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Q9NQ90

- ANO2_HUMAN

UniProt

Q9NQ90 - ANO2_HUMAN

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Protein

Anoctamin-2

Gene

ANO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.4 Publications

Enzyme regulationi

Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).By similarity

GO - Molecular functioni

  1. intracellular calcium activated chloride channel activity Source: UniProtKB

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. ion transmembrane transport Source: Reactome
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
REACT_267716. Orphan transporters.

Protein family/group databases

TCDBi1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-2
Alternative name(s):
Transmembrane protein 16B
Gene namesi
Name:ANO2
Synonyms:C12orf3, TMEM16B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1183. ANO2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 365365CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Topological domaini387 – 43448ExtracellularSequence AnalysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST
Topological domaini456 – 53883CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence AnalysisAdd
BLAST
Topological domaini560 – 58223ExtracellularSequence AnalysisAdd
BLAST
Transmembranei583 – 60321HelicalSequence AnalysisAdd
BLAST
Topological domaini604 – 62320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence AnalysisAdd
BLAST
Topological domaini645 – 748104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei749 – 76921HelicalSequence AnalysisAdd
BLAST
Topological domaini770 – 80132CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei802 – 82221HelicalSequence AnalysisAdd
BLAST
Topological domaini823 – 90785ExtracellularSequence AnalysisAdd
BLAST
Transmembranei908 – 92821HelicalSequence AnalysisAdd
BLAST
Topological domaini929 – 100375CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
  2. nucleus Source: HPA
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003Anoctamin-2PRO_0000072564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi841 – 8411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi849 – 8491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NQ90.
PRIDEiQ9NQ90.

PTM databases

PhosphoSiteiQ9NQ90.

Expressioni

Tissue specificityi

Retina, especially in the photoreceptor synaptic terminals.1 Publication

Gene expression databases

BgeeiQ9NQ90.
CleanExiHS_ANO2.
ExpressionAtlasiQ9NQ90. baseline and differential.
GenevestigatoriQ9NQ90.

Organism-specific databases

HPAiHPA036276.

Interactioni

Subunit structurei

Component of a presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. Interacts with DLG4 by its C-terminal region (By similarity).By similarity

Protein-protein interaction databases

BioGridi121367. 1 interaction.
STRINGi9606.ENSP00000314048.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1001 – 10033DLG4 binding (PDZ)

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320103.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ9NQ90.
OMAiDRFPGYL.
OrthoDBiEOG7BS48W.
PhylomeDBiQ9NQ90.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NQ90-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPGPRDIP LLPGSPRRLS PQAGSRGGQG PKHGQQCLKM PGPRAPGLQG
60 70 80 90 100
GSNRDPGQPC GGESTRSSSV INNYLDANEP VSLEARLSRM HFHDSQRKVD
110 120 130 140 150
YVLAYHYRKR GVHLAQGFPG HSLAIVSNGE TGKEPHAGGP GDIELGPLDA
160 170 180 190 200
LEEERKEQRE EFEHNLMEAG LELEKDLENK SQGSIFVRIH APWQVLAREA
210 220 230 240 250
EFLKIKVPTK KEMYEIKAGG SIAKKFSAAL QKLSSHLQPR VPEHSNNKMK
260 270 280 290 300
NLSYPFSREK MYLYNIQEKD TFFDNATRSR IVHEILKRTA CSRANNTMGI
310 320 330 340 350
NSLIANNIYE AAYPLHDGEY DSPEDDMNDR KLLYQEWARY GVFYKFQPID
360 370 380 390 400
LIRKYFGEKI GLYFAWLGLY TSFLIPSSVI GVIVFLYGCA TIEEDIPSRE
410 420 430 440 450
MCDQQNAFTM CPLCDKSCDY WNLSSACGTA QASHLFDNPA TVFFSIFMAL
460 470 480 490 500
WATMFLENWK RLQMRLGYFW DLTGIEEEEE RAQEHSRPEY ETKVREKMLK
510 520 530 540 550
ESNQSAVQKL ETNTTECGDE DDEDKLTWKD RFPGYLMNFA SILFMIALTF
560 570 580 590 600
SIVFGVIVYR ITTAAALSLN KATRSNVRVT VTATAVIINL VVILILDEIY
610 620 630 640 650
GAVAKWLTKI EVPKTEQTFE ERLILKAFLL KFVNAYSPIF YVAFFKGRFV
660 670 680 690 700
GRPGSYVYVF DGYRMEECAP GGCLMELCIQ LSIIMLGKQL IQNNIFEIGV
710 720 730 740 750
PKLKKLFRKL KDETEAGETD SAHSKHPEQW DLDYSLEPYT GLTPEYMEMI
760 770 780 790 800
IQFGFVTLFV ASFPLAPVFA LLNNVIEVRL DAKKFVTELR RPDAVRTKDI
810 820 830 840 850
GIWFDILSGI GKFSVISNAF VIAITSDFIP RLVYQYSYSH NGTLHGFVNH
860 870 880 890 900
TLSFFNVSQL KEGTQPENSQ FDQEVQFCRF KDYREPPWAP NPYEFSKQYW
910 920 930 940 950
FILSARLAFV IIFQNLVMFL SVLVDWMIPD IPTDISDQIK KEKSLLVDFF
960 970 980 990 1000
LKEEHEKLKL MDEPALRSPG GGDRSRSRAA SSAPSGQSQL GSMMSSGSQH

TNV

Note: Splice site between exons 4 and 5 is non-canonical.

