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Q9NQV6

- PRD10_HUMAN

UniProt

Q9NQV6 - PRD10_HUMAN

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Protein
PR domain zinc finger protein 10
Gene
PRDM10, KIAA1231, PFM7, TRIS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1
Add
BLAST
Zinc fingeri530 – 55223C2H2-type 2
Add
BLAST
Zinc fingeri560 – 58223C2H2-type 3
Add
BLAST
Zinc fingeri588 – 61023C2H2-type 4
Add
BLAST
Zinc fingeri616 – 63924C2H2-type 5
Add
BLAST
Zinc fingeri644 – 66623C2H2-type 6
Add
BLAST
Zinc fingeri672 – 69524C2H2-type 7
Add
BLAST
Zinc fingeri727 – 75024C2H2-type 8
Add
BLAST
Zinc fingeri772 – 79524C2H2-type 9
Add
BLAST
Zinc fingeri834 – 85724C2H2-type 10
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

SignaLinkiQ9NQV6.

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 10 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 10
Tristanin
Gene namesi
Name:PRDM10
Synonyms:KIAA1231, PFM7, TRIS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13995. PRDM10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11471147PR domain zinc finger protein 10
PRO_0000047767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei424 – 4241Phosphoserine2 Publications
Modified residuei428 – 4281Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NQV6.
PaxDbiQ9NQV6.
PRIDEiQ9NQV6.

PTM databases

PhosphoSiteiQ9NQV6.

Expressioni

Gene expression databases

ArrayExpressiQ9NQV6.
BgeeiQ9NQV6.
CleanExiHS_PRDM10.
GenevestigatoriQ9NQV6.

Organism-specific databases

HPAiHPA026997.

Interactioni

Protein-protein interaction databases

BioGridi121298. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi203 – 2064
Beta strandi212 – 2143
Turni216 – 2183
Beta strandi220 – 2256
Beta strandi248 – 2503
Turni278 – 2803
Helixi283 – 2864
Turni293 – 2953
Beta strandi298 – 3025
Beta strandi304 – 31310
Beta strandi323 – 3253
Helixi327 – 3326

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IHXX-ray2.50A/B/C/D188-339[»]
ProteinModelPortaliQ9NQV6.
SMRiQ9NQV6. Positions 167-374, 523-825.

Miscellaneous databases

EvolutionaryTraceiQ9NQV6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 326119SET
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi866 – 91651Thr-rich
Add
BLAST
Compositional biasi918 – 1031114Gln-rich
Add
BLAST
Compositional biasi1131 – 11344Poly-Thr

Domaini

The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.
Contains 1 SET domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG053664.
InParanoidiQ9NQV6.
OMAiHDPQTYT.
OrthoDBiEOG70GMFD.
TreeFamiTF350894.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q9NQV6-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV     50
YTADGASYTS VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS 100
LPVHNQVLPS IESVDGSDPL ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE 150
DGEDTDLDDW EPDPPRPFDP HDLWCEECNN AHASVCPKHG PLHPIPNRPV 200
LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL VRGSELKDCY 250
IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 300
YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE 350
QEKNWPCYEC NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG 400
PGRRPGRPPK FIRLEITSEN GEKSDDGTQD LLHFPTKEQF DEAEPATLNG 450
LDQPEQTTIP IPQLPQETQS SLEHEPETHT LHLQPQHEES VVPTQSTLTA 500
DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR 550
FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL 600
DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD 650
KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE 700
AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH 750
PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL 800
PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV 850
QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT 900
QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA 950
SATSPHQSQQ STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ 1000
GLSPSHIQGS SSTQGQALQQ QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ 1050
MMTLPPGQFV ITDSGVATPV TTGQVKAVTS GHYVLSESQS ELEEKQTSAL 1100
SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP 1147
Length:1,147
Mass (Da):130,136
Last modified:January 9, 2013 - v3
Checksum:iE565CA8822CB2934
GO
Isoform 2 (identifier: Q9NQV6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     511-514: Missing.
     952-985: Missing.

Show »
Length:1,023
Mass (Da):116,444
Checksum:iB5680EAEA32A4299
GO
Isoform 1 (identifier: Q9NQV6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

Show »
Length:1,061
Mass (Da):120,711
Checksum:iC712D4CDA514D995
GO
Isoform 4 (identifier: Q9NQV6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,156
Mass (Da):130,865
Checksum:i0DF87B79FBAAE62C
GO
Isoform 5 (identifier: Q9NQV6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,074
Mass (Da):121,924
Checksum:i7F7B76F86712D167
GO
Isoform 6 (identifier: Q9NQV6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA
     1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

Note: No experimental confirmation available.

Show »
Length:1,214
Mass (Da):137,427
Checksum:i05D1A8B9136B7413
GO
Isoform 7 (identifier: Q9NQV6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Show »
Length:1,160
Mass (Da):131,349
Checksum:i1CCEC654DC42F464
GO

Sequence cautioni

The sequence BAA91026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221A → T.
Corresponds to variant rs11221912 [ dbSNP | Ensembl ].
VAR_054418
Natural varianti573 – 5731T → A.3 Publications
Corresponds to variant rs2241571 [ dbSNP | Ensembl ].
VAR_019984

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5.
VSP_036351Add
BLAST
Alternative sequencei511 – 5144Missing in isoform 2, isoform 4 and isoform 6.
VSP_035655
Alternative sequencei952 – 98534Missing in isoform 2.
VSP_035656Add
BLAST
Alternative sequencei984 – 9841I → IQVSEPTASAPSSA in isoform 4, isoform 5, isoform 6 and isoform 7.
VSP_036352
Alternative sequencei1132 – 114716TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6.
VSP_036353Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461P → S in AAI12935. 1 Publication
Sequence conflicti387 – 3871T → A in BAA91026. 1 Publication
Sequence conflicti569 – 5691F → L in BX648944. 1 Publication
Sequence conflicti621 – 6211C → Y in BX648944. 1 Publication
Sequence conflicti1112 – 11121S → N in BX648944. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503171 mRNA. Translation: AAP30847.1.
AF275817 mRNA. Translation: AAF87243.1.
AB033057 mRNA. Translation: BAA86545.2.
BX648944 mRNA. No translation available.
AP003041 Genomic DNA. No translation available.
AP003326 Genomic DNA. No translation available.
AP003327 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67761.1.
BC112934 mRNA. Translation: AAI12935.1.
BC117415 mRNA. Translation: AAI17416.1.
BC143612 mRNA. Translation: AAI43613.1.
AK000234 mRNA. Translation: BAA91026.1. Different initiation.
CCDSiCCDS44771.1. [Q9NQV6-7]
CCDS44772.1. [Q9NQV6-1]
CCDS8484.1. [Q9NQV6-4]
CCDS8485.1. [Q9NQV6-2]
RefSeqiNP_064613.2. NM_020228.2. [Q9NQV6-7]
NP_955469.1. NM_199437.1. [Q9NQV6-4]
NP_955470.1. NM_199438.1. [Q9NQV6-1]
NP_955471.1. NM_199439.1. [Q9NQV6-2]
UniGeneiHs.275086.

Genome annotation databases

EnsembliENST00000304538; ENSP00000302669; ENSG00000170325. [Q9NQV6-2]
ENST00000358825; ENSP00000351686; ENSG00000170325. [Q9NQV6-7]
ENST00000360871; ENSP00000354118; ENSG00000170325. [Q9NQV6-4]
ENST00000423662; ENSP00000398431; ENSG00000170325. [Q9NQV6-1]
ENST00000526082; ENSP00000432237; ENSG00000170325. [Q9NQV6-5]
GeneIDi56980.
KEGGihsa:56980.
UCSCiuc001qfj.3. human. [Q9NQV6-1]
uc001qfk.3. human. [Q9NQV6-2]
uc001qfl.3. human. [Q9NQV6-5]
uc001qfn.3. human.

Polymorphism databases

DMDMi442570289.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503171 mRNA. Translation: AAP30847.1 .
AF275817 mRNA. Translation: AAF87243.1 .
AB033057 mRNA. Translation: BAA86545.2 .
BX648944 mRNA. No translation available.
AP003041 Genomic DNA. No translation available.
AP003326 Genomic DNA. No translation available.
AP003327 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67761.1 .
BC112934 mRNA. Translation: AAI12935.1 .
BC117415 mRNA. Translation: AAI17416.1 .
BC143612 mRNA. Translation: AAI43613.1 .
AK000234 mRNA. Translation: BAA91026.1 . Different initiation.
CCDSi CCDS44771.1. [Q9NQV6-7 ]
CCDS44772.1. [Q9NQV6-1 ]
CCDS8484.1. [Q9NQV6-4 ]
CCDS8485.1. [Q9NQV6-2 ]
RefSeqi NP_064613.2. NM_020228.2. [Q9NQV6-7 ]
NP_955469.1. NM_199437.1. [Q9NQV6-4 ]
NP_955470.1. NM_199438.1. [Q9NQV6-1 ]
NP_955471.1. NM_199439.1. [Q9NQV6-2 ]
UniGenei Hs.275086.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IHX X-ray 2.50 A/B/C/D 188-339 [» ]
ProteinModelPortali Q9NQV6.
SMRi Q9NQV6. Positions 167-374, 523-825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121298. 2 interactions.

PTM databases

PhosphoSitei Q9NQV6.

Polymorphism databases

DMDMi 442570289.

Proteomic databases

MaxQBi Q9NQV6.
PaxDbi Q9NQV6.
PRIDEi Q9NQV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304538 ; ENSP00000302669 ; ENSG00000170325 . [Q9NQV6-2 ]
ENST00000358825 ; ENSP00000351686 ; ENSG00000170325 . [Q9NQV6-7 ]
ENST00000360871 ; ENSP00000354118 ; ENSG00000170325 . [Q9NQV6-4 ]
ENST00000423662 ; ENSP00000398431 ; ENSG00000170325 . [Q9NQV6-1 ]
ENST00000526082 ; ENSP00000432237 ; ENSG00000170325 . [Q9NQV6-5 ]
GeneIDi 56980.
KEGGi hsa:56980.
UCSCi uc001qfj.3. human. [Q9NQV6-1 ]
uc001qfk.3. human. [Q9NQV6-2 ]
uc001qfl.3. human. [Q9NQV6-5 ]
uc001qfn.3. human.

Organism-specific databases

CTDi 56980.
GeneCardsi GC11M129803.
HGNCi HGNC:13995. PRDM10.
HPAi HPA026997.
neXtProti NX_Q9NQV6.
PharmGKBi PA33708.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG053664.
InParanoidi Q9NQV6.
OMAi HDPQTYT.
OrthoDBi EOG70GMFD.
TreeFami TF350894.

Enzyme and pathway databases

SignaLinki Q9NQV6.

Miscellaneous databases

ChiTaRSi PRDM10. human.
EvolutionaryTracei Q9NQV6.
GenomeRNAii 56980.
NextBioi 35535048.
PROi Q9NQV6.

Gene expression databases

ArrayExpressi Q9NQV6.
Bgeei Q9NQV6.
CleanExi HS_PRDM10.
Genevestigatori Q9NQV6.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR022755. Znf_C2H2_jaz.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development."
    Siegel D.A., Huang M.K., Becker S.F.
    Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The yin-yang of PR-domain family genes in tumorigenesis."
    Jiang G.L., Huang S.
    Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), VARIANT ALA-573.
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573.
    Tissue: Brain and Uterus.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573.
    Tissue: Colon mucosa.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424 AND THR-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Methyltransferase domain of human PR domain-containing protein 10."
    Structural genomics consortium (SGC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 188-339.

Entry informationi

Entry nameiPRD10_HUMAN
AccessioniPrimary (citable) accession number: Q9NQV6
Secondary accession number(s): B7ZL71
, G3XAE5, J3KP23, Q17R90, Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 9, 2013
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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