Reviewed, UniProtKB/Swiss-Prot Q9NQV6 (PRD10_HUMAN)

Names and origin

Protein names

Recommended name:
    PR domain zinc finger protein 10
Alternative name(s):
    PR domain-containing protein 10
    Tristanin

Gene names

Name:	PRDM10
Synonyms:	KIAA1231, PFM7, TRIS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Domain	The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7
Sequence similarities	Contains 10 C2H2-type zinc fingers. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9NQV6-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     511-514: Missing.
     952-985: Missing.

Isoform 1 (identifier: Q9NQV6-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA

Isoform 4 (identifier: Q9NQV6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NQV6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MDSKDESSHV...AYVQQDATAQ → MSAYSVPSTFA
     984-984: I → IQVSEPTASAPSSA

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9NQV6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     511-514: Missing.
     984-984: I → IQVSEPTASAPSSA
     1132-1147: TTTNGNGSSEVHITKP → AGSKVIQNEF...IVFKRISKRI

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1147	1147	PR domain zinc finger protein 10		PRO_0000047767
Regions
	Domain	206 – 330	125	SET
	Zinc finger	355 – 377	23	C2H2-type 1
	Zinc finger	530 – 552	23	C2H2-type 2
	Zinc finger	560 – 582	23	C2H2-type 3
	Zinc finger	588 – 610	23	C2H2-type 4
	Zinc finger	616 – 639	24	C2H2-type 5
	Zinc finger	644 – 666	23	C2H2-type 6
	Zinc finger	672 – 695	24	C2H2-type 7
	Zinc finger	727 – 750	24	C2H2-type 8
	Zinc finger	772 – 795	24	C2H2-type 9
	Zinc finger	834 – 857	24	C2H2-type 10
	Compositional bias	866 – 916	51	Thr-rich
	Compositional bias	918 – 1031	114	Gln-rich
	Compositional bias	1131 – 1134	4	Poly-Thr
Amino acid modifications
	Modified residue	424	1	Phosphoserine Ref.7
	Modified residue	428	1	Phosphothreonine Ref.7
	Modified residue	1088	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 97	97	MDSKD…DATAQ → MSAYSVPSTFA in isoform 1, isoform 2 and isoform 5.		VSP_036351
	Alternative sequence	511 – 514	4	Missing in isoform 2, isoform 4 and isoform 6.		VSP_035655
	Alternative sequence	952 – 985	34	Missing in isoform 2.		VSP_035656
	Alternative sequence	984	1	I → IQVSEPTASAPSSA in isoform 4, isoform 5 and isoform 6.		VSP_036352
	Alternative sequence	1132 – 1147	16	TTTNG…HITKP → AGSKVIQNEFTVGEECELET MTGEKVKTVVQLEGDNKLVT TFKNIKSVTELNGDIITNTM TLGDIVFKRISKRI in isoform 6.		VSP_036353
	Natural variant	22	1	A → T: dbSNP rs11221912.		VAR_054418
	Natural variant	573	1	T → A: dbSNP rs2241571. Ref.5 Ref.6		VAR_019984
Experimental info
	Sequence conflict	387	1	T → A in BAA91026. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: 77B5E5E74F5BA468	FASTA	1,147	130,126
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPSQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR 550 560 570 580 590 600 EKDKLDQHLR FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL 610 620 630 640 650 660 DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD KAFCRPDKLR 670 680 690 700 710 720 LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE AKKADRISRS KTFKPRITST 730 740 750 760 770 780 DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV 790 800 810 820 830 840 YKSASKRKAH ILKNHPGAEL PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS 850 860 870 880 890 900 KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT 910 920 930 940 950 960 QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA SATSPHQSQQ 970 980 990 1000 1010 1020 STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ GLSPSHIQGS SSTQGQALQQ 1030 1040 1050 1060 1070 1080 QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ MMTLPPGQFV ITDSGVATPV TTGQVKAVTS 1090 1100 1110 1120 1130 1140 GHYVLSESQS ELEEKQTSAL SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS EVHITKP
	Isoform 2. Checksum: B5680EAEA32A4299	FASTA	1,023	116,444
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRNAALQH LFIRKSFRPF KCLQCGKAFR EKDKLDQHLR FHGREGNCPL TCDLCNKGFI 490 500 510 520 530 540 SSTSLESHMK LHSDQKTYSC IFCPESFDRL DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ 550 560 570 580 590 600 VKKHVRSFHS EKIYQCTECD KAFCRPDKLR LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH 610 620 630 640 650 660 MQRMHNPERE AKKADRISRS KTFKPRITST DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH 670 680 690 700 710 720 PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV YKSASKRKAH ILKNHPGAEL PPSIRKLRPA 730 740 750 760 770 780 GPGEPDPMLS THTQLTGTIA TPPVCCPHCS KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP 790 800 810 820 830 840 LTTAVISATP AVLTTDSATG ETVVTTDLLT QAMTELSQTL TTDYRTPQGD YQRIQYIPVS 850 860 870 880 890 900 QSASGLQQPQ HIQLQVVQVA SVSGQPLSPS AQQAQQGLSP SHIQGSSSTQ GQALQQQQQQ 910 920 930 940 950 960 QQNSSVQHTY LPSAWNSFRG YSSEIQMMTL PPGQFVITDS GVATPVTTGQ VKAVTSGHYV 970 980 990 1000 1010 1020 LSESQSELEE KQTSALSGGV QVEPPAHSDS LDPQTNSQQQ TTQYIITTTT NGNGSSEVHI TKP
	Isoform 1. Checksum: C712D4CDA514D995	FASTA	1,061	120,711
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRLELQNA ALQHLFIRKS FRPFKCLQCG KAFREKDKLD QHLRFHGREG NCPLTCDLCN 490 500 510 520 530 540 KGFISSTSLE SHMKLHSDQK TYSCIFCPES FDRLDLLKDH VAIHINDGYF TCPTCKKRFP 550 560 570 580 590 600 DFIQVKKHVR SFHSEKIYQC TECDKAFCRP DKLRLHMLRH SDRKDFLCST CGKQFKRKDK 610 620 630 640 650 660 LREHMQRMHN PEREAKKADR ISRSKTFKPR ITSTDYDSFT FKCRLCMMGF RRRGMLVNHL 670 680 690 700 710 720 SKRHPDMKIE EVPELTLPII KPNRDYFCQY CDKVYKSASK RKAHILKNHP GAELPPSIRK 730 740 750 760 770 780 LRPAGPGEPD PMLSTHTQLT GTIATPPVCC PHCSKQYSSK TKMVQHIRKK HPEFAQLSNT 790 800 810 820 830 840 IHTPLTTAVI SATPAVLTTD SATGETVVTT DLLTQAMTEL SQTLTTDYRT PQGDYQRIQY 850 860 870 880 890 900 IPVSQSASGL QQPQHIQLQV VQVASATSPH QSQQSTVDVG QLHDPQPYPQ HAIQVQHIQV 910 920 930 940 950 960 SGQPLSPSAQ QAQQGLSPSH IQGSSSTQGQ ALQQQQQQQQ NSSVQHTYLP SAWNSFRGYS 970 980 990 1000 1010 1020 SEIQMMTLPP GQFVITDSGV ATPVTTGQVK AVTSGHYVLS ESQSELEEKQ TSALSGGVQV 1030 1040 1050 1060 EPPAHSDSLD PQTNSQQQTT QYIITTTTNG NGSSEVHITK P
	Isoform 4. Checksum: DE14B446386AD5FE	FASTA	1,156	130,855
