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Protein

Protein Jade-2

Gene

JADE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 24951PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H3 acetylation Source: UniProtKB
  2. histone H4-K12 acetylation Source: UniProtKB
  3. histone H4-K5 acetylation Source: UniProtKB
  4. histone H4-K8 acetylation Source: UniProtKB
  5. SMAD protein signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_264245. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jade-2
Alternative name(s):
Jade family PHD finger protein 2
PHD finger protein 15
Gene namesi
Name:JADE2
Synonyms:KIAA0239, PHF15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:22984. JADE2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. histone acetyltransferase complex Source: UniProtKB
  3. nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394627.

Polymorphism and mutation databases

BioMutaiPHF15.
DMDMi116242597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Protein Jade-2PRO_0000059308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine1 Publication
Modified residuei32 – 321N6-acetyllysine1 Publication
Modified residuei38 – 381N6-acetyllysine1 Publication
Modified residuei298 – 2981N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NQC1.
PaxDbiQ9NQC1.
PRIDEiQ9NQC1.

Expressioni

Gene expression databases

BgeeiQ9NQC1.
CleanExiHS_PHF15.
ExpressionAtlasiQ9NQC1. baseline and differential.
GenevestigatoriQ9NQC1.

Organism-specific databases

HPAiHPA025959.
HPA055789.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GORASP2Q9H8Y83EBI-10311936,EBI-739467
ING5Q8WYH83EBI-2796167,EBI-488533

Protein-protein interaction databases

BioGridi116924. 20 interactions.
IntActiQ9NQC1. 9 interactions.
STRINGi9606.ENSP00000378451.

Structurei

3D structure databases

ProteinModelPortaliQ9NQC1.
SMRiQ9NQC1. Positions 197-246, 301-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi601 – 732132Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the JADE family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 24951PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5141.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ9NQC1.
PhylomeDBiQ9NQC1.
TreeFamiTF316118.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS
60 70 80 90 100
EVFRTDLITA MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE
110 120 130 140 150
PVVRILPPLE GPPAQASPSS TMLGEGSQPD WPGGSRYDLD EIDAYWLELI
160 170 180 190 200
NSELKEMERP ELDELTLERV LEELETLCHQ NMARAIETQE GLGIEYDEDV
210 220 230 240 250
VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS WLCRTCALGV
260 270 280 290 300
QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS
310 320 330 340 350
HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA
360 370 380 390 400
DNDEVKFKSF CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL
410 420 430 440 450
EEDFYELVEP AEVAERLDLA EALVDFIYQY WKLKRKANAN QPLLTPKTDE
460 470 480 490 500
VDNLAQQEQD VLYRRLKLFT HLRQDLERVR NLCYMVTRRE RTKHAICKLQ
510 520 530 540 550
EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI TAENMAMSEW
560 570 580 590 600
PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL
610 620 630 640 650
PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR
660 670 680 690 700
TSSHLPSSPA AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA
710 720 730 740 750
SPKPLGRLRP PRESKVTRRL PGARPDAGMG PPSAVAERPK VSLHFDTETD
760 770 780 790
GYFSDGEMSD SDVEAEDGGV QRGPREAGAE EVVRMGVLAS
Length:790
Mass (Da):87,466
Last modified:October 17, 2006 - v2
Checksum:i22C1B1A0360BC1AE
GO
Isoform 2 (identifier: Q9NQC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: Missing.

Show »
Length:789
Mass (Da):87,409
Checksum:iEFCA863CE55B6297
GO
Isoform 3 (identifier: Q9NQC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-790: GLSTSFPIDG...EVVRMGVLAS → ERSGRRAKGK...PDSVLGQLGE

Note: No experimental confirmation available.

Show »
Length:562
Mass (Da):63,466
Checksum:i6C53A5098E9966BA
GO

Sequence cautioni

The sequence BAA13245.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84949.1 differs from that shown. Reason: Frameshift at position 11. Curated
The sequence CAB94935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti331 – 3311T → I in BAA13245 (PubMed:9039502).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti581 – 5811R → G.
Corresponds to variant rs34200923 [ dbSNP | Ensembl ].
VAR_053778

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei518 – 790273GLSTS…GVLAS → ERSGRRAKGKKSDSKRKGCE GSKGSTEKKEKVKAGPDSVL GQLGE in isoform 3. 1 PublicationVSP_021050Add
BLAST
Alternative sequencei518 – 5181Missing in isoform 2. 2 PublicationsVSP_021051

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87076 mRNA. Translation: BAA13245.2. Different initiation.
AK074123 mRNA. Translation: BAB84949.1. Frameshift.
BC009307 mRNA. Translation: AAH09307.2.
BC021962 mRNA. Translation: AAH21962.2.
AC005355 Genomic DNA. No translation available.
AC106763 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62253.1.
CH471062 Genomic DNA. Translation: EAW62254.1.
AJ251833 mRNA. Translation: CAB94935.1. Different initiation.
BN000288 mRNA. Translation: CAE30501.1.
CCDSiCCDS4176.1. [Q9NQC1-1]
RefSeqiNP_001276913.1. NM_001289984.1.
NP_001276914.1. NM_001289985.1.
NP_056103.4. NM_015288.5. [Q9NQC1-1]
UniGeneiHs.732155.

Genome annotation databases

EnsembliENST00000395003; ENSP00000378451; ENSG00000043143. [Q9NQC1-1]
GeneIDi23338.
KEGGihsa:23338.
UCSCiuc003kzl.2. human. [Q9NQC1-3]
uc003kzm.2. human.
uc003kzo.1. human. [Q9NQC1-1]

Polymorphism and mutation databases

BioMutaiPHF15.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87076 mRNA. Translation: BAA13245.2. Different initiation.
AK074123 mRNA. Translation: BAB84949.1. Frameshift.
BC009307 mRNA. Translation: AAH09307.2.
BC021962 mRNA. Translation: AAH21962.2.
AC005355 Genomic DNA. No translation available.
AC106763 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62253.1.
CH471062 Genomic DNA. Translation: EAW62254.1.
AJ251833 mRNA. Translation: CAB94935.1. Different initiation.
BN000288 mRNA. Translation: CAE30501.1.
CCDSiCCDS4176.1. [Q9NQC1-1]
RefSeqiNP_001276913.1. NM_001289984.1.
NP_001276914.1. NM_001289985.1.
NP_056103.4. NM_015288.5. [Q9NQC1-1]
UniGeneiHs.732155.

3D structure databases

ProteinModelPortaliQ9NQC1.
SMRiQ9NQC1. Positions 197-246, 301-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116924. 20 interactions.
IntActiQ9NQC1. 9 interactions.
STRINGi9606.ENSP00000378451.

Polymorphism and mutation databases

BioMutaiPHF15.
DMDMi116242597.

Proteomic databases

MaxQBiQ9NQC1.
PaxDbiQ9NQC1.
PRIDEiQ9NQC1.

Protocols and materials databases

DNASUi23338.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395003; ENSP00000378451; ENSG00000043143. [Q9NQC1-1]
GeneIDi23338.
KEGGihsa:23338.
UCSCiuc003kzl.2. human. [Q9NQC1-3]
uc003kzm.2. human.
uc003kzo.1. human. [Q9NQC1-1]

Organism-specific databases

CTDi23338.
GeneCardsiGC05P133861.
H-InvDBHIX0005181.
HGNCiHGNC:22984. JADE2.
HPAiHPA025959.
HPA055789.
MIMi610515. gene.
neXtProtiNX_Q9NQC1.
PharmGKBiPA128394627.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5141.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000220882.
HOVERGENiHBG053585.
InParanoidiQ9NQC1.
PhylomeDBiQ9NQC1.
TreeFamiTF316118.

Enzyme and pathway databases

ReactomeiREACT_264245. HATs acetylate histones.

Miscellaneous databases

GenomeRNAii23338.
NextBioi35489874.
PROiQ9NQC1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NQC1.
CleanExiHS_PHF15.
ExpressionAtlasiQ9NQC1. baseline and differential.
GenevestigatoriQ9NQC1.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
    Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
    DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Spleen.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Melanoma and Uterus.
  6. "Isolation and characterisation of a 64 kDa protein associated with the lysosomal/autophagic compartment."
    Tesmann S., Biederbick A., Elsaesser H.P.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-790 (ISOFORM 1).
  7. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
    Tzouanacou E., Tweedie S., Wilson V.
    Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
    Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
    Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-38 AND LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiJADE2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQC1
Secondary accession number(s): D3DQA3
, Q6IE80, Q8TEK0, Q92513, Q96GQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.