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Protein

WAS protein family homolog 6

Gene

WASH6P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WAS protein family homolog 6
Alternative name(s):
Protein FAM39A
Gene namesi
Name:WASH6P
Synonyms:CXYorf1, FAM39A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31685. WASH6P.

Subcellular locationi

  • Early endosome membrane By similarity
  • Recycling endosome membrane By similarity

  • Note: Localization to the endosome membrane is mediated via its interaction with FAM21.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi284018158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447WAS protein family homolog 6PRO_0000344530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NQA3.
MaxQBiQ9NQA3.
PeptideAtlasiQ9NQA3.
PRIDEiQ9NQA3.

Expressioni

Organism-specific databases

HPAiHPA002689.

Interactioni

Subunit structurei

Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9NQA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini343 – 36523WH2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 149149WHD1Add
BLAST
Regioni331 – 447117VCABy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi250 – 31263Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the WASH1 family.Curated
Contains 1 WH2 domain.Curated

Phylogenomic databases

HOGENOMiHOG000007381.
HOVERGENiHBG066686.
InParanoidiQ9NQA3.
PhylomeDBiQ9NQA3.

Family and domain databases

InterProiIPR028290. WASH1.
IPR021854. WASH1_WAHD.
[Graphical view]
PANTHERiPTHR23331. PTHR23331. 1 hit.
PfamiPF11945. WASH_WAHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFHEMQAHK NALGTSGEQQ AADITGPTPH QGGWKQVEQS RSQVQAIGEK
60 70 80 90 100
VSLAQAKIEK IKGSKKAIKV FSSAKYPAPE RLQEYGSIFT GAQDPGLQRR
110 120 130 140 150
PRHRIQSKHR PLDERALQEK LKDFPVCVST KPEPEDDAEE GLGGLPSNIS
160 170 180 190 200
SVSSLLLFNT TENLYKKYVF LDPLAGAVTK THVMLGAETE EKLFDAPLSI
210 220 230 240 250
SKREQLEQQV PENYFYVPDL GQVPEIDVPS YLPDLPSIAN DLMYSADLGP
260 270 280 290 300
GIAPSAPGTI PELPTFHTEV AEPLKADLQD GVLTPPPPPP PPPPAPEVLA
310 320 330 340 350
SAPPLPPSTA APVGQGARQD DGSSSASPSV QGAPREVVDP SGGWATLLES
360 370 380 390 400
IRQAGGIGKA KLRSMKERKL EKKKQKEQEQ VRATSQGGHL MSDLFNKLVM
410 420 430 440
RRKGISGKGP GAGEGPGGAF ARVSDSIPPV PPPQQPQAEE DEDDWES
Length:447
Mass (Da):47,990
Last modified:January 19, 2010 - v3
Checksum:i7B1217DC3CF9DDAA
GO

Sequence cautioni

The sequence CAB96818 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271736 Genomic DNA. Translation: CAB96818.1. Sequence problems.
CR595583 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271736 Genomic DNA. Translation: CAB96818.1. Sequence problems.
CR595583 mRNA. No translation available.

3D structure databases

ProteinModelPortaliQ9NQA3.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi284018158.

Proteomic databases

EPDiQ9NQA3.
MaxQBiQ9NQA3.
PeptideAtlasiQ9NQA3.
PRIDEiQ9NQA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiWASH6P.
H-InvDBHIX0176556.
HIX0177643.
HGNCiHGNC:31685. WASH6P.
HPAiHPA002689.
neXtProtiNX_Q9NQA3.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000007381.
HOVERGENiHBG066686.
InParanoidiQ9NQA3.
PhylomeDBiQ9NQA3.

Miscellaneous databases

PROiQ9NQA3.

Family and domain databases

InterProiIPR028290. WASH1.
IPR021854. WASH1_WAHD.
[Graphical view]
PANTHERiPTHR23331. PTHR23331. 1 hit.
PfamiPF11945. WASH_WAHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWASH6_HUMAN
AccessioniPrimary (citable) accession number: Q9NQA3
Secondary accession number(s): A6NGF1, Q8N305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: January 19, 2010
Last modified: September 7, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.1 Publication

Caution

The WASH6P N-terminus differs from WASH3 for which it is shown to be required for the WASH complex assembly. Hence is association within the WASH complex is ambiguous. However, WASH6P retains the regions implicated in interaction with FAM21 and confering in vitro NPF activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.