Q9NQT6 (FSCN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fascin-3

Alternative name(s):
Testis fascin

Gene names

Name:

FSCN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as an actin bundling protein By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Expressed in testis.
Sequence similarities	Belongs to the fascin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	actin cytoskeleton Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Fascin-3		PRO_0000219383
Natural variations
	Natural variant	24	1	A → S. Corresponds to variant rs3779536 [ dbSNP | Ensembl ].		VAR_022021
	Natural variant	428	1	H → L. Corresponds to variant rs34394613 [ dbSNP | Ensembl ].		VAR_033939

Sequences

	Sequence		Length	Mass (Da)
	Q9NQT6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: FF9A1BE44F7D4354	FASTA	498	56,624
	10 20 30 40 50 60 MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW EILVSNEHET 70 80 90 100 110 120 QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH RNSKWTLQCL ISGRYLESNG 130 140 150 160 170 180 KDVFCTSHVL SAYHMWTPRP ALHVHVILYS PIHRCYARAD PTMGRIWVDA AVPCLEECGF 190 200 210 220 230 240 LLHFRDGCYH LETSTHHFLS HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT 250 260 270 280 290 300 HLLLGMGCNP MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE 310 320 330 340 350 360 CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL QSCRGRFLGI 370 380 390 400 410 420 APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS SSGHDLIQCN QDQPDRIHLL 430 440 450 460 470 480 PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSNLLTVLAP NGFYMRADQS 490 GTLLADSEDI TRECIWEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head." Tubb B., Mulholland D.J., Vogl W., Lan Z.J., Niederberger C., Cooney A., Bryan J. Exp. Cell Res. 275:92-109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF281049 mRNA. Translation: AAF91439.1. AK314050 mRNA. Translation: BAG36759.1. AC000357 Genomic DNA. No translation available. CH236947 Genomic DNA. Translation: EAL24319.1. CH471070 Genomic DNA. Translation: EAW83632.1. BC035606 mRNA. Translation: AAH35606.1.
IPI	IPI00006902.
RefSeq	NP_065102.1. NM_020369.2.
UniGene	Hs.712692.
3D structure databases
ProteinModelPortal	Q9NQT6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000265825.
PTM databases
PhosphoSite	Q9NQT6.
Polymorphism databases
DMDM	18203315.
Proteomic databases
PaxDb	Q9NQT6.
PRIDE	Q9NQT6.
Protocols and materials databases
DNASU	29999.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265825; ENSP00000265825; ENSG00000106328.
GeneID	29999.
KEGG	hsa:29999.
UCSC	uc003vmd.2. human.
Organism-specific databases
CTD	29999.
GeneCards	GC07P127232.
HGNC	HGNC:3961. FSCN3.
neXtProt	NX_Q9NQT6.
PharmGKB	PA28379.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85029.
HOGENOM	HOG000029285.
HOVERGEN	HBG051663.
InParanoid	Q9NQT6.
OMA	WGKFALN.
OrthoDB	EOG469QTH.
Gene expression databases
ArrayExpress	Q9NQT6.
Bgee	Q9NQT6.
CleanEx	HS_FSCN3.
Genevestigator	Q9NQT6.
GermOnline	ENSG00000106328. Homo sapiens.
Family and domain databases
InterPro	IPR008999. Actin_cross-linking. IPR010431. Fascin. IPR022768. Fascin-domain. IPR024703. Fascin_metazoans. [Graphical view]
PANTHER	PTHR10551. PTHR10551. 1 hit.
Pfam	PF06268. Fascin. 2 hits. [Graphical view]
PIRSF	PIRSF005682. Fascin. 1 hit.
SUPFAM	SSF50405. Actin_crosslink. 4 hits.
ProtoNet	Search...
Other
ChiTaRS	FSCN3. human.
GenomeRNAi	29999.
NextBio	52808.

Entry information

Entry name

FSCN3_HUMAN

Accession

Primary (citable) accession number: Q9NQT6
Secondary accession number(s): A4D0Z2, A6NLL7, B2RA62

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.