ID   DMRT3_HUMAN             Reviewed;         472 AA.
AC   Q9NQL9; Q7LA03; Q7LCH8; Q96SC7; Q9NRQ9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 158.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor 3;
GN   Name=DMRT3; Synonyms=DMRTA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 46-169.
RC   TISSUE=Testis;
RX   PubMed=11863363; DOI=10.1006/geno.2002.6711;
RA   Ottolenghi C., Fellous M., Barbieri M., McElreavey K.;
RT   "Novel paralogy relations among human chromosomes support a link between
RT   the phylogeny of doublesex-related genes and the evolution of sex
RT   determination.";
RL   Genomics 79:333-343(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 130-472, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=10729223; DOI=10.1006/geno.2000.6121;
RA   Ottolenghi C., Veitia R., Quintana-Murci L., Torchard D., Scapoli L.,
RA   Souleyreau-Therville N., Beckmann J., Fellous M., McElreavey K.;
RT   "The region on 9p associated with 46,XY sex reversal contains several
RT   transcripts expressed in the urogenital system and a novel doublesex-
RT   related domain.";
RL   Genomics 64:170-178(2000).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   INTERACTION WITH UBIQUITIN, AND DOMAIN.
RX   PubMed=33021200; DOI=10.7554/elife.59614;
RA   Bayer E.A., Stecky R.C., Neal L., Katsamba P.S., Ahlsen G., Balaji V.,
RA   Hoppe T., Shapiro L., Oren-Suissa M., Hobert O.;
RT   "Ubiquitin-dependent regulation of a conserved DMRT protein controls
RT   sexually dimorphic synaptic connectivity and behavior.";
RL   Elife 9:0-0(2020).
CC   -!- FUNCTION: Probable transcription factor that plays a role in
CC       configuring the spinal circuits controlling stride in vertebrates.
CC       Involved in neuronal specification within specific subdivision of
CC       spinal cord neurons and in the development of a coordinated locomotor
CC       network controlling limb movements. May regulate transcription during
CC       sexual development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: May homodimerize. {ECO:0000269|PubMed:33021200}.
CC   -!- INTERACTION:
CC       Q9NQL9; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-9679045, EBI-357530;
CC       Q9NQL9; Q86U10: ASPG; NbExp=3; IntAct=EBI-9679045, EBI-19946665;
CC       Q9NQL9; Q86V38: ATN1; NbExp=3; IntAct=EBI-9679045, EBI-11954292;
CC       Q9NQL9; P61421: ATP6V0D1; NbExp=3; IntAct=EBI-9679045, EBI-954063;
CC       Q9NQL9; O95273: CCNDBP1; NbExp=3; IntAct=EBI-9679045, EBI-748961;
CC       Q9NQL9; Q9H5F2: CFAP68; NbExp=3; IntAct=EBI-9679045, EBI-718615;
CC       Q9NQL9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9679045, EBI-3867333;
CC       Q9NQL9; Q13643: FHL3; NbExp=3; IntAct=EBI-9679045, EBI-741101;
CC       Q9NQL9; Q5TD97: FHL5; NbExp=3; IntAct=EBI-9679045, EBI-750641;
CC       Q9NQL9; O15353: FOXN1; NbExp=3; IntAct=EBI-9679045, EBI-11319000;
CC       Q9NQL9; O43559: FRS3; NbExp=3; IntAct=EBI-9679045, EBI-725515;
CC       Q9NQL9; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-9679045, EBI-10261098;
CC       Q9NQL9; P28799: GRN; NbExp=3; IntAct=EBI-9679045, EBI-747754;
CC       Q9NQL9; O75031: HSF2BP; NbExp=3; IntAct=EBI-9679045, EBI-7116203;
CC       Q9NQL9; Q0VD86: INCA1; NbExp=6; IntAct=EBI-9679045, EBI-6509505;
CC       Q9NQL9; O75525: KHDRBS3; NbExp=3; IntAct=EBI-9679045, EBI-722504;
CC       Q9NQL9; Q5T749: KPRP; NbExp=5; IntAct=EBI-9679045, EBI-10981970;
CC       Q9NQL9; Q15323: KRT31; NbExp=6; IntAct=EBI-9679045, EBI-948001;
CC       Q9NQL9; O76011: KRT34; NbExp=3; IntAct=EBI-9679045, EBI-1047093;
CC       Q9NQL9; Q92764: KRT35; NbExp=3; IntAct=EBI-9679045, EBI-1058674;
CC       Q9NQL9; O76013-2: KRT36; NbExp=3; IntAct=EBI-9679045, EBI-11958506;
CC       Q9NQL9; O76015: KRT38; NbExp=3; IntAct=EBI-9679045, EBI-1047263;
CC       Q9NQL9; Q6A162: KRT40; NbExp=6; IntAct=EBI-9679045, EBI-10171697;
CC       Q9NQL9; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-9679045, EBI-11959885;
CC       Q9NQL9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-9679045, EBI-11749135;
CC       Q9NQL9; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-9679045, EBI-11741292;
CC       Q9NQL9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-9679045, EBI-10172290;
CC       Q9NQL9; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-9679045, EBI-10171774;
CC       Q9NQL9; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-9679045, EBI-10172052;
CC       Q9NQL9; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-9679045, EBI-1048945;
CC       Q9NQL9; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-9679045, EBI-14065470;
CC       Q9NQL9; Q9BYR8: KRTAP3-1; NbExp=5; IntAct=EBI-9679045, EBI-9996449;
CC       Q9NQL9; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-9679045, EBI-3957694;
CC       Q9NQL9; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-9679045, EBI-11987425;
CC       Q9NQL9; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-9679045, EBI-3958099;
CC       Q9NQL9; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-9679045, EBI-11962084;
CC       Q9NQL9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-9679045, EBI-1044640;
CC       Q9NQL9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-9679045, EBI-1043191;
CC       Q9NQL9; Q14847-2: LASP1; NbExp=3; IntAct=EBI-9679045, EBI-9088686;
CC       Q9NQL9; P25791-3: LMO2; NbExp=3; IntAct=EBI-9679045, EBI-11959475;
CC       Q9NQL9; Q99750: MDFI; NbExp=6; IntAct=EBI-9679045, EBI-724076;
CC       Q9NQL9; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-9679045, EBI-16439278;
CC       Q9NQL9; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-9679045, EBI-10172526;
CC       Q9NQL9; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-9679045, EBI-742948;
CC       Q9NQL9; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-9679045, EBI-11522433;
CC       Q9NQL9; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-9679045, EBI-5662487;
CC       Q9NQL9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-9679045, EBI-10271199;
CC       Q9NQL9; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-9679045, EBI-12868744;
CC       Q9NQL9; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-9679045, EBI-945833;
CC       Q9NQL9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-9679045, EBI-22310682;
CC       Q9NQL9; O43482: OIP5; NbExp=3; IntAct=EBI-9679045, EBI-536879;
CC       Q9NQL9; Q99471: PFDN5; NbExp=3; IntAct=EBI-9679045, EBI-357275;
CC       Q9NQL9; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-9679045, EBI-742388;
CC       Q9NQL9; O15162: PLSCR1; NbExp=3; IntAct=EBI-9679045, EBI-740019;
CC       Q9NQL9; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-9679045, EBI-3957793;
CC       Q9NQL9; P86480: PRR20D; NbExp=3; IntAct=EBI-9679045, EBI-12754095;
CC       Q9NQL9; P25788: PSMA3; NbExp=3; IntAct=EBI-9679045, EBI-348380;
CC       Q9NQL9; P61289: PSME3; NbExp=3; IntAct=EBI-9679045, EBI-355546;
CC       Q9NQL9; Q93062: RBPMS; NbExp=3; IntAct=EBI-9679045, EBI-740322;
CC       Q9NQL9; Q04864: REL; NbExp=3; IntAct=EBI-9679045, EBI-307352;
CC       Q9NQL9; Q04864-2: REL; NbExp=3; IntAct=EBI-9679045, EBI-10829018;
CC       Q9NQL9; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-9679045, EBI-746118;
CC       Q9NQL9; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-9679045, EBI-6257312;
CC       Q9NQL9; P21673: SAT1; NbExp=6; IntAct=EBI-9679045, EBI-711613;
CC       Q9NQL9; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-9679045, EBI-11959123;
CC       Q9NQL9; P15884: TCF4; NbExp=3; IntAct=EBI-9679045, EBI-533224;
CC       Q9NQL9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-9679045, EBI-11741437;
CC       Q9NQL9; Q13077: TRAF1; NbExp=3; IntAct=EBI-9679045, EBI-359224;
CC       Q9NQL9; P36406: TRIM23; NbExp=3; IntAct=EBI-9679045, EBI-740098;
CC       Q9NQL9; P14373: TRIM27; NbExp=6; IntAct=EBI-9679045, EBI-719493;
CC       Q9NQL9; Q15654: TRIP6; NbExp=3; IntAct=EBI-9679045, EBI-742327;
CC       Q9NQL9; Q86WV8: TSC1; NbExp=3; IntAct=EBI-9679045, EBI-12806590;
CC       Q9NQL9; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-9679045, EBI-948354;
CC       Q9NQL9; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-9679045, EBI-1380492;
CC       Q9NQL9; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-9679045, EBI-11975223;
CC       Q9NQL9; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-9679045, EBI-12040603;
CC       Q9NQL9; P08048: ZFY; NbExp=3; IntAct=EBI-9679045, EBI-12239601;
CC       Q9NQL9; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-9679045, EBI-12030590;
CC       Q9NQL9; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-9679045, EBI-11962468;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:10729223}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in 4 to 5 weeks embryos.
CC       {ECO:0000269|PubMed:10729223}.
CC   -!- DOMAIN: DMA domain interacts with ubiquitin.
CC       {ECO:0000269|PubMed:33021200}.
CC   -!- MISCELLANEOUS: DMRT3 is a marker for a subset of spinal cord neurons
CC       (dI6).
CC   -!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=A gait on the wildside
CC       - Issue 154 of November 2013;
CC       URL="https://web.expasy.org/spotlight/back_issues/154/";
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DR   EMBL; AL136365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC113584; AAI13585.1; -; mRNA.
DR   EMBL; BC117245; AAI17246.1; -; mRNA.
DR   EMBL; AJ301581; CAC37947.1; -; mRNA.
DR   EMBL; AF193873; AAF78892.1; -; mRNA.
DR   CCDS; CCDS6443.1; -.
DR   RefSeq; NP_067063.1; NM_021240.3.
DR   AlphaFoldDB; Q9NQL9; -.
DR   SMR; Q9NQL9; -.
DR   BioGRID; 121844; 88.
DR   IntAct; Q9NQL9; 79.
DR   MINT; Q9NQL9; -.
DR   STRING; 9606.ENSP00000190165; -.
DR   GlyGen; Q9NQL9; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9NQL9; -.
DR   PhosphoSitePlus; Q9NQL9; -.
DR   BioMuta; DMRT3; -.
DR   DMDM; 74752905; -.
DR   MassIVE; Q9NQL9; -.
DR   PaxDb; 9606-ENSP00000190165; -.
DR   PeptideAtlas; Q9NQL9; -.
DR   ProteomicsDB; 82163; -.
DR   Antibodypedia; 23783; 175 antibodies from 24 providers.
DR   DNASU; 58524; -.
DR   Ensembl; ENST00000190165.3; ENSP00000190165.2; ENSG00000064218.5.
DR   GeneID; 58524; -.
DR   KEGG; hsa:58524; -.
DR   MANE-Select; ENST00000190165.3; ENSP00000190165.2; NM_021240.4; NP_067063.1.
DR   UCSC; uc003zgw.3; human.
DR   AGR; HGNC:13909; -.
DR   CTD; 58524; -.
DR   DisGeNET; 58524; -.
DR   GeneCards; DMRT3; -.
DR   HGNC; HGNC:13909; DMRT3.
DR   HPA; ENSG00000064218; Tissue enhanced (choroid plexus, parathyroid gland, testis).
DR   MalaCards; DMRT3; -.
DR   MIM; 614754; gene.
DR   neXtProt; NX_Q9NQL9; -.
DR   OpenTargets; ENSG00000064218; -.
DR   Orphanet; 251510; 46,XY partial gonadal dysgenesis.
DR   PharmGKB; PA27383; -.
DR   VEuPathDB; HostDB:ENSG00000064218; -.
DR   eggNOG; KOG3815; Eukaryota.
DR   GeneTree; ENSGT00940000160420; -.
DR   HOGENOM; CLU_052449_1_0_1; -.
DR   InParanoid; Q9NQL9; -.
DR   OMA; RWASEPQ; -.
DR   OrthoDB; 2915919at2759; -.
DR   PhylomeDB; Q9NQL9; -.
DR   TreeFam; TF317837; -.
DR   PathwayCommons; Q9NQL9; -.
DR   SignaLink; Q9NQL9; -.
DR   BioGRID-ORCS; 58524; 10 hits in 1164 CRISPR screens.
DR   ChiTaRS; DMRT3; human.
DR   GenomeRNAi; 58524; -.
DR   Pharos; Q9NQL9; Tbio.
DR   PRO; PR:Q9NQL9; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q9NQL9; Protein.
DR   Bgee; ENSG00000064218; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 77 other cell types or tissues.
DR   ExpressionAtlas; Q9NQL9; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0046661; P:male sex differentiation; IBA:GO_Central.
DR   GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007548; P:sex differentiation; NAS:UniProtKB.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl.
DR   CDD; cd14419; CUE_DMA_DMRTA3; 1.
DR   Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR   InterPro; IPR001275; DM_DNA-bd.
DR   InterPro; IPR036407; DM_DNA-bd_sf.
DR   InterPro; IPR005173; DMA.
DR   InterPro; IPR026607; DMRT.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR   PANTHER; PTHR12322:SF120; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3; 1.
DR   Pfam; PF00751; DM; 1.
DR   Pfam; PF03474; DMA; 1.
DR   SMART; SM00301; DM; 1.
DR   SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
DR   Genevisible; Q9NQL9; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Sexual differentiation; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..472
FT                   /note="Doublesex- and mab-3-related transcription factor 3"
FT                   /id="PRO_0000277794"
FT   DOMAIN          249..284
FT                   /note="DMA"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        29..76
FT                   /note="DM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00070"
FT   REGION          89..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          430..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..122
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         164
FT                   /note="A -> T (in dbSNP:rs10978001)"
FT                   /id="VAR_030591"
FT   VARIANT         261
FT                   /note="N -> T (in dbSNP:rs7854621)"
FT                   /id="VAR_030592"
FT   VARIANT         356
FT                   /note="G -> V (in dbSNP:rs16927037)"
FT                   /id="VAR_030593"
SQ   SEQUENCE   472 AA;  51199 MW;  BD76C5BE0B100A50 CRC64;
     MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL
     IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAVAAPQPP PASQPSQPQP
     PRPAAELAAA AALRWTAEPQ PGALQAQLAK PDLTEERLGD GKSADNTEVF SDKDTDQRSS
     PDVAKSKGCF TPESPEIVSV EEGGYAVQKN GGNPESRPDS PKCHAEQNHL LIEGPSGTVS
     LPFSLKANRP PLEVLKKIFP NQKPTVLELI LKGCGGDLVS AVEVLLSSRS SVTGAERTSA
     EPESLALPSN GHIFEHTLSS YPISSSKWSV GSAFRVPDTL RFSADSSNVV PSPLAGPLQP
     PFPQPPRYPL MLRNTLARSQ SSPFLPNDVT LWNTMTLQQQ YQLRSQYVSP FPSNSTSVFR
     SSPVLPARAT EDPRISIPDD GCPFVSKQSI YTEDDYDERS DSSDSRTLNT SS
//