Length:1,003
Mass (Da):113,969
Last modified:November 3, 2009 - v2
Checksum:i32939EADC8AFE5C8
GO
Isoform 2 (identifier: Q9NQ90-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     5-7: GPR → MPE

Note: Splice site between exons 4 and 5 is non-canonical.

Show »
Length:999
Mass (Da):113,616
Checksum:iB9B4F56161AE1B00
GO

Sequence cautioni

The sequence BAB14773.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121V → A.
Corresponds to variant rs3741903 [ dbSNP | Ensembl ].
VAR_021932
Natural varianti147 – 1471P → S.
Corresponds to variant rs3741901 [ dbSNP | Ensembl ].
VAR_057286
Natural varianti401 – 4011M → I.
Corresponds to variant rs17788563 [ dbSNP | Ensembl ].
VAR_061853
Natural varianti505 – 5051S → A.
Corresponds to variant rs1860961 [ dbSNP | Ensembl ].
VAR_020331

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44Missing in isoform 2. 1 PublicationVSP_040493
Alternative sequencei5 – 73GPR → MPE in isoform 2. 1 PublicationVSP_040494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272204 mRNA. Translation: CAC01125.1.
FJ384095 mRNA. Translation: ACL36050.1.
AC006431 Genomic DNA. No translation available.
AC006560 Genomic DNA. No translation available.
AC137627 Genomic DNA. No translation available.
AK024010 mRNA. Translation: BAB14773.1. Different initiation.
CCDSiCCDS44807.2. [Q9NQ90-2]
RefSeqiNP_001265525.1. NM_001278596.1. [Q9NQ90-1]
NP_001265526.1. NM_001278597.1. [Q9NQ90-2]
UniGeneiHs.148970.

Genome annotation databases

EnsembliENST00000327087; ENSP00000314048; ENSG00000047617. [Q9NQ90-2]
ENST00000356134; ENSP00000348453; ENSG00000047617. [Q9NQ90-2]
GeneIDi57101.
KEGGihsa:57101.

Polymorphism databases

DMDMi262527528.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272204 mRNA. Translation: CAC01125.1 .
FJ384095 mRNA. Translation: ACL36050.1 .
AC006431 Genomic DNA. No translation available.
AC006560 Genomic DNA. No translation available.
AC137627 Genomic DNA. No translation available.
AK024010 mRNA. Translation: BAB14773.1 . Different initiation.
CCDSi CCDS44807.2. [Q9NQ90-2 ]
RefSeqi NP_001265525.1. NM_001278596.1. [Q9NQ90-1 ]
NP_001265526.1. NM_001278597.1. [Q9NQ90-2 ]
UniGenei Hs.148970.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121367. 1 interaction.
STRINGi 9606.ENSP00000314048.

Protein family/group databases

TCDBi 1.A.17.1.3. the calcium-dependent chloride channel (ca-clc) family.

PTM databases

PhosphoSitei Q9NQ90.

Polymorphism databases

DMDMi 262527528.

Proteomic databases

PaxDbi Q9NQ90.
PRIDEi Q9NQ90.

Protocols and materials databases

DNASUi 57101.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327087 ; ENSP00000314048 ; ENSG00000047617 . [Q9NQ90-2 ]
ENST00000356134 ; ENSP00000348453 ; ENSG00000047617 . [Q9NQ90-2 ]
GeneIDi 57101.
KEGGi hsa:57101.

Organism-specific databases

CTDi 57101.
GeneCardsi GC12M005671.
HGNCi HGNC:1183. ANO2.
HPAi HPA036276.
MIMi 610109. gene.
neXtProti NX_Q9NQ90.
PharmGKBi PA25504.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320103.
GeneTreei ENSGT00760000119015.
HOGENOMi HOG000006509.
HOVERGENi HBG069519.
InParanoidi Q9NQ90.
OMAi DRFPGYL.
OrthoDBi EOG7BS48W.
PhylomeDBi Q9NQ90.
TreeFami TF314265.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.
REACT_267716. Orphan transporters.

Miscellaneous databases

ChiTaRSi ANO2. human.
GenomeRNAii 57101.
NextBioi 62929.
PROi Q9NQ90.
SOURCEi Search...

Gene expression databases

Bgeei Q9NQ90.
CleanExi HS_ANO2.
ExpressionAtlasi Q9NQ90. baseline and differential.
Genevestigatori Q9NQ90.

Family and domain databases

InterProi IPR007632. Anoctamin.
[Graphical view ]
PANTHERi PTHR12308. PTHR12308. 1 hit.
Pfami PF04547. Anoctamin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcripts in 12p13.3."
    Lorenz B., White K.E., Econs M.J., Strom T.M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Retina.
  2. "TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals."
    Stoehr H., Heisig J.B., Benz P.M., Schoeberl S., Milenkovic V.M., Strauss O., Aartsen W.M., Wijnholds J., Weber B.H.F., Schulz H.L.
    J. Neurosci. 29:6809-6818(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, GLYCOSYLATION, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Retina.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-999 (ISOFORMS 1/2).
    Tissue: Retinoblastoma.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. Cited for: REVIEW.
  8. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.
  10. "Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction."
    Pifferi S., Cenedese V., Menini A.
    Exp. Physiol. 97:193-199(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.

Entry informationi

Entry nameiANO2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ90
Secondary accession number(s): C4N787, Q9H847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 3, 2009
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3