ID   OR2S1_HUMAN             Reviewed;         319 AA.
AC   Q9NQN1; Q2M3L0; Q6IF19; Q96R42;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   24-JAN-2024, entry version 171.
DE   RecName: Full=Olfactory receptor 2S2;
DE   AltName: Full=Olfactory receptor OR9-3;
GN   Name=OR2S2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-290.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2S2";
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DR   EMBL; AL135841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC104869; AAI04870.1; -; mRNA.
DR   EMBL; BC113651; AAI13652.1; -; mRNA.
DR   EMBL; AF399601; AAK95086.1; -; Genomic_DNA.
DR   EMBL; BK004443; DAA04841.1; -; Genomic_DNA.
DR   CCDS; CCDS6596.2; -.
DR   RefSeq; NP_063950.2; NM_019897.2.
DR   AlphaFoldDB; Q9NQN1; -.
DR   SMR; Q9NQN1; -.
DR   BioGRID; 121169; 2.
DR   IntAct; Q9NQN1; 1.
DR   STRING; 9606.ENSP00000344040; -.
DR   GlyCosmos; Q9NQN1; 1 site, No reported glycans.
DR   GlyGen; Q9NQN1; 1 site.
DR   iPTMnet; Q9NQN1; -.
DR   PhosphoSitePlus; Q9NQN1; -.
DR   BioMuta; OR2S2; -.
DR   DMDM; 14423818; -.
DR   MassIVE; Q9NQN1; -.
DR   PaxDb; 9606-ENSP00000485066; -.
DR   PeptideAtlas; Q9NQN1; -.
DR   Antibodypedia; 79068; 46 antibodies from 15 providers.
DR   DNASU; 56656; -.
DR   Ensembl; ENST00000341959.2; ENSP00000344040.2; ENSG00000278889.4.
DR   GeneID; 56656; -.
DR   KEGG; hsa:56656; -.
DR   MANE-Select; ENST00000341959.2; ENSP00000344040.2; NM_019897.2; NP_063950.2.
DR   UCSC; uc011lpi.2; human.
DR   AGR; HGNC:8276; -.
DR   CTD; 56656; -.
DR   GeneCards; OR2S2; -.
DR   HGNC; HGNC:8276; OR2S2.
DR   HPA; ENSG00000278889; Not detected.
DR   neXtProt; NX_Q9NQN1; -.
DR   PharmGKB; PA32200; -.
DR   VEuPathDB; HostDB:ENSG00000278889; -.
DR   eggNOG; ENOG502TDYB; Eukaryota.
DR   GeneTree; ENSGT01040000240406; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q9NQN1; -.
DR   OMA; VSQKCFR; -.
DR   OrthoDB; 4632618at2759; -.
DR   PhylomeDB; Q9NQN1; -.
DR   TreeFam; TF352686; -.
DR   PathwayCommons; Q9NQN1; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9NQN1; -.
DR   BioGRID-ORCS; 56656; 12 hits in 744 CRISPR screens.
DR   GeneWiki; OR2S2; -.
DR   GenomeRNAi; 56656; -.
DR   Pharos; Q9NQN1; Tdark.
DR   PRO; PR:Q9NQN1; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q9NQN1; Protein.
DR   Bgee; ENSG00000278889; Expressed in colonic mucosa and 4 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15430; 7tmA_OR13-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF176; OLFACTORY RECEPTOR 2S2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9NQN1; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Olfactory receptor 2S2"
FT                   /id="PRO_0000150495"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..279
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..299
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         17
FT                   /note="R -> G (in dbSNP:rs2233558)"
FT                   /id="VAR_059994"
FT   VARIANT         30
FT                   /note="V -> M (in dbSNP:rs2233559)"
FT                   /id="VAR_059995"
FT   VARIANT         89
FT                   /note="P -> S (in dbSNP:rs2233560)"
FT                   /id="VAR_059996"
FT   VARIANT         123
FT                   /note="R -> H (in dbSNP:rs2233563)"
FT                   /id="VAR_059997"
FT   VARIANT         143
FT                   /note="M -> V (in dbSNP:rs2233564)"
FT                   /id="VAR_059998"
FT   VARIANT         161
FT                   /note="T -> A (in dbSNP:rs2233565)"
FT                   /id="VAR_059999"
FT   VARIANT         287
FT                   /note="V -> A (in dbSNP:rs2233570)"
FT                   /id="VAR_060000"
SQ   SEQUENCE   319 AA;  35172 MW;  602602FCA96A179F CRC64;
     MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT ILDSRLHTPM
     YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV QMALSFAMAG TECLLLSMMA
     FDRYVAICNP LRYSVIMSKA AYMPMAASSW AIGGAASVVH TSLAIQLPFC GDNVINHFTC
     EILAVLKLAC ADISINVISM EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS
     TCSAHLTVVI VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR
     NKDVKAAVRR LLRPKGFTQ
//