Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prefoldin subunit 4

Gene

PFDN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • chaperone binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101132-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Protein C-1
Gene namesi
Name:PFDN4
Synonyms:PFD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:8868. PFDN4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
  • prefoldin complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5203.
OpenTargetsiENSG00000101132.
PharmGKBiPA33209.

Polymorphism and mutation databases

BioMutaiPFDN4.
DMDMi12643815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248422 – 134Prefoldin subunit 4Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQP4.
MaxQBiQ9NQP4.
PaxDbiQ9NQP4.
PeptideAtlasiQ9NQP4.
PRIDEiQ9NQP4.
TopDownProteomicsiQ9NQP4.

PTM databases

iPTMnetiQ9NQP4.
PhosphoSitePlusiQ9NQP4.

Expressioni

Gene expression databases

BgeeiENSG00000101132.
CleanExiHS_PFDN4.
ExpressionAtlasiQ9NQP4. baseline and differential.
GenevisibleiQ9NQP4. HS.

Organism-specific databases

HPAiHPA024055.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VBP1P617583EBI-357021,EBI-357430

GO - Molecular functioni

  • chaperone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111225. 60 interactors.
IntActiQ9NQP4. 17 interactors.
MINTiMINT-1131938.
STRINGi9606.ENSP00000360473.

Structurei

3D structure databases

ProteinModelPortaliQ9NQP4.
SMRiQ9NQP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG1760. Eukaryota.
COG1382. LUCA.
GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
HOVERGENiHBG005034.
InParanoidiQ9NQP4.
KOiK09550.
OrthoDBiEOG091G10MO.
PhylomeDBiQ9NQP4.
TreeFamiTF106491.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21100:SF9. PTHR21100:SF9. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL
60 70 80 90 100
EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA
110 120 130
LESRVESIQR VLADLKVQLY AKFGSNINLE ADES
Length:134
Mass (Da):15,314
Last modified:October 1, 2000 - v1
Checksum:iC727F0FCB9343DC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41816 mRNA. Translation: AAB17063.1.
AL133335 Genomic DNA. Translation: CAI19316.1.
BC010953 mRNA. Translation: AAH10953.1.
CCDSiCCDS13445.1.
RefSeqiNP_002614.2. NM_002623.3.
UniGeneiHs.91161.

Genome annotation databases

EnsembliENST00000371419; ENSP00000360473; ENSG00000101132.
GeneIDi5203.
KEGGihsa:5203.
UCSCiuc002xwx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41816 mRNA. Translation: AAB17063.1.
AL133335 Genomic DNA. Translation: CAI19316.1.
BC010953 mRNA. Translation: AAH10953.1.
CCDSiCCDS13445.1.
RefSeqiNP_002614.2. NM_002623.3.
UniGeneiHs.91161.

3D structure databases

ProteinModelPortaliQ9NQP4.
SMRiQ9NQP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111225. 60 interactors.
IntActiQ9NQP4. 17 interactors.
MINTiMINT-1131938.
STRINGi9606.ENSP00000360473.

PTM databases

iPTMnetiQ9NQP4.
PhosphoSitePlusiQ9NQP4.

Polymorphism and mutation databases

BioMutaiPFDN4.
DMDMi12643815.

Proteomic databases

EPDiQ9NQP4.
MaxQBiQ9NQP4.
PaxDbiQ9NQP4.
PeptideAtlasiQ9NQP4.
PRIDEiQ9NQP4.
TopDownProteomicsiQ9NQP4.

Protocols and materials databases

DNASUi5203.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371419; ENSP00000360473; ENSG00000101132.
GeneIDi5203.
KEGGihsa:5203.
UCSCiuc002xwx.4. human.

Organism-specific databases

CTDi5203.
DisGeNETi5203.
GeneCardsiPFDN4.
HGNCiHGNC:8868. PFDN4.
HPAiHPA024055.
MIMi604898. gene.
neXtProtiNX_Q9NQP4.
OpenTargetsiENSG00000101132.
PharmGKBiPA33209.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1760. Eukaryota.
COG1382. LUCA.
GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
HOVERGENiHBG005034.
InParanoidiQ9NQP4.
KOiK09550.
OrthoDBiEOG091G10MO.
PhylomeDBiQ9NQP4.
TreeFamiTF106491.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101132-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

ChiTaRSiPFDN4. human.
GeneWikiiPFDN4.
GenomeRNAii5203.
PROiQ9NQP4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101132.
CleanExiHS_PFDN4.
ExpressionAtlasiQ9NQP4. baseline and differential.
GenevisibleiQ9NQP4. HS.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR016661. PFDN4.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR21100:SF9. PTHR21100:SF9. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NQP4
Secondary accession number(s): Q5TD11, Q92779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.