Q9NQ90 (ANO2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anoctamin-2

Alternative name(s):
Transmembrane protein 16B

Gene names

Name:	ANO2
Synonyms:	C12orf3, TMEM16B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1003 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Ref.2 Ref.5 Ref.9 Ref.10
Enzyme regulation	Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) By similarity.
Subunit structure	Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminus region By similarity. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.5.
Tissue specificity	Retina, especially in the photoreceptor synaptic terminals. Ref.2
Miscellaneous	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Sequence similarities	Belongs to the anoctamin family.
Sequence caution	The sequence BAB14773.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Calcium Chloride
Molecular function	Chloride channel Ion channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	intracellular calcium activated chloride channel activity Inferred from direct assay Ref.2Ref.9. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NQ90-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Splice site between exons 4 and 5 is non-canonical.

Isoform 2 (identifier: Q9NQ90-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-7: GPR → MPE

Note: Splice site between exons 4 and 5 is non-canonical.

Isoform 3 (identifier: Q9NQ90-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-7: GPR → MPE
     212-212: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1003	1003	Anoctamin-2		PRO_0000072564
Regions
	Topological domain	1 – 365	365	Cytoplasmic Potential
	Transmembrane	366 – 386	21	Helical; Potential
	Topological domain	387 – 434	48	Extracellular Potential
	Transmembrane	435 – 455	21	Helical; Potential
	Topological domain	456 – 538	83	Cytoplasmic Potential
	Transmembrane	539 – 559	21	Helical; Potential
	Topological domain	560 – 582	23	Extracellular Potential
	Transmembrane	583 – 603	21	Helical; Potential
	Topological domain	604 – 623	20	Cytoplasmic Potential
	Transmembrane	624 – 644	21	Helical; Potential
	Topological domain	645 – 748	104	Extracellular Potential
	Transmembrane	749 – 769	21	Helical; Potential
	Topological domain	770 – 801	32	Cytoplasmic Potential
	Transmembrane	802 – 822	21	Helical; Potential
	Topological domain	823 – 907	85	Extracellular Potential
	Transmembrane	908 – 928	21	Helical; Potential
	Topological domain	929 – 1003	75	Cytoplasmic Potential
	Motif	1001 – 1003	3	DLG4 binding (PDZ)
Amino acid modifications
	Glycosylation	422	1	N-linked (GlcNAc...) Potential
	Glycosylation	841	1	N-linked (GlcNAc...) Potential
	Glycosylation	849	1	N-linked (GlcNAc...) Potential
	Glycosylation	856	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 4	4	Missing in isoform 2 and isoform 3.		VSP_040493
	Alternative sequence	5 – 7	3	GPR → MPE in isoform 2 and isoform 3.		VSP_040494
	Alternative sequence	212	1	Missing in isoform 3.		VSP_040495
	Natural variant	112	1	V → A. Corresponds to variant rs3741903 [ dbSNP | Ensembl ].		VAR_021932
	Natural variant	147	1	P → S. Corresponds to variant rs3741901 [ dbSNP | Ensembl ].		VAR_057286
	Natural variant	401	1	M → I. Corresponds to variant rs17788563 [ dbSNP | Ensembl ].		VAR_061853
	Natural variant	505	1	S → A. Corresponds to variant rs1860961 [ dbSNP | Ensembl ].		VAR_020331

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 3, 2009. Version 2. Checksum: 32939EADC8AFE5C8	FASTA	1,003	113,969
	10 20 30 40 50 60 MATPGPRDIP LLPGSPRRLS PQAGSRGGQG PKHGQQCLKM PGPRAPGLQG GSNRDPGQPC 70 80 90 100 110 120 GGESTRSSSV INNYLDANEP VSLEARLSRM HFHDSQRKVD YVLAYHYRKR GVHLAQGFPG 130 140 150 160 170 180 HSLAIVSNGE TGKEPHAGGP GDIELGPLDA LEEERKEQRE EFEHNLMEAG LELEKDLENK 190 200 210 220 230 240 SQGSIFVRIH APWQVLAREA EFLKIKVPTK KEMYEIKAGG SIAKKFSAAL QKLSSHLQPR 250 260 270 280 290 300 VPEHSNNKMK NLSYPFSREK MYLYNIQEKD TFFDNATRSR IVHEILKRTA CSRANNTMGI 310 320 330 340 350 360 NSLIANNIYE AAYPLHDGEY DSPEDDMNDR KLLYQEWARY GVFYKFQPID LIRKYFGEKI 370 380 390 400 410 420 GLYFAWLGLY TSFLIPSSVI GVIVFLYGCA TIEEDIPSRE MCDQQNAFTM CPLCDKSCDY 430 440 450 460 470 480 WNLSSACGTA QASHLFDNPA TVFFSIFMAL WATMFLENWK RLQMRLGYFW DLTGIEEEEE 490 500 510 520 530 540 RAQEHSRPEY ETKVREKMLK ESNQSAVQKL ETNTTECGDE DDEDKLTWKD RFPGYLMNFA 550 560 570 580 590 600 SILFMIALTF SIVFGVIVYR ITTAAALSLN KATRSNVRVT VTATAVIINL VVILILDEIY 610 620 630 640 650 660 GAVAKWLTKI EVPKTEQTFE ERLILKAFLL KFVNAYSPIF YVAFFKGRFV GRPGSYVYVF 670 680 690 700 710 720 DGYRMEECAP GGCLMELCIQ LSIIMLGKQL IQNNIFEIGV PKLKKLFRKL KDETEAGETD 730 740 750 760 770 780 SAHSKHPEQW DLDYSLEPYT GLTPEYMEMI IQFGFVTLFV ASFPLAPVFA LLNNVIEVRL 790 800 810 820 830 840 DAKKFVTELR RPDAVRTKDI GIWFDILSGI GKFSVISNAF VIAITSDFIP RLVYQYSYSH 850 860 870 880 890 900 NGTLHGFVNH TLSFFNVSQL KEGTQPENSQ FDQEVQFCRF KDYREPPWAP NPYEFSKQYW 910 920 930 940 950 960 FILSARLAFV IIFQNLVMFL SVLVDWMIPD IPTDISDQIK KEKSLLVDFF LKEEHEKLKL 970 980 990 1000 MDEPALRSPG GGDRSRSRAA SSAPSGQSQL GSMMSSGSQH TNV
	Isoform 2 [UniParc]. Checksum: B9B4F56161AE1B00	FASTA	999	113,616
	10 20 30 40 50 60 MPEDIPLLPG SPRRLSPQAG SRGGQGPKHG QQCLKMPGPR APGLQGGSNR DPGQPCGGES 70 80 90 100 110 120 TRSSSVINNY LDANEPVSLE ARLSRMHFHD SQRKVDYVLA YHYRKRGVHL AQGFPGHSLA 130 140 150 160 170 180 IVSNGETGKE PHAGGPGDIE LGPLDALEEE RKEQREEFEH NLMEAGLELE KDLENKSQGS 190 200 210 220 230 240 IFVRIHAPWQ VLAREAEFLK IKVPTKKEMY EIKAGGSIAK KFSAALQKLS SHLQPRVPEH 250 260 270 280 290 300 SNNKMKNLSY PFSREKMYLY NIQEKDTFFD NATRSRIVHE ILKRTACSRA NNTMGINSLI 310 320 330 340 350 360 ANNIYEAAYP LHDGEYDSPE DDMNDRKLLY QEWARYGVFY KFQPIDLIRK YFGEKIGLYF 370 380 390 400 410 420 AWLGLYTSFL IPSSVIGVIV FLYGCATIEE DIPSREMCDQ QNAFTMCPLC DKSCDYWNLS 430 440 450 460 470 480 SACGTAQASH LFDNPATVFF SIFMALWATM FLENWKRLQM RLGYFWDLTG IEEEEERAQE 490 500 510 520 530 540 HSRPEYETKV REKMLKESNQ SAVQKLETNT TECGDEDDED KLTWKDRFPG YLMNFASILF 550 560 570 580 590 600 MIALTFSIVF GVIVYRITTA AALSLNKATR SNVRVTVTAT AVIINLVVIL ILDEIYGAVA 610 620 630 640 650 660 KWLTKIEVPK TEQTFEERLI LKAFLLKFVN AYSPIFYVAF FKGRFVGRPG SYVYVFDGYR 670 680 690 700 710 720 MEECAPGGCL