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Protein

Reticulon-4

Gene

RTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037). Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).By similarity6 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • axonal fasciculation Source: UniProtKB
  • cardiac epithelial to mesenchymal transition Source: Ensembl
  • cerebral cortex radial glia guided migration Source: UniProtKB
  • endoplasmic reticulum tubular network assembly Source: UniProtKB
  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • negative regulation of axon extension Source: UniProtKB
  • negative regulation of axonogenesis Source: Reactome
  • negative regulation of cell growth Source: DFLAT
  • nuclear pore complex assembly Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of branching morphogenesis of a nerve Source: UniProtKB
  • regulation of cell migration Source: MGI
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115310-MONOMER.
ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiQ9NQC3.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4
Alternative name(s):
Foocen
Neurite outgrowth inhibitor
Short name:
Nogo protein
Neuroendocrine-specific protein
Short name:
NSP
Neuroendocrine-specific protein C homolog
RTN-x
Reticulon-5
Gene namesi
Name:RTN4
Synonyms:KIAA0886, NOGO
ORF Names:My043, SP1507
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14085. RTN4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 1018CytoplasmicSequence analysisAdd BLAST1018
Transmembranei1019 – 1039HelicalSequence analysisAdd BLAST21
Topological domaini1040 – 1133LumenalSequence analysisAdd BLAST94
Transmembranei1134 – 1154HelicalSequence analysisAdd BLAST21
Topological domaini1155 – 1192CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cell projection Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • intracellular Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • plasma membrane Source: Reactome
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57142.
OpenTargetsiENSG00000115310.
PharmGKBiPA34883.

Chemistry databases

GuidetoPHARMACOLOGYi2838.

Polymorphism and mutation databases

BioMutaiRTN4.
DMDMi17369290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681651 – 1192Reticulon-4Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1 Publication1
Modified residuei107PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei184PhosphoserineBy similarity1
Modified residuei361PhosphoserineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei450PhosphothreonineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei858PhosphothreonineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei991PhosphoserineCombined sources1
Modified residuei1104N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQC3.
MaxQBiQ9NQC3.
PaxDbiQ9NQC3.
PeptideAtlasiQ9NQC3.
PRIDEiQ9NQC3.
TopDownProteomicsiQ9NQC3-2. [Q9NQC3-2]
Q9NQC3-3. [Q9NQC3-3]
Q9NQC3-4. [Q9NQC3-4]
Q9NQC3-5. [Q9NQC3-5]
Q9NQC3-6. [Q9NQC3-6]

PTM databases

iPTMnetiQ9NQC3.
PhosphoSitePlusiQ9NQC3.
SwissPalmiQ9NQC3.

Miscellaneous databases

PMAP-CutDBQ9NQC3.

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.

Gene expression databases

BgeeiENSG00000115310.
ExpressionAtlasiQ9NQC3. baseline and differential.
GenevisibleiQ9NQC3. HS.

Organism-specific databases

HPAiCAB005388.
HPA023977.

Interactioni

Subunit structurei

Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1. Interacts with TMEM170A (PubMed:26906412). Isoform 3 interacts with TMEM33 (PubMed:25612671).8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-715945,EBI-714543
ATL1Q8WXF72EBI-715972,EBI-2410266
NCK2O436392EBI-715945,EBI-713635
SNX1Q135963EBI-715945,EBI-2822329
SNX15Q9NRS64EBI-715945,EBI-725924
SYT16Q17RD73EBI-715945,EBI-10238936
ZFYVE21Q9BQ243EBI-10296096,EBI-2849569

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi121400. 105 interactors.
DIPiDIP-42003N.
IntActiQ9NQC3. 44 interactors.
MINTiMINT-154434.
STRINGi9606.ENSP00000337838.

Structurei

Secondary structure

11192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni1059 – 1062Combined sources4
Helixi1063 – 1070Combined sources8
Helixi1074 – 1094Combined sources21
Helixi1095 – 1097Combined sources3
Helixi1100 – 1107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G31NMR-A1055-1114[»]
2JV5NMR-A1055-1108[»]
DisProtiDP00524.
ProteinModelPortaliQ9NQC3.
SMRiQ9NQC3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQC3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1005 – 1192ReticulonPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 47Poly-GluAdd BLAST18
Compositional biasi143 – 148Poly-Pro6

Domaini

Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).By similarity

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000015254.
HOVERGENiHBG023134.
InParanoidiQ9NQC3.
KOiK20720.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ9NQC3.
TreeFamiTF105431.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQC3-1) [UniParc]FASTAAdd to basket
Also known as: RTN 4A, Nogo-A, RTN-xL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDLDQSPLV SSSDSPPRPQ PAFKYQFVRE PEDEEEEEEE EEEDEDEDLE
60 70 80 90 100
ELEVLERKPA AGLSAAPVPT APAAGAPLMD FGNDFVPPAP RGPLPAAPPV
110 120 130 140 150
APERQPSWDP SPVSSTVPAP SPLSAAAVSP SKLPEDDEPP ARPPPPPPAS
160 170 180 190 200
VSPQAEPVWT PPAPAPAAPP STPAAPKRRG SSGSVDETLF ALPAASEPVI
210 220 230 240 250
RSSAENMDLK EQPGNTISAG QEDFPSVLLE TAASLPSLSP LSAASFKEHE
260 270 280 290 300
YLGNLSTVLP TEGTLQENVS EASKEVSEKA KTLLIDRDLT EFSELEYSEM
310 320 330 340 350
GSSFSVSPKA ESAVIVANPR EEIIVKNKDE EEKLVSNNIL HNQQELPTAL
360 370 380 390 400
TKLVKEDEVV SSEKAKDSFN EKRVAVEAPM REEYADFKPF ERVWEVKDSK
410 420 430 440 450
EDSDMLAAGG KIESNLESKV DKKCFADSLE QTNHEKDSES SNDDTSFPST
460 470 480 490 500
PEGIKDRSGA YITCAPFNPA ATESIATNIF PLLGDPTSEN KTDEKKIEEK
510 520 530 540 550
KAQIVTEKNT STKTSNPFLV AAQDSETDYV TTDNLTKVTE EVVANMPEGL
560 570 580 590 600
TPDLVQEACE SELNEVTGTK IAYETKMDLV QTSEVMQESL YPAAQLCPSF
610 620 630 640 650
EESEATPSPV LPDIVMEAPL NSAVPSAGAS VIQPSSSPLE ASSVNYESIK
660 670 680 690 700
HEPENPPPYE EAMSVSLKKV SGIKEEIKEP ENINAALQET EAPYISIACD
710 720 730 740 750
LIKETKLSAE PAPDFSDYSE MAKVEQPVPD HSELVEDSSP DSEPVDLFSD
760 770 780 790 800
DSIPDVPQKQ DETVMLVKES LTETSFESMI EYENKEKLSA LPPEGGKPYL
810 820 830 840 850
ESFKLSLDNT KDTLLPDEVS TLSKKEKIPL QMEELSTAVY SNDDLFISKE
860 870 880 890 900
AQIRETETFS DSSPIEIIDE FPTLISSKTD SFSKLAREYT DLEVSHKSEI
910 920 930 940 950
ANAPDGAGSL PCTELPHDLS LKNIQPKVEE KISFSDDFSK NGSATSKVLL
960 970 980 990 1000
LPPDVSALAT QAEIESIVKP KVLVKEAEKK LPSDTEKEDR SPSAIFSAEL
1010 1020 1030 1040 1050
SKTSVVDLLY WRDIKKTGVV FGASLFLLLS LTVFSIVSVT AYIALALLSV
1060 1070 1080 1090 1100
TISFRIYKGV IQAIQKSDEG HPFRAYLESE VAISEELVQK YSNSALGHVN
1110 1120 1130 1140 1150
CTIKELRRLF LVDDLVDSLK FAVLMWVFTY VGALFNGLTL LILALISLFS
1160 1170 1180 1190
VPVIYERHQA QIDHYLGLAN KNVKDAMAKI QAKIPGLKRK AE
Length:1,192
Mass (Da):129,931
Last modified:November 16, 2001 - v2
Checksum:iCDE239BBF31589CA
GO
Isoform 2 (identifier: Q9NQC3-2) [UniParc]FASTAAdd to basket
Also known as: RTN 4B, ASY, Nogo-B, RTN-xS, Foocen-M

The sequence of this isoform differs from the canonical sequence as follows:
     186-1004: Missing.

Show »
Length:373
Mass (Da):40,318
Checksum:i8A19379EF91A59B4
GO
Isoform 3 (identifier: Q9NQC3-3) [UniParc]FASTAAdd to basket
Also known as: RTN 4C, Nogo-C, Foocen-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-993: Missing.
     994-1004: AIFSAELSKTS → MDGQKKNWKDK

Show »
Length:199
Mass (Da):22,395
Checksum:iC60161DF3FB34D80
GO
Isoform 4 (identifier: Q9NQC3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-289: Missing.

Show »
Length:960
Mass (Da):106,360
Checksum:i51B5E94CF103BA74
GO
Isoform 5 (identifier: Q9NQC3-5) [UniParc]FASTAAdd to basket
Also known as: RTN4-B2

The sequence of this isoform differs from the canonical sequence as follows:
     205-1004: Missing.

Show »
Length:392
Mass (Da):42,274
Checksum:iD7B2AA5E839E58AD
GO
Isoform 6 (identifier: Q9NQC3-6) [UniParc]FASTAAdd to basket
Also known as: Rtn-T

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.

Show »
Length:986
Mass (Da):108,450
Checksum:i0CDE8F647036415A
GO

Sequence cautioni

The sequence AAD39920 differs from that shown. Reason: Frameshift at positions 1149 and 1156.Curated
The sequence AAG43160 differs from that shown. Reason: Frameshift at positions 684 and 700.Curated
The sequence AAG43160 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA74909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107S → C in BAA83712 (Ref. 6) Curated1
Sequence conflicti135E → Q in BAA83712 (Ref. 6) Curated1
Sequence conflicti458S → P in CAB99248 (PubMed:10667780).Curated1
Sequence conflicti564N → S in AAK20831 (PubMed:11866689).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053633357D → V.Corresponds to variant rs11677099dbSNPEnsembl.1
Natural variantiVAR_035904429L → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053634899E → Q.Corresponds to variant rs6757519dbSNPEnsembl.1
Natural variantiVAR_053635920S → C.Corresponds to variant rs6757705dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056521 – 993Missing in isoform 3. 8 PublicationsAdd BLAST993
Alternative sequenceiVSP_0371121 – 206Missing in isoform 6. 2 PublicationsAdd BLAST206
Alternative sequenceiVSP_00565458 – 289Missing in isoform 4. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_005655186 – 1004Missing in isoform 2. 7 PublicationsAdd BLAST819
Alternative sequenceiVSP_037113205 – 1004Missing in isoform 5. 2 PublicationsAdd BLAST800
Alternative sequenceiVSP_005653994 – 1004AIFSAELSKTS → MDGQKKNWKDK in isoform 3. 8 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087901 mRNA. Translation: AAG12205.1.
AF148537 mRNA. Translation: AAG12176.1.
AF148538 mRNA. Translation: AAG12177.1.
AJ251383 mRNA. Translation: CAB99248.1.
AJ251384 mRNA. Translation: CAB99249.1.
AJ251385 mRNA. Translation: CAB99250.1.
AB040462 mRNA. Translation: BAB18927.1.
AB040463 mRNA. Translation: BAB18928.1.
AF333336 mRNA. Translation: AAK20831.1.
AY102285 Genomic DNA. Translation: AAM64240.1.
AY102285 Genomic DNA. Translation: AAM64241.1.
AY102285 Genomic DNA. Translation: AAM64242.1.
AY102285 Genomic DNA. Translation: AAM64243.1.
AY102285 Genomic DNA. Translation: AAM64244.1.
AY102276 mRNA. Translation: AAM64245.1.
AY102277 mRNA. Translation: AAM64246.1.
AY102278 mRNA. Translation: AAM64247.1.
AY102279 mRNA. Translation: AAM64248.1.
AY123245 mRNA. Translation: AAM64249.1.
AY123246 mRNA. Translation: AAM64250.1.
AY123247 mRNA. Translation: AAM64251.1.
AY123248 mRNA. Translation: AAM64252.1.
AY123249 mRNA. Translation: AAM64253.1.
AY123250 mRNA. Translation: AAM64254.1.
AB015639 mRNA. Translation: BAA83712.1.
AF077050 mRNA. Translation: AAD27783.1.
AF132047 mRNA. Translation: AAD31021.1.
AF132048 mRNA. Translation: AAD31022.1.
AF320999 mRNA. Translation: AAG40878.1.
AB020693 mRNA. Translation: BAA74909.2. Different initiation.
AF125103 mRNA. Translation: AAD39920.1. Frameshift.
AF177332 mRNA. Translation: AAG17976.1.
AC013414 Genomic DNA. No translation available.
AC092461 Genomic DNA. No translation available.
AC093165 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00115.1.
CH471053 Genomic DNA. Translation: EAX00116.1.
CH471053 Genomic DNA. Translation: EAX00117.1.
CH471053 Genomic DNA. Translation: EAX00118.1.
CH471053 Genomic DNA. Translation: EAX00119.1.
CH471053 Genomic DNA. Translation: EAX00121.1.
CH471053 Genomic DNA. Translation: EAX00122.1.
CH471053 Genomic DNA. Translation: EAX00123.1.
CH471053 Genomic DNA. Translation: EAX00124.1.
CH471053 Genomic DNA. Translation: EAX00125.1.
CH471053 Genomic DNA. Translation: EAX00127.1.
CH471053 Genomic DNA. Translation: EAX00130.1.
CH471053 Genomic DNA. Translation: EAX00132.1.
BC001035 mRNA. Translation: AAH01035.1.
BC007109 mRNA. Translation: AAH07109.1.
BC010737 mRNA. Translation: AAH10737.1.
BC012619 mRNA. Translation: AAH12619.1.
BC014366 mRNA. Translation: AAH14366.1.
BC016165 mRNA. Translation: AAH16165.1.
BC026788 mRNA. Translation: AAH26788.1.
BC068991 mRNA. Translation: AAH68991.1.
BC150182 mRNA. Translation: AAI50183.1.
BC152425 mRNA. Translation: AAI52426.1.
BC152555 mRNA. Translation: AAI52556.1.
AF063601 mRNA. Translation: AAG43160.1. Sequence problems.
CCDSiCCDS1851.1. [Q9NQC3-2]
CCDS1852.1. [Q9NQC3-6]
CCDS42683.1. [Q9NQC3-5]
CCDS42684.1. [Q9NQC3-1]
CCDS42685.1. [Q9NQC3-3]
RefSeqiNP_001308788.1. NM_001321859.1. [Q9NQC3-6]
NP_001308789.1. NM_001321860.1. [Q9NQC3-6]
NP_001308790.1. NM_001321861.1. [Q9NQC3-6]
NP_001308791.1. NM_001321862.1. [Q9NQC3-6]
NP_001308792.1. NM_001321863.1. [Q9NQC3-6]
NP_001308833.1. NM_001321904.1. [Q9NQC3-6]
NP_008939.1. NM_007008.2. [Q9NQC3-3]
NP_065393.1. NM_020532.4. [Q9NQC3-1]
NP_722550.1. NM_153828.2. [Q9NQC3-2]
NP_997403.1. NM_207520.1. [Q9NQC3-5]
NP_997404.1. NM_207521.1. [Q9NQC3-6]
XP_005264491.1. XM_005264434.3. [Q9NQC3-6]
XP_016860007.1. XM_017004518.1. [Q9NQC3-6]
XP_016860008.1. XM_017004519.1. [Q9NQC3-6]
UniGeneiHs.637850.

Genome annotation databases

EnsembliENST00000317610; ENSP00000322147; ENSG00000115310. [Q9NQC3-2]
ENST00000337526; ENSP00000337838; ENSG00000115310. [Q9NQC3-1]
ENST00000357376; ENSP00000349944; ENSG00000115310. [Q9NQC3-6]
ENST00000357732; ENSP00000350365; ENSG00000115310. [Q9NQC3-5]
ENST00000394609; ENSP00000378107; ENSG00000115310. [Q9NQC3-3]
ENST00000394611; ENSP00000378109; ENSG00000115310. [Q9NQC3-6]
ENST00000404909; ENSP00000385650; ENSG00000115310. [Q9NQC3-6]
ENST00000405240; ENSP00000384471; ENSG00000115310. [Q9NQC3-6]
GeneIDi57142.
KEGGihsa:57142.
UCSCiuc002ryc.4. human. [Q9NQC3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Protein Spotlight

