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Q9NQT6 (FSCN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fascin-3
Alternative name(s):
Testis fascin
Gene names
Name:FSCN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an actin bundling protein By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Expressed in testis.

Sequence similarities

Belongs to the fascin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentactin cytoskeleton

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Traceable author statement PubMed 10783262. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Fascin-3
PRO_0000219383

Natural variations

Natural variant241A → S.
Corresponds to variant rs3779536 [ dbSNP | Ensembl ].
VAR_022021
Natural variant4281H → L.
Corresponds to variant rs34394613 [ dbSNP | Ensembl ].
VAR_033939

Sequences

Sequence LengthMass (Da)Tools
Q9NQT6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FF9A1BE44F7D4354

FASTA49856,624
        10         20         30         40         50         60 
MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW EILVSNEHET 

        70         80         90        100        110        120 
QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH RNSKWTLQCL ISGRYLESNG 

       130        140        150        160        170        180 
KDVFCTSHVL SAYHMWTPRP ALHVHVILYS PIHRCYARAD PTMGRIWVDA AVPCLEECGF 

       190        200        210        220        230        240 
LLHFRDGCYH LETSTHHFLS HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT 

       250        260        270        280        290        300 
HLLLGMGCNP MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE 

       310        320        330        340        350        360 
CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL QSCRGRFLGI 

       370        380        390        400        410        420 
APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS SSGHDLIQCN QDQPDRIHLL 

       430        440        450        460        470        480 
PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSNLLTVLAP NGFYMRADQS 

       490 
GTLLADSEDI TRECIWEF 

« Hide

References

« Hide 'large scale' references
[1]"Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head."
Tubb B., Mulholland D.J., Vogl W., Lan Z.J., Niederberger C., Cooney A., Bryan J.
Exp. Cell Res. 275:92-109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF281049 mRNA. Translation: AAF91439.1.
AK314050 mRNA. Translation: BAG36759.1.
AC000357 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24319.1.
CH471070 Genomic DNA. Translation: EAW83632.1.
BC035606 mRNA. Translation: AAH35606.1.
CCDSCCDS34746.1.
RefSeqNP_065102.1. NM_020369.2.
UniGeneHs.712692.

3D structure databases

ProteinModelPortalQ9NQT6.
SMRQ9NQT6. Positions 12-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265825.

PTM databases

PhosphoSiteQ9NQT6.

Polymorphism databases

DMDM18203315.

Proteomic databases

PaxDbQ9NQT6.
PRIDEQ9NQT6.

Protocols and materials databases

DNASU29999.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265825; ENSP00000265825; ENSG00000106328.
GeneID29999.
KEGGhsa:29999.
UCSCuc003vmd.2. human.

Organism-specific databases

CTD29999.
GeneCardsGC07P127232.
HGNCHGNC:3961. FSCN3.
neXtProtNX_Q9NQT6.
PharmGKBPA28379.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85029.
HOGENOMHOG000029285.
HOVERGENHBG051663.
InParanoidQ9NQT6.
KOK17456.
OMAWGKFALN.
OrthoDBEOG7WT40W.
PhylomeDBQ9NQT6.
TreeFamTF323992.

Gene expression databases

ArrayExpressQ9NQT6.
BgeeQ9NQT6.
CleanExHS_FSCN3.
GenevestigatorQ9NQT6.

Family and domain databases

InterProIPR008999. Actin_cross-linking.
IPR010431. Fascin.
IPR022768. Fascin-domain.
IPR024703. Fascin_metazoans.
[Graphical view]
PANTHERPTHR10551. PTHR10551. 1 hit.
PfamPF06268. Fascin. 2 hits.
[Graphical view]
PIRSFPIRSF005682. Fascin. 1 hit.
SUPFAMSSF50405. SSF50405. 4 hits.
ProtoNetSearch...

Other

ChiTaRSFSCN3. human.
GeneWikiFSCN3.
GenomeRNAi29999.
NextBio52808.
PROQ9NQT6.

Entry information

Entry nameFSCN3_HUMAN
AccessionPrimary (citable) accession number: Q9NQT6
Secondary accession number(s): A4D0Z2, A6NLL7, B2RA62
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM