Q9NQS1 (AVEN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell death regulator Aven

Gene names

Name:

AVEN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protects against apoptosis mediated by Apaf-1.
Subunit structure	Binds Apaf-1, BCL-2 and BAD (Bcl-xl).
Subcellular location	Endomembrane system; Peripheral membrane protein. Note: Associated with intracellular membranes.
Tissue specificity	Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from direct assay Ref.1. Source: UniProtKB apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell intracellular Inferred from direct assay Ref.1. Source: UniProtKB membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Cell death regulator Aven		PRO_0000064768
Regions
	Compositional bias	5 – 85	81	Ala/Gly-rich
Amino acid modifications
	Modified residue	94	1	Phosphoserine Ref.3
Natural variations
	Natural variant	228	1	Q → R. Corresponds to variant rs2241647 [ dbSNP | Ensembl ].		VAR_020144

Sequences

	Sequence		Length	Mass (Da)
	Q9NQS1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D86517BA087232D4	FASTA	362	38,506
	10 20 30 40 50 60 MQAERGARGG RGRRPGRGRP GGDRHSERPG AAAAVARGGG GGGGGDGGGR RGRGRGRGFR 70 80 90 100 110 120 GARGGRGGGG APRGSRREPG GWGAGASAPV EDDSDAETYG EENDEQGNYS KRKIVSNWDR 130 140 150 160 170 180 YQDIEKEVNN ESGESQRGTD FSVLLSSAGD SFSQFRFAEE KEWDSEASCP KQNSAFYVDS 190 200 210 220 230 240 ELLVRALQEL PLCLRLNVAA ELVQGTVPLE VPQVKPKRTD DGKGLGMQLK GPLGPGGRGP 250 260 270 280 290 300 IFELKSVAAG CPVLLGKDNP SPGPSRDSQK PTSPLQSAGD HLEEELDLLL NLDAPIKEGD 310 320 330 340 350 360 NILPDQTSQD LKSKEDGEVV QEEEVCAKPS VTEEKNMEPE QPSTSKNVTE EELEDWLDSM IS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1." Chau B.N., Cheng E.H.-Y., Kerr D.A., Hardwick J.M. Mol. Cell 6:31-40(2000) [PubMed: 10949025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Placenta.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF283508 mRNA. Translation: AAF91470.1. BC010488 mRNA. Translation: AAH10488.1. BC063533 mRNA. Translation: AAH63533.1.
IPI	IPI00006904.
RefSeq	NP_065104.1. NM_020371.2.
UniGene	Hs.555966.
3D structure databases
ProteinModelPortal	Q9NQS1.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-143075.
STRING	Q9NQS1.
PTM databases
PhosphoSite	Q9NQS1.
Polymorphism databases
DMDM	20454834.
Proteomic databases
PeptideAtlas	Q9NQS1.
PRIDE	Q9NQS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306730; ENSP00000306822; ENSG00000169857.
GeneID	57099.
KEGG	hsa:57099.
UCSC	uc001zhj.1. human.
Organism-specific databases
CTD	57099.
GeneCards	GC15M034158.
H-InvDB	HIX0012083.
HGNC	HGNC:13509. AVEN.
HPA	HPA020863.
MIM	605265. gene.
neXtProt	NX_Q9NQS1.
PharmGKB	PA134874337.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09243.
GeneTree	ENSGT00390000003299.
HOGENOM	HBG713765.
HOVERGEN	HBG024370.
InParanoid	Q9NQS1.
OMA	WDSEASC.
OrthoDB	EOG4PVP0B.
PhylomeDB	Q9NQS1.
Gene expression databases
ArrayExpress	Q9NQS1.
Bgee	Q9NQS1.
CleanEx	HS_AVEN.
Genevestigator	Q9NQS1.
GermOnline	ENSG00000169857. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	62925.
PMAP-CutDB	Q9NQS1.
SOURCE	Search...

Entry information

Entry name

AVEN_HUMAN

Accession

Primary (citable) accession number: Q9NQS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.