Q9NQV5 (PRD11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PR domain-containing protein 11

Gene names

Name:	PRDM11
Synonyms:	PFM8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 SET domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NQV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 511

511

PR domain-containing protein 11

PRO_0000047768

Regions

Domain

149 – 264

116

SET

Amino acid modifications

Modified residue

63

1

Phosphoserine Ref.4

Natural variations

Alternative sequence

1 – 34

34

Missing in isoform 2.

VSP_039836

Experimental info

Sequence conflict

48

1

A → V in BAC04425. Ref.2

Sequence conflict

58 – 67

10

KTEVCSPLRD → NPS in AAF87244. Ref.1

Sequence conflict

214

1

K → E in AAF87244. Ref.1

Secondary structure

1

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511

Helix Strand Turn

Details...

Beta strand

108 – 110

3

Turn

111 – 114

4

Beta strand

115 – 121

7

Turn

122 – 124

3

Beta strand

128 – 130

3

Helix

142 – 145

4

Beta strand

151 – 155

5

Beta strand

161 – 165

5

Beta strand

174 – 176

3

Beta strand

181 – 184

4

Beta strand

194 – 198

5

Beta strand

204 – 208

5

Turn

212 – 214

3

Helix

217 – 220

4

Turn

227 – 229

3

Beta strand

232 – 237

6

Beta strand

240 – 247

8

Beta strand

256 – 259

4

Helix

261 – 267

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: 81DCAA502315EA5B	FASTA	511	57,863
	10 20 30 40 50 60 MLKMAEPIAS LMIVECRACL RCSPLFLYQR EKDRMTENMK ECLAQTNAAV GDMVTVVKTE 70 80 90 100 110 120 VCSPLRDQEY GQPCSRRPDS SAMEVEPKKL KGKRDLIVPK SFQQVDFWFC ESCQEYFVDE 130 140 150 160 170 180 CPNHGPPVFV SDTPVPVGIP DRAALTIPQG MEVVKDTSGE SDVRCVNEVI PKGHIFGPYE 190 200 210 220 230 240 GQISTQDKSA GFFSWLIVDK NNRYKSIDGS DETKANWMRY VVISREEREQ NLLAFQHSER 250 260 270 280 290 300 IYFRACRDIR PGEWLRVWYS EDYMKRLHSM SQETIHRNLA RGEKRLQREK SEQVLDNPED 310 320 330 340 350 360 LRGPIHLSVL RQGKSPYKRG FDEGDVHPQA KKKKIDLIFK DVLEASLESA KVEAHQLALS 370 380 390 400 410 420 TSLVIRKVPK YQDDAYSQCA TTMTHGVQNI GQTQGEGDWK VPQGVSKEPG QLEDEEEEPS 430 440 450 460 470 480 SFKADSPAEA SLASDPHELP TTSFCPNCIR LKKKVRELQA ELDMLKSGKL PEPPVLPPQV 490 500 510 LELPEFSDPA GKLVWMRLLS EGRVRSGLCG G
	Isoform 2 [UniParc]. Checksum: 70133F1E616A817D	FASTA	477	53,865
	10 20 30 40 50 60 MTENMKECLA QTNAAVGDMV TVVKTEVCSP LRDQEYGQPC SRRPDSSAME VEPKKLKGKR 70 80 90 100 110 120 DLIVPKSFQQ VDFWFCESCQ EYFVDECPNH GPPVFVSDTP VPVGIPDRAA LTIPQGMEVV 130 140 150 160 170 180 KDTSGESDVR CVNEVIPKGH IFGPYEGQIS TQDKSAGFFS WLIVDKNNRY KSIDGSDETK 190 200 210 220 230 240 ANWMRYVVIS REEREQNLLA FQHSERIYFR ACRDIRPGEW LRVWYSEDYM KRLHSMSQET 250 260 270 280 290 300 IHRNLARGEK RLQREKSEQV LDNPEDLRGP IHLSVLRQGK SPYKRGFDEG DVHPQAKKKK 310 320 330 340 350 360 IDLIFKDVLE ASLESAKVEA HQLALSTSLV IRKVPKYQDD AYSQCATTMT HGVQNIGQTQ 370 380 390 400 410 420 GEGDWKVPQG VSKEPGQLED EEEEPSSFKA DSPAEASLAS DPHELPTTSF CPNCIRLKKK 430 440 450 460 470 VRELQAELDM LKSGKLPEPP VLPPQVLELP EFSDPAGKLV WMRLLSEGRV RSGLCGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of novel PR-domain (PRDM) genes as candidate tumor suppressors." Yang X.-H., Huang S. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Crystal structure of methyltransferase domain of human PR domain-containing protein 11." Structural genomics consortium (SGC) Submitted (APR-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 79-314.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF275818 mRNA. Translation: AAF87244.1.
AK094792 mRNA. Translation: BAC04425.1.
AC103681 Genomic DNA. No translation available.

IPI

IPI00329589.
IPI00970895.

RefSeq

NP_001243624.1. NM_001256695.1.
NP_001243625.1. NM_001256696.1.

UniGene

Hs.178715.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3RAY	X-ray	1.73	A	79-314	[»]

ProteinModelPortal

Q9NQV5.

SMR

Q9NQV5. Positions 106-269.

ModBase

Search...

PTM databases

PhosphoSite

Q9NQV5.

Polymorphism databases

DMDM

308153475.

Proteomic databases

PaxDb

Q9NQV5.

PRIDE

Q9NQV5.

Protocols and materials databases

DNASU

56981.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000263765; ENSP00000263765; ENSG00000019485.
ENST00000424263; ENSP00000394314; ENSG00000019485.
ENST00000530656; ENSP00000435976; ENSG00000019485.

GeneID

56981.

KEGG

hsa:56981.

UCSC

uc001myo.3. human.

Organism-specific databases

CTD

56981.

GeneCards

GC11P045072.

HGNC

HGNC:13996. PRDM11.

HPA

HPA057072.

neXtProt

NX_Q9NQV5.

PharmGKB

PA33709.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG279614.

HOGENOM

HOG000231445.

HOVERGEN

HBG053665.

InParanoid

Q9NQV5.

OMA

EREQNLM.

OrthoDB

EOG4Q84X8.

PhylomeDB

Q9NQV5.

Gene expression databases

ArrayExpress

Q9NQV5.

Bgee

Q9NQV5.

CleanEx

HS_PRDM11.

Genevestigator

Q9NQV5.

GermOnline

ENSG00000019485. Homo sapiens.

Family and domain databases

InterPro

IPR001214. SET_dom.
[Graphical view]

SMART

SM00317. SET. 1 hit.
[Graphical view]

PROSITE

PS50280. SET. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

56981.

NextBio

62653.

Entry information

Entry name

PRD11_HUMAN

Accession

Primary (citable) accession number: Q9NQV5
Secondary accession number(s): Q8N9F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.