Q9NQC1D3DQA3Q6IE80Q8TEK0Q92513Q96GQ6JADE2_HUMANE3 ubiquitin-protein ligase Jade-22.3.2.27Jade family PHD finger protein 2PHD finger protein 15JADE2KIAA0239PHF15Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoPrediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)The DNA sequence and comparative analysis of human chromosome 5.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)Isolation and characterisation of a 64 kDa protein associated with the lysosomal/autophagic compartment.NUCLEOTIDE SEQUENCE [MRNA] OF 202-790 (ISOFORM 1)Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.IDENTIFICATIONING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.FUNCTION IN HISTONE H4 ACETYLATIONIDENTIFICATION BY MASS SPECTROMETRYIDENTIFICATION IN THE HBO1 COMPLEXA quantitative atlas of mitotic phosphorylation.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Lysine acetylation targets protein complexes and co-regulates major cellular functions.ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-38 AND LYS-298IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Toward a comprehensive characterization of a human cancer cell phosphoproteome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.FUNCTIONCATALYTIC ACTIVITYINTERACTION WITH KDM1ADOMAINMUTAGENESIS OF CYS-202 AND CYS-243Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.Protein modification; protein ubiquitination.Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (PubMed:16387653). Interacts (via C-terminus) with KDM1A (via AOD/Tower domain) (PubMed:25018020).Q9NQC1Q8WYH8false4Q9NQC1-2P01100false3Q9NQC1-2Q9H8Y8false3Q9NQC1-2P62993false3Q9NQC1-11Q9NQC1-22Q9NQC1-33The first PHD domain is essential for its E3 ubiquitin ligase activity.Belongs to the JADE family.Extended N-terminus.Truncated N-terminus.AcetylationAlternative splicingMetal-bindingPhosphoproteinReference proteomeRepeatTransferaseUbl conjugation pathwayZincZinc-fingerGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLASERSGRRAKGKKSDSKRKGCEGSKGSTEKKEKVKAGPDSVLGQLGERGCACATIMEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSSTMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQNMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLAEALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLPGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAEEVVRMGVLAS
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