MELCIQLSII MLGKQLIQNN IFEIGVPKLK KLFRKLKDET EAGETDSAHS 730 740 750 760 770 780 KHPEQWDLDY SLEPYTGLTP EYMEMIIQFG FVTLFVASFP LAPVFALLNN VIEVRLDAKK 790 800 810 820 830 840 FVTELRRPDA VRTKDIGIWF DILSGIGKFS VISNAFVIAI TSDFIPRLVY QYSYSHNGTL 850 860 870 880 890 900 HGFVNHTLSF FNVSQLKEGT QPENSQFDQE VQFCRFKDYR EPPWAPNPYE FSKQYWFILS 910 920 930 940 950 960 ARLAFVIIFQ NLVMFLSVLV DWMIPDIPTD ISDQIKKEKS LLVDFFLKEE HEKLKLMDEP 970 980 990 ALRSPGGGDR SRSRAASSAP SGQSQLGSMM SSGSQHTNV
	Isoform 3 [UniParc]. Checksum: A1CC10B50E9A487A	FASTA	998	113,487
	10 20 30 40 50 60 MPEDIPLLPG SPRRLSPQAG SRGGQGPKHG QQCLKMPGPR APGLQGGSNR DPGQPCGGES 70 80 90 100 110 120 TRSSSVINNY LDANEPVSLE ARLSRMHFHD SQRKVDYVLA YHYRKRGVHL AQGFPGHSLA 130 140 150 160 170 180 IVSNGETGKE PHAGGPGDIE LGPLDALEEE RKEQREEFEH NLMEAGLELE KDLENKSQGS 190 200 210 220 230 240 IFVRIHAPWQ VLAREAEFLK IKVPTKKMYE IKAGGSIAKK FSAALQKLSS HLQPRVPEHS 250 260 270 280 290 300 NNKMKNLSYP FSREKMYLYN IQEKDTFFDN ATRSRIVHEI LKRTACSRAN NTMGINSLIA 310 320 330 340 350 360 NNIYEAAYPL HDGEYDSPED DMNDRKLLYQ EWARYGVFYK FQPIDLIRKY FGEKIGLYFA 370 380 390 400 410 420 WLGLYTSFLI PSSVIGVIVF LYGCATIEED IPSREMCDQQ NAFTMCPLCD KSCDYWNLSS 430 440 450 460 470 480 ACGTAQASHL FDNPATVFFS IFMALWATMF LENWKRLQMR LGYFWDLTGI EEEEERAQEH 490 500 510 520 530 540 SRPEYETKVR EKMLKESNQS AVQKLETNTT ECGDEDDEDK LTWKDRFPGY LMNFASILFM 550 560 570 580 590 600 IALTFSIVFG VIVYRITTAA ALSLNKATRS NVRVTVTATA VIINLVVILI LDEIYGAVAK 610 620 630 640 650 660 WLTKIEVPKT EQTFEERLIL KAFLLKFVNA YSPIFYVAFF KGRFVGRPGS YVYVFDGYRM 670 680 690 700 710 720 EECAPGGCLM ELCIQLSIIM LGKQLIQNNI FEIGVPKLKK LFRKLKDETE AGETDSAHSK 730 740 750 760 770 780 HPEQWDLDYS LEPYTGLTPE YMEMIIQFGF VTLFVASFPL APVFALLNNV IEVRLDAKKF 790 800 810 820 830 840 VTELRRPDAV RTKDIGIWFD ILSGIGKFSV ISNAFVIAIT SDFIPRLVYQ YSYSHNGTLH 850 860 870 880 890 900 GFVNHTLSFF NVSQLKEGTQ PENSQFDQEV QFCRFKDYRE PPWAPNPYEF SKQYWFILSA 910 920 930 940 950 960 RLAFVIIFQN LVMFLSVLVD WMIPDIPTDI SDQIKKEKSL LVDFFLKEEH EKLKLMDEPA 970 980 990 LRSPGGGDRS RSRAASSAPS GQSQLGSMMS SGSQHTNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcripts in 12p13.3." Lorenz B., White K.E., Econs M.J., Strom T.M. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Retina.
[2]	"TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals." Stoehr H., Heisig J.B., Benz P.M., Schoeberl S., Milenkovic V.M., Strauss O., Aartsen W.M., Wijnholds J., Weber B.H.F., Schulz H.L. J. Neurosci. 29:6809-6818(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY. Tissue: Retina.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-999 (ISOFORMS 1 AND 2). Tissue: Retinoblastoma.
