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Protein

Solute carrier family 35 member C2

Gene

SLC35C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080189-MONOMER.

Protein family/group databases

TCDBi2.A.7.9.16. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:SLC35C2
Synonyms:C20orf5, OVCOV1
ORF Names:CGI-15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:17117. SLC35C2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000080189.
PharmGKBiPA32850.

Polymorphism and mutation databases

DMDMi41017506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133991 – 365Solute carrier family 35 member C2Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NQQ7.
PaxDbiQ9NQQ7.
PeptideAtlasiQ9NQQ7.
PRIDEiQ9NQQ7.
TopDownProteomicsiQ9NQQ7-2. [Q9NQQ7-2]

PTM databases

iPTMnetiQ9NQQ7.
PhosphoSitePlusiQ9NQQ7.

Expressioni

Tissue specificityi

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Inductioni

In hypoxic trophoblast cells.

Gene expression databases

BgeeiENSG00000080189.
CleanExiHS_SLC35C2.
ExpressionAtlasiQ9NQQ7. baseline and differential.
GenevisibleiQ9NQQ7. HS.

Organism-specific databases

HPAiHPA027011.

Interactioni

Protein-protein interaction databases

BioGridi119214. 1 interactor.
IntActiQ9NQQ7. 2 interactors.
STRINGi9606.ENSP00000243896.

Structurei

3D structure databases

ProteinModelPortaliQ9NQQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1443. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ9NQQ7.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG091G09SR.
PhylomeDBiQ9NQQ7.
TreeFamiTF314994.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYVTV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQMLLQKA ELGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL RVLGSLFLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE
360
GDNEEEEYFV AQGQQ
Length:365
Mass (Da):40,432
Last modified:June 1, 2001 - v2
Checksum:i5EACE6A4953411A9
GO
Isoform 2 (identifier: Q9NQQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Show »
Length:344
Mass (Da):38,154
Checksum:i20DCAF1DC8048736
GO
Isoform 3 (identifier: Q9NQQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRVSTSHQPLRGVPAPADSGAPVLQPPRM

Show »
Length:394
Mass (Da):43,393
Checksum:i4D09EDA573349783
GO

Sequence cautioni

The sequence AAD27724 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66L → S in AAD27724 (PubMed:10810093).Curated1
Sequence conflicti126I → V in BAD96648 (Ref. 4) Curated1
Sequence conflicti247F → L in BAH13392 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0567291M → MGRVSTSHQPLRGVPAPADS GAPVLQPPRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_009229137 – 157Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455052 mRNA. Translation: AAL59605.1.
AF132949 mRNA. Translation: AAD27724.1. Frameshift.
AK301022 mRNA. Translation: BAH13392.1.
AK222928 mRNA. Translation: BAD96648.1.
AL133227 Genomic DNA. Translation: CAC00659.2.
AL133227 Genomic DNA. Translation: CAI40552.1.
CH471077 Genomic DNA. Translation: EAW75748.1.
CH471077 Genomic DNA. Translation: EAW75747.1.
CH471077 Genomic DNA. Translation: EAW75750.1.
CH471077 Genomic DNA. Translation: EAW75751.1.
CH471077 Genomic DNA. Translation: EAW75752.1.
BC014191 mRNA. Translation: AAH14191.1.
BC021138 mRNA. Translation: AAH21138.1.
BC025277 mRNA. Translation: AAH25277.1.
CCDSiCCDS13396.1. [Q9NQQ7-1]
CCDS13397.1. [Q9NQQ7-2]
CCDS63292.1. [Q9NQQ7-3]
RefSeqiNP_001268386.1. NM_001281457.1.
NP_001268387.1. NM_001281458.1. [Q9NQQ7-3]
NP_001268388.1. NM_001281459.1.
NP_001268389.1. NM_001281460.1. [Q9NQQ7-1]
NP_057029.8. NM_015945.11. [Q9NQQ7-1]
NP_775096.1. NM_173073.3. [Q9NQQ7-2]
NP_775271.1. NM_173179.3. [Q9NQQ7-1]
XP_011527133.1. XM_011528831.1. [Q9NQQ7-1]
XP_011527134.1. XM_011528832.1. [Q9NQQ7-1]
XP_011527135.1. XM_011528833.1. [Q9NQQ7-1]
XP_016883345.1. XM_017027856.1. [Q9NQQ7-1]
XP_016883346.1. XM_017027857.1. [Q9NQQ7-1]
XP_016883347.1. XM_017027858.1. [Q9NQQ7-1]
XP_016883348.1. XM_017027859.1. [Q9NQQ7-1]
XP_016883349.1. XM_017027860.1. [Q9NQQ7-1]
XP_016883350.1. XM_017027861.1. [Q9NQQ7-2]
UniGeneiHs.593344.
Hs.723629.

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189. [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189. [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189. [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189. [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189. [Q9NQQ7-2]
GeneIDi51006.
KEGGihsa:51006.
UCSCiuc002xrp.5. human. [Q9NQQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455052 mRNA. Translation: AAL59605.1.
AF132949 mRNA. Translation: AAD27724.1. Frameshift.
AK301022 mRNA. Translation: BAH13392.1.
AK222928 mRNA. Translation: BAD96648.1.
AL133227 Genomic DNA. Translation: CAC00659.2.
AL133227 Genomic DNA. Translation: CAI40552.1.
CH471077 Genomic DNA. Translation: EAW75748.1.
CH471077 Genomic DNA. Translation: EAW75747.1.
CH471077 Genomic DNA. Translation: EAW75750.1.
CH471077 Genomic DNA. Translation: EAW75751.1.
CH471077 Genomic DNA. Translation: EAW75752.1.
BC014191 mRNA. Translation: AAH14191.1.
BC021138 mRNA. Translation: AAH21138.1.
BC025277 mRNA. Translation: AAH25277.1.
CCDSiCCDS13396.1. [Q9NQQ7-1]
CCDS13397.1. [Q9NQQ7-2]
CCDS63292.1. [Q9NQQ7-3]
RefSeqiNP_001268386.1. NM_001281457.1.
NP_001268387.1. NM_001281458.1. [Q9NQQ7-3]
NP_001268388.1. NM_001281459.1.
NP_001268389.1. NM_001281460.1. [Q9NQQ7-1]
NP_057029.8. NM_015945.11. [Q9NQQ7-1]
NP_775096.1. NM_173073.3. [Q9NQQ7-2]
NP_775271.1. NM_173179.3. [Q9NQQ7-1]
XP_011527133.1. XM_011528831.1. [Q9NQQ7-1]
XP_011527134.1. XM_011528832.1. [Q9NQQ7-1]
XP_011527135.1. XM_011528833.1. [Q9NQQ7-1]
XP_016883345.1. XM_017027856.1. [Q9NQQ7-1]
XP_016883346.1. XM_017027857.1. [Q9NQQ7-1]
XP_016883347.1. XM_017027858.1. [Q9NQQ7-1]
XP_016883348.1. XM_017027859.1. [Q9NQQ7-1]
XP_016883349.1. XM_017027860.1. [Q9NQQ7-1]
XP_016883350.1. XM_017027861.1. [Q9NQQ7-2]
UniGeneiHs.593344.
Hs.723629.

3D structure databases

ProteinModelPortaliQ9NQQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119214. 1 interactor.
IntActiQ9NQQ7. 2 interactors.
STRINGi9606.ENSP00000243896.

Protein family/group databases

TCDBi2.A.7.9.16. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ9NQQ7.
PhosphoSitePlusiQ9NQQ7.

Polymorphism and mutation databases

DMDMi41017506.

Proteomic databases

MaxQBiQ9NQQ7.
PaxDbiQ9NQQ7.
PeptideAtlasiQ9NQQ7.
PRIDEiQ9NQQ7.
TopDownProteomicsiQ9NQQ7-2. [Q9NQQ7-2]

Protocols and materials databases

DNASUi51006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243896; ENSP00000243896; ENSG00000080189. [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189. [Q9NQQ7-3]
ENST00000372227; ENSP00000361301; ENSG00000080189. [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189. [Q9NQQ7-1]
ENST00000543605; ENSP00000439974; ENSG00000080189. [Q9NQQ7-2]
GeneIDi51006.
KEGGihsa:51006.
UCSCiuc002xrp.5. human. [Q9NQQ7-1]

Organism-specific databases

CTDi51006.
GeneCardsiSLC35C2.
H-InvDBHIX0015879.
HGNCiHGNC:17117. SLC35C2.
HPAiHPA027011.
neXtProtiNX_Q9NQQ7.
OpenTargetsiENSG00000080189.
PharmGKBiPA32850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1443. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ9NQQ7.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG091G09SR.
PhylomeDBiQ9NQQ7.
TreeFamiTF314994.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080189-MONOMER.

Miscellaneous databases

ChiTaRSiSLC35C2. human.
GeneWikiiSLC35C2.
GenomeRNAii51006.
PROiQ9NQQ7.

Gene expression databases

BgeeiENSG00000080189.
CleanExiHS_SLC35C2.
ExpressionAtlasiQ9NQQ7. baseline and differential.
GenevisibleiQ9NQQ7. HS.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35C2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQQ7
Secondary accession number(s): B7Z6V6
, E1P5T0, Q53GK3, Q5JW05, Q96CJ8, Q9Y304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.