Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NQC1

- JADE2_HUMAN

UniProt

Q9NQC1 - JADE2_HUMAN

Protein

Protein Jade-2

Gene

JADE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri199 – 24951PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone H3 acetylation Source: UniProtKB
    2. histone H4-K12 acetylation Source: UniProtKB
    3. histone H4-K5 acetylation Source: UniProtKB
    4. histone H4-K8 acetylation Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Jade-2
    Alternative name(s):
    Jade family PHD finger protein 2
    PHD finger protein 15
    Gene namesi
    Name:JADE2
    Synonyms:KIAA0239, PHF15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:22984. JADE2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. histone acetyltransferase complex Source: UniProtKB
    3. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394627.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 790790Protein Jade-2PRO_0000059308Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei32 – 321N6-acetyllysine1 Publication
    Modified residuei38 – 381N6-acetyllysine1 Publication
    Modified residuei298 – 2981N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NQC1.
    PaxDbiQ9NQC1.
    PRIDEiQ9NQC1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NQC1.
    BgeeiQ9NQC1.
    CleanExiHS_PHF15.
    GenevestigatoriQ9NQC1.

    Organism-specific databases

    HPAiHPA025959.
    HPA055789.

    Interactioni

    Subunit structurei

    Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.1 Publication

    Protein-protein interaction databases

    BioGridi116924. 8 interactions.
    IntActiQ9NQC1. 7 interactions.
    STRINGi9606.ENSP00000378451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQC1.
    SMRiQ9NQC1. Positions 197-246, 301-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi601 – 732132Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the JADE family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri199 – 24951PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5141.
    HOGENOMiHOG000220882.
    HOVERGENiHBG053585.
    PhylomeDBiQ9NQC1.
    TreeFamiTF316118.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10513. EPL1. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQC1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS    50
    EVFRTDLITA MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE 100
    PVVRILPPLE GPPAQASPSS TMLGEGSQPD WPGGSRYDLD EIDAYWLELI 150
    NSELKEMERP ELDELTLERV LEELETLCHQ NMARAIETQE GLGIEYDEDV 200
    VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS WLCRTCALGV 250
    QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS 300
    HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA 350
    DNDEVKFKSF CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL 400
    EEDFYELVEP AEVAERLDLA EALVDFIYQY WKLKRKANAN QPLLTPKTDE 450
    VDNLAQQEQD VLYRRLKLFT HLRQDLERVR NLCYMVTRRE RTKHAICKLQ 500
    EQIFHLQMKL IEQDLCRGLS TSFPIDGTFF NSWLAQSVQI TAENMAMSEW 550
    PLNNGHREDP APGLLSEELL QDEETLLSFM RDPSLRPGDP ARKARGRTRL 600
    PAKKKPPPPP PQDGPGSRTT PDKAPKKTWG QDAGSGKGGQ GPPTRKPPRR 650
    TSSHLPSSPA AGDCPILATP ESPPPLAPET PDEAASVAAD SDVQVPGPAA 700
    SPKPLGRLRP PRESKVTRRL PGARPDAGMG PPSAVAERPK VSLHFDTETD 750
    GYFSDGEMSD SDVEAEDGGV QRGPREAGAE EVVRMGVLAS 790
    Length:790
    Mass (Da):87,466
    Last modified:October 17, 2006 - v2
    Checksum:i22C1B1A0360BC1AE
    GO
    Isoform 2 (identifier: Q9NQC1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         518-518: Missing.

    Show »
    Length:789
    Mass (Da):87,409
    Checksum:iEFCA863CE55B6297
    GO
    Isoform 3 (identifier: Q9NQC1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         518-790: GLSTSFPIDG...EVVRMGVLAS → ERSGRRAKGK...PDSVLGQLGE

    Note: No experimental confirmation available.

    Show »
    Length:562
    Mass (Da):63,466
    Checksum:i6C53A5098E9966BA
    GO

    Sequence cautioni

    The sequence BAB84949.1 differs from that shown. Reason: Frameshift at position 11.
    The sequence BAA13245.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAB94935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti331 – 3311T → I in BAA13245. (PubMed:9039502)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti581 – 5811R → G.
    Corresponds to variant rs34200923 [ dbSNP | Ensembl ].
    VAR_053778

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei518 – 790273GLSTS…GVLAS → ERSGRRAKGKKSDSKRKGCE GSKGSTEKKEKVKAGPDSVL GQLGE in isoform 3. 1 PublicationVSP_021050Add
    BLAST
    Alternative sequencei518 – 5181Missing in isoform 2. 2 PublicationsVSP_021051

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87076 mRNA. Translation: BAA13245.2. Different initiation.
    AK074123 mRNA. Translation: BAB84949.1. Frameshift.
    BC009307 mRNA. Translation: AAH09307.2.
    BC021962 mRNA. Translation: AAH21962.2.
    AC005355 Genomic DNA. No translation available.
    AC106763 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62253.1.
    CH471062 Genomic DNA. Translation: EAW62254.1.
    AJ251833 mRNA. Translation: CAB94935.1. Different initiation.
    BN000288 mRNA. Translation: CAE30501.1.
    CCDSiCCDS4176.1. [Q9NQC1-1]
    RefSeqiNP_001276913.1. NM_001289984.1.
    NP_001276914.1. NM_001289985.1.
    NP_056103.4. NM_015288.5. [Q9NQC1-1]
    UniGeneiHs.732155.

    Genome annotation databases

    EnsembliENST00000361895; ENSP00000354425; ENSG00000043143.
    ENST00000395003; ENSP00000378451; ENSG00000043143. [Q9NQC1-1]
    GeneIDi23338.
    KEGGihsa:23338.
    UCSCiuc003kzl.2. human. [Q9NQC1-3]
    uc003kzm.2. human.
    uc003kzo.1. human. [Q9NQC1-1]

    Polymorphism databases

    DMDMi116242597.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87076 mRNA. Translation: BAA13245.2 . Different initiation.
    AK074123 mRNA. Translation: BAB84949.1 . Frameshift.
    BC009307 mRNA. Translation: AAH09307.2 .
    BC021962 mRNA. Translation: AAH21962.2 .
    AC005355 Genomic DNA. No translation available.
    AC106763 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62253.1 .
    CH471062 Genomic DNA. Translation: EAW62254.1 .
    AJ251833 mRNA. Translation: CAB94935.1 . Different initiation.
    BN000288 mRNA. Translation: CAE30501.1 .
    CCDSi CCDS4176.1. [Q9NQC1-1 ]
    RefSeqi NP_001276913.1. NM_001289984.1.
    NP_001276914.1. NM_001289985.1.
    NP_056103.4. NM_015288.5. [Q9NQC1-1 ]
    UniGenei Hs.732155.

    3D structure databases

    ProteinModelPortali Q9NQC1.
    SMRi Q9NQC1. Positions 197-246, 301-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116924. 8 interactions.
    IntActi Q9NQC1. 7 interactions.
    STRINGi 9606.ENSP00000378451.

    Polymorphism databases

    DMDMi 116242597.

    Proteomic databases

    MaxQBi Q9NQC1.
    PaxDbi Q9NQC1.
    PRIDEi Q9NQC1.

    Protocols and materials databases

    DNASUi 23338.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361895 ; ENSP00000354425 ; ENSG00000043143 .
    ENST00000395003 ; ENSP00000378451 ; ENSG00000043143 . [Q9NQC1-1 ]
    GeneIDi 23338.
    KEGGi hsa:23338.
    UCSCi uc003kzl.2. human. [Q9NQC1-3 ]
    uc003kzm.2. human.
    uc003kzo.1. human. [Q9NQC1-1 ]

    Organism-specific databases

    CTDi 23338.
    GeneCardsi GC05P133860.
    H-InvDB HIX0005181.
    HGNCi HGNC:22984. JADE2.
    HPAi HPA025959.
    HPA055789.
    MIMi 610515. gene.
    neXtProti NX_Q9NQC1.
    PharmGKBi PA128394627.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5141.
    HOGENOMi HOG000220882.
    HOVERGENi HBG053585.
    PhylomeDBi Q9NQC1.
    TreeFami TF316118.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi PHF15. human.
    GenomeRNAii 23338.
    NextBioi 35489874.
    PROi Q9NQC1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQC1.
    Bgeei Q9NQC1.
    CleanExi HS_PHF15.
    Genevestigatori Q9NQC1.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019542. Enhancer_polycomb-like_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10513. EPL1. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.
    2. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.
      DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Spleen.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Melanoma and Uterus.
    6. "Isolation and characterisation of a 64 kDa protein associated with the lysosomal/autophagic compartment."
      Tesmann S., Biederbick A., Elsaesser H.P.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-790 (ISOFORM 1).
    7. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."
      Tzouanacou E., Tweedie S., Wilson V.
      Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
      Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
      Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE HBO1 COMPLEX.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-38 AND LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiJADE2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQC1
    Secondary accession number(s): D3DQA3
    , Q6IE80, Q8TEK0, Q92513, Q96GQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3