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Q9NQ90

- ANO2_HUMAN

UniProt

Q9NQ90 - ANO2_HUMAN

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Protein
Anoctamin-2
Gene
ANO2, C12orf3, TMEM16B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.4 Publications

Enzyme regulationi

Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) By similarity.

GO - Molecular functioni

  1. intracellular calcium activated chloride channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. ion transmembrane transport Source: Reactome
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-2
Alternative name(s):
Transmembrane protein 16B
Gene namesi
Name:ANO2
Synonyms:C12orf3, TMEM16B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1183. ANO2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 365365Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Topological domaini387 – 43448Extracellular Reviewed prediction
Add
BLAST
Transmembranei435 – 45521Helical; Reviewed prediction
Add
BLAST
Topological domaini456 – 53883Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei539 – 55921Helical; Reviewed prediction
Add
BLAST
Topological domaini560 – 58223Extracellular Reviewed prediction
Add
BLAST
Transmembranei583 – 60321Helical; Reviewed prediction
Add
BLAST
Topological domaini604 – 62320Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Reviewed prediction
Add
BLAST
Topological domaini645 – 748104Extracellular Reviewed prediction
Add
BLAST
Transmembranei749 – 76921Helical; Reviewed prediction
Add
BLAST
Topological domaini770 – 80132Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei802 – 82221Helical; Reviewed prediction
Add
BLAST
Topological domaini823 – 90785Extracellular Reviewed prediction
Add
BLAST
Transmembranei908 – 92821Helical; Reviewed prediction
Add
BLAST
Topological domaini929 – 100375Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
  2. nucleus Source: HPA
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003Anoctamin-2
PRO_0000072564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi841 – 8411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi849 – 8491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi856 – 8561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NQ90.
PRIDEiQ9NQ90.

PTM databases

PhosphoSiteiQ9NQ90.

Expressioni

Tissue specificityi

Retina, especially in the photoreceptor synaptic terminals.1 Publication

Gene expression databases

ArrayExpressiQ9NQ90.
BgeeiQ9NQ90.
CleanExiHS_ANO2.
GenevestigatoriQ9NQ90.

Organism-specific databases

HPAiHPA036276.

Interactioni

Subunit structurei

Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region By similarity.1 Publication

Protein-protein interaction databases

BioGridi121367. 1 interaction.
STRINGi9606.ENSP00000314048.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1001 – 10033DLG4 binding (PDZ)

Sequence similaritiesi

Belongs to the anoctamin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320103.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ9NQ90.
OMAiDRFPGYL.
OrthoDBiEOG7BS48W.
PhylomeDBiQ9NQ90.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQ90-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATPGPRDIP LLPGSPRRLS PQAGSRGGQG PKHGQQCLKM PGPRAPGLQG     50
GSNRDPGQPC GGESTRSSSV INNYLDANEP VSLEARLSRM HFHDSQRKVD 100
YVLAYHYRKR GVHLAQGFPG HSLAIVSNGE TGKEPHAGGP GDIELGPLDA 150
LEEERKEQRE EFEHNLMEAG LELEKDLENK SQGSIFVRIH APWQVLAREA 200
EFLKIKVPTK KEMYEIKAGG SIAKKFSAAL QKLSSHLQPR VPEHSNNKMK 250
NLSYPFSREK MYLYNIQEKD TFFDNATRSR IVHEILKRTA CSRANNTMGI 300
NSLIANNIYE AAYPLHDGEY DSPEDDMNDR KLLYQEWARY GVFYKFQPID 350
LIRKYFGEKI GLYFAWLGLY TSFLIPSSVI GVIVFLYGCA TIEEDIPSRE 400
MCDQQNAFTM CPLCDKSCDY WNLSSACGTA QASHLFDNPA TVFFSIFMAL 450
WATMFLENWK RLQMRLGYFW DLTGIEEEEE RAQEHSRPEY ETKVREKMLK 500
ESNQSAVQKL ETNTTECGDE DDEDKLTWKD RFPGYLMNFA SILFMIALTF 550
SIVFGVIVYR ITTAAALSLN KATRSNVRVT VTATAVIINL VVILILDEIY 600
GAVAKWLTKI EVPKTEQTFE ERLILKAFLL KFVNAYSPIF YVAFFKGRFV 650
GRPGSYVYVF DGYRMEECAP GGCLMELCIQ LSIIMLGKQL IQNNIFEIGV 700
PKLKKLFRKL KDETEAGETD SAHSKHPEQW DLDYSLEPYT GLTPEYMEMI 750
IQFGFVTLFV ASFPLAPVFA LLNNVIEVRL DAKKFVTELR RPDAVRTKDI 800
GIWFDILSGI GKFSVISNAF VIAITSDFIP RLVYQYSYSH NGTLHGFVNH 850
TLSFFNVSQL KEGTQPENSQ FDQEVQFCRF KDYREPPWAP NPYEFSKQYW 900
FILSARLAFV IIFQNLVMFL SVLVDWMIPD IPTDISDQIK KEKSLLVDFF 950
LKEEHEKLKL MDEPALRSPG GGDRSRSRAA SSAPSGQSQL GSMMSSGSQH 1000
TNV 1003

Note: Splice site between exons 4 and 5 is non-canonical.

Length:1,003
Mass (Da):113,969
Last modified:November 3, 2009 - v2
Checksum:i32939EADC8AFE5C8
GO
Isoform 2 (identifier: Q9NQ90-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-7: GPR → MPE

Note: Splice site between exons 4 and 5 is non-canonical.

Show »
Length:999
Mass (Da):113,616
Checksum:iB9B4F56161AE1B00
GO

Sequence cautioni

The sequence BAB14773.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121V → A.
Corresponds to variant rs3741903 [ dbSNP | Ensembl ].
VAR_021932
Natural varianti147 – 1471P → S.
Corresponds to variant rs3741901 [ dbSNP | Ensembl ].
VAR_057286
Natural varianti401 – 4011M → I.
Corresponds to variant rs17788563 [ dbSNP | Ensembl ].
VAR_061853
Natural varianti505 – 5051S → A.
Corresponds to variant rs1860961 [ dbSNP | Ensembl ].
VAR_020331

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44Missing in isoform 2.
VSP_040493
Alternative sequencei5 – 73GPR → MPE in isoform 2.
VSP_040494

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272204 mRNA. Translation: CAC01125.1.
FJ384095 mRNA. Translation: ACL36050.1.
AC006431 Genomic DNA. No translation available.
AC006560 Genomic DNA. No translation available.
AC137627 Genomic DNA. No translation available.
AK024010 mRNA. Translation: BAB14773.1. Different initiation.
CCDSiCCDS44807.1. [Q9NQ90-2]
RefSeqiNP_001265525.1. NM_001278596.1. [Q9NQ90-1]
NP_001265526.1. NM_001278597.1. [Q9NQ90-2]
UniGeneiHs.148970.

Genome annotation databases

EnsembliENST00000356134; ENSP00000348453; ENSG00000047617. [Q9NQ90-2]
GeneIDi57101.
KEGGihsa:57101.

Polymorphism databases

DMDMi262527528.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272204 mRNA. Translation: CAC01125.1 .
FJ384095 mRNA. Translation: ACL36050.1 .
AC006431 Genomic DNA. No translation available.
AC006560 Genomic DNA. No translation available.
AC137627 Genomic DNA. No translation available.
AK024010 mRNA. Translation: BAB14773.1 . Different initiation.
CCDSi CCDS44807.1. [Q9NQ90-2 ]
RefSeqi NP_001265525.1. NM_001278596.1. [Q9NQ90-1 ]
NP_001265526.1. NM_001278597.1. [Q9NQ90-2 ]
UniGenei Hs.148970.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 121367. 1 interaction.
STRINGi 9606.ENSP00000314048.

Protein family/group databases

TCDBi 1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

PhosphoSitei Q9NQ90.

Polymorphism databases

DMDMi 262527528.

Proteomic databases

PaxDbi Q9NQ90.
PRIDEi Q9NQ90.

Protocols and materials databases

DNASUi 57101.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356134 ; ENSP00000348453 ; ENSG00000047617 . [Q9NQ90-2 ]
GeneIDi 57101.
KEGGi hsa:57101.

Organism-specific databases

CTDi 57101.
GeneCardsi GC12M005671.
HGNCi HGNC:1183. ANO2.
HPAi HPA036276.
MIMi 610109. gene.
neXtProti NX_Q9NQ90.
PharmGKBi PA25504.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320103.
HOGENOMi HOG000006509.
HOVERGENi HBG069519.
InParanoidi Q9NQ90.
OMAi DRFPGYL.
OrthoDBi EOG7BS48W.
PhylomeDBi Q9NQ90.
TreeFami TF314265.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

GenomeRNAii 57101.
NextBioi 62929.
PROi Q9NQ90.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NQ90.
Bgeei Q9NQ90.
CleanExi HS_ANO2.
Genevestigatori Q9NQ90.

Family and domain databases

InterProi IPR007632. Anoctamin.
[Graphical view ]
PANTHERi PTHR12308. PTHR12308. 1 hit.
Pfami PF04547. Anoctamin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcripts in 12p13.3."
    Lorenz B., White K.E., Econs M.J., Strom T.M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Retina.
  2. "TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals."
    Stoehr H., Heisig J.B., Benz P.M., Schoeberl S., Milenkovic V.M., Strauss O., Aartsen W.M., Wijnholds J., Weber B.H.F., Schulz H.L.
    J. Neurosci. 29:6809-6818(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Retina.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-999 (ISOFORMS 1/2).
    Tissue: Retinoblastoma.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. Cited for: REVIEW.
  8. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.
  10. "Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction."
    Pifferi S., Cenedese V., Menini A.
    Exp. Physiol. 97:193-199(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.

Entry informationi

Entry nameiANO2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ90
Secondary accession number(s): C4N787, Q9H847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 3, 2009
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi