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Q9NQQ7 (S35C2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene names
Name:SLC35C2
Synonyms:C20orf5, OVCOV1
ORF Names:CGI-15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in the cellular response to tissue hypoxia.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Induction

In hypoxic trophoblast cells.

Sequence similarities

Belongs to the TPT transporter family. SLC35C subfamily.

Sequence caution

The sequence AAD27724.1 differs from that shown. Reason: Frameshift at positions 168, 211 and 305.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NQQ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NQQ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-157: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Solute carrier family 35 member C2
PRO_0000213399

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane242 – 26221Helical; Potential
Transmembrane294 – 31623Helical; Potential

Amino acid modifications

Modified residue3351Phosphoserine Ref.8
Glycosylation1021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence137 – 15721Missing in isoform 2.
VSP_009229

Experimental info

Sequence conflict661L → S in AAD27724. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 5EACE6A4953411A9

FASTA36540,432
        10         20         30         40         50         60 
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS 

        70         80         90        100        110        120 
ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA 

       130        140        150        160        170        180 
VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW 

       190        200        210        220        230        240 
TLTQMLLQKA ELGLQNPIDT MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL 

       250        260        270        280        290        300 
RVLGSLFLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 

       310        320        330        340        350        360 
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE GDNEEEEYFV 


AQGQQ 

« Hide

Isoform 2 [UniParc].

Checksum: 20DCAF1DC8048736
Show »

FASTA34438,154

References

« Hide 'large scale' references
[1]"Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization."
Leach R.E., Duniec-Dmuchowski Z.M., Tanaka T.S., Ko M.S.H., Krawetz S.A.
Cytogenet. Cell Genet. 94:252-253(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Colon and Skin.
[6]"Identification, molecular characterization, and tissue expression of OVCOV1."
Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A.
Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF455052 mRNA. Translation: AAL59605.1.
AF132949 mRNA. Translation: AAD27724.1. Frameshift.
AL133227 Genomic DNA. Translation: CAC00659.2.
AL133227 Genomic DNA. Translation: CAI40552.1.
CH471077 Genomic DNA. Translation: EAW75748.1.
CH471077 Genomic DNA. Translation: EAW75747.1.
CH471077 Genomic DNA. Translation: EAW75750.1.
CH471077 Genomic DNA. Translation: EAW75751.1.
CH471077 Genomic DNA. Translation: EAW75752.1.
BC014191 mRNA. Translation: AAH14191.1.
BC021138 mRNA. Translation: AAH21138.1.
BC025277 mRNA. Translation: AAH25277.1.
CCDSCCDS13396.1. [Q9NQQ7-1]
CCDS13397.1. [Q9NQQ7-2]
RefSeqNP_001268386.1. NM_001281457.1.
NP_001268387.1. NM_001281458.1.
NP_001268388.1. NM_001281459.1.
NP_001268389.1. NM_001281460.1. [Q9NQQ7-1]
NP_057029.8. NM_015945.11. [Q9NQQ7-1]
NP_775096.1. NM_173073.3. [Q9NQQ7-2]
NP_775271.1. NM_173179.3. [Q9NQQ7-1]
XP_005260471.1. XM_005260414.1. [Q9NQQ7-1]
UniGeneHs.593344.
Hs.723629.

3D structure databases

ProteinModelPortalQ9NQQ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119214. 1 interaction.
IntActQ9NQQ7. 2 interactions.
STRING9606.ENSP00000243896.

Protein family/group databases

TCDB2.A.7.9.16. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ9NQQ7.

Polymorphism databases

DMDM41017506.

Proteomic databases

MaxQBQ9NQQ7.
PaxDbQ9NQQ7.
PRIDEQ9NQQ7.

Protocols and materials databases

DNASU51006.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243896; ENSP00000243896; ENSG00000080189. [Q9NQQ7-1]
ENST00000317734; ENSP00000318960; ENSG00000080189. [Q9NQQ7-2]
ENST00000372227; ENSP00000361301; ENSG00000080189. [Q9NQQ7-1]
ENST00000372230; ENSP00000361304; ENSG00000080189. [Q9NQQ7-1]
GeneID51006.
KEGGhsa:51006.
UCSCuc002xro.3. human. [Q9NQQ7-1]
uc002xrp.3. human. [Q9NQQ7-2]

Organism-specific databases

CTD51006.
GeneCardsGC20M044978.
H-InvDBHIX0015879.
HGNCHGNC:17117. SLC35C2.
HPAHPA027011.
neXtProtNX_Q9NQQ7.
PharmGKBPA32850.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0697.
HOVERGENHBG055852.
InParanoidQ9NQQ7.
KOK15280.
OrthoDBEOG7TTQ93.
PhylomeDBQ9NQQ7.
TreeFamTF314994.

Gene expression databases

ArrayExpressQ9NQQ7.
BgeeQ9NQQ7.
CleanExHS_SLC35C2.
GenevestigatorQ9NQQ7.

Family and domain databases

InterProIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC35C2. human.
GeneWikiSLC35C2.
GenomeRNAi51006.
NextBio53478.
PROQ9NQQ7.

Entry information

Entry nameS35C2_HUMAN
AccessionPrimary (citable) accession number: Q9NQQ7
Secondary accession number(s): E1P5T0 expand/collapse secondary AC list , Q5JW05, Q96CJ8, Q9Y304
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM