Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coordinator of PRMT5 and differentiation stimulator

Gene

COPRS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Coordinator of PRMT5 and differentiation stimulator
Alternative name(s):
Cooperator of PRMT5
Protein TTP1
Gene namesi
Name:COPRS
Synonyms:C17orf79, COPR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28848. COPRS.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485403.

Polymorphism and mutation databases

BioMutaiCOPRS.
DMDMi189082907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Coordinator of PRMT5 and differentiation stimulatorPRO_0000336077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication
Modified residuei66 – 661PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQ92.
MaxQBiQ9NQ92.
PaxDbiQ9NQ92.
PeptideAtlasiQ9NQ92.
PRIDEiQ9NQ92.

PTM databases

iPTMnetiQ9NQ92.
PhosphoSiteiQ9NQ92.

Expressioni

Gene expression databases

BgeeiENSG00000172301.
CleanExiHS_C17orf79.
ExpressionAtlasiQ9NQ92. baseline and differential.
GenevisibleiQ9NQ92. HS.

Organism-specific databases

HPAiHPA052552.

Interactioni

Subunit structurei

Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3. Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HIST2H4BP628053EBI-1642558,EBI-302023
PRMT5O147446EBI-1642558,EBI-351098

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120632. 33 interactions.
IntActiQ9NQ92. 9 interactions.
MINTiMINT-6543180.
STRINGi9606.ENSP00000304327.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4CS. Eukaryota.
ENOG4111D7J. LUCA.
GeneTreeiENSGT00390000007384.
HOGENOMiHOG000111893.
InParanoidiQ9NQ92.
OMAiDLNTWEL.
OrthoDBiEOG091G0W9H.
PhylomeDBiQ9NQ92.
TreeFamiTF338109.

Family and domain databases

InterProiIPR029289. COPR5.
[Graphical view]
PfamiPF15340. COPR5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NQ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLQAAGAQA QGAAEPSRGP PLPSARGAPP SPEAGFATAD HSSQERETEK
60 70 80 90 100
AMDRLARGTQ SIPNDSPARG EGTHSEEEGF AMDEEDSDGE LNTWELSEGT
110 120 130 140 150
NCPPKEQPGD LFNEDWDSEL KADQGNPYDA DDIQESISQE LKPWVCCAPQ
160 170 180
GDMIYDPSWH HPPPLIPYYS KMVFETGQFD DAED
Length:184
Mass (Da):20,066
Last modified:May 20, 2008 - v3
Checksum:i38D3E94C34C48745
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431S → G.3 Publications
Corresponds to variant rs8068049 [ dbSNP | Ensembl ].
VAR_043538

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272196 mRNA. Translation: CAB77267.2.
AF407672 mRNA. Translation: AAK97661.1.
AC004253 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80262.1.
CH471147 Genomic DNA. Translation: EAW80263.1.
BC012386 mRNA. Translation: AAH12386.1.
CCDSiCCDS11268.1.
RefSeqiNP_060875.2. NM_018405.3.
UniGeneiHs.462729.

Genome annotation databases

EnsembliENST00000302362; ENSP00000304327; ENSG00000172301.
GeneIDi55352.
KEGGihsa:55352.
UCSCiuc002hgp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272196 mRNA. Translation: CAB77267.2.
AF407672 mRNA. Translation: AAK97661.1.
AC004253 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80262.1.
CH471147 Genomic DNA. Translation: EAW80263.1.
BC012386 mRNA. Translation: AAH12386.1.
CCDSiCCDS11268.1.
RefSeqiNP_060875.2. NM_018405.3.
UniGeneiHs.462729.

3D structure databases

ProteinModelPortaliQ9NQ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120632. 33 interactions.
IntActiQ9NQ92. 9 interactions.
MINTiMINT-6543180.
STRINGi9606.ENSP00000304327.

PTM databases

iPTMnetiQ9NQ92.
PhosphoSiteiQ9NQ92.

Polymorphism and mutation databases

BioMutaiCOPRS.
DMDMi189082907.

Proteomic databases

EPDiQ9NQ92.
MaxQBiQ9NQ92.
PaxDbiQ9NQ92.
PeptideAtlasiQ9NQ92.
PRIDEiQ9NQ92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302362; ENSP00000304327; ENSG00000172301.
GeneIDi55352.
KEGGihsa:55352.
UCSCiuc002hgp.4. human.

Organism-specific databases

CTDi55352.
GeneCardsiCOPRS.
H-InvDBHIX0202424.
HGNCiHGNC:28848. COPRS.
HPAiHPA052552.
neXtProtiNX_Q9NQ92.
PharmGKBiPA143485403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4CS. Eukaryota.
ENOG4111D7J. LUCA.
GeneTreeiENSGT00390000007384.
HOGENOMiHOG000111893.
InParanoidiQ9NQ92.
OMAiDLNTWEL.
OrthoDBiEOG091G0W9H.
PhylomeDBiQ9NQ92.
TreeFamiTF338109.

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.

Miscellaneous databases

GenomeRNAii55352.
PROiQ9NQ92.

Gene expression databases

BgeeiENSG00000172301.
CleanExiHS_C17orf79.
ExpressionAtlasiQ9NQ92. baseline and differential.
GenevisibleiQ9NQ92. HS.

Family and domain databases

InterProiIPR029289. COPR5.
[Graphical view]
PfamiPF15340. COPR5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPRS_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ92
Secondary accession number(s): A6NP14
, E1P656, Q96EF5, Q96P75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.