00000358825; ENSP00000351686; ENSG00000170325. [Q9NQV6-7]
    ENST00000360871; ENSP00000354118; ENSG00000170325. [Q9NQV6-4]
    ENST00000423662; ENSP00000398431; ENSG00000170325. [Q9NQV6-1]
    ENST00000526082; ENSP00000432237; ENSG00000170325. [Q9NQV6-5]
    GeneIDi56980.
    KEGGihsa:56980.
    UCSCiuc001qfj.3. human. [Q9NQV6-1]
    uc001qfk.3. human. [Q9NQV6-2]
    uc001qfl.3. human. [Q9NQV6-5]
    uc001qfn.3. human.

    Polymorphism databases

    DMDMi442570289.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503171 mRNA. Translation: AAP30847.1 .
    AF275817 mRNA. Translation: AAF87243.1 .
    AB033057 mRNA. Translation: BAA86545.2 .
    BX648944 mRNA. No translation available.
    AP003041 Genomic DNA. No translation available.
    AP003326 Genomic DNA. No translation available.
    AP003327 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67761.1 .
    BC112934 mRNA. Translation: AAI12935.1 .
    BC117415 mRNA. Translation: AAI17416.1 .
    BC143612 mRNA. Translation: AAI43613.1 .
    AK000234 mRNA. Translation: BAA91026.1 . Different initiation.
    CCDSi CCDS44771.1. [Q9NQV6-7 ]
    CCDS44772.1. [Q9NQV6-1 ]
    CCDS8484.1. [Q9NQV6-4 ]
    CCDS8485.1. [Q9NQV6-2 ]
    RefSeqi NP_064613.2. NM_020228.2. [Q9NQV6-7 ]
    NP_955469.1. NM_199437.1. [Q9NQV6-4 ]
    NP_955470.1. NM_199438.1. [Q9NQV6-1 ]
    NP_955471.1. NM_199439.1. [Q9NQV6-2 ]
    UniGenei Hs.275086.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IHX X-ray 2.50 A/B/C/D 188-339 [» ]
    ProteinModelPortali Q9NQV6.
    SMRi Q9NQV6. Positions 167-374, 523-825.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121298. 2 interactions.

    PTM databases

    PhosphoSitei Q9NQV6.

    Polymorphism databases

    DMDMi 442570289.

    Proteomic databases

    MaxQBi Q9NQV6.
    PaxDbi Q9NQV6.
    PRIDEi Q9NQV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304538 ; ENSP00000302669 ; ENSG00000170325 . [Q9NQV6-2 ]
    ENST00000358825 ; ENSP00000351686 ; ENSG00000170325 . [Q9NQV6-7 ]
    ENST00000360871 ; ENSP00000354118 ; ENSG00000170325 . [Q9NQV6-4 ]
    ENST00000423662 ; ENSP00000398431 ; ENSG00000170325 . [Q9NQV6-1 ]
    ENST00000526082 ; ENSP00000432237 ; ENSG00000170325 . [Q9NQV6-5 ]
    GeneIDi 56980.
    KEGGi hsa:56980.
    UCSCi uc001qfj.3. human. [Q9NQV6-1 ]
    uc001qfk.3. human. [Q9NQV6-2 ]
    uc001qfl.3. human. [Q9NQV6-5 ]
    uc001qfn.3. human.

    Organism-specific databases

    CTDi 56980.
    GeneCardsi GC11M129803.
    HGNCi HGNC:13995. PRDM10.
    HPAi HPA026997.
    neXtProti NX_Q9NQV6.
    PharmGKBi PA33708.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG053664.
    InParanoidi Q9NQV6.
    OMAi HDPQTYT.
    OrthoDBi EOG70GMFD.
    TreeFami TF350894.

    Enzyme and pathway databases

    SignaLinki Q9NQV6.

    Miscellaneous databases

    ChiTaRSi PRDM10. human.
    EvolutionaryTracei Q9NQV6.
    GenomeRNAii 56980.
    NextBioi 35535048.
    PROi Q9NQV6.

    Gene expression databases

    ArrayExpressi Q9NQV6.
    Bgeei Q9NQV6.
    CleanExi HS_PRDM10.
    Genevestigatori Q9NQV6.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR022755. Znf_C2H2_jaz.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 4 hits.
    PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development."
      Siegel D.A., Huang M.K., Becker S.F.
      Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The yin-yang of PR-domain family genes in tumorigenesis."
      Jiang G.L., Huang S.
      Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ALA-573.
      Tissue: Amygdala.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573.
      Tissue: Brain and Uterus.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573.
      Tissue: Colon mucosa.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424 AND THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Methyltransferase domain of human PR domain-containing protein 10."
      Structural genomics consortium (SGC)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 188-339.

    Entry informationi

    Entry nameiPRD10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQV6
    Secondary accession number(s): B7ZL71
    , G3XAE5, J3KP23, Q17R90, Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3