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Protein

Doublesex- and mab-3-related transcription factor 3

Gene

DMRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).By similarity

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 76DMPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 3
Gene namesi
Name:DMRT3
Synonyms:DMRTA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000064218.4
HGNCiHGNC:13909 DMRT3
MIMi614754 gene
neXtProtiNX_Q9NQL9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58524
MalaCardsiDMRT3
OpenTargetsiENSG00000064218
PharmGKBiPA27383

Polymorphism and mutation databases

DMDMi74752905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002777941 – 472Doublesex- and mab-3-related transcription factor 3Add BLAST472

Proteomic databases

PaxDbiQ9NQL9
PeptideAtlasiQ9NQL9
PRIDEiQ9NQL9

PTM databases

iPTMnetiQ9NQL9
PhosphoSitePlusiQ9NQL9

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Developmental stagei

Expressed in 4 to 5 weeks embryos.1 Publication

Gene expression databases

BgeeiENSG00000064218
CleanExiHS_DMRT3
ExpressionAtlasiQ9NQL9 baseline and differential
GenevisibleiQ9NQL9 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121844, 26 interactors
IntActiQ9NQL9, 69 interactors
MINTiQ9NQL9

Structurei

3D structure databases

ProteinModelPortaliQ9NQL9
SMRiQ9NQL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00550000074486
HOGENOMiHOG000112230
HOVERGENiHBG080568
InParanoidiQ9NQL9
KOiK19490
OMAiSNGHLFE
OrthoDBiEOG091G08TD
PhylomeDBiQ9NQL9
TreeFamiTF317837

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR005173 DMA
IPR026607 DMRT/dsx/mab-3
IPR009060 UBA-like_sf
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
PF03474 DMA, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NQL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF
60 70 80 90 100
KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP
110 120 130 140 150
GDAVAAPQPP PASQPSQPQP PRPAAELAAA AALRWTAEPQ PGALQAQLAK
160 170 180 190 200
PDLTEERLGD GKSADNTEVF SDKDTDQRSS PDVAKSKGCF TPESPEIVSV
210 220 230 240 250
EEGGYAVQKN GGNPESRPDS PKCHAEQNHL LIEGPSGTVS LPFSLKANRP
260 270 280 290 300
PLEVLKKIFP NQKPTVLELI LKGCGGDLVS AVEVLLSSRS SVTGAERTSA
310 320 330 340 350
EPESLALPSN GHIFEHTLSS YPISSSKWSV GSAFRVPDTL RFSADSSNVV
360 370 380 390 400
PSPLAGPLQP PFPQPPRYPL MLRNTLARSQ SSPFLPNDVT LWNTMTLQQQ
410 420 430 440 450
YQLRSQYVSP FPSNSTSVFR SSPVLPARAT EDPRISIPDD GCPFVSKQSI
460 470
YTEDDYDERS DSSDSRTLNT SS
Length:472
Mass (Da):51,199
Last modified:October 1, 2000 - v1
Checksum:iBD76C5BE0B100A50
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030591164A → T. Corresponds to variant dbSNP:rs10978001Ensembl.1
Natural variantiVAR_030592261N → T. Corresponds to variant dbSNP:rs7854621Ensembl.1
Natural variantiVAR_030593356G → V. Corresponds to variant dbSNP:rs16927037Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136365 Genomic DNA No translation available.
BC113584 mRNA Translation: AAI13585.1
BC117245 mRNA Translation: AAI17246.1
AJ301581 mRNA Translation: CAC37947.1
AF193873 mRNA Translation: AAF78892.1
CCDSiCCDS6443.1
RefSeqiNP_067063.1, NM_021240.3
UniGeneiHs.189174
Hs.672740
Hs.744394

Genome annotation databases

EnsembliENST00000190165; ENSP00000190165; ENSG00000064218
GeneIDi58524
KEGGihsa:58524
UCSCiuc003zgw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDMRT3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQL9
Secondary accession number(s): Q7LA03
, Q7LCH8, Q96SC7, Q9NRQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

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