SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NQA5

- TRPV5_HUMAN

UniProt

Q9NQA5 - TRPV5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transient receptor potential cation channel subfamily V member 5
Gene
TRPV5, ECAC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating By similarity.1 Publication

Enzyme regulationi

Activated by WNK3.1 Publication

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. calcium ion transmembrane transport Source: Reactome
  2. calcium ion transport Source: UniProtKB
  3. calcium ion transport into cytosol Source: Ensembl
  4. ion transmembrane transport Source: Reactome
  5. protein tetramerization Source: UniProtKB
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_169333. TRP channels.

Protein family/group databases

TCDBi1.A.4.2.10. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Calcium transport protein 2
Short name:
CaT2
Epithelial calcium channel 1
Short name:
ECaC
Short name:
ECaC1
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:TRPV5
Synonyms:ECAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3145. TRPV5.

Subcellular locationi

Apical cell membrane; Multi-pass membrane protein
Note: Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells By similarity. The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 327327Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei328 – 34821Helical; Reviewed prediction
Add
BLAST
Topological domaini349 – 38739Extracellular Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST
Topological domaini409 – 41911Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei420 – 44021Helical; Reviewed prediction
Add
BLAST
Topological domaini441 – 4488Extracellular Reviewed prediction
Transmembranei449 – 46921Helical; Reviewed prediction
Add
BLAST
Topological domaini470 – 49223Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei493 – 51321Helical; Reviewed prediction
Add
BLAST
Intramembranei524 – 54421Pore-forming; Inferred
Add
BLAST
Transmembranei557 – 57721Helical; Reviewed prediction
Add
BLAST
Topological domaini578 – 729152Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi358 – 3581N → Q: Loss of glycosylation. 1 Publication

Organism-specific databases

PharmGKBiPA35045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Transient receptor potential cation channel subfamily V member 5
PRO_0000215350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi358 – 3581N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NQA5.
PRIDEiQ9NQA5.

PTM databases

PhosphoSiteiQ9NQA5.

Expressioni

Tissue specificityi

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.2 Publications

Gene expression databases

ArrayExpressiQ9NQA5.
BgeeiQ9NQA5.
CleanExiHS_TRPV5.
GenevestigatoriQ9NQA5.

Interactioni

Subunit structurei

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
CALB1P059374EBI-1053443,EBI-4286943

Protein-protein interaction databases

BioGridi121137. 3 interactions.
IntActiQ9NQA5. 1 interaction.
MINTiMINT-1470011.
STRINGi9606.ENSP00000265310.

Structurei

3D structure databases

ProteinModelPortaliQ9NQA5.
SMRiQ9NQA5. Positions 8-614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 7431ANK 1
Add
BLAST
Repeati78 – 10730ANK 2
Add
BLAST
Repeati116 – 14530ANK 3
Add
BLAST
Repeati162 – 19130ANK 4
Add
BLAST
Repeati239 – 26830ANK 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni598 – 6025Interaction with S100A10 By similarity
Regioni650 – 6534Involved in Ca(2+)-dependent inactivation By similarity
Regioni700 – 72930Involved in Ca(2+)-dependent inactivation By similarity
Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278734.
HOGENOMiHOG000234397.
HOVERGENiHBG061442.
InParanoidiQ9NQA5.
KOiK04974.
OMAiLCEPFVG.
PhylomeDBiQ9NQA5.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view]
PANTHERiPTHR10582:SF11. PTHR10582:SF11. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQA5-1 [UniParc]FASTAAdd to Basket

« Hide

MGGFLPKAEG PGSQLQKLLP SFLVREQDWD QHLDKLHMLQ QKRILESPLL    50
RASKENDLSV LRQLLLDCTC DVRQRGALGE TALHIAALYD NLEAALVLME 100
AAPELVFEPT TCEAFAGQTA LHIAVVNQNV NLVRALLTRR ASVSARATGT 150
AFRRSPRNLI YFGEHPLSFA ACVNSEEIVR LLIEHGADIR AQDSLGNTVL 200
HILILQPNKT FACQMYNLLL SYDGHGDHLQ PLDLVPNHQG LTPFKLAGVE 250
GNTVMFQHLM QKRRHIQWTY GPLTSILYDL TEIDSWGEEL SFLELVVSSD 300
KREARQILEQ TPVKELVSFK WNKYGRPYFC ILAALYLLYM ICFTTCCVYR 350
PLKFRGGNRT HSRDITILQQ KLLQEAYETR EDIIRLVGEL VSIVGAVIIL 400
LLEIPDIFRV GASRYFGKTI LGGPFHVIII TYASLVLVTM VMRLTNTNGE 450
VVPMSFALVL GWCSVMYFTR GFQMLGPFTI MIQKMIFGDL MRFCWLMAVV 500
ILGFASAFYI IFQTEDPTSL GQFYDYPMAL FTTFELFLTV IDAPANYDVD 550
LPFMFSIVNF AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT 600
TVMLERKLPR CLWPRSGICG CEFGLGDRWF LRVENHNDQN PLRVLRYVEV 650
FKNSDKEDDQ EHPSEKQPSG AESGTLARAS LALPTSSLSR TASQSSSHRG 700
WEILRQNTLG HLNLGLNLSE GDGEEVYHF 729
Length:729
Mass (Da):82,551
Last modified:March 1, 2002 - v2
Checksum:iA10FB80205FD0DBB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81A → V.1 Publication
Corresponds to variant rs4252372 [ dbSNP | Ensembl ].
VAR_022247
Natural varianti154 – 1541R → H.2 Publications
Corresponds to variant rs4236480 [ dbSNP | Ensembl ].
VAR_022248
Natural varianti563 – 5631A → T.1 Publication
Corresponds to variant rs4252499 [ dbSNP | Ensembl ].
VAR_022249
Natural varianti712 – 7121L → F.1 Publication
Corresponds to variant rs4252509 [ dbSNP | Ensembl ].
VAR_022250

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271207 mRNA. Translation: CAB96365.2.
AF304464 mRNA. Translation: AAL04015.1.
AJ487965 mRNA. Translation: CAD32312.2.
AY206695 Genomic DNA. Translation: AAO13488.1.
CH236959 Genomic DNA. Translation: EAL23777.1.
CH471198 Genomic DNA. Translation: EAW51896.1.
CCDSiCCDS5875.1.
RefSeqiNP_062815.2. NM_019841.5.
UniGeneiHs.283369.

Genome annotation databases

EnsembliENST00000265310; ENSP00000265310; ENSG00000127412.
ENST00000566839; ENSP00000457041; ENSG00000261264.
GeneIDi56302.
KEGGihsa:56302.
UCSCiuc003wby.1. human.

Polymorphism databases

DMDMi62901471.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271207 mRNA. Translation: CAB96365.2 .
AF304464 mRNA. Translation: AAL04015.1 .
AJ487965 mRNA. Translation: CAD32312.2 .
AY206695 Genomic DNA. Translation: AAO13488.1 .
CH236959 Genomic DNA. Translation: EAL23777.1 .
CH471198 Genomic DNA. Translation: EAW51896.1 .
CCDSi CCDS5875.1.
RefSeqi NP_062815.2. NM_019841.5.
UniGenei Hs.283369.

3D structure databases

ProteinModelPortali Q9NQA5.
SMRi Q9NQA5. Positions 8-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121137. 3 interactions.
IntActi Q9NQA5. 1 interaction.
MINTi MINT-1470011.
STRINGi 9606.ENSP00000265310.

Chemistry

ChEMBLi CHEMBL1628474.
GuidetoPHARMACOLOGYi 511.

Protein family/group databases

TCDBi 1.A.4.2.10. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei Q9NQA5.

Polymorphism databases

DMDMi 62901471.

Proteomic databases

PaxDbi Q9NQA5.
PRIDEi Q9NQA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265310 ; ENSP00000265310 ; ENSG00000127412 .
ENST00000566839 ; ENSP00000457041 ; ENSG00000261264 .
GeneIDi 56302.
KEGGi hsa:56302.
UCSCi uc003wby.1. human.

Organism-specific databases

CTDi 56302.
GeneCardsi GC07M142606.
HGNCi HGNC:3145. TRPV5.
MIMi 606679. gene.
neXtProti NX_Q9NQA5.
PharmGKBi PA35045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278734.
HOGENOMi HOG000234397.
HOVERGENi HBG061442.
InParanoidi Q9NQA5.
KOi K04974.
OMAi LCEPFVG.
PhylomeDBi Q9NQA5.
TreeFami TF314711.

Enzyme and pathway databases

Reactomei REACT_169333. TRP channels.

Miscellaneous databases

GeneWikii TRPV5.
GenomeRNAii 56302.
NextBioi 61971.
PROi Q9NQA5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQA5.
Bgeei Q9NQA5.
CleanExi HS_TRPV5.
Genevestigatori Q9NQA5.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view ]
PANTHERi PTHR10582:SF11. PTHR10582:SF11. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTi SM00248. ANK. 5 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial calcium channel (ECAC1)."
    Mueller D., Hoenderop J.G., Meij I.C., van den Heuvel L.P.J., Knoers N.V., den Hollander A.I., Eggert P., Garcia-Nieto V., Claverie-Martin F., Bindels R.J.M.
    Genomics 67:48-53(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Structural conservation of the genes encoding CaT1, CaT2, and related cation channels."
    Peng J.-B., Brown E.M., Hediger M.A.
    Genomics 76:99-109(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Kelsell R.E.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-154.
  4. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-8; HIS-154; THR-563 AND PHE-712.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway."
    Zhang W., Na T., Peng J.B.
    Am. J. Physiol. 295:F1472-F1484(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-358, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS OF ASN-358.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTRPV5_HUMAN
AccessioniPrimary (citable) accession number: Q9NQA5
Secondary accession number(s): A4D2H7
, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi