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Protein

Prefoldin subunit 4

Gene

PFDN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • protein folding Source: UniProtKB

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Protein C-1
Gene namesi
Name:PFDN4
Synonyms:PFD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101132.9.
HGNCiHGNC:8868. PFDN4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5203.
OpenTargetsiENSG00000101132.
PharmGKBiPA33209.

Polymorphism and mutation databases

BioMutaiPFDN4.
DMDMi12643815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001248422 – 134Prefoldin subunit 4Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQP4.
MaxQBiQ9NQP4.
PaxDbiQ9NQP4.
PeptideAtlasiQ9NQP4.
PRIDEiQ9NQP4.
TopDownProteomicsiQ9NQP4.

PTM databases

iPTMnetiQ9NQP4.
PhosphoSitePlusiQ9NQP4.

Expressioni

Gene expression databases

BgeeiENSG00000101132.
CleanExiHS_PFDN4.
ExpressionAtlasiQ9NQP4. baseline and differential.
GenevisibleiQ9NQP4. HS.

Organism-specific databases

HPAiHPA024055.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VBP1P617585EBI-357021,EBI-357430

GO - Molecular functioni

  • chaperone binding Source: UniProtKB
  • unfolded protein binding Source: InterPro

Protein-protein interaction databases

BioGridi111225. 65 interactors.
CORUMiQ9NQP4.
IntActiQ9NQP4. 19 interactors.
MINTiMINT-1131938.
STRINGi9606.ENSP00000360473.

Structurei

3D structure databases

ProteinModelPortaliQ9NQP4.
SMRiQ9NQP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG1760. Eukaryota.
COG1382. LUCA.
GeneTreeiENSGT00390000006696.
HOGENOMiHOG000204477.
HOVERGENiHBG005034.
InParanoidiQ9NQP4.
KOiK09550.
OrthoDBiEOG091G10MO.
PhylomeDBiQ9NQP4.
TreeFamiTF106491.

Family and domain databases

InterProiView protein in InterPro
IPR002777. PFD_beta-like.
IPR016661. PFDN4.
PfamiView protein in Pfam
PF01920. Prefoldin_2. 1 hit.
PIRSFiPIRSF016477. Prefoldin_subunit_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL
60 70 80 90 100
EDACDDIMLA DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA
110 120 130
LESRVESIQR VLADLKVQLY AKFGSNINLE ADES
Length:134
Mass (Da):15,314
Last modified:October 1, 2000 - v1
Checksum:iC727F0FCB9343DC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41816 mRNA. Translation: AAB17063.1.
AL133335 Genomic DNA. No translation available.
BC010953 mRNA. Translation: AAH10953.1.
CCDSiCCDS13445.1.
RefSeqiNP_002614.2. NM_002623.3.
UniGeneiHs.91161.

Genome annotation databases

EnsembliENST00000371419; ENSP00000360473; ENSG00000101132.
GeneIDi5203.
KEGGihsa:5203.
UCSCiuc002xwx.4. human.

Similar proteinsi

Entry informationi

Entry nameiPFD4_HUMAN
AccessioniPrimary (citable) accession number: Q9NQP4
Secondary accession number(s): Q5TD11, Q92779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families