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPSQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR NAALQHLFIR KSFRPFKCLQ CGKAFREKDK 550 560 570 580 590 600 LDQHLRFHGR EGNCPLTCDL CNKGFISSTS LESHMKLHSD QKTYSCIFCP ESFDRLDLLK 610 620 630 640 650 660 DHVAIHINDG YFTCPTCKKR FPDFIQVKKH VRSFHSEKIY QCTECDKAFC RPDKLRLHML 670 680 690 700 710 720 RHSDRKDFLC STCGKQFKRK DKLREHMQRM HNPEREAKKA DRISRSKTFK PRITSTDYDS 730 740 750 760 770 780 FTFKCRLCMM GFRRRGMLVN HLSKRHPDMK IEEVPELTLP IIKPNRDYFC QYCDKVYKSA 790 800 810 820 830 840 SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ LTGTIATPPV CCPHCSKQYS 850 860 870 880 890 900 SKTKMVQHIR KKHPEFAQLS NTIHTPLTTA VISATPAVLT TDSATGETVV TTDLLTQAMT 910 920 930 940 950 960 ELSQTLTTDY RTPQGDYQRI QYIPVSQSAS GLQQPQHIQL QVVQVASATS PHQSQQSTVD 970 980 990 1000 1010 1020 VGQLHDPQPY PQHAIQVQHI QVSEPTASAP SSAQVSGQPL SPSAQQAQQG LSPSHIQGSS 1030 1040 1050 1060 1070 1080 STQGQALQQQ QQQQQNSSVQ HTYLPSAWNS FRGYSSEIQM MTLPPGQFVI TDSGVATPVT 1090 1100 1110 1120 1130 1140 TGQVKAVTSG HYVLSESQSE LEEKQTSALS GGVQVEPPAH SDSLDPQTNS QQQTTQYIIT 1150 TTTNGNGSSE VHITKP
	Isoform 5. Checksum: 7F7B76F86712D167	FASTA	1,074	121,924
	10 20 30 40 50 60 MSAYSVPSTF AQASLPVHNQ VLPSIESVDG SDPLATLQTP LGRLEAKEEE DEDEDEDTEE 70 80 90 100 110 120 DEEEDGEDTD LDDWEPDPPR PFDPHDLWCE ECNNAHASVC PKHGPLHPIP NRPVLTRARA 130 140 150 160 170 180 SLPLVLYIDR FLGGVFSKRR IPKRTQFGPV EGPLVRGSEL KDCYIHLKVS LDKGDRKERD 190 200 210 220 230 240 LHEDLWFELS DETLCNWMMF VRPAQNHLEQ NLVAYQYGHH VYYTTIKNVE PKQELKVWYA 250 260 270 280 290 300 ASYAEFVNQK IHDISEEERK VLREQEKNWP CYECNRRFIS SEQLQQHLNS HDEKLDVFSR 310 320 330 340 350 360 TRGRGRGRGK RRFGPGRRPG RPPKFIRLEI TSENGEKSDD GTQDLLHFPT KEQFDEAEPA 370 380 390 400 410 420 TLNGLDQPEQ TTIPIPQLPQ ETQSSLEHEP ETHTLHLQPQ HEESVVPTQS TLTADDMRRA 430 440 450 460 470 480 KRIRLELQNA ALQHLFIRKS FRPFKCLQCG KAFREKDKLD QHLRFHGREG NCPLTCDLCN 490 500 510 520 530 540 KGFISSTSLE SHMKLHSDQK TYSCIFCPES FDRLDLLKDH VAIHINDGYF TCPTCKKRFP 550 560 570 580 590 600 DFIQVKKHVR SFHSEKIYQC TECDKAFCRP DKLRLHMLRH SDRKDFLCST CGKQFKRKDK 610 620 630 640 650 660 LREHMQRMHN PEREAKKADR ISRSKTFKPR ITSTDYDSFT FKCRLCMMGF RRRGMLVNHL 670 680 690 700 710 720 SKRHPDMKIE EVPELTLPII KPNRDYFCQY CDKVYKSASK RKAHILKNHP GAELPPSIRK 730 740 750 760 770 780 LRPAGPGEPD PMLSTHTQLT GTIATPPVCC PHCSKQYSSK TKMVQHIRKK HPEFAQLSNT 790 800 810 820 830 840 IHTPLTTAVI SATPAVLTTD SATGETVVTT DLLTQAMTEL SQTLTTDYRT PQGDYQRIQY 850 860 870 880 890 900 IPVSQSASGL QQPQHIQLQV VQVASATSPH QSQQSTVDVG QLHDPQPYPQ HAIQVQHIQV 910 920 930 940 950 960 SEPTASAPSS AQVSGQPLSP SAQQAQQGLS PSHIQGSSST QGQALQQQQQ QQQNSSVQHT 970 980 990 1000 1010 1020 YLPSAWNSFR GYSSEIQMMT LPPGQFVITD SGVATPVTTG QVKAVTSGHY VLSESQSELE 1030 1040 1050 1060 1070 EKQTSALSGG VQVEPPAHSD SLDPQTNSQQ QTTQYIITTT TNGNGSSEVH ITKP
	Isoform 6. Checksum: 06CCF514F0CA6A13	FASTA	1,214	137,417
	10 20 30 40 50 60 MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPSQQVV YTADGASYTS 70 80 90 100 110 120 VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL 130 140 150 160 170 180 ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN 190 200 210 220 230 240 AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL 250 260 270 280 290 300 VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA 310 320 330 340 350 360 YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC 370 380 390 400 410 420 NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN 430 440 450 460 470 480 GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT 490 500 510 520 530 540 LHLQPQHEES VVPTQSTLTA DDMRRAKRIR NAALQHLFIR KSFRPFKCLQ CGKAFREKDK 