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Q9NQN1 (OR2S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2S2
Alternative name(s):
Olfactory receptor OR9-3
Gene names
Name:OR2S2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Olfactory receptor 2S2
PRO_0000150495

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5024Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27919Extracellular Potential
Transmembrane280 – 29920Helical; Name=7; Potential
Topological domain300 – 31920Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant171R → G.
Corresponds to variant rs2233558 [ dbSNP | Ensembl ].
VAR_059994
Natural variant301V → M.
Corresponds to variant rs2233559 [ dbSNP | Ensembl ].
VAR_059995
Natural variant891P → S.
Corresponds to variant rs2233560 [ dbSNP | Ensembl ].
VAR_059996
Natural variant1231R → H.
Corresponds to variant rs2233563 [ dbSNP | Ensembl ].
VAR_059997
Natural variant1431M → V.
Corresponds to variant rs2233564 [ dbSNP | Ensembl ].
VAR_059998
Natural variant1611T → A.
Corresponds to variant rs2233565 [ dbSNP | Ensembl ].
VAR_059999
Natural variant2871V → A.
Corresponds to variant rs2233570 [ dbSNP | Ensembl ].
VAR_060000

Sequences

Sequence LengthMass (Da)Tools
Q9NQN1 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 602602FCA96A179F

FASTA31935,172
        10         20         30         40         50         60 
MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT ILDSRLHTPM 

        70         80         90        100        110        120 
YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV QMALSFAMAG TECLLLSMMA 

       130        140        150        160        170        180 
FDRYVAICNP LRYSVIMSKA AYMPMAASSW AIGGAASVVH TSLAIQLPFC GDNVINHFTC 

       190        200        210        220        230        240 
EILAVLKLAC ADISINVISM EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS 

       250        260        270        280        290        300 
TCSAHLTVVI VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR 

       310 
NKDVKAAVRR LLRPKGFTQ 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-290.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL135841 Genomic DNA. Translation: CAB96728.2.
BC104869 mRNA. Translation: AAI04870.1.
BC113651 mRNA. Translation: AAI13652.1.
AF399601 Genomic DNA. Translation: AAK95086.1.
BK004443 Genomic DNA. Translation: DAA04841.1.
CCDSCCDS6596.2.
RefSeqNP_063950.2. NM_019897.2.
UniGeneHs.553540.

3D structure databases

ProteinModelPortalQ9NQN1.
SMRQ9NQN1. Positions 30-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000344040.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423818.

Proteomic databases

PaxDbQ9NQN1.
PRIDEQ9NQN1.

Protocols and materials databases

DNASU56656.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341959; ENSP00000344040; ENSG00000122718.
GeneID56656.
KEGGhsa:56656.
UCSCuc011lpi.2. human.

Organism-specific databases

CTD56656.
GeneCardsGC09M035947.
HGNCHGNC:8276. OR2S2.
neXtProtNX_Q9NQN1.
PharmGKBPA32200.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87339.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ9NQN1.
KOK04257.
OMAHTSLVIQ.
OrthoDBEOG7GXPC0.
PhylomeDBQ9NQN1.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2S2.
GenevestigatorQ9NQN1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2S2.
GenomeRNAi56656.
NextBio62125.
PROQ9NQN1.

Entry information

Entry nameOR2S1_HUMAN
AccessionPrimary (citable) accession number: Q9NQN1
Secondary accession number(s): Q2M3L0, Q6IF19, Q96R42
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries