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Q9NQC1 (JADE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Jade-2
Alternative name(s):
Jade family PHD finger protein 2
PHD finger protein 15
Gene names
Name:JADE2
Synonyms:KIAA0239, PHF15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length790 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Ref.8

Subunit structure

Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Ref.8

Sequence similarities

Belongs to the JADE family.

Contains 1 PHD-type zinc finger.

Sequence caution

The sequence BAA13245.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB84949.1 differs from that shown. Reason: Frameshift at position 11.

The sequence CAB94935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NQC1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NQC1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: Missing.
Isoform 3 (identifier: Q9NQC1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     518-790: GLSTSFPIDG...EVVRMGVLAS → ERSGRRAKGK...PDSVLGQLGE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 790790Protein Jade-2
PRO_0000059308

Regions

Zinc finger199 – 24951PHD-type
Compositional bias601 – 732132Pro-rich

Amino acid modifications

Modified residue321N6-acetyllysine Ref.10
Modified residue381N6-acetyllysine Ref.10
Modified residue2981N6-acetyllysine Ref.10

Natural variations

Alternative sequence518 – 790273GLSTS…GVLAS → ERSGRRAKGKKSDSKRKGCE GSKGSTEKKEKVKAGPDSVL GQLGE in isoform 3.
VSP_021050
Alternative sequence5181Missing in isoform 2.
VSP_021051
Natural variant5811R → G.
Corresponds to variant rs34200923 [ dbSNP | Ensembl ].
VAR_053778

Experimental info

Sequence conflict3311T → I in BAA13245. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 22C1B1A0360BC1AE

FASTA79087,466
        10         20         30         40         50         60 
MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS EVFRTDLITA 

        70         80         90        100        110        120 
MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE PVVRILPPLE GPPAQASPSS 

       130        140        150        160        170        180 
TMLGEGSQPD WPGGSRYDLD EIDAYWLELI NSELKEMERP ELDELTLERV LEELETLCHQ 

       190        200        210        220        230        240 
NMARAIETQE GLGIEYDEDV VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS 

       250        260        270        280        290        300 
WLCRTCALGV QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS 

       310        320        330        340        350        360 
HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA DNDEVKFKSF 

       370        380        390        400        410        420 
CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL EEDFYELVEP AEVAERLDLA 

       430        440        450        460        470        480 
EALVDFIYQY WKLKRKANAN QPLLTPKTDE VDNLAQQEQD VLYRRLKLFT HLRQDLERVR 

       490        500        510        520        530        540 
NLCYMVTRRE RTKHAICKLQ EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI 

       550        560        570        580        590        600 
TAENMAMSEW PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL 

       610        620        630        640        650        660 
PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR TSSHLPSSPA 

       670        680        690        700        710        720 
AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA SPKPLGRLRP PRESKVTRRL 

       730        740        750        760        770        780 
PGARPDAGMG PPSAVAERPK VSLHFDTETD GYFSDGEMSD SDVEAEDGGV QRGPREAGAE 

       790 
EVVRMGVLAS 

« Hide

Isoform 2 [UniParc].

Checksum: EFCA863CE55B6297
Show »

FASTA78987,409
Isoform 3 [UniParc].

Checksum: 6C53A5098E9966BA
Show »

FASTA56263,466

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Bone marrow.
[2]"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Spleen.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Melanoma and Uterus.
[6]"Isolation and characterisation of a 64 kDa protein associated with the lysosomal/autophagic compartment."
Tesmann S., Biederbick A., Elsaesser H.P.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-790 (ISOFORM 1).
[7]"Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
Tzouanacou E., Tweedie S., Wilson V.
Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-38 AND LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87076 mRNA. Translation: BAA13245.2. Different initiation.
AK074123 mRNA. Translation: BAB84949.1. Frameshift.
BC009307 mRNA. Translation: AAH09307.2.
BC021962 mRNA. Translation: AAH21962.2.
AC005355 Genomic DNA. No translation available.
AC106763 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62253.1.
CH471062 Genomic DNA. Translation: EAW62254.1.
AJ251833 mRNA. Translation: CAB94935.1. Different initiation.
BN000288 mRNA. Translation: CAE30501.1.
CCDSCCDS4176.1. [Q9NQC1-1]
RefSeqNP_001276913.1. NM_001289984.1.
NP_001276914.1. NM_001289985.1.
NP_056103.4. NM_015288.5. [Q9NQC1-1]
UniGeneHs.732155.

3D structure databases

ProteinModelPortalQ9NQC1.
SMRQ9NQC1. Positions 197-246, 301-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116924. 8 interactions.
IntActQ9NQC1. 7 interactions.
STRING9606.ENSP00000378451.

Polymorphism databases

DMDM116242597.

Proteomic databases

MaxQBQ9NQC1.
PaxDbQ9NQC1.
PRIDEQ9NQC1.

Protocols and materials databases

DNASU23338.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361895; ENSP00000354425; ENSG00000043143.
ENST00000395003; ENSP00000378451; ENSG00000043143. [Q9NQC1-1]
GeneID23338.
KEGGhsa:23338.
UCSCuc003kzl.2. human. [Q9NQC1-3]
uc003kzm.2. human.
uc003kzo.1. human. [Q9NQC1-1]

Organism-specific databases

CTD23338.
GeneCardsGC05P133860.
H-InvDBHIX0005181.
HGNCHGNC:22984. JADE2.
HPAHPA025959.
HPA055789.
MIM610515. gene.
neXtProtNX_Q9NQC1.
PharmGKBPA128394627.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5141.
HOGENOMHOG000220882.
HOVERGENHBG053585.
PhylomeDBQ9NQC1.
TreeFamTF316118.

Enzyme and pathway databases

ReactomeREACT_172623. Chromatin organization.

Gene expression databases

ArrayExpressQ9NQC1.
BgeeQ9NQC1.
CleanExHS_PHF15.
GenevestigatorQ9NQC1.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF10513. EPL1. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPHF15. human.
GenomeRNAi23338.
NextBio35489874.
PROQ9NQC1.
SOURCESearch...

Entry information

Entry nameJADE2_HUMAN
AccessionPrimary (citable) accession number: Q9NQC1
Secondary accession number(s): D3DQA3 expand/collapse secondary AC list , Q6IE80, Q8TEK0, Q92513, Q96GQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM