Q9NQS1 (AVEN_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cell death regulator Aven | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 362 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Protects against apoptosis mediated by Apaf-1. |
| Subunit structure | Binds Apaf-1, BCL-2 and BAD (Bcl-xl). |
| Subcellular location | Endomembrane system; Peripheral membrane protein. Note: Associated with intracellular membranes. |
| Tissue specificity | Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | anti-apoptosis Inferred from direct assay Ref.1. Source: UniProtKB apoptotic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell intracellularInferred from direct assay Ref.1. Source: UniProtKB membraneInferred from electronic annotation. Source: UniProtKB-KW membrane fractionInferred from direct assay Ref.1. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction Ref.1. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 362 | 362 | Cell death regulator Aven | PRO_0000064768 | |||||
Regions | |||||||||
| Compositional bias | 5 – 85 | 81 | Ala/Gly-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 94 | 1 | Phosphoserine Ref.3 | ||||||
Natural variations | |||||||||
| Natural variant | 228 | 1 | Q → R. Corresponds to variant rs2241647 [ dbSNP | Ensembl ]. | VAR_020144 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1." Chau B.N., Cheng E.H.-Y., Kerr D.A., Hardwick J.M. Mol. Cell 6:31-40(2000) [PubMed: 10949025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Placenta. |
| [3] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF283508 mRNA. Translation: AAF91470.1. BC010488 mRNA. Translation: AAH10488.1. BC063533 mRNA. Translation: AAH63533.1. |
| IPI | IPI00006904. |
| RefSeq | NP_065104.1. NM_020371.2. |
| UniGene | Hs.555966. |
3D structure databases | |
| ProteinModelPortal | Q9NQS1. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-143075. |
| STRING | Q9NQS1. |
PTM databases | |
| PhosphoSite | Q9NQS1. |
Polymorphism databases | |
| DMDM | 20454834. |
Proteomic databases | |
| PeptideAtlas | Q9NQS1. |
| PRIDE | Q9NQS1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000306730; ENSP00000306822; ENSG00000169857. |
| GeneID | 57099. |
| KEGG | hsa:57099. |
| UCSC | uc001zhj.1. human. |
Organism-specific databases | |
| CTD | 57099. |
| GeneCards | GC15M034158. |
| H-InvDB | HIX0012083. |
| HGNC | HGNC:13509. AVEN. |
| HPA | HPA020863. |
| MIM | 605265. gene. |
| neXtProt | NX_Q9NQS1. |
| PharmGKB | PA134874337. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG09243. |
| GeneTree | ENSGT00390000003299. |
| HOGENOM | HBG713765. |
| HOVERGEN | HBG024370. |
| InParanoid | Q9NQS1. |
| OMA | WDSEASC. |
| OrthoDB | EOG4PVP0B. |
| PhylomeDB | Q9NQS1. |
Gene expression databases | |
| ArrayExpress | Q9NQS1. |
| Bgee | Q9NQS1. |
| CleanEx | HS_AVEN. |
| Genevestigator | Q9NQS1. |
| GermOnline | ENSG00000169857. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other | |
| NextBio | 62925. |
| PMAP-CutDB | Q9NQS1. |
| SOURCE | Search... |
Entry information
| Entry name | AVEN_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NQS1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

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