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Q9NQQ7

- S35C2_HUMAN

UniProt

Q9NQQ7 - S35C2_HUMAN

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Protein
Solute carrier family 35 member C2
Gene
SLC35C2, C20orf5, OVCOV1, CGI-15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia.

GO - Biological processi

  1. negative regulation of gene expression Source: Ensembl
  2. positive regulation of Notch signaling pathway Source: Ensembl
  3. protein O-linked fucosylation Source: Ensembl
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.9.16. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:SLC35C2
Synonyms:C20orf5, OVCOV1
ORF Names:CGI-15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:17117. SLC35C2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Reviewed prediction
Add
BLAST
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Transmembranei294 – 31623Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cis-Golgi network Source: MGI
  2. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Solute carrier family 35 member C2
PRO_0000213399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Modified residuei335 – 3351Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NQQ7.
PaxDbiQ9NQQ7.
PRIDEiQ9NQQ7.

PTM databases

PhosphoSiteiQ9NQQ7.

Expressioni

Tissue specificityi

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Inductioni

In hypoxic trophoblast cells.

Gene expression databases

ArrayExpressiQ9NQQ7.
BgeeiQ9NQQ7.
CleanExiHS_SLC35C2.
GenevestigatoriQ9NQQ7.

Organism-specific databases

HPAiHPA027011.

Interactioni

Protein-protein interaction databases

BioGridi119214. 1 interaction.
IntActiQ9NQQ7. 2 interactions.
STRINGi9606.ENSP00000243896.

Structurei

3D structure databases

ProteinModelPortaliQ9NQQ7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
HOVERGENiHBG055852.
InParanoidiQ9NQQ7.
KOiK15280.
OrthoDBiEOG7TTQ93.
PhylomeDBiQ9NQQ7.
TreeFamiTF314994.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQQ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM    50
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL 100
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG 150
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT 200
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG 250
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 300
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE 350
GDNEEEEYFV AQGQQ 365
Length:365
Mass (Da):40,432
Last modified:June 1, 2001 - v2
Checksum:i5EACE6A4953411A9
GO
Isoform 2 (identifier: Q9NQQ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Show »
Length:344
Mass (Da):38,154
Checksum:i20DCAF1DC8048736
GO

Sequence cautioni

The sequence AAD27724.1 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei137 – 15721Missing in isoform 2.
VSP_009229Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661L → S in AAD27724. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF455052 mRNA. Translation: AAL59605.1.
AF132949 mRNA. Translation: AAD27724.1. Frameshift.
AL133227 Genomic DNA. Translation: CAC00659.2.
AL133227 Genomic DNA. Translation: CAI40552.1.
CH471077 Genomic DNA. Translation: EAW75748.1.
CH471077 Genomic DNA. Translation: EAW75747.1.
CH471077 Genomic DNA. Translation: EAW75750.1.
CH471077 Genomic DNA. Translation: EAW75751.1.
CH471077 Genomic DNA. Translation: EAW75752.1.
BC014191 mRNA. Translation: AAH14191.1.
BC021138 mRNA. Translation: AAH21138.1.
BC025277 mRNA. Translation: AAH25277.1.
CCDSiCCDS13396.1. [Q9NQQ7-1]
CCDS13397.1. [Q9NQQ7-2]
RefSeqiNP_001268386.1. NM_001281457.1.
NP_001268387.1. NM_001281458.1.
NP_001268388.1. NM_001281459.1.
NP_001268389.1. NM_001281460.1. [Q9NQQ7-1]
NP_057029.8. NM_015945.11. [Q9NQQ7-1]
NP_775096.1. NM_173073.3. [Q9NQQ7-2]
NP_775271.1. NM_173179.3. [Q9NQQ7-1]
XP_005260471.1. XM_005260414.1. [Q9NQQ7-1]
UniGeneiHs.593344.
Hs.723629.

