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Protein

Olfactory receptor 2S2

Gene

OR2S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2S2
Alternative name(s):
Olfactory receptor OR9-3
Gene namesi
Name:OR2S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8276. OR2S2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei280 – 29920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini300 – 31920CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 2S2PRO_0000150495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NQN1.
PRIDEiQ9NQN1.

Expressioni

Gene expression databases

CleanExiHS_OR2S2.
GenevestigatoriQ9NQN1.

Interactioni

Protein-protein interaction databases

BioGridi121169. 2 interactions.
STRINGi9606.ENSP00000344040.

Structurei

3D structure databases

ProteinModelPortaliQ9NQN1.
SMRiQ9NQN1. Positions 30-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG87339.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9NQN1.
KOiK04257.
OMAiHTSLVIQ.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ9NQN1.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT
60 70 80 90 100
ILDSRLHTPM YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV
110 120 130 140 150
QMALSFAMAG TECLLLSMMA FDRYVAICNP LRYSVIMSKA AYMPMAASSW
160 170 180 190 200
AIGGAASVVH TSLAIQLPFC GDNVINHFTC EILAVLKLAC ADISINVISM
210 220 230 240 250
EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS TCSAHLTVVI
260 270 280 290 300
VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR
310
NKDVKAAVRR LLRPKGFTQ
Length:319
Mass (Da):35,172
Last modified:June 20, 2001 - v2
Checksum:i602602FCA96A179F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171R → G.
Corresponds to variant rs2233558 [ dbSNP | Ensembl ].
VAR_059994
Natural varianti30 – 301V → M.
Corresponds to variant rs2233559 [ dbSNP | Ensembl ].
VAR_059995
Natural varianti89 – 891P → S.
Corresponds to variant rs2233560 [ dbSNP | Ensembl ].
VAR_059996
Natural varianti123 – 1231R → H.
Corresponds to variant rs2233563 [ dbSNP | Ensembl ].
VAR_059997
Natural varianti143 – 1431M → V.
Corresponds to variant rs2233564 [ dbSNP | Ensembl ].
VAR_059998
Natural varianti161 – 1611T → A.
Corresponds to variant rs2233565 [ dbSNP | Ensembl ].
VAR_059999
Natural varianti287 – 2871V → A.
Corresponds to variant rs2233570 [ dbSNP | Ensembl ].
VAR_060000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135841 Genomic DNA. Translation: CAB96728.2.
BC104869 mRNA. Translation: AAI04870.1.
BC113651 mRNA. Translation: AAI13652.1.
AF399601 Genomic DNA. Translation: AAK95086.1.
BK004443 Genomic DNA. Translation: DAA04841.1.
CCDSiCCDS6596.2.
RefSeqiNP_063950.2. NM_019897.2.
UniGeneiHs.553540.

Genome annotation databases

EnsembliENST00000341959; ENSP00000344040; ENSG00000278889.
ENST00000623973; ENSP00000485516; ENSG00000278889.
ENST00000625188; ENSP00000485066; ENSG00000122718.
GeneIDi56656.
KEGGihsa:56656.
UCSCiuc011lpi.2. human.

Polymorphism databases

DMDMi14423818.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135841 Genomic DNA. Translation: CAB96728.2.
BC104869 mRNA. Translation: AAI04870.1.
BC113651 mRNA. Translation: AAI13652.1.
AF399601 Genomic DNA. Translation: AAK95086.1.
BK004443 Genomic DNA. Translation: DAA04841.1.
CCDSiCCDS6596.2.
RefSeqiNP_063950.2. NM_019897.2.
UniGeneiHs.553540.

3D structure databases

ProteinModelPortaliQ9NQN1.
SMRiQ9NQN1. Positions 30-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121169. 2 interactions.
STRINGi9606.ENSP00000344040.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi14423818.

Proteomic databases

PaxDbiQ9NQN1.
PRIDEiQ9NQN1.

Protocols and materials databases

DNASUi56656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341959; ENSP00000344040; ENSG00000278889.
ENST00000623973; ENSP00000485516; ENSG00000278889.
ENST00000625188; ENSP00000485066; ENSG00000122718.
GeneIDi56656.
KEGGihsa:56656.
UCSCiuc011lpi.2. human.

Organism-specific databases

CTDi56656.
GeneCardsiGC09M035947.
HGNCiHGNC:8276. OR2S2.
neXtProtiNX_Q9NQN1.
PharmGKBiPA32200.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87339.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9NQN1.
KOiK04257.
OMAiHTSLVIQ.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ9NQN1.
TreeFamiTF352686.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2S2.
GenomeRNAii56656.
NextBioi62125.
PROiQ9NQN1.

Gene expression databases

CleanExiHS_OR2S2.
GenevestigatoriQ9NQN1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-290.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR2S1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQN1
Secondary accession number(s): Q2M3L0, Q6IF19, Q96R42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: January 7, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.