[5]	"Expression and function of epithelial anoctamins." Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M., Martins J.R., Kunzelmann K. J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	"Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?" Duran C., Hartzell H.C. Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Anoctamins." Kunzelmann K., Tian Y., Martins J.R., Faria D., Kongsuphol P., Ousingsawat J., Thevenod F., Roussa E., Rock J., Schreiber R. Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age." Winpenny J.P., Gray M.A. Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[9]	"The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels." Scudieri P., Sondo E., Ferrera L., Galietta L.J. Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, FUNCTION.
[10]	"Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction." Pifferi S., Cenedese V., Menini A. Exp. Physiol. 97:193-199(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ272204 mRNA. Translation: CAC01125.1. FJ384095 mRNA. Translation: ACL36050.1. AC006431 Genomic DNA. No translation available. AC006560 Genomic DNA. No translation available. AC137627 Genomic DNA. No translation available. AK024010 mRNA. Translation: BAB14773.1. Different initiation.
IPI	IPI00033553. IPI00479837. IPI00973586.
RefSeq	NP_065106.2. NM_020373.2.
UniGene	Hs.148970.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000314048.
Protein family/group databases
TCDB	1.A.17.1.3. calcium-dependent chloride channel (Ca-ClC) family.
PTM databases
PhosphoSite	Q9NQ90.
Polymorphism databases
DMDM	262527528.
Proteomic databases
PaxDb	Q9NQ90.
PRIDE	Q9NQ90.
Protocols and materials databases
DNASU	57101.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327087; ENSP00000314048; ENSG00000047617. ENST00000356134; ENSP00000348453; ENSG00000047617.
GeneID	57101.
KEGG	hsa:57101.
UCSC	uc001qnm.2. human.
Organism-specific databases
CTD	57101.
GeneCards	GC12M005671.
HGNC	HGNC:1183. ANO2.
HPA	HPA036276.
MIM	610109. gene.
neXtProt	NX_Q9NQ90.
PharmGKB	PA25504.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320103.
HOGENOM	HOG000006509.
HOVERGEN	HBG069519.
InParanoid	Q9NQ90.
OMA	VPTKKEM.
OrthoDB	EOG470TGS.
Gene expression databases
ArrayExpress	Q9NQ90.
Bgee	Q9NQ90.
CleanEx	HS_ANO2.
Genevestigator	Q9NQ90.
GermOnline	ENSG00000047617. Homo sapiens.
Family and domain databases
InterPro	IPR007632. Anoctamin. [Graphical view]
PANTHER	PTHR12308. PTHR12308. 1 hit.
Pfam	PF04547. Anoctamin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57101.
NextBio	62929.
SOURCE	Search...

Entry information

Entry name

ANO2_HUMAN

Accession

Primary (citable) accession number: Q9NQ90
Secondary accession number(s): C4N787, Q9H847

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	November 3, 2009
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.