550 560 570 580 590 600 LDQHLRFHGR EGNCPLTCDL CNKGFISSTS LESHMKLHSD QKTYSCIFCP ESFDRLDLLK 610 620 630 640 650 660 DHVAIHINDG YFTCPTCKKR FPDFIQVKKH VRSFHSEKIY QCTECDKAFC RPDKLRLHML 670 680 690 700 710 720 RHSDRKDFLC STCGKQFKRK DKLREHMQRM HNPEREAKKA DRISRSKTFK PRITSTDYDS 730 740 750 760 770 780 FTFKCRLCMM GFRRRGMLVN HLSKRHPDMK IEEVPELTLP IIKPNRDYFC QYCDKVYKSA 790 800 810 820 830 840 SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ LTGTIATPPV CCPHCSKQYS 850 860 870 880 890 900 SKTKMVQHIR KKHPEFAQLS NTIHTPLTTA VISATPAVLT TDSATGETVV TTDLLTQAMT 910 920 930 940 950 960 ELSQTLTTDY RTPQGDYQRI QYIPVSQSAS GLQQPQHIQL QVVQVASATS PHQSQQSTVD 970 980 990 1000 1010 1020 VGQLHDPQPY PQHAIQVQHI QVSEPTASAP SSAQVSGQPL SPSAQQAQQG LSPSHIQGSS 1030 1040 1050 1060 1070 1080 STQGQALQQQ QQQQQNSSVQ HTYLPSAWNS FRGYSSEIQM MTLPPGQFVI TDSGVATPVT 1090 1100 1110 1120 1130 1140 TGQVKAVTSG HYVLSESQSE LEEKQTSALS GGVQVEPPAH SDSLDPQTNS QQQTTQYIIT 1150 1160 1170 1180 1190 1200 AGSKVIQNEF TVGEECELET MTGEKVKTVV QLEGDNKLVT TFKNIKSVTE LNGDIITNTM 1210 TLGDIVFKRI SKRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development." Siegel D.A., Huang M.K., Becker S.F. Int. J. Dev. Neurosci. 20:373-389(2002) [PubMed: 12175877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The yin-yang of PR-domain family genes in tumorigenesis." Jiang G.L., Huang S. Histol. Histopathol. 15:109-117(2000) [PubMed: 10668202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ALA-573. Tissue: Brain and Uterus.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-1147 (ISOFORM 6), VARIANT ALA-573. Tissue: Colon mucosa.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; THR-428 AND SER-1088, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF503171 mRNA. Translation: AAP30847.1. AF275817 mRNA. Translation: AAF87243.1. AB033057 mRNA. Translation: BAA86545.2. AP003326 Genomic DNA. No translation available. AP003327 Genomic DNA. No translation available. BC112934 mRNA. Translation: AAI12935.1. BC117415 mRNA. Translation: AAI17416.1. AK000234 mRNA. Translation: BAA91026.1. Different initiation.
IPI	IPI00299681. IPI00398772. IPI00399316. IPI00411675. IPI00921029. IPI00921092.
RefSeq	NP_064613.2. NP_955469.1. NP_955470.1. NP_955471.1.
UniGene	Hs.275086
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9NQV6.
Genome annotation databases
Ensembl	ENSG00000170325. Homo sapiens. [Contig view]
GeneID	56980.
KEGG	hsa:56980.
Organism-specific databases
GeneCards	GC11M129274.
HGNC	HGNC:13995. PRDM10.
PharmGKB	PA33708.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NQV6.
Gene expression databases
ArrayExpress	Q9NQV6.
Bgee	Q9NQV6.
CleanEx	HS_PRDM10.
GermOnline	ENSG00000170325. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
Pfam	PF00096. zf-C2H2. 7 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 9 hits. [Graphical view]
PROSITE	PS50280. SET. False negative. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62643.

Entry information

Entry name

PRD10_HUMAN

Accession

Primary (citable) accession number: Q9NQV6
Secondary accession number(s): Q17R90 , Q2KHR4, Q863Z2, Q9NXI4, Q9ULI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	February 10, 2009
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)