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Protein

Protein PIH1D3

Gene

PIH1D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cytoplasmic pre-assembly of axonemal dynein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PIH1D3
Alternative name(s):
PIH1 domain-containing protein 3
Sarcoma antigen NY-SAR-97
Gene namesi
Name:PIH1D3
Synonyms:CXorf41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28570. PIH1D3.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Localized to the cytoplasm of spermatogenic cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882142.

Polymorphism and mutation databases

BioMutaiPIH1D3.
DMDMi71153251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Protein PIH1D3PRO_0000079736Add
BLAST

Proteomic databases

PaxDbiQ9NQM4.
PeptideAtlasiQ9NQM4.
PRIDEiQ9NQM4.

PTM databases

iPTMnetiQ9NQM4.
PhosphoSiteiQ9NQM4.

Expressioni

Tissue specificityi

Expressed in testis, small intestine, prostate, adrenal gland, spleen, lung, bladder, breast and ovary.1 Publication

Gene expression databases

BgeeiQ9NQM4.
CleanExiHS_CXorf41.
GenevisibleiQ9NQM4. HS.

Organism-specific databases

HPAiHPA051099.

Interactioni

Subunit structurei

Interacts with HSPA1A/B, HSP90AA1 and DNAI2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BTAF1Q2M1V93EBI-10239299,EBI-10239305
CCAR1Q8IX123EBI-10239299,EBI-356265
CDKL3Q8IVW43EBI-10239299,EBI-3919850
KAT5Q929933EBI-10239299,EBI-399080
KIF13AQ9H1H93EBI-10239299,EBI-1759129
P2RX4Q995713EBI-10239299,EBI-2828248

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126551. 6 interactions.
IntActiQ9NQM4. 6 interactions.
STRINGi9606.ENSP00000337757.

Structurei

3D structure databases

ProteinModelPortaliQ9NQM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIH1 family.Curated

Phylogenomic databases

eggNOGiENOG410IN3D. Eukaryota.
ENOG4111RQI. LUCA.
GeneTreeiENSGT00390000015219.
HOGENOMiHOG000007078.
HOVERGENiHBG070057.
InParanoidiQ9NQM4.
OMAiNNEDIWN.
OrthoDBiEOG7R56VC.
PhylomeDBiQ9NQM4.
TreeFamiTF325677.

Family and domain databases

InterProiIPR026697. PIH1D3.
[Graphical view]
PANTHERiPTHR21083. PTHR21083. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NQM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESENMDSEN MKTENMESQN VDFESVSSVT ALEALSKLLN PEEEDDSDYG
60 70 80 90 100
QTNGLSTIGA MGPGNIGPPQ IEELKVIPET SEENNEDIWN SEEIPEGAEY
110 120 130 140 150
DDMWDVREIP EYEIIFRQQV GTEDIFLGLS KKDSSTGCCS ELVAKIKLPN
160 170 180 190 200
TNPSDIQIDI QETILDLRTP QKKLLITLPE LVECTSAKAF YIPETETLEI
210
TMTMKRELDI ANFF
Length:214
Mass (Da):24,069
Last modified:October 1, 2000 - v1
Checksum:iF86B2E210BBC06F6
GO

Sequence cautioni

The sequence AAO65181.1 differs from that shown. Reason: Frameshift at position 162. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136112 Genomic DNA. Translation: CAB92764.1.
CH471120 Genomic DNA. Translation: EAX02716.1.
CH471120 Genomic DNA. Translation: EAX02717.1.
BC033510 mRNA. Translation: AAH33510.1.
AY211928 mRNA. Translation: AAO65181.1. Frameshift.
CCDSiCCDS14528.1.
RefSeqiNP_001162625.1. NM_001169154.1.
NP_775765.1. NM_173494.1.
XP_011529157.1. XM_011530855.1.
UniGeneiHs.128836.

Genome annotation databases

EnsembliENST00000336387; ENSP00000337757; ENSG00000080572.
ENST00000372453; ENSP00000361531; ENSG00000080572.
ENST00000535523; ENSP00000441930; ENSG00000080572.
GeneIDi139212.
KEGGihsa:139212.
UCSCiuc004enc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136112 Genomic DNA. Translation: CAB92764.1.
CH471120 Genomic DNA. Translation: EAX02716.1.
CH471120 Genomic DNA. Translation: EAX02717.1.
BC033510 mRNA. Translation: AAH33510.1.
AY211928 mRNA. Translation: AAO65181.1. Frameshift.
CCDSiCCDS14528.1.
RefSeqiNP_001162625.1. NM_001169154.1.
NP_775765.1. NM_173494.1.
XP_011529157.1. XM_011530855.1.
UniGeneiHs.128836.

3D structure databases

ProteinModelPortaliQ9NQM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126551. 6 interactions.
IntActiQ9NQM4. 6 interactions.
STRINGi9606.ENSP00000337757.

PTM databases

iPTMnetiQ9NQM4.
PhosphoSiteiQ9NQM4.

Polymorphism and mutation databases

BioMutaiPIH1D3.
DMDMi71153251.

Proteomic databases

PaxDbiQ9NQM4.
PeptideAtlasiQ9NQM4.
PRIDEiQ9NQM4.

Protocols and materials databases

DNASUi139212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336387; ENSP00000337757; ENSG00000080572.
ENST00000372453; ENSP00000361531; ENSG00000080572.
ENST00000535523; ENSP00000441930; ENSG00000080572.
GeneIDi139212.
KEGGihsa:139212.
UCSCiuc004enc.3. human.

Organism-specific databases

CTDi139212.
GeneCardsiPIH1D3.
H-InvDBHIX0028359.
HGNCiHGNC:28570. PIH1D3.
HPAiHPA051099.
MIMi300933. gene.
neXtProtiNX_Q9NQM4.
PharmGKBiPA134882142.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN3D. Eukaryota.
ENOG4111RQI. LUCA.
GeneTreeiENSGT00390000015219.
HOGENOMiHOG000007078.
HOVERGENiHBG070057.
InParanoidiQ9NQM4.
OMAiNNEDIWN.
OrthoDBiEOG7R56VC.
PhylomeDBiQ9NQM4.
TreeFamiTF325677.

Miscellaneous databases

GenomeRNAii139212.
PROiQ9NQM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQM4.
CleanExiHS_CXorf41.
GenevisibleiQ9NQM4. HS.

Family and domain databases

InterProiIPR026697. PIH1D3.
[Graphical view]
PANTHERiPTHR21083. PTHR21083. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195, TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiPIHD3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQM4
Secondary accession number(s): D3DUX5, Q86WE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.