Reviewed,
UniProtKB/Swiss-Prot Q9NQS5 (GPR84_HUMAN)
Last modified
November 3, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G-protein coupled receptor 84 Alternative name(s): Inflammation-related G-protein coupled receptor EX33 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. Ref.5 |
| Subcellular location | |
| Tissue specificity | Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peipheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes. Ref.5 Ref.1 Ref.2 |
| Induction | By lipopolysaccharide in the monocytic leukaemia cell line THP-1. Ref.5 |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | G-protein coupled receptor 84 | PRO_0000069589 | |||||
Regions | |||||||||
| Topological domain | 1 – 26 | 26 | Extracellular Potential | ||||||
| Transmembrane | 27 – 47 | 21 | 1 Potential | ||||||
| Topological domain | 48 – 57 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 58 – 78 | 21 | 2 Potential | ||||||
| Topological domain | 79 – 94 | 16 | Extracellular Potential | ||||||
| Transmembrane | 95 – 115 | 21 | 3 Potential | ||||||
| Topological domain | 116 – 144 | 29 | Cytoplasmic Potential | ||||||
| Transmembrane | 145 – 165 | 21 | 4 Potential | ||||||
| Topological domain | 166 – 180 | 15 | Extracellular Potential | ||||||
| Transmembrane | 181 – 201 | 21 | 5 Potential | ||||||
| Topological domain | 202 – 320 | 119 | Cytoplasmic Potential | ||||||
| Transmembrane | 321 – 341 | 21 | 6 Potential | ||||||
| Topological domain | 342 – 352 | 11 | Extracellular Potential | ||||||
| Transmembrane | 353 – 373 | 21 | 7 Potential | ||||||
| Topological domain | 374 – 396 | 23 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 221 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 224 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 391 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 3 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 8 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 37 | 1 | G → D: dbSNP rs11170883. | VAR_049397 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes." Yousefi S., Cooper P.R., Potter S.L., Mueck B., Jarai G. J. Leukoc. Biol. 69:1045-1052(2001) [PubMed: 11404393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors." Wittenberger T., Schaller H.C., Hellebrand S. J. Mol. Biol. 307:799-813(2001) [PubMed: 11273702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [3] | "Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed: 12044878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84." Wang J., Wu X., Simonavicius N., Tian H., Ling L. J. Biol. Chem. 281:34457-34464(2006) [PubMed: 16966319] [Abstract] Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| AF282693 mRNA. Translation: AAF91467.1. AF237762 mRNA. Translation: AAK01857.1. AB083586 Genomic DNA. Translation: BAB89299.1. BC020614 mRNA. Translation: AAH20614.1. | |
| IPI | IPI00006903. |
| RefSeq | NP_065103.1. |
| UniGene | Hs.306199 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NQS5. |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | Q9NQS5. |
Genome annotation databases | |
| Ensembl | ENST00000267015; ENSP00000267015; ENSG00000139572; Homo sapiens. [Genome view] |
| GeneID | 53831. |
| KEGG | hsa:53831. |
| UCSC | uc001sfu.1. human. |
Organism-specific databases | |
| CTD | 53831. |
| GeneCards | GC12M053042. |
| HGNC | HGNC:4535. GPR84. |
| MIM | 606383. gene. |
| PharmGKB | PA28928. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NQS5. |
| HOVERGEN | Q9NQS5. |
| OMA | ADLLYCT. |
Gene expression databases | |
| ArrayExpress | Q9NQS5. |
| Bgee | Q9NQS5. |
| CleanEx | HS_GPR84. |
| Genevestigator | Q9NQS5. |
| GermOnline | ENSG00000139572. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 56158. |
| SOURCE | Search... |
Entry information
| Entry name | GPR84_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NQS5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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