Q9NQN1 (OR2S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2S2

Alternative name(s):
Olfactory receptor OR9-3

Gene names

Name:

OR2S2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Olfactory receptor 2S2		PRO_0000150495
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 50	24	Helical; Name=1; Potential
	Topological domain	51 – 58	8	Cytoplasmic Potential
	Transmembrane	59 – 80	22	Helical; Name=2; Potential
	Topological domain	81 – 101	21	Extracellular Potential
	Transmembrane	102 – 121	20	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 159	19	Helical; Name=4; Potential
	Topological domain	160 – 196	37	Extracellular Potential
	Transmembrane	197 – 220	24	Helical; Name=5; Potential
	Topological domain	221 – 237	17	Cytoplasmic Potential
	Transmembrane	238 – 260	23	Helical; Name=6; Potential
	Topological domain	261 – 279	19	Extracellular Potential
	Transmembrane	280 – 299	20	Helical; Name=7; Potential
	Topological domain	300 – 319	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	17	1	R → G. Corresponds to variant rs2233558 [ dbSNP | Ensembl ].		VAR_059994
	Natural variant	30	1	V → M. Corresponds to variant rs2233559 [ dbSNP | Ensembl ].		VAR_059995
	Natural variant	89	1	P → S. Corresponds to variant rs2233560 [ dbSNP | Ensembl ].		VAR_059996
	Natural variant	123	1	R → H. Corresponds to variant rs2233563 [ dbSNP | Ensembl ].		VAR_059997
	Natural variant	143	1	M → V. Corresponds to variant rs2233564 [ dbSNP | Ensembl ].		VAR_059998
	Natural variant	161	1	T → A. Corresponds to variant rs2233565 [ dbSNP | Ensembl ].		VAR_059999
	Natural variant	287	1	V → A. Corresponds to variant rs2233570 [ dbSNP | Ensembl ].		VAR_060000

Sequences

	Sequence		Length	Mass (Da)
	Q9NQN1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 602602FCA96A179F	FASTA	319	35,172
	10 20 30 40 50 60 MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT ILDSRLHTPM 70 80 90 100 110 120 YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV QMALSFAMAG TECLLLSMMA 130 140 150 160 170 180 FDRYVAICNP LRYSVIMSKA AYMPMAASSW AIGGAASVVH TSLAIQLPFC GDNVINHFTC 190 200 210 220 230 240 EILAVLKLAC ADISINVISM EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS 250 260 270 280 290 300 TCSAHLTVVI VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR 310 NKDVKAAVRR LLRPKGFTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-290.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL135841 Genomic DNA. Translation: CAB96728.2. BC104869 mRNA. Translation: AAI04870.1. BC113651 mRNA. Translation: AAI13652.1. AF399601 Genomic DNA. Translation: AAK95086.1. BK004443 Genomic DNA. Translation: DAA04841.1.
IPI	IPI00015852.
RefSeq	NP_063950.2. NM_019897.2.
UniGene	Hs.553540.
3D structure databases
ProteinModelPortal	Q9NQN1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000344040.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423818.
Proteomic databases
PaxDb	Q9NQN1.
PRIDE	Q9NQN1.
Protocols and materials databases
DNASU	56656.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341959; ENSP00000344040; ENSG00000122718.
GeneID	56656.
KEGG	hsa:56656.
UCSC	uc011lpi.2. human.
Organism-specific databases
CTD	56656.
GeneCards	GC09M035947.
HGNC	HGNC:8276. OR2S2.
neXtProt	NX_Q9NQN1.
PharmGKB	PA32200.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87339.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q9NQN1.
KO	K04257.
OMA	DSFLTPQ.
OrthoDB	EOG4F7NKH.
PhylomeDB	Q9NQN1.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2S2.
Genevestigator	Q9NQN1.
GermOnline	ENSG00000122718. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56656.
NextBio	62125.

Entry information

Entry name

OR2S1_HUMAN

Accession

Primary (citable) accession number: Q9NQN1
Secondary accession number(s): Q2M3L0, Q6IF19, Q96R42

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.