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Q9NQT6

- FSCN3_HUMAN

UniProt

Q9NQT6 - FSCN3_HUMAN

Protein

Fascin-3

Gene

FSCN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Acts as an actin bundling protein.By similarity

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fascin-3
    Alternative name(s):
    Testis fascin
    Gene namesi
    Name:FSCN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:3961. FSCN3.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Fascin-3PRO_0000219383Add
    BLAST

    Proteomic databases

    PaxDbiQ9NQT6.
    PRIDEiQ9NQT6.

    PTM databases

    PhosphoSiteiQ9NQT6.

    Expressioni

    Tissue specificityi

    Expressed in testis.

    Gene expression databases

    ArrayExpressiQ9NQT6.
    BgeeiQ9NQT6.
    CleanExiHS_FSCN3.
    GenevestigatoriQ9NQT6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265825.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQT6.
    SMRiQ9NQT6. Positions 12-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the fascin family.Curated

    Phylogenomic databases

    eggNOGiNOG85029.
    HOGENOMiHOG000029285.
    HOVERGENiHBG051663.
    InParanoidiQ9NQT6.
    KOiK17456.
    OMAiWGKFALN.
    OrthoDBiEOG7WT40W.
    PhylomeDBiQ9NQT6.
    TreeFamiTF323992.

    Family and domain databases

    InterProiIPR008999. Actin_cross-linking.
    IPR010431. Fascin.
    IPR022768. Fascin-domain.
    IPR024703. Fascin_metazoans.
    [Graphical view]
    PANTHERiPTHR10551. PTHR10551. 1 hit.
    PfamiPF06268. Fascin. 2 hits.
    [Graphical view]
    PIRSFiPIRSF005682. Fascin. 1 hit.
    SUPFAMiSSF50405. SSF50405. 4 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9NQT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW    50
    EILVSNEHET QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH 100
    RNSKWTLQCL ISGRYLESNG KDVFCTSHVL SAYHMWTPRP ALHVHVILYS 150
    PIHRCYARAD PTMGRIWVDA AVPCLEECGF LLHFRDGCYH LETSTHHFLS 200
    HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT HLLLGMGCNP 250
    MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE 300
    CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL 350
    QSCRGRFLGI APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS 400
    SSGHDLIQCN QDQPDRIHLL PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK 450
    FALNFCIELQ GSNLLTVLAP NGFYMRADQS GTLLADSEDI TRECIWEF 498
    Length:498
    Mass (Da):56,624
    Last modified:October 1, 2000 - v1
    Checksum:iFF9A1BE44F7D4354
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241A → S.
    Corresponds to variant rs3779536 [ dbSNP | Ensembl ].
    VAR_022021
    Natural varianti428 – 4281H → L.
    Corresponds to variant rs34394613 [ dbSNP | Ensembl ].
    VAR_033939

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281049 mRNA. Translation: AAF91439.1.
    AK314050 mRNA. Translation: BAG36759.1.
    AC000357 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24319.1.
    CH471070 Genomic DNA. Translation: EAW83632.1.
    BC035606 mRNA. Translation: AAH35606.1.
    CCDSiCCDS34746.1.
    RefSeqiNP_065102.1. NM_020369.2.
    UniGeneiHs.712692.

    Genome annotation databases

    EnsembliENST00000265825; ENSP00000265825; ENSG00000106328.
    GeneIDi29999.
    KEGGihsa:29999.
    UCSCiuc003vmd.2. human.

    Polymorphism databases

    DMDMi18203315.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF281049 mRNA. Translation: AAF91439.1 .
    AK314050 mRNA. Translation: BAG36759.1 .
    AC000357 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24319.1 .
    CH471070 Genomic DNA. Translation: EAW83632.1 .
    BC035606 mRNA. Translation: AAH35606.1 .
    CCDSi CCDS34746.1.
    RefSeqi NP_065102.1. NM_020369.2.
    UniGenei Hs.712692.

    3D structure databases

    ProteinModelPortali Q9NQT6.
    SMRi Q9NQT6. Positions 12-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265825.

    PTM databases

    PhosphoSitei Q9NQT6.

    Polymorphism databases

    DMDMi 18203315.

    Proteomic databases

    PaxDbi Q9NQT6.
    PRIDEi Q9NQT6.

    Protocols and materials databases

    DNASUi 29999.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265825 ; ENSP00000265825 ; ENSG00000106328 .
    GeneIDi 29999.
    KEGGi hsa:29999.
    UCSCi uc003vmd.2. human.

    Organism-specific databases

    CTDi 29999.
    GeneCardsi GC07P127232.
    HGNCi HGNC:3961. FSCN3.
    MIMi 615800. gene.
    neXtProti NX_Q9NQT6.
    PharmGKBi PA28379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85029.
    HOGENOMi HOG000029285.
    HOVERGENi HBG051663.
    InParanoidi Q9NQT6.
    KOi K17456.
    OMAi WGKFALN.
    OrthoDBi EOG7WT40W.
    PhylomeDBi Q9NQT6.
    TreeFami TF323992.

    Miscellaneous databases

    ChiTaRSi FSCN3. human.
    GeneWikii FSCN3.
    GenomeRNAii 29999.
    NextBioi 52808.
    PROi Q9NQT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQT6.
    Bgeei Q9NQT6.
    CleanExi HS_FSCN3.
    Genevestigatori Q9NQT6.

    Family and domain databases

    InterProi IPR008999. Actin_cross-linking.
    IPR010431. Fascin.
    IPR022768. Fascin-domain.
    IPR024703. Fascin_metazoans.
    [Graphical view ]
    PANTHERi PTHR10551. PTHR10551. 1 hit.
    Pfami PF06268. Fascin. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF005682. Fascin. 1 hit.
    SUPFAMi SSF50405. SSF50405. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head."
      Tubb B., Mulholland D.J., Vogl W., Lan Z.J., Niederberger C., Cooney A., Bryan J.
      Exp. Cell Res. 275:92-109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiFSCN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQT6
    Secondary accession number(s): A4D0Z2, A6NLL7, B2RA62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3