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Protein

Fascin-3

Gene

FSCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an actin bundling protein.By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin-3
Alternative name(s):
Testis fascin
Gene namesi
Name:FSCN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3961. FSCN3.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Fascin-3PRO_0000219383Add
BLAST

Proteomic databases

PaxDbiQ9NQT6.
PRIDEiQ9NQT6.

PTM databases

PhosphoSiteiQ9NQT6.

Expressioni

Tissue specificityi

Expressed in testis.

Gene expression databases

BgeeiQ9NQT6.
CleanExiHS_FSCN3.
ExpressionAtlasiQ9NQT6. baseline and differential.
GenevestigatoriQ9NQT6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265825.

Structurei

3D structure databases

ProteinModelPortaliQ9NQT6.
SMRiQ9NQT6. Positions 12-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiNOG85029.
GeneTreeiENSGT00530000063373.
HOGENOMiHOG000029285.
HOVERGENiHBG051663.
InParanoidiQ9NQT6.
KOiK17456.
OMAiWGKFALN.
OrthoDBiEOG7WT40W.
PhylomeDBiQ9NQT6.
TreeFamiTF323992.

Family and domain databases

InterProiIPR008999. Actin_cross-linking.
IPR010431. Fascin.
IPR022768. Fascin-domain.
IPR024703. Fascin_metazoans.
IPR030143. FSCN3.
[Graphical view]
PANTHERiPTHR10551. PTHR10551. 1 hit.
PTHR10551:SF1. PTHR10551:SF1. 1 hit.
PfamiPF06268. Fascin. 2 hits.
[Graphical view]
PIRSFiPIRSF005682. Fascin. 1 hit.
SUPFAMiSSF50405. SSF50405. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQT6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW
60 70 80 90 100
EILVSNEHET QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH
110 120 130 140 150
RNSKWTLQCL ISGRYLESNG KDVFCTSHVL SAYHMWTPRP ALHVHVILYS
160 170 180 190 200
PIHRCYARAD PTMGRIWVDA AVPCLEECGF LLHFRDGCYH LETSTHHFLS
210 220 230 240 250
HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT HLLLGMGCNP
260 270 280 290 300
MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE
310 320 330 340 350
CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL
360 370 380 390 400
QSCRGRFLGI APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS
410 420 430 440 450
SSGHDLIQCN QDQPDRIHLL PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK
460 470 480 490
FALNFCIELQ GSNLLTVLAP NGFYMRADQS GTLLADSEDI TRECIWEF
Length:498
Mass (Da):56,624
Last modified:October 1, 2000 - v1
Checksum:iFF9A1BE44F7D4354
GO
Isoform 2 (identifier: Q9NQT6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     431-485: AQGGSFWSIT...RADQSGTLLA → GGILLVNNIL...RPKWHPVGRQ
     486-498: Missing.

Note: No experimental confirmation available.

Show »
Length:351
Mass (Da):39,835
Checksum:i6AB08C1B8994E916
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241A → S.
Corresponds to variant rs3779536 [ dbSNP | Ensembl ].
VAR_022021
Natural varianti428 – 4281H → L.
Corresponds to variant rs34394613 [ dbSNP | Ensembl ].
VAR_033939

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134Missing in isoform 2. 1 PublicationVSP_057001Add
BLAST
Alternative sequencei431 – 48555AQGGS…GTLLA → GGILLVNNILWHLSPLGQVC PQLLYRASGEQLTHCTGPQW LLHASRPKWHPVGRQ in isoform 2. 1 PublicationVSP_057002Add
BLAST
Alternative sequencei486 – 49813Missing in isoform 2. VSP_057003Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281049 mRNA. Translation: AAF91439.1.
AK300518 mRNA. Translation: BAG62230.1.
AK314050 mRNA. Translation: BAG36759.1.
AC000357 Genomic DNA. No translation available.
AC073934 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24319.1.
CH471070 Genomic DNA. Translation: EAW83632.1.
BC035606 mRNA. Translation: AAH35606.1.
CCDSiCCDS34746.1. [Q9NQT6-1]
RefSeqiNP_065102.1. NM_020369.2. [Q9NQT6-1]
UniGeneiHs.712692.

Genome annotation databases

EnsembliENST00000265825; ENSP00000265825; ENSG00000106328. [Q9NQT6-1]
GeneIDi29999.
KEGGihsa:29999.
UCSCiuc003vmd.2. human. [Q9NQT6-1]

Polymorphism databases

DMDMi18203315.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281049 mRNA. Translation: AAF91439.1.
AK300518 mRNA. Translation: BAG62230.1.
AK314050 mRNA. Translation: BAG36759.1.
AC000357 Genomic DNA. No translation available.
AC073934 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24319.1.
CH471070 Genomic DNA. Translation: EAW83632.1.
BC035606 mRNA. Translation: AAH35606.1.
CCDSiCCDS34746.1. [Q9NQT6-1]
RefSeqiNP_065102.1. NM_020369.2. [Q9NQT6-1]
UniGeneiHs.712692.

3D structure databases

ProteinModelPortaliQ9NQT6.
SMRiQ9NQT6. Positions 12-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265825.

PTM databases

PhosphoSiteiQ9NQT6.

Polymorphism databases

DMDMi18203315.

Proteomic databases

PaxDbiQ9NQT6.
PRIDEiQ9NQT6.

Protocols and materials databases

DNASUi29999.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265825; ENSP00000265825; ENSG00000106328. [Q9NQT6-1]
GeneIDi29999.
KEGGihsa:29999.
UCSCiuc003vmd.2. human. [Q9NQT6-1]

Organism-specific databases

CTDi29999.
GeneCardsiGC07P127232.
HGNCiHGNC:3961. FSCN3.
MIMi615800. gene.
neXtProtiNX_Q9NQT6.
PharmGKBiPA28379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85029.
GeneTreeiENSGT00530000063373.
HOGENOMiHOG000029285.
HOVERGENiHBG051663.
InParanoidiQ9NQT6.
KOiK17456.
OMAiWGKFALN.
OrthoDBiEOG7WT40W.
PhylomeDBiQ9NQT6.
TreeFamiTF323992.

Miscellaneous databases

GeneWikiiFSCN3.
GenomeRNAii29999.
NextBioi35475110.
PROiQ9NQT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQT6.
CleanExiHS_FSCN3.
ExpressionAtlasiQ9NQT6. baseline and differential.
GenevestigatoriQ9NQT6.

Family and domain databases

InterProiIPR008999. Actin_cross-linking.
IPR010431. Fascin.
IPR022768. Fascin-domain.
IPR024703. Fascin_metazoans.
IPR030143. FSCN3.
[Graphical view]
PANTHERiPTHR10551. PTHR10551. 1 hit.
PTHR10551:SF1. PTHR10551:SF1. 1 hit.
PfamiPF06268. Fascin. 2 hits.
[Graphical view]
PIRSFiPIRSF005682. Fascin. 1 hit.
SUPFAMiSSF50405. SSF50405. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head."
    Tubb B., Mulholland D.J., Vogl W., Lan Z.J., Niederberger C., Cooney A., Bryan J.
    Exp. Cell Res. 275:92-109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Prostate and Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiFSCN3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQT6
Secondary accession number(s): A4D0Z2
, A6NLL7, B2RA62, B4DU68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.