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Q9NQ90

- ANO2_HUMAN

UniProt

Q9NQ90 - ANO2_HUMAN

Protein

Anoctamin-2

Gene

ANO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.4 Publications

    Enzyme regulationi

    Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).By similarity

    GO - Molecular functioni

    1. intracellular calcium activated chloride channel activity Source: UniProtKB

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. ion transmembrane transport Source: Reactome
    3. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Chloride

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anoctamin-2
    Alternative name(s):
    Transmembrane protein 16B
    Gene namesi
    Name:ANO2
    Synonyms:C12orf3, TMEM16B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1183. ANO2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. chloride channel complex Source: UniProtKB-KW
    2. nucleus Source: HPA
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25504.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10031003Anoctamin-2PRO_0000072564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi841 – 8411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi849 – 8491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9NQ90.
    PRIDEiQ9NQ90.

    PTM databases

    PhosphoSiteiQ9NQ90.

    Expressioni

    Tissue specificityi

    Retina, especially in the photoreceptor synaptic terminals.1 Publication

    Gene expression databases

    ArrayExpressiQ9NQ90.
    BgeeiQ9NQ90.
    CleanExiHS_ANO2.
    GenevestigatoriQ9NQ90.

    Organism-specific databases

    HPAiHPA036276.

    Interactioni

    Subunit structurei

    Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121367. 1 interaction.
    STRINGi9606.ENSP00000314048.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 365365CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini387 – 43448ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini456 – 53883CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini560 – 58223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini604 – 62320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini645 – 748104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini770 – 80132CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini823 – 90785ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini929 – 100375CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei749 – 76921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei802 – 82221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei908 – 92821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1001 – 10033DLG4 binding (PDZ)

    Sequence similaritiesi

    Belongs to the anoctamin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320103.
    HOGENOMiHOG000006509.
    HOVERGENiHBG069519.
    InParanoidiQ9NQ90.
    OMAiDRFPGYL.
    OrthoDBiEOG7BS48W.
    PhylomeDBiQ9NQ90.
    TreeFamiTF314265.

    Family and domain databases

    InterProiIPR007632. Anoctamin.
    [Graphical view]
    PANTHERiPTHR12308. PTHR12308. 1 hit.
    PfamiPF04547. Anoctamin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQ90-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATPGPRDIP LLPGSPRRLS PQAGSRGGQG PKHGQQCLKM PGPRAPGLQG     50
    GSNRDPGQPC GGESTRSSSV INNYLDANEP VSLEARLSRM HFHDSQRKVD 100
    YVLAYHYRKR GVHLAQGFPG HSLAIVSNGE TGKEPHAGGP GDIELGPLDA 150
    LEEERKEQRE EFEHNLMEAG LELEKDLENK SQGSIFVRIH APWQVLAREA 200
    EFLKIKVPTK KEMYEIKAGG SIAKKFSAAL QKLSSHLQPR VPEHSNNKMK 250
    NLSYPFSREK MYLYNIQEKD TFFDNATRSR IVHEILKRTA CSRANNTMGI 300
    NSLIANNIYE AAYPLHDGEY DSPEDDMNDR KLLYQEWARY GVFYKFQPID 350
    LIRKYFGEKI GLYFAWLGLY TSFLIPSSVI GVIVFLYGCA TIEEDIPSRE 400
    MCDQQNAFTM CPLCDKSCDY WNLSSACGTA QASHLFDNPA TVFFSIFMAL 450
    WATMFLENWK RLQMRLGYFW DLTGIEEEEE RAQEHSRPEY ETKVREKMLK 500
    ESNQSAVQKL ETNTTECGDE DDEDKLTWKD RFPGYLMNFA SILFMIALTF 550
    SIVFGVIVYR ITTAAALSLN KATRSNVRVT VTATAVIINL VVILILDEIY 600
    GAVAKWLTKI EVPKTEQTFE ERLILKAFLL KFVNAYSPIF YVAFFKGRFV 650
    GRPGSYVYVF DGYRMEECAP GGCLMELCIQ LSIIMLGKQL IQNNIFEIGV 700
    PKLKKLFRKL KDETEAGETD SAHSKHPEQW DLDYSLEPYT GLTPEYMEMI 750
    IQFGFVTLFV ASFPLAPVFA LLNNVIEVRL DAKKFVTELR RPDAVRTKDI 800
    GIWFDILSGI GKFSVISNAF VIAITSDFIP RLVYQYSYSH NGTLHGFVNH 850
    TLSFFNVSQL KEGTQPENSQ FDQEVQFCRF KDYREPPWAP NPYEFSKQYW 900
    FILSARLAFV IIFQNLVMFL SVLVDWMIPD IPTDISDQIK KEKSLLVDFF 950
    LKEEHEKLKL MDEPALRSPG GGDRSRSRAA SSAPSGQSQL GSMMSSGSQH 1000
    TNV 1003

    Note: Splice site between exons 4 and 5 is non-canonical.

