Reviewed,
UniProtKB/Swiss-Prot Q9NQV6 (PRD10_HUMAN)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: PR domain zinc finger protein 10 Alternative name(s): PR domain-containing protein 10 Tristanin | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1147 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in transcriptional regulation By similarity. |
| Subcellular location | Nucleus By similarity. |
| Domain | The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 |
| Sequence similarities | Contains 10 C2H2-type zinc fingers. Contains 1 SET domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 6 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 3 (identifier: Q9NQV6-3) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9NQV6-2) The sequence of this isoform differs from the canonical sequence as follows: 1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA 511-514: Missing. 952-985: Missing. | ||||||
| Isoform 1 (identifier: Q9NQV6-1) The sequence of this isoform differs from the canonical sequence as follows: 1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA | ||||||
| Isoform 4 (identifier: Q9NQV6-4) The sequence of this isoform differs from the canonical sequence as follows: 511-514: Missing. 984-984: I → IQVSEPTASAPSSA | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 5 (identifier: Q9NQV6-5) The sequence of this isoform differs from the canonical sequence as follows: 1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA 984-984: I → IQVSEPTASAPSSA | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 6 (identifier: Q9NQV6-6) The sequence of this isoform differs from the canonical sequence as follows: 511-514: Missing. 984-984: I → IQVSEPTASAPSSA 1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1147 | 1147 | PR domain zinc finger protein 10 | PRO_0000047767 | |||||
Regions | |||||||||
| Domain | 206 – 330 | 125 | SET | ||||||
| Zinc finger | 355 – 377 | 23 | C2H2-type 1 | ||||||
| Zinc finger | 530 – 552 | 23 | C2H2-type 2 | ||||||
| Zinc finger | 560 – 582 | 23 | C2H2-type 3 | ||||||
| Zinc finger | 588 – 610 | 23 | C2H2-type 4 | ||||||
| Zinc finger | 616 – 639 | 24 | C2H2-type 5 | ||||||
| Zinc finger | 644 – 666 | 23 | C2H2-type 6 | ||||||
| Zinc finger | 672 – 695 | 24 | C2H2-type 7 | ||||||
| Zinc finger | 727 – 750 | 24 | C2H2-type 8 | ||||||
| Zinc finger | 772 – 795 | 24 | C2H2-type 9 | ||||||
| Zinc finger | 834 – 857 | 24 | C2H2-type 10 | ||||||
| Compositional bias | 866 – 916 | 51 | Thr-rich | ||||||
| Compositional bias | 918 – 1031 | 114 | Gln-rich | ||||||
| Compositional bias | 1131 – 1134 | 4 | Poly-Thr | ||||||
Amino acid modifications | |||||||||
| Modified residue | 424 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 428 | 1 | Phosphothreonine Ref.7 | ||||||
| Modified residue | 1088 | 1 | Phosphoserine Ref.7 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 97 | 97 | MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5. | VSP_036351 | |||||
| Alternative sequence | 511 – 514 | 4 | Missing in isoform 2, isoform 4 and isoform 6. | VSP_035655 | |||||
| Alternative sequence | 952 – 985 | 34 | Missing in isoform 2. | VSP_035656 | |||||
| Alternative sequence | 984 | 1 | I → IQVSEPTASAPSSA in isoform 4, isoform 5 and isoform 6. | VSP_036352 | |||||
| Alternative sequence | 1132 – 1147 | 16 | TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6. | VSP_036353 | |||||
| Natural variant | 22 | 1 | A → T: dbSNP rs11221912. | VAR_054418 | |||||
| Natural variant | 573 | 1 | T → A: dbSNP rs2241571. Ref.5 Ref.6 | VAR_019984 | |||||
Experimental info | |||||||||
| Sequence conflict | 387 | 1 | T → A in BAA91026. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development." Siegel D.A., Huang M.K., Becker S.F. Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed: 12175877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain. |
| [2] | "The yin-yang of PR-domain family genes in tumorigenesis." Jiang G.L., Huang S. Histol. Histopathol. 15:109-117(2000) [PubMed: 10668202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [4] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573. Tissue: Brain and Uterus. |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573. Tissue: Colon mucosa. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; THR-428 AND SER-1088, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF503171 mRNA. Translation: AAP30847.1. AF275817 mRNA. Translation: AAF87243.1. AB033057 mRNA. Translation: BAA86545.2. AP003326 Genomic DNA. No translation available. AP003327 Genomic DNA. No translation available. BC112934 mRNA. Translation: AAI12935.1. BC117415 mRNA. Translation: AAI17416.1. AK000234 mRNA. Translation: BAA91026.1. Different initiation. | |
| IPI | IPI00299681. IPI00398772. IPI00399316. IPI00411675. IPI00921029. IPI00921092. |
| RefSeq | NP_064613.2. NP_955469.1. NP_955470.1. NP_955471.1. |
| UniGene | Hs.275086 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9NQV6. |
Genome annotation databases | |
| Ensembl | ENSG00000170325. Homo sapiens. [Contig view] |
| GeneID | 56980. |
| KEGG | hsa:56980. |
Organism-specific databases | |
| GeneCards | GC11M129274. |
| HGNC | HGNC:13995. PRDM10. |
| PharmGKB | PA33708. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9NQV6. |
Gene expression databases | |
| ArrayExpress | Q9NQV6. |
| Bgee | Q9NQV6. |
| CleanEx | HS_PRDM10. |
| GermOnline | ENSG00000170325. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view] |
| Pfam | PF00096. zf-C2H2. 7 hits. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 9 hits. [Graphical view] |
| PROSITE | PS50280. SET. False negative. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62643. |
Entry information
| Entry name | PRD10_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NQV6 Secondary accession number(s): Q17R90 Q9ULI9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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