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Q9NQC1

- JADE2_HUMAN

UniProt

Q9NQC1 - JADE2_HUMAN

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Protein
Protein Jade-2
Gene
JADE2, KIAA0239, PHF15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 24951PHD-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H3 acetylation Source: UniProtKB
  2. histone H4-K12 acetylation Source: UniProtKB
  3. histone H4-K5 acetylation Source: UniProtKB
  4. histone H4-K8 acetylation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-2
Alternative name(s):
Jade family PHD finger protein 2
PHD finger protein 15
Gene namesi
Name:JADE2
Synonyms:KIAA0239, PHF15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:22984. JADE2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. histone acetyltransferase complex Source: UniProtKB
  3. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Protein Jade-2
PRO_0000059308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321N6-acetyllysine1 Publication
Modified residuei38 – 381N6-acetyllysine1 Publication
Modified residuei298 – 2981N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NQC1.
PaxDbiQ9NQC1.
PRIDEiQ9NQC1.

Expressioni

Gene expression databases

ArrayExpressiQ9NQC1.
BgeeiQ9NQC1.
CleanExiHS_PHF15.
GenevestigatoriQ9NQC1.

Organism-specific databases

HPAiHPA025959.
HPA055789.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.1 Publication

Protein-protein interaction databases

BioGridi116924. 8 interactions.
IntActiQ9NQC1. 7 interactions.
STRINGi9606.ENSP00000378451.

Structurei

3D structure databases

ProteinModelPortaliQ9NQC1.
SMRiQ9NQC1. Positions 197-246, 301-346.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi601 – 732132Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the JADE family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5141.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
PhylomeDBiQ9NQC1.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQC1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS    50
EVFRTDLITA MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE 100
PVVRILPPLE GPPAQASPSS TMLGEGSQPD WPGGSRYDLD EIDAYWLELI 150
NSELKEMERP ELDELTLERV LEELETLCHQ NMARAIETQE GLGIEYDEDV 200
VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS WLCRTCALGV 250
QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS 300
HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA 350
DNDEVKFKSF CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL 400
EEDFYELVEP AEVAERLDLA EALVDFIYQY WKLKRKANAN QPLLTPKTDE 450
VDNLAQQEQD VLYRRLKLFT HLRQDLERVR NLCYMVTRRE RTKHAICKLQ 500
EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI TAENMAMSEW 550
PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL 600
PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR 650
TSSHLPSSPA AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA 700
SPKPLGRLRP PRESKVTRRL PGARPDAGMG PPSAVAERPK VSLHFDTETD 750
GYFSDGEMSD SDVEAEDGGV QRGPREAGAE EVVRMGVLAS 790
Length:790
Mass (Da):87,466
Last modified:October 17, 2006 - v2
Checksum:i22C1B1A0360BC1AE
GO
Isoform 2 (identifier: Q9NQC1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: Missing.

Show »
Length:789
Mass (Da):87,409
Checksum:iEFCA863CE55B6297
GO
Isoform 3 (identifier: Q9NQC1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-790: GLSTSFPIDG...EVVRMGVLAS → ERSGRRAKGK...PDSVLGQLGE

Note: No experimental confirmation available.

Show »
Length:562
Mass (Da):63,466
Checksum:i6C53A5098E9966BA
GO

Sequence cautioni

The sequence BAB84949.1 differs from that shown. Reason: Frameshift at position 11.
The sequence BAA13245.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAB94935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti581 – 5811R → G.
Corresponds to variant rs34200923 [ dbSNP | Ensembl ].
VAR_053778

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei518 – 790273GLSTS…GVLAS → ERSGRRAKGKKSDSKRKGCE GSKGSTEKKEKVKAGPDSVL GQLGE in isoform 3.
VSP_021050Add
BLAST
Alternative sequencei518 – 5181Missing in isoform 2.
VSP_021051

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311T → I in BAA13245. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87076 mRNA. Translation: BAA13245.2. Different initiation.
AK074123 mRNA. Translation: BAB84949.1. Frameshift.
BC009307 mRNA. Translation: AAH09307.2.
BC021962 mRNA. Translation: AAH21962.2.
AC005355 Genomic DNA. No translation available.
AC106763 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62253.1.
CH471062 Genomic DNA. Translation: EAW62254.1.
AJ251833 mRNA. Translation: CAB94935.1. Different initiation.
BN000288 mRNA. Translation: CAE30501.1.
CCDSiCCDS4176.1. [Q9NQC1-1]
RefSeqiNP_001276913.1. NM_001289984.1.
NP_001276914.1. NM_001289985.1.
NP_056103.4. NM_015288.5. [Q9NQC1-1]
UniGeneiHs.732155.

Genome annotation databases

EnsembliENST00000361895; ENSP00000354425; ENSG00000043143.
ENST00000395003; ENSP00000378451; ENSG00000043143. [Q9NQC1-1]
GeneIDi23338.
KEGGihsa:23338.
UCSCiuc003kzl.2. human. [Q9NQC1-3]
uc003kzm.2. human.
uc003kzo.1. human. [Q9NQC1-1]

Polymorphism databases

DMDMi116242597.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87076 mRNA. Translation: BAA13245.2 . Different initiation.
AK074123 mRNA. Translation: BAB84949.1 . Frameshift.
BC009307 mRNA. Translation: AAH09307.2 .
BC021962 mRNA. Translation: AAH21962.2 .
AC005355 Genomic DNA. No translation available.
AC106763 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62253.1 .
CH471062 Genomic DNA. Translation: EAW62254.1 .
AJ251833 mRNA. Translation: CAB94935.1 . Different initiation.
BN000288 mRNA. Translation: CAE30501.1 .
CCDSi CCDS4176.1. [Q9NQC1-1 ]
RefSeqi NP_001276913.1. NM_001289984.1.
NP_001276914.1. NM_001289985.1.
NP_056103.4. NM_015288.5. [Q9NQC1-1 ]
UniGenei Hs.732155.

3D structure databases

ProteinModelPortali Q9NQC1.
SMRi Q9NQC1. Positions 197-246, 301-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116924. 8 interactions.
IntActi Q9NQC1. 7 interactions.
STRINGi 9606.ENSP00000378451.

Polymorphism databases

DMDMi 116242597.

Proteomic databases

MaxQBi Q9NQC1.
PaxDbi Q9NQC1.
PRIDEi Q9NQC1.

Protocols and materials databases

DNASUi 23338.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361895 ; ENSP00000354425 ; ENSG00000043143 .
ENST00000395003 ; ENSP00000378451 ; ENSG00000043143 . [Q9NQC1-1 ]
GeneIDi 23338.
KEGGi hsa:23338.
UCSCi uc003kzl.2. human. [Q9NQC1-3 ]
uc003kzm.2. human.
uc003kzo.1. human. [Q9NQC1-1 ]

Organism-specific databases

CTDi 23338.
GeneCardsi GC05P133860.
H-InvDB HIX0005181.
HGNCi HGNC:22984. JADE2.
HPAi HPA025959.
HPA055789.
MIMi 610515. gene.
neXtProti NX_Q9NQC1.
PharmGKBi PA128394627.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5141.
HOGENOMi HOG000220882.
HOVERGENi HBG053585.
PhylomeDBi Q9NQC1.
TreeFami TF316118.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi PHF15. human.
GenomeRNAii 23338.
NextBioi 35489874.
PROi Q9NQC1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQC1.
Bgeei Q9NQC1.
CleanExi HS_PHF15.
Genevestigatori Q9NQC1.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF10513. EPL1. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Melanoma and Uterus.
  6. "Isolation and characterisation of a 64 kDa protein associated with the lysosomal/autophagic compartment."
    Tesmann S., Biederbick A., Elsaesser H.P.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-790 (ISOFORM 1).
  7. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
    Tzouanacou E., Tweedie S., Wilson V.
    Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
    Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
    Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-38 AND LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJADE2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQC1
Secondary accession number(s): D3DQA3
, Q6IE80, Q8TEK0, Q92513, Q96GQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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