    Length:1,003
    Mass (Da):113,969
    Last modified:November 3, 2009 - v2
    Checksum:i32939EADC8AFE5C8
    GO
    Isoform 2 (identifier: Q9NQ90-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.
         5-7: GPR → MPE

    Note: Splice site between exons 4 and 5 is non-canonical.

    Show »
    Length:999
    Mass (Da):113,616
    Checksum:iB9B4F56161AE1B00
    GO

    Sequence cautioni

    The sequence BAB14773.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121V → A.
    Corresponds to variant rs3741903 [ dbSNP | Ensembl ].
    VAR_021932
    Natural varianti147 – 1471P → S.
    Corresponds to variant rs3741901 [ dbSNP | Ensembl ].
    VAR_057286
    Natural varianti401 – 4011M → I.
    Corresponds to variant rs17788563 [ dbSNP | Ensembl ].
    VAR_061853
    Natural varianti505 – 5051S → A.
    Corresponds to variant rs1860961 [ dbSNP | Ensembl ].
    VAR_020331

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44Missing in isoform 2. 1 PublicationVSP_040493
    Alternative sequencei5 – 73GPR → MPE in isoform 2. 1 PublicationVSP_040494

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272204 mRNA. Translation: CAC01125.1.
    FJ384095 mRNA. Translation: ACL36050.1.
    AC006431 Genomic DNA. No translation available.
    AC006560 Genomic DNA. No translation available.
    AC137627 Genomic DNA. No translation available.
    AK024010 mRNA. Translation: BAB14773.1. Different initiation.
    CCDSiCCDS44807.1. [Q9NQ90-2]
    RefSeqiNP_001265525.1. NM_001278596.1. [Q9NQ90-1]
    NP_001265526.1. NM_001278597.1. [Q9NQ90-2]
    UniGeneiHs.148970.

    Genome annotation databases

    EnsembliENST00000356134; ENSP00000348453; ENSG00000047617. [Q9NQ90-2]
    GeneIDi57101.
    KEGGihsa:57101.

    Polymorphism databases

    DMDMi262527528.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272204 mRNA. Translation: CAC01125.1 .
    FJ384095 mRNA. Translation: ACL36050.1 .
    AC006431 Genomic DNA. No translation available.
    AC006560 Genomic DNA. No translation available.
    AC137627 Genomic DNA. No translation available.
    AK024010 mRNA. Translation: BAB14773.1 . Different initiation.
    CCDSi CCDS44807.1. [Q9NQ90-2 ]
    RefSeqi NP_001265525.1. NM_001278596.1. [Q9NQ90-1 ]
    NP_001265526.1. NM_001278597.1. [Q9NQ90-2 ]
    UniGenei Hs.148970.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121367. 1 interaction.
    STRINGi 9606.ENSP00000314048.

    Protein family/group databases

    TCDBi 1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

    PTM databases

    PhosphoSitei Q9NQ90.

    Polymorphism databases

    DMDMi 262527528.

    Proteomic databases

    PaxDbi Q9NQ90.
    PRIDEi Q9NQ90.

    Protocols and materials databases

    DNASUi 57101.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356134 ; ENSP00000348453 ; ENSG00000047617 . [Q9NQ90-2 ]
    GeneIDi 57101.
    KEGGi hsa:57101.

    Organism-specific databases

    CTDi 57101.
    GeneCardsi GC12M005671.
    HGNCi HGNC:1183. ANO2.
    HPAi HPA036276.
    MIMi 610109. gene.
    neXtProti NX_Q9NQ90.
    PharmGKBi PA25504.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320103.
    HOGENOMi HOG000006509.
    HOVERGENi HBG069519.
    InParanoidi Q9NQ90.
    OMAi DRFPGYL.
    OrthoDBi EOG7BS48W.
    PhylomeDBi Q9NQ90.
    TreeFami TF314265.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    GenomeRNAii 57101.
    NextBioi 62929.
    PROi Q9NQ90.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQ90.
    Bgeei Q9NQ90.
    CleanExi HS_ANO2.
    Genevestigatori Q9NQ90.

    Family and domain databases

    InterProi IPR007632. Anoctamin.
    [Graphical view ]
    PANTHERi PTHR12308. PTHR12308. 1 hit.
    Pfami PF04547. Anoctamin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcripts in 12p13.3."
      Lorenz B., White K.E., Econs M.J., Strom T.M.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Retina.
    2. "TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals."
      Stoehr H., Heisig J.B., Benz P.M., Schoeberl S., Milenkovic V.M., Strauss O., Aartsen W.M., Wijnholds J., Weber B.H.F., Schulz H.L.
      J. Neurosci. 29:6809-6818(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Retina.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-999 (ISOFORMS 1/2).
      Tissue: Retinoblastoma.
    5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
      Duran C., Hartzell H.C.
      Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. Cited for: REVIEW.
    8. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
      Winpenny J.P., Gray M.A.
      Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
      Scudieri P., Sondo E., Ferrera L., Galietta L.J.
      Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, FUNCTION.
    10. "Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction."
      Pifferi S., Cenedese V., Menini A.
      Exp. Physiol. 97:193-199(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, FUNCTION.

    Entry informationi

    Entry nameiANO2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ90
    Secondary accession number(s): C4N787, Q9H847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3