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Protein

Protein C12orf4

Gene

C12orf4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in mast cell degranulation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C12orf4
Gene namesi
Name:C12orf4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000047621.11.
HGNCiHGNC:1184. C12orf4.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047621.
PharmGKBiPA25505.

Polymorphism and mutation databases

BioMutaiC12orf4.
DMDMi71153007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898421 – 552Protein C12orf4Add BLAST552

Proteomic databases

EPDiQ9NQ89.
MaxQBiQ9NQ89.
PaxDbiQ9NQ89.
PeptideAtlasiQ9NQ89.
PRIDEiQ9NQ89.

PTM databases

iPTMnetiQ9NQ89.
PhosphoSitePlusiQ9NQ89.

Expressioni

Gene expression databases

BgeeiENSG00000047621.
CleanExiHS_C12orf4.
ExpressionAtlasiQ9NQ89. baseline and differential.
GenevisibleiQ9NQ89. HS.

Organism-specific databases

HