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Q9NQT8

- KI13B_HUMAN

UniProt

Q9NQT8 - KI13B_HUMAN

Protein

Kinesin-like protein KIF13B

Gene

KIF13B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 14-3-3 protein binding Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. microtubule motor activity Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: GOC
    2. microtubule-based movement Source: UniProtKB
    3. protein targeting Source: UniProtKB
    4. regulation of axonogenesis Source: UniProtKB
    5. signal transduction Source: UniProtKB
    6. T cell activation Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF13B
    Alternative name(s):
    Kinesin-like protein GAKIN
    Gene namesi
    Name:KIF13B
    Synonyms:GAKIN, KIAA0639
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14405. KIF13B.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell projectionaxon 1 Publication
    Note: accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. kinesin complex Source: InterPro
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1381 – 13811S → A: Abolishes phosphorylation by MARK2; when associated with A-1410. 1 Publication
    Mutagenesisi1410 – 14101S → A: Abolishes phosphorylation by MARK2; when associated with A-1389. 1 Publication

    Organism-specific databases

    PharmGKBiPA30099.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18261826Kinesin-like protein KIF13BPRO_0000125448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei661 – 6611Phosphoserine1 Publication
    Modified residuei1379 – 13791Phosphoserine1 Publication
    Modified residuei1381 – 13811Phosphoserine; by MARK21 Publication
    Modified residuei1382 – 13821Phosphoserine1 Publication
    Modified residuei1410 – 14101Phosphoserine; by MARK22 Publications
    Modified residuei1432 – 14321Phosphoserine1 Publication
    Modified residuei1438 – 14381Phosphoserine1 Publication
    Modified residuei1644 – 16441Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NQT8.
    PaxDbiQ9NQT8.
    PRIDEiQ9NQT8.

    PTM databases

    PhosphoSiteiQ9NQT8.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    CleanExiHS_KIF13B.
    GenevestigatoriQ9NQT8.

    Organism-specific databases

    HPAiHPA025023.

    Interactioni

    Subunit structurei

    Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DLG1Q12959-23EBI-766408,EBI-357500

    Protein-protein interaction databases

    BioGridi116895. 9 interactions.
    DIPiDIP-34586N.
    IntActiQ9NQT8. 5 interactions.
    STRINGi9606.ENSP00000350459.

    Structurei

    Secondary structure

    1
    1826
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 127
    Helixi17 – 226
    Beta strandi28 – 314
    Beta strandi34 – 374
    Beta strandi54 – 574
    Beta strandi59 – 635
    Turni70 – 723
    Helixi76 – 9217
    Beta strandi97 – 1037
    Helixi109 – 1135
    Beta strandi117 – 1204
    Helixi122 – 13716
    Beta strandi142 – 15413
    Beta strandi157 – 1604
    Beta strandi189 – 1913
    Helixi194 – 20613
    Beta strandi222 – 23514
    Beta strandi241 – 25313
    Helixi272 – 29221
    Helixi305 – 3073
    Helixi309 – 3135
    Helixi315 – 3184
    Beta strandi323 – 3308
    Helixi334 – 3363
    Helixi337 – 35014
    Beta strandi449 – 4524
    Turni457 – 4604
    Beta strandi464 – 4663
    Beta strandi469 – 4768
    Beta strandi480 – 4823
    Beta strandi493 – 4975
    Beta strandi503 – 5075
    Beta strandi513 – 5153
    Beta strandi524 – 5263
    Beta strandi531 – 5344
    Turni535 – 5373
    Beta strandi538 – 5436
    Beta strandi1706 – 17083
    Beta strandi1710 – 17123
    Beta strandi1714 – 17218
    Beta strandi1724 – 17285
    Beta strandi1730 – 17345
    Beta strandi1736 – 17383
    Beta strandi1743 – 17464
    Beta strandi1760 – 17623
    Helixi1764 – 17663

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2COWNMR-A1685-1771[»]
    3FM8X-ray2.30A/B440-545[»]
    3GBJX-ray2.10A/B/C4-352[»]
    3MDBX-ray2.95A/B440-545[»]
    ProteinModelPortaliQ9NQT8.
    SMRiQ9NQT8. Positions 5-351, 448-545, 1679-1773.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NQT8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 353349Kinesin motorPROSITE-ProRule annotationAdd
    BLAST
    Domaini471 – 53565FHAAdd
    BLAST
    Domaini1721 – 176343CAP-GlyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili364 – 43976Sequence AnalysisAdd
    BLAST
    Coiled coili607 – 710104Sequence AnalysisAdd
    BLAST
    Coiled coili752 – 77221Sequence AnalysisAdd
    BLAST
    Coiled coili1096 – 114348Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 CAP-Gly domain.PROSITE-ProRule annotation
    Contains 1 FHA domain.Curated
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5244.
    HOGENOMiHOG000230729.
    HOVERGENiHBG052244.
    KOiK17914.
    OMAiMKALGSN.
    OrthoDBiEOG72G16D.
    PhylomeDBiQ9NQT8.
    TreeFamiTF105221.

    Family and domain databases

    Gene3Di2.30.30.190. 1 hit.
    2.60.200.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProiIPR000938. CAP-Gly_domain.
    IPR000253. FHA_dom.
    IPR022140. KIF1B.
    IPR022164. Kinesin-like.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF01302. CAP_GLY. 1 hit.
    PF12473. DUF3694. 2 hits.
    PF00498. FHA. 1 hit.
    PF12423. KIF1B. 1 hit.
    PF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM01052. CAP_GLY. 1 hit.
    SM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF74924. SSF74924. 1 hit.
    PROSITEiPS00845. CAP_GLY_1. 1 hit.
    PS50245. CAP_GLY_2. 1 hit.
    PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQT8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDSKVKVAV RIRPMNRRET DLHTKCVVDV DANKVILNPV NTNLSKGDAR     50
    GQPKVFAYDH CFWSMDESVK EKYAGQDIVF KCLGENILQN AFDGYNACIF 100
    AYGQTGSGKS YTMMGTADQP GLIPRLCSGL FERTQKEENE EQSFKVEVSY 150
    MEIYNEKVRD LLDPKGSRQT LKVREHSVLG PYVDGLSKLA VTSYKDIESL 200
    MSEGNKSRTV AATNMNEESS RSHAVFKITL THTLYDVKSG TSGEKVGKLS 250
    LVDLAGSERA TKTGAAGDRL KEGSNINKSL TTLGLVISAL ADQSAGKNKN 300
    KFVPYRDSVL TWLLKDSLGG NSKTAMVATV SPAADNYDET LSTLRYADRA 350
    KHIVNHAVVN EDPNARIIRD LREEVEKLRE QLTKAEAMKS PELKDRLEES 400
    EKLIQEMTVT WEEKLRKTEE IAQERQKQLE SLGISLQSSG IKVGDDKCFL 450
    VNLNADPALN ELLVYYLKEH TLIGSANSQD IQLCGMGILP EHCIIDITSE 500
    GQVMLTPQKN TRTFVNGSSV SSPIQLHHGD RILWGNNHFF RLNLPKKKKK 550
    AEREDEDQDP SMKNENSSEQ LDVDGDSSSE VSSEVNFNYE YAQMEVTMKA 600
    LGSNDPMQSI LNSLEQQHEE EKRSALERQR LMYEHELEQL RRRLSPEKQN 650
    CRSMDRFSFH SPSAQQRLRQ WAEEREATLN NSLMRLREQI VKANLLVREA 700
    NYIAEELDKR TEYKVTLQIP ASSLDANRKR GSLLSEPAIQ VRRKGKGKQI 750
    WSLEKLDNRL LDMRDLYQEW KECEEDNPVI RSYFKRADPF YDEQENHSLI 800
    GVANVFLESL FYDVKLQYAV PIINQKGEVA GRLHVEVMRL SGDVGERIAG 850
    GDEVAEVSFE KETQENKLVC MVKILQATGL PQHLSHFVFC KYSFWDQQEP 900
    VIVAPEVDTS SSSVSKEPHC MVVFDHCNEF SVNITEDFIE HLSEGALAIE 950
    VYGHKINDPR KNPALWDLGI IQAKTRSLRD RWSEVTRKLE FWVQILEQNE 1000
    NGEYCPVEVI SAKDVPTGGI FQLRQGQSRR VQVEVKSVQE SGTLPLMEEC 1050
    ILSVGIGCVK VRPLRAPRTH ETFHEEEEDM DSYQDRDLER LRRKWLNALT 1100
    KRQEYLDQQL QKLVSKRDKT EDDADREAQL LEMRLTLTEE RNAVMVPSAG 1150
    SGIPGAPAEW TPVPGMETHI PVIFLDLNAD DFSSQDNLDD PEAGGWDATL 1200
    TGEEEEEFFE LQIVKQHDGE VKAEASWDSA VHGCPQLSRG TPVDERLFLI 1250
    VRVTVQLSHP ADMQLVLRKR ICVNVHGRQG FAQSLLKKMS HRSSIPGCGV 1300
    TFEIVSNIPE DAQGVEEREA LARMAANVEN PASADSEAYI EKYLRSVLAV 1350
    ENLLTLDRLR QEVAVKEQLT GKGKLSRRSI SSPNVNRLSG SRQDLIPSYS 1400
    LGSNKGRWES QQDVSQTTVS RGIAPAPALS VSPQNNHSPD PGLSNLAASY 1450
    LNPVKSFVPQ MPKLLKSLFP VRDEKRGKRP SPLAHQPVPR IMVQSASPDI 1500
    RVTRMEEAQP EMGPDVLVQT MGAPALKICD KPAKVPSPPP VIAVTAVTPA 1550
    PEAQDGPPSP LSEASSGYFS HSVSTATLSD ALGPGLDAAA PPGSMPTAPE 1600
    AEPEAPISHP PPPTAVPAEE PPGPQQLVSP GRERPDLEAP APGSPFRVRR 1650
    VRASELRSFS RMLAGDPGCS PGAEGNAPAP GAGGQALASD SEEADEVPEW 1700
    LREGEFVTVG AHKTGVVRYV GPADFQEGTW VGVELDLPSG KNDGSIGGKQ 1750
    YFRCNPGYGL LVRPSRVRRA TGPVRRRSTG LRLGAPEARR SATLSGSATN 1800
    LASLTAALAK ADRSHKNPEN RKSWAS 1826
    Length:1,826
    Mass (Da):202,789
    Last modified:June 26, 2013 - v2
    Checksum:i7A336B3C5BDA21E6
    GO
    Isoform 2 (identifier: Q9NQT8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1460: Missing.
         1487-1507: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:345
    Mass (Da):35,860
    Checksum:i54A705E9CBB2F535
    GO

    Sequence cautioni

    The sequence BAA31614.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551V → C in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti191 – 1911V → A in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti226 – 2261F → L in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti237 – 2371V → A in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti278 – 2781K → E in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti356 – 3561H → N in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti797 – 7971H → L in AAF81263. (PubMed:10859302)Curated
    Sequence conflicti858 – 8581S → P in AAF81263. (PubMed:10859302)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1471 – 14711V → I.
    Corresponds to variant rs17526980 [ dbSNP | Ensembl ].
    VAR_055982

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 14601460Missing in isoform 2. 1 PublicationVSP_056360Add
    BLAST
    Alternative sequencei1487 – 150721Missing in isoform 2. 1 PublicationVSP_056361Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279865 mRNA. Translation: AAF81263.1.
    AB014539 mRNA. Translation: BAA31614.3. Different initiation.
    AK294837 mRNA. Translation: BAG57946.1.
    AC084262 Genomic DNA. No translation available.
    AC103830 Genomic DNA. No translation available.
    AC108449 Genomic DNA. No translation available.
    AL583912 mRNA. Translation: CAC29496.1.
    CCDSiCCDS55217.1.
    RefSeqiNP_056069.2. NM_015254.3.
    UniGeneiHs.444767.

    Genome annotation databases

    EnsembliENST00000404075; ENSP00000384054; ENSG00000197892.
    ENST00000524189; ENSP00000427900; ENSG00000197892.
    GeneIDi23303.
    KEGGihsa:23303.

    Polymorphism databases

    DMDMi519668668.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279865 mRNA. Translation: AAF81263.1 .
    AB014539 mRNA. Translation: BAA31614.3 . Different initiation.
    AK294837 mRNA. Translation: BAG57946.1 .
    AC084262 Genomic DNA. No translation available.
    AC103830 Genomic DNA. No translation available.
    AC108449 Genomic DNA. No translation available.
    AL583912 mRNA. Translation: CAC29496.1 .
    CCDSi CCDS55217.1.
    RefSeqi NP_056069.2. NM_015254.3.
    UniGenei Hs.444767.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2COW NMR - A 1685-1771 [» ]
    3FM8 X-ray 2.30 A/B 440-545 [» ]
    3GBJ X-ray 2.10 A/B/C 4-352 [» ]
    3MDB X-ray 2.95 A/B 440-545 [» ]
    ProteinModelPortali Q9NQT8.
    SMRi Q9NQT8. Positions 5-351, 448-545, 1679-1773.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116895. 9 interactions.
    DIPi DIP-34586N.
    IntActi Q9NQT8. 5 interactions.
    STRINGi 9606.ENSP00000350459.

    PTM databases

    PhosphoSitei Q9NQT8.

    Polymorphism databases

    DMDMi 519668668.

    Proteomic databases

    MaxQBi Q9NQT8.
    PaxDbi Q9NQT8.
    PRIDEi Q9NQT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000404075 ; ENSP00000384054 ; ENSG00000197892 .
    ENST00000524189 ; ENSP00000427900 ; ENSG00000197892 .
    GeneIDi 23303.
    KEGGi hsa:23303.

    Organism-specific databases

    CTDi 23303.
    GeneCardsi GC08M028924.
    H-InvDB HIX0021580.
    HGNCi HGNC:14405. KIF13B.
    HPAi HPA025023.
    MIMi 607350. gene.
    neXtProti NX_Q9NQT8.
    PharmGKBi PA30099.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5244.
    HOGENOMi HOG000230729.
    HOVERGENi HBG052244.
    KOi K17914.
    OMAi MKALGSN.
    OrthoDBi EOG72G16D.
    PhylomeDBi Q9NQT8.
    TreeFami TF105221.

    Miscellaneous databases

    ChiTaRSi KIF13B. human.
    EvolutionaryTracei Q9NQT8.
    GenomeRNAii 23303.
    NextBioi 45145.
    PROi Q9NQT8.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_KIF13B.
    Genevestigatori Q9NQT8.

    Family and domain databases

    Gene3Di 2.30.30.190. 1 hit.
    2.60.200.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProi IPR000938. CAP-Gly_domain.
    IPR000253. FHA_dom.
    IPR022140. KIF1B.
    IPR022164. Kinesin-like.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF01302. CAP_GLY. 1 hit.
    PF12473. DUF3694. 2 hits.
    PF00498. FHA. 1 hit.
    PF12423. KIF1B. 1 hit.
    PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM01052. CAP_GLY. 1 hit.
    SM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF74924. SSF74924. 1 hit.
    PROSITEi PS00845. CAP_GLY_1. 1 hit.
    PS50245. CAP_GLY_2. 1 hit.
    PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes."
      Hanada T., Lin L., Tibaldi E.V., Reinherz E.L., Chishti A.H.
      J. Biol. Chem. 275:28774-28784(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH DLG1 AND DLG4.
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Ohara O., Suyama M., Nagase T., Ishikawa K.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1096-1826 (ISOFORM 1).
      Tissue: Amygdala.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1379; SER-1382; SER-1432 AND SER-1438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation."
      Yoshimura Y., Terabayashi T., Miki H.
      Mol. Cell. Biol. 30:2206-2219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH 14-3-3, MUTAGENESIS OF SER-1381 AND SER-1410, PHOSPHORYLATION AT SER-1381 AND SER-1410.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of the CAP-Gly domain in human kinesin-like protein KIF13B."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1684-1771.

    Entry informationi

    Entry nameiKI13B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQT8
    Secondary accession number(s): B4DGY5
    , B5MC45, F8VPJ2, O75134, Q9BYJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3