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189. [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189. [Q9NQQ7-2]
ENST00000372227; ENSP00000361301; ENSG00000080189. [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189. [Q9NQQ7-1]
GeneIDi51006.
KEGGihsa:51006.
UCSCiuc002xro.3. human. [Q9NQQ7-1]
uc002xrp.3. human. [Q9NQQ7-2]

Polymorphism databases

DMDMi41017506.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF455052 mRNA. Translation: AAL59605.1 .
AF132949 mRNA. Translation: AAD27724.1 . Frameshift.
AL133227 Genomic DNA. Translation: CAC00659.2 .
AL133227 Genomic DNA. Translation: CAI40552.1 .
CH471077 Genomic DNA. Translation: EAW75748.1 .
CH471077 Genomic DNA. Translation: EAW75747.1 .
CH471077 Genomic DNA. Translation: EAW75750.1 .
CH471077 Genomic DNA. Translation: EAW75751.1 .
CH471077 Genomic DNA. Translation: EAW75752.1 .
BC014191 mRNA. Translation: AAH14191.1 .
BC021138 mRNA. Translation: AAH21138.1 .
BC025277 mRNA. Translation: AAH25277.1 .
CCDSi CCDS13396.1. [Q9NQQ7-1 ]
CCDS13397.1. [Q9NQQ7-2 ]
RefSeqi NP_001268386.1. NM_001281457.1.
NP_001268387.1. NM_001281458.1.
NP_001268388.1. NM_001281459.1.
NP_001268389.1. NM_001281460.1. [Q9NQQ7-1 ]
NP_057029.8. NM_015945.11. [Q9NQQ7-1 ]
NP_775096.1. NM_173073.3. [Q9NQQ7-2 ]
NP_775271.1. NM_173179.3. [Q9NQQ7-1 ]
XP_005260471.1. XM_005260414.1. [Q9NQQ7-1 ]
UniGenei Hs.593344.
Hs.723629.

3D structure databases

ProteinModelPortali Q9NQQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119214. 1 interaction.
IntActi Q9NQQ7. 2 interactions.
STRINGi 9606.ENSP00000243896.

Protein family/group databases

TCDBi 2.A.7.9.16. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q9NQQ7.

Polymorphism databases

DMDMi 41017506.

Proteomic databases

MaxQBi Q9NQQ7.
PaxDbi Q9NQQ7.
PRIDEi Q9NQQ7.

Protocols and materials databases

DNASUi 51006.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243896 ; ENSP00000243896 ; ENSG00000080189 . [Q9NQQ7-1 ]
ENST00000317734 ; ENSP00000318960 ; ENSG00000080189 . [Q9NQQ7-2 ]
ENST00000372227 ; ENSP00000361301 ; ENSG00000080189 . [Q9NQQ7-1 ]
ENST00000372230 ; ENSP00000361304 ; ENSG00000080189 . [Q9NQQ7-1 ]
GeneIDi 51006.
KEGGi hsa:51006.
UCSCi uc002xro.3. human. [Q9NQQ7-1 ]
uc002xrp.3. human. [Q9NQQ7-2 ]

Organism-specific databases

CTDi 51006.
GeneCardsi GC20M044978.
H-InvDB HIX0015879.
HGNCi HGNC:17117. SLC35C2.
HPAi HPA027011.
neXtProti NX_Q9NQQ7.
PharmGKBi PA32850.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
HOVERGENi HBG055852.
InParanoidi Q9NQQ7.
KOi K15280.
OrthoDBi EOG7TTQ93.
PhylomeDBi Q9NQQ7.
TreeFami TF314994.

Miscellaneous databases

ChiTaRSi SLC35C2. human.
GeneWikii SLC35C2.
GenomeRNAii 51006.
NextBioi 53478.
PROi Q9NQQ7.

Gene expression databases

ArrayExpressi Q9NQQ7.
Bgeei Q9NQQ7.
CleanExi HS_SLC35C2.
Genevestigatori Q9NQQ7.

Family and domain databases

InterProi IPR004853. Tpt_PEP_trans_dom.
[Graphical view ]
Pfami PF03151. TPT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization."
    Leach R.E., Duniec-Dmuchowski Z.M., Tanaka T.S., Ko M.S.H., Krawetz S.A.
    Cytogenet. Cell Genet. 94:252-253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Colon and Skin.
  6. "Identification, molecular characterization, and tissue expression of OVCOV1."
    Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A.
    Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS35C2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQQ7
Secondary accession number(s): E1P5T0
, Q5JW05, Q96CJ8, Q9Y304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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