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Protein

G-protein coupled receptor 84

Gene

GPR84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 84
Alternative name(s):
Inflammation-related G-protein coupled receptor EX33
Gene namesi
Name:GPR84
Synonyms:EX33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4535. GPR84.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 5710CytoplasmicSequence analysis
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9416ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 14429CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 18015ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 320119CytoplasmicSequence analysisAdd
BLAST
Transmembranei321 – 34121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini342 – 35211ExtracellularSequence analysisAdd
BLAST
Transmembranei353 – 37321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini374 – 39623CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28928.

Chemistry

GuidetoPHARMACOLOGYi120.

Polymorphism and mutation databases

BioMutaiGPR84.
DMDMi66774035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396G-protein coupled receptor 84PRO_0000069589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Modified residuei221 – 2211PhosphoserineBy similarity
Modified residuei224 – 2241PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NQS5.
PaxDbiQ9NQS5.
PRIDEiQ9NQS5.

PTM databases

iPTMnetiQ9NQS5.
PhosphoSiteiQ9NQS5.

Expressioni

Tissue specificityi

Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes.3 Publications

Inductioni

By bacterial lipopolysaccharides (LPS) in the monocytic leukemia cell line THP-1.1 Publication

Gene expression databases

BgeeiQ9NQS5.
CleanExiHS_GPR84.
GenevisibleiQ9NQS5. HS.

Organism-specific databases

HPAiHPA027603.

Interactioni

Protein-protein interaction databases

BioGridi119803. 3 interactions.
STRINGi9606.ENSP00000267015.

Structurei

3D structure databases

ProteinModelPortaliQ9NQS5.
SMRiQ9NQS5. Positions 19-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129973.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ9NQS5.
KOiK08421.
OMAiAMNRQFR.
OrthoDBiEOG7M6D7X.
PhylomeDBiQ9NQS5.
TreeFamiTF333474.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNSSDANFS CYHESVLGYR YVAVSWGVVV AVTGTVGNVL TLLALAIQPK
60 70 80 90 100
LRTRFNLLIA NLTLADLLYC TLLQPFSVDT YLHLHWRTGA TFCRVFGLLL
110 120 130 140 150
FASNSVSILT LCLIALGRYL LIAHPKLFPQ VFSAKGIVLA LVSTWVVGVA
160 170 180 190 200
SFAPLWPIYI LVPVVCTCSF DRIRGRPYTT ILMGIYFVLG LSSVGIFYCL
210 220 230 240 250
IHRQVKRAAQ ALDQYKLRQA SIHSNHVART DEAMPGRFQE LDSRLASGGP
260 270 280 290 300
SEGISSEPVS AATTQTLEGD SSEVGDQINS KRAKQMAEKS PPEASAKAQP
310 320 330 340 350
IKGARRAPDS SSEFGKVTRM CFAVFLCFAL SYIPFLLLNI LDARVQAPRV
360 370 380 390
VHMLAANLTW LNGCINPVLY AAMNRQFRQA YGSILKRGPR SFHRLH
Length:396
Mass (Da):43,705
Last modified:October 1, 2000 - v1
Checksum:iBEEA467DFEB7520B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371G → D.
Corresponds to variant rs11170883 [ dbSNP | Ensembl ].
VAR_049397
Natural varianti367 – 3671P → R.1 Publication
VAR_069393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282693 mRNA. Translation: AAF91467.1.
AF237762 mRNA. Translation: AAK01857.1.
FJ348261 mRNA. Translation: ACI96305.1.
AB083586 Genomic DNA. Translation: BAB89299.1.
CH471054 Genomic DNA. Translation: EAW96776.1.
BC020614 mRNA. Translation: AAH20614.1.
CCDSiCCDS8878.1.
RefSeqiNP_065103.1. NM_020370.2.
XP_011536797.1. XM_011538495.1.
UniGeneiHs.306199.

Genome annotation databases

EnsembliENST00000267015; ENSP00000267015; ENSG00000139572.
ENST00000551809; ENSP00000450310; ENSG00000139572.
GeneIDi53831.
KEGGihsa:53831.
UCSCiuc001sfu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282693 mRNA. Translation: AAF91467.1.
AF237762 mRNA. Translation: AAK01857.1.
FJ348261 mRNA. Translation: ACI96305.1.
AB083586 Genomic DNA. Translation: BAB89299.1.
CH471054 Genomic DNA. Translation: EAW96776.1.
BC020614 mRNA. Translation: AAH20614.1.
CCDSiCCDS8878.1.
RefSeqiNP_065103.1. NM_020370.2.
XP_011536797.1. XM_011538495.1.
UniGeneiHs.306199.

3D structure databases

ProteinModelPortaliQ9NQS5.
SMRiQ9NQS5. Positions 19-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119803. 3 interactions.
STRINGi9606.ENSP00000267015.

Chemistry

GuidetoPHARMACOLOGYi120.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NQS5.
PhosphoSiteiQ9NQS5.

Polymorphism and mutation databases

BioMutaiGPR84.
DMDMi66774035.

Proteomic databases

EPDiQ9NQS5.
PaxDbiQ9NQS5.
PRIDEiQ9NQS5.

Protocols and materials databases

DNASUi53831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267015; ENSP00000267015; ENSG00000139572.
ENST00000551809; ENSP00000450310; ENSG00000139572.
GeneIDi53831.
KEGGihsa:53831.
UCSCiuc001sfu.4. human.

Organism-specific databases

CTDi53831.
GeneCardsiGPR84.
HGNCiHGNC:4535. GPR84.
HPAiHPA027603.
MIMi606383. gene.
neXtProtiNX_Q9NQS5.
PharmGKBiPA28928.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129973.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ9NQS5.
KOiK08421.
OMAiAMNRQFR.
OrthoDBiEOG7M6D7X.
PhylomeDBiQ9NQS5.
TreeFamiTF333474.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR84.
GenomeRNAii53831.
PROiQ9NQS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQS5.
CleanExiHS_GPR84.
GenevisibleiQ9NQS5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes."
    Yousefi S., Cooper P.R., Potter S.L., Mueck B., Jarai G.
    J. Leukoc. Biol. 69:1045-1052(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "Isolation of cDNA coding for Homo sapiens G protein-coupled receptor 84 (GPR84)."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  4. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84."
    Wang J., Wu X., Simonavicius N., Tian H., Ling L.
    J. Biol. Chem. 281:34457-34464(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
  8. Cited for: VARIANT ARG-367.

Entry informationi

Entry nameiGPR84_HUMAN
AccessioniPrimary (citable) accession number: Q9NQS5
Secondary accession number(s): B6V9G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.