Q9NQQ7 (S35C2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member C2

Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein

Gene names

Name:	SLC35C2
Synonyms:	C20orf5, OVCOV1
ORF Names:	CGI-15

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in the cellular response to tissue hypoxia.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
Induction	In hypoxic trophoblast cells.
Sequence similarities	Belongs to the TPT transporter family. SLC35C subfamily.
Sequence caution	The sequence AAD27724.1 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cis-Golgi network Inferred from direct assay PubMed 20837470. Source: MGI endoplasmic reticulum-Golgi intermediate compartment Inferred from direct assay PubMed 20837470. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NQQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Solute carrier family 35 member C2		PRO_0000213399
Regions
	Transmembrane	14 – 34	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	202 – 222	21	Helical; Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Transmembrane	294 – 316	23	Helical; Potential
Amino acid modifications
	Modified residue	335	1	Phosphoserine Ref.8
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	137 – 157	21	Missing in isoform 2.		VSP_009229
Experimental info
	Sequence conflict	66	1	L → S in AAD27724. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 5EACE6A4953411A9	FASTA	365	40,432
	10 20 30 40 50 60 MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS 70 80 90 100 110 120 ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA 130 140 150 160 170 180 VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW 190 200 210 220 230 240 TLTQMLLQKA ELGLQNPIDT MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL 250 260 270 280 290 300 RVLGSLFLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 310 320 330 340 350 360 LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE GDNEEEEYFV AQGQQ
	Isoform 2 [UniParc]. Checksum: 20DCAF1DC8048736	FASTA	344	38,154
	10 20 30 40 50 60 MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS 70 80 90 100 110 120 ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA 130 140 150 160 170 180 VLFILIFSLI FKLEELSTQF NVEGFALVLG ASFIGGIRWT LTQMLLQKAE LGLQNPIDTM 190 200 210 220 230 240 FHLQPLMFLG LFPLFAVFEG LHLSTSEKIF RFQDTGLLLR VLGSLFLGGI LAFGLGFSEF 250 260 270 280 290 300 LLVSRTSSLT LSIAGIFKEV CTLLLAAHLL GDQISLLNWL GFALCLSGIS LHVALKALHS 310 320 330 340 RGDGGPKALK GLGSSPDLEL LLRSSQREEG DNEEEEYFVA QGQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization." Leach R.E., Duniec-Dmuchowski Z.M., Tanaka T.S., Ko M.S.H., Krawetz S.A. Cytogenet. Cell Genet. 94:252-253(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain, Colon and Skin.
[6]	"Identification, molecular characterization, and tissue expression of OVCOV1." Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A. Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF455052 mRNA. Translation: AAL59605.1. AF132949 mRNA. Translation: AAD27724.1. Frameshift. AL133227 Genomic DNA. Translation: CAC00659.2. AL133227 Genomic DNA. Translation: CAI40552.1. CH471077 Genomic DNA. Translation: EAW75748.1. CH471077 Genomic DNA. Translation: EAW75747.1. CH471077 Genomic DNA. Translation: EAW75750.1. CH471077 Genomic DNA. Translation: EAW75751.1. CH471077 Genomic DNA. Translation: EAW75752.1. BC014191 mRNA. Translation: AAH14191.1. BC021138 mRNA. Translation: AAH21138.1. BC025277 mRNA. Translation: AAH25277.1.
IPI	IPI00010838. IPI01012447.
RefSeq	NP_057029.8. NM_015945.10. NP_775096.1. NM_173073.2. NP_775271.1. NM_173179.2.
UniGene	Hs.593344.
3D structure databases
ProteinModelPortal	Q9NQQ7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NQQ7. 1 interaction.
STRING	9606.ENSP00000243896.
PTM databases
PhosphoSite	Q9NQQ7.
Polymorphism databases
DMDM	41017506.
Proteomic databases
PaxDb	Q9NQQ7.
PRIDE	Q9NQQ7.
Protocols and materials databases
DNASU	51006.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243896; ENSP00000243896; ENSG00000080189. ENST00000317734; ENSP00000318960; ENSG00000080189. ENST00000372227; ENSP00000361301; ENSG00000080189. ENST00000372230; ENSP00000361304; ENSG00000080189.
GeneID	51006.
KEGG	hsa:51006.
UCSC	uc002xro.3. human. uc002xrp.3. human.
Organism-specific databases
CTD	51006.
GeneCards	GC20M044978.
H-InvDB	HIX0015879.
HGNC	HGNC:17117. SLC35C2.
neXtProt	NX_Q9NQQ7.
PharmGKB	PA32850.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0697.
HOVERGEN	HBG055852.
InParanoid	Q9NQQ7.
KO	K15280.
OrthoDB	EOG40VVQC.
PhylomeDB	Q9NQQ7.
Gene expression databases
ArrayExpress	Q9NQQ7.
Bgee	Q9NQQ7.
CleanEx	HS_SLC35C2.
Genevestigator	Q9NQQ7.
GermOnline	ENSG00000080189. Homo sapiens.
Family and domain databases
InterPro	IPR004853. DUF250. [Graphical view]
Pfam	PF03151. TPT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC35C2. human.
GenomeRNAi	51006.
NextBio	53478.

Entry information

Entry name

S35C2_HUMAN

Accession

Primary (citable) accession number: Q9NQQ7
Secondary accession number(s): E1P5T0 , Q5JW05, Q96CJ8, Q9Y304

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.