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Protein

Cell death regulator Aven

Gene

AVEN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protects against apoptosis mediated by Apaf-1.

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death regulator Aven
Gene namesi
Name:AVEN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:13509. AVEN.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • intracellular Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57099.
OpenTargetsiENSG00000169857.
PharmGKBiPA134874337.

Polymorphism and mutation databases

BioMutaiAVEN.
DMDMi20454834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647681 – 362Cell death regulator AvenAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineCombined sources1
Modified residuei230N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NQS1.
MaxQBiQ9NQS1.
PaxDbiQ9NQS1.
PeptideAtlasiQ9NQS1.
PRIDEiQ9NQS1.

PTM databases

iPTMnetiQ9NQS1.
PhosphoSitePlusiQ9NQS1.

Miscellaneous databases

PMAP-CutDBQ9NQS1.

Expressioni

Tissue specificityi

Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Gene expression databases

BgeeiENSG00000169857.
CleanExiHS_AVEN.
ExpressionAtlasiQ9NQS1. baseline and differential.
GenevisibleiQ9NQS1. HS.

Organism-specific databases

HPAiHPA020863.

Interactioni

Subunit structurei

Binds Apaf-1, BCL-2 and BAD (Bcl-xl).

Protein-protein interaction databases

BioGridi121366. 10 interactors.
IntActiQ9NQS1. 5 interactors.
MINTiMINT-143075.
STRINGi9606.ENSP00000306822.

Structurei

3D structure databases

ProteinModelPortaliQ9NQS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 85Ala/Gly-richAdd BLAST81

Phylogenomic databases

eggNOGiENOG410IKTA. Eukaryota.
ENOG4111U7Z. LUCA.
GeneTreeiENSGT00390000003299.
HOGENOMiHOG000231429.
HOVERGENiHBG024370.
InParanoidiQ9NQS1.
OMAiWDRYQDI.
OrthoDBiEOG091G0N3H.
PhylomeDBiQ9NQS1.
TreeFamiTF332067.

Family and domain databases

InterProiIPR026187. Aven.
[Graphical view]
PANTHERiPTHR16524. PTHR16524. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NQS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR
60 70 80 90 100
RGRGRGRGFR GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG
110 120 130 140 150
EENDEQGNYS KRKIVSNWDR YQDIEKEVNN ESGESQRGTD FSVLLSSAGD
160 170 180 190 200
SFSQFRFAEE KEWDSEASCP KQNSAFYVDS ELLVRALQEL PLCLRLNVAA
210 220 230 240 250
ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP IFELKSVAAG
260 270 280 290 300
CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD
310 320 330 340 350
NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE
360
EELEDWLDSM IS
Length:362
Mass (Da):38,506
Last modified:October 1, 2000 - v1
Checksum:iD86517BA087232D4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020144228Q → R.Corresponds to variant rs2241647dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283508 mRNA. Translation: AAF91470.1.
BC010488 mRNA. Translation: AAH10488.1.
BC063533 mRNA. Translation: AAH63533.1.
CCDSiCCDS10030.1.
RefSeqiNP_065104.1. NM_020371.2.
UniGeneiHs.555966.

Genome annotation databases

EnsembliENST00000306730; ENSP00000306822; ENSG00000169857.
GeneIDi57099.
KEGGihsa:57099.
UCSCiuc001zhj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283508 mRNA. Translation: AAF91470.1.
BC010488 mRNA. Translation: AAH10488.1.
BC063533 mRNA. Translation: AAH63533.1.
CCDSiCCDS10030.1.
RefSeqiNP_065104.1. NM_020371.2.
UniGeneiHs.555966.

3D structure databases

ProteinModelPortaliQ9NQS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121366. 10 interactors.
IntActiQ9NQS1. 5 interactors.
MINTiMINT-143075.
STRINGi9606.ENSP00000306822.

PTM databases

iPTMnetiQ9NQS1.
PhosphoSitePlusiQ9NQS1.

Polymorphism and mutation databases

BioMutaiAVEN.
DMDMi20454834.

Proteomic databases

EPDiQ9NQS1.
MaxQBiQ9NQS1.
PaxDbiQ9NQS1.
PeptideAtlasiQ9NQS1.
PRIDEiQ9NQS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306730; ENSP00000306822; ENSG00000169857.
GeneIDi57099.
KEGGihsa:57099.
UCSCiuc001zhj.4. human.

Organism-specific databases

CTDi57099.
DisGeNETi57099.
GeneCardsiAVEN.
HGNCiHGNC:13509. AVEN.
HPAiHPA020863.
MIMi605265. gene.
neXtProtiNX_Q9NQS1.
OpenTargetsiENSG00000169857.
PharmGKBiPA134874337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKTA. Eukaryota.
ENOG4111U7Z. LUCA.
GeneTreeiENSGT00390000003299.
HOGENOMiHOG000231429.
HOVERGENiHBG024370.
InParanoidiQ9NQS1.
OMAiWDRYQDI.
OrthoDBiEOG091G0N3H.
PhylomeDBiQ9NQS1.
TreeFamiTF332067.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169857-MONOMER.

Miscellaneous databases

GenomeRNAii57099.
PMAP-CutDBQ9NQS1.
PROiQ9NQS1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169857.
CleanExiHS_AVEN.
ExpressionAtlasiQ9NQS1. baseline and differential.
GenevisibleiQ9NQS1. HS.

Family and domain databases

InterProiIPR026187. Aven.
[Graphical view]
PANTHERiPTHR16524. PTHR16524. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAVEN_HUMAN
AccessioniPrimary (citable) accession number: Q9NQS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.