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Protein

Thymus-specific serine protease

Gene

PRSS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protease that may play a role in T-cell development.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851Charge relay systemSequence analysis
Active sitei447 – 4471Charge relay systemSequence analysis
Active sitei472 – 4721Charge relay systemSequence analysis

GO - Molecular functioni

GO - Biological processi

  • protein catabolic process Source: UniProtKB
  • proteolysis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERihuman-PRSS16. Prolylcarboxypeptidase.
MEROPSiS28.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymus-specific serine protease (EC:3.4.-.-)
Alternative name(s):
Serine protease 16
Gene namesi
Name:PRSS16
Synonyms:TSSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9480. PRSS16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • endosome Source: UniProtKB
  • lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33832.

Polymorphism and mutation databases

BioMutaiPRSS16.
DMDMi13633990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 514490Thymus-specific serine proteasePRO_0000027320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NQE7.
PaxDbiQ9NQE7.
PRIDEiQ9NQE7.

PTM databases

PhosphoSiteiQ9NQE7.

Expressioni

Tissue specificityi

Expressed predominantly in cortical thymic epithelial cells.

Developmental stagei

Expressed in fetal thymus.

Gene expression databases

BgeeiQ9NQE7.
CleanExiHS_PRSS16.
ExpressionAtlasiQ9NQE7. baseline and differential.
GenevisibleiQ9NQE7. HS.

Organism-specific databases

HPAiHPA017743.

Interactioni

Protein-protein interaction databases

BioGridi115568. 1 interaction.
STRINGi9606.ENSP00000230582.

Structurei

3D structure databases

ProteinModelPortaliQ9NQE7.
SMRiQ9NQE7. Positions 61-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2182. Eukaryota.
ENOG410XSGG. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000267153.
HOVERGENiHBG018007.
InParanoidiQ9NQE7.
KOiK09649.
OMAiPEANETN.
PhylomeDBiQ9NQE7.
TreeFamiTF314855.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWLAQWLG PLLLVSLWGL LAPASLLRRL GEHIQQFQES SAQGLGLSLG
60 70 80 90 100
PGAAALPKVG WLEQLLDPFN VSDRRSFLQR YWVNDQHWVG QDGPIFLHLG
110 120 130 140 150
GEGSLGPGSV MRGHPAALAP AWGALVISLE HRFYGLSIPA GGLEMAQLRF
160 170 180 190 200
LSSRLALADV VSARLALSRL FNISSSSPWI CFGGSYAGSL AAWARLKFPH
210 220 230 240 250
LIFASVASSA PVRAVLDFSE YNDVVSRSLM STAIGGSLEC RAAVSVAFAE
260 270 280 290 300
VERRLRSGGA AQAALRTELS ACGPLGRAEN QAELLGALQA LVGGVVQYDG
310 320 330 340 350
QTGAPLSVRQ LCGLLLGGGG NRSHSTPYCG LRRAVQIVLH SLGQKCLSFS
360 370 380 390 400
RAETVAQLRS TEPQLSGVGD RQWLYQTCTE FGFYVTCENP RCPFSQLPAL
410 420 430 440 450
PSQLDLCEQV FGLSALSVAQ AVAQTNSYYG GQTPGANKVL FVNGDTDPWH
460 470 480 490 500
VLSVTQALGS SESTLLIRTG SHCLDMAPER PSDSPSLRLG RQNIFQQLQT
510
WLKLAKESQI KGEV
Length:514
Mass (Da):55,049
Last modified:April 27, 2001 - v2
Checksum:iEF39BC06C560709A
GO

Sequence cautioni

The sequence CAB94769.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041S → I.
Corresponds to variant rs5030965 [ dbSNP | Ensembl ].
VAR_051826
Natural varianti204 – 2041A → G.
Corresponds to variant rs35466700 [ dbSNP | Ensembl ].
VAR_051827

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052514 mRNA. Translation: AAC33563.1.
AL021808 Genomic DNA. Translation: CAB94769.1. Sequence problems.
CCDSiCCDS4623.1.
RefSeqiNP_005856.1. NM_005865.3.
UniGeneiHs.274407.

Genome annotation databases

EnsembliENST00000230582; ENSP00000230582; ENSG00000112812.
GeneIDi10279.
KEGGihsa:10279.
UCSCiuc003nja.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052514 mRNA. Translation: AAC33563.1.
AL021808 Genomic DNA. Translation: CAB94769.1. Sequence problems.
CCDSiCCDS4623.1.
RefSeqiNP_005856.1. NM_005865.3.
UniGeneiHs.274407.

3D structure databases

ProteinModelPortaliQ9NQE7.
SMRiQ9NQE7. Positions 61-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115568. 1 interaction.
STRINGi9606.ENSP00000230582.

Protein family/group databases

ESTHERihuman-PRSS16. Prolylcarboxypeptidase.
MEROPSiS28.003.

PTM databases

PhosphoSiteiQ9NQE7.

Polymorphism and mutation databases

BioMutaiPRSS16.
DMDMi13633990.

Proteomic databases

EPDiQ9NQE7.
PaxDbiQ9NQE7.
PRIDEiQ9NQE7.

Protocols and materials databases

DNASUi10279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230582; ENSP00000230582; ENSG00000112812.
GeneIDi10279.
KEGGihsa:10279.
UCSCiuc003nja.4. human.

Organism-specific databases

CTDi10279.
GeneCardsiPRSS16.
HGNCiHGNC:9480. PRSS16.
HPAiHPA017743.
MIMi607169. gene.
neXtProtiNX_Q9NQE7.
PharmGKBiPA33832.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2182. Eukaryota.
ENOG410XSGG. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000267153.
HOVERGENiHBG018007.
InParanoidiQ9NQE7.
KOiK09649.
OMAiPEANETN.
PhylomeDBiQ9NQE7.
TreeFamiTF314855.

Miscellaneous databases

GeneWikiiPRSS16.
GenomeRNAii10279.
NextBioi38942.
PROiQ9NQE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQE7.
CleanExiHS_PRSS16.
ExpressionAtlasiQ9NQE7. baseline and differential.
GenevisibleiQ9NQE7. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus."
    Bowlus C.L., Ahn J., Chu T., Gruen J.R.
    Cell. Immunol. 196:80-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSSP_HUMAN
AccessioniPrimary (citable) accession number: Q9NQE7
Secondary accession number(s): O75416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: March 16, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.