Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled receptor 84

Gene

GPR84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139572-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 84
Alternative name(s):
Inflammation-related G-protein coupled receptor EX33
Gene namesi
Name:GPR84
Synonyms:EX33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4535. GPR84.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 57CytoplasmicSequence analysis10
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 94ExtracellularSequence analysisAdd BLAST16
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 144CytoplasmicSequence analysisAdd BLAST29
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 180ExtracellularSequence analysisAdd BLAST15
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 320CytoplasmicSequence analysisAdd BLAST119
Transmembranei321 – 341Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini342 – 352ExtracellularSequence analysisAdd BLAST11
Transmembranei353 – 373Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini374 – 396CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139572.
PharmGKBiPA28928.

Chemistry databases

GuidetoPHARMACOLOGYi120.

Polymorphism and mutation databases

BioMutaiGPR84.
DMDMi66774035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695891 – 396G-protein coupled receptor 84Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Modified residuei221PhosphoserineBy similarity1
Modified residuei224PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NQS5.
PaxDbiQ9NQS5.
PeptideAtlasiQ9NQS5.
PRIDEiQ9NQS5.

PTM databases

iPTMnetiQ9NQS5.
PhosphoSitePlusiQ9NQS5.

Expressioni

Tissue specificityi

Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes.3 Publications

Inductioni

By bacterial lipopolysaccharides (LPS) in the monocytic leukemia cell line THP-1.1 Publication

Gene expression databases

BgeeiENSG00000139572.
CleanExiHS_GPR84.
GenevisibleiQ9NQS5. HS.

Organism-specific databases

HPAiHPA027603.

Interactioni

Protein-protein interaction databases

BioGridi119803. 3 interactors.
STRINGi9606.ENSP00000267015.

Structurei

3D structure databases

ProteinModelPortaliQ9NQS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129973.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ9NQS5.
KOiK08421.
OMAiAMNRQFR.
OrthoDBiEOG091G0DQ9.
PhylomeDBiQ9NQS5.
TreeFamiTF333474.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNSSDANFS CYHESVLGYR YVAVSWGVVV AVTGTVGNVL TLLALAIQPK
60 70 80 90 100
LRTRFNLLIA NLTLADLLYC TLLQPFSVDT YLHLHWRTGA TFCRVFGLLL
110 120 130 140 150
FASNSVSILT LCLIALGRYL LIAHPKLFPQ VFSAKGIVLA LVSTWVVGVA
160 170 180 190 200
SFAPLWPIYI LVPVVCTCSF DRIRGRPYTT ILMGIYFVLG LSSVGIFYCL
210 220 230 240 250
IHRQVKRAAQ ALDQYKLRQA SIHSNHVART DEAMPGRFQE LDSRLASGGP
260 270 280 290 300
SEGISSEPVS AATTQTLEGD SSEVGDQINS KRAKQMAEKS PPEASAKAQP
310 320 330 340 350
IKGARRAPDS SSEFGKVTRM CFAVFLCFAL SYIPFLLLNI LDARVQAPRV
360 370 380 390
VHMLAANLTW LNGCINPVLY AAMNRQFRQA YGSILKRGPR SFHRLH
Length:396
Mass (Da):43,705
Last modified:October 1, 2000 - v1
Checksum:iBEEA467DFEB7520B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04939737G → D.Corresponds to variant rs11170883dbSNPEnsembl.1
Natural variantiVAR_069393367P → R.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282693 mRNA. Translation: AAF91467.1.
AF237762 mRNA. Translation: AAK01857.1.
FJ348261 mRNA. Translation: ACI96305.1.
AB083586 Genomic DNA. Translation: BAB89299.1.
CH471054 Genomic DNA. Translation: EAW96776.1.
BC020614 mRNA. Translation: AAH20614.1.
CCDSiCCDS8878.1.
RefSeqiNP_065103.1. NM_020370.2.
XP_011536797.1. XM_011538495.2.
UniGeneiHs.306199.

Genome annotation databases

EnsembliENST00000267015; ENSP00000267015; ENSG00000139572.
ENST00000551809; ENSP00000450310; ENSG00000139572.
GeneIDi53831.
KEGGihsa:53831.
UCSCiuc001sfu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282693 mRNA. Translation: AAF91467.1.
AF237762 mRNA. Translation: AAK01857.1.
FJ348261 mRNA. Translation: ACI96305.1.
AB083586 Genomic DNA. Translation: BAB89299.1.
CH471054 Genomic DNA. Translation: EAW96776.1.
BC020614 mRNA. Translation: AAH20614.1.
CCDSiCCDS8878.1.
RefSeqiNP_065103.1. NM_020370.2.
XP_011536797.1. XM_011538495.2.
UniGeneiHs.306199.

3D structure databases

ProteinModelPortaliQ9NQS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119803. 3 interactors.
STRINGi9606.ENSP00000267015.

Chemistry databases

GuidetoPHARMACOLOGYi120.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NQS5.
PhosphoSitePlusiQ9NQS5.

Polymorphism and mutation databases

BioMutaiGPR84.
DMDMi66774035.

Proteomic databases

EPDiQ9NQS5.
PaxDbiQ9NQS5.
PeptideAtlasiQ9NQS5.
PRIDEiQ9NQS5.

Protocols and materials databases

DNASUi53831.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267015; ENSP00000267015; ENSG00000139572.
ENST00000551809; ENSP00000450310; ENSG00000139572.
GeneIDi53831.
KEGGihsa:53831.
UCSCiuc001sfu.4. human.

Organism-specific databases

CTDi53831.
GeneCardsiGPR84.
HGNCiHGNC:4535. GPR84.
HPAiHPA027603.
MIMi606383. gene.
neXtProtiNX_Q9NQS5.
OpenTargetsiENSG00000139572.
PharmGKBiPA28928.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129973.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ9NQS5.
KOiK08421.
OMAiAMNRQFR.
OrthoDBiEOG091G0DQ9.
PhylomeDBiQ9NQS5.
TreeFamiTF333474.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139572-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GeneWikiiGPR84.
GenomeRNAii53831.
PROiQ9NQS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139572.
CleanExiHS_GPR84.
GenevisibleiQ9NQS5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR84_HUMAN
AccessioniPrimary (citable) accession number: Q9NQS5
Secondary accession number(s): B6V9G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.