Nerve regrowth: nipped by a no-go - Issue 69 of April 2006

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087901 mRNA. Translation: AAG12205.1.
AF148537 mRNA. Translation: AAG12176.1.
AF148538 mRNA. Translation: AAG12177.1.
AJ251383 mRNA. Translation: CAB99248.1.
AJ251384 mRNA. Translation: CAB99249.1.
AJ251385 mRNA. Translation: CAB99250.1.
AB040462 mRNA. Translation: BAB18927.1.
AB040463 mRNA. Translation: BAB18928.1.
AF333336 mRNA. Translation: AAK20831.1.
AY102285 Genomic DNA. Translation: AAM64240.1.
AY102285 Genomic DNA. Translation: AAM64241.1.
AY102285 Genomic DNA. Translation: AAM64242.1.
AY102285 Genomic DNA. Translation: AAM64243.1.
AY102285 Genomic DNA. Translation: AAM64244.1.
AY102276 mRNA. Translation: AAM64245.1.
AY102277 mRNA. Translation: AAM64246.1.
AY102278 mRNA. Translation: AAM64247.1.
AY102279 mRNA. Translation: AAM64248.1.
AY123245 mRNA. Translation: AAM64249.1.
AY123246 mRNA. Translation: AAM64250.1.
AY123247 mRNA. Translation: AAM64251.1.
AY123248 mRNA. Translation: AAM64252.1.
AY123249 mRNA. Translation: AAM64253.1.
AY123250 mRNA. Translation: AAM64254.1.
AB015639 mRNA. Translation: BAA83712.1.
AF077050 mRNA. Translation: AAD27783.1.
AF132047 mRNA. Translation: AAD31021.1.
AF132048 mRNA. Translation: AAD31022.1.
AF320999 mRNA. Translation: AAG40878.1.
AB020693 mRNA. Translation: BAA74909.2. Different initiation.
AF125103 mRNA. Translation: AAD39920.1. Frameshift.
AF177332 mRNA. Translation: AAG17976.1.
AC013414 Genomic DNA. No translation available.
AC092461 Genomic DNA. No translation available.
AC093165 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00115.1.
CH471053 Genomic DNA. Translation: EAX00116.1.
CH471053 Genomic DNA. Translation: EAX00117.1.
CH471053 Genomic DNA. Translation: EAX00118.1.
CH471053 Genomic DNA. Translation: EAX00119.1.
CH471053 Genomic DNA. Translation: EAX00121.1.
CH471053 Genomic DNA. Translation: EAX00122.1.
CH471053 Genomic DNA. Translation: EAX00123.1.
CH471053 Genomic DNA. Translation: EAX00124.1.
CH471053 Genomic DNA. Translation: EAX00125.1.
CH471053 Genomic DNA. Translation: EAX00127.1.
CH471053 Genomic DNA. Translation: EAX00130.1.
CH471053 Genomic DNA. Translation: EAX00132.1.
BC001035 mRNA. Translation: AAH01035.1.
BC007109 mRNA. Translation: AAH07109.1.
BC010737 mRNA. Translation: AAH10737.1.
BC012619 mRNA. Translation: AAH12619.1.
BC014366 mRNA. Translation: AAH14366.1.
BC016165 mRNA. Translation: AAH16165.1.
BC026788 mRNA. Translation: AAH26788.1.
BC068991 mRNA. Translation: AAH68991.1.
BC150182 mRNA. Translation: AAI50183.1.
BC152425 mRNA. Translation: AAI52426.1.
BC152555 mRNA. Translation: AAI52556.1.
AF063601 mRNA. Translation: AAG43160.1. Sequence problems.
CCDSiCCDS1851.1. [Q9NQC3-2]
CCDS1852.1. [Q9NQC3-6]
CCDS42683.1. [Q9NQC3-5]
CCDS42684.1. [Q9NQC3-1]
CCDS42685.1. [Q9NQC3-3]
RefSeqiNP_001308788.1. NM_001321859.1. [Q9NQC3-6]
NP_001308789.1. NM_001321860.1. [Q9NQC3-6]
NP_001308790.1. NM_001321861.1. [Q9NQC3-6]
NP_001308791.1. NM_001321862.1. [Q9NQC3-6]
NP_001308792.1. NM_001321863.1. [Q9NQC3-6]
NP_001308833.1. NM_001321904.1. [Q9NQC3-6]
NP_008939.1. NM_007008.2. [Q9NQC3-3]
NP_065393.1. NM_020532.4. [Q9NQC3-1]
NP_722550.1. NM_153828.2. [Q9NQC3-2]
NP_997403.1. NM_207520.1. [Q9NQC3-5]
NP_997404.1. NM_207521.1. [Q9NQC3-6]
XP_005264491.1. XM_005264434.3. [Q9NQC3-6]
XP_016860007.1. XM_017004518.1. [Q9NQC3-6]
XP_016860008.1. XM_017004519.1. [Q9NQC3-6]
UniGeneiHs.637850.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G31NMR-A1055-1114[»]
2JV5NMR-A1055-1108[»]
DisProtiDP00524.
ProteinModelPortaliQ9NQC3.
SMRiQ9NQC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121400. 105 interactors.
DIPiDIP-42003N.
IntActiQ9NQC3. 44 interactors.
MINTiMINT-154434.
STRINGi9606.ENSP00000337838.

Chemistry databases

GuidetoPHARMACOLOGYi2838.

PTM databases

iPTMnetiQ9NQC3.
PhosphoSitePlusiQ9NQC3.
SwissPalmiQ9NQC3.

Polymorphism and mutation databases

BioMutaiRTN4.
DMDMi17369290.

Proteomic databases

EPDiQ9NQC3.
MaxQBiQ9NQC3.
PaxDbiQ9NQC3.
PeptideAtlasiQ9NQC3.
PRIDEiQ9NQC3.
TopDownProteomicsiQ9NQC3-2. [Q9NQC3-2]
Q9NQC3-3. [Q9NQC3-3]
Q9NQC3-4. [Q9NQC3-4]
Q9NQC3-5. [Q9NQC3-5]
Q9NQC3-6. [Q9NQC3-6]

Protocols and materials databases

DNASUi57142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317610; ENSP00000322147; ENSG00000115310. [Q9NQC3-2]
ENST00000337526; ENSP00000337838; ENSG00000115310. [Q9NQC3-1]
ENST00000357376; ENSP00000349944; ENSG00000115310. [Q9NQC3-6]
ENST00000357732; ENSP00000350365; ENSG00000115310. [Q9NQC3-5]
ENST00000394609; ENSP00000378107; ENSG00000115310. [Q9NQC3-3]
ENST00000394611; ENSP00000378109; ENSG00000115310. [Q9NQC3-6]
ENST00000404909; ENSP00000385650; ENSG00000115310. [Q9NQC3-6]
ENST00000405240; ENSP00000384471; ENSG00000115310. [Q9NQC3-6]
GeneIDi57142.
KEGGihsa:57142.
UCSCiuc002ryc.4. human. [Q9NQC3-1]

Organism-specific databases

CTDi57142.
DisGeNETi57142.
GeneCardsiRTN4.
H-InvDBHIX0002059.
HGNCiHGNC:14085. RTN4.
HPAiCAB005388.
HPA023977.
MIMi604475. gene.
neXtProtiNX_Q9NQC3.
OpenTargetsiENSG00000115310.
PharmGKBiPA34883.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000015254.
HOVERGENiHBG023134.
InParanoidiQ9NQC3.
KOiK20720.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ9NQC3.
TreeFamiTF105431.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115310-MONOMER.
ReactomeiR-HSA-193634. Axonal growth inhibition (RHOA activation).
SIGNORiQ9NQC3.

Miscellaneous databases

ChiTaRSiRTN4. human.
EvolutionaryTraceiQ9NQC3.
GeneWikiiReticulon_4.
GenomeRNAii57142.
PMAP-CutDBQ9NQC3.
PROiQ9NQC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115310.
ExpressionAtlasiQ9NQC3. baseline and differential.
GenevisibleiQ9NQC3. HS.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN4_HUMAN
AccessioniPrimary (citable) accession number: Q9NQC3
Secondary accession number(s): O94962
, Q7L7Q5, Q7L7Q6, Q7L7Q8, Q8IUA4, Q96B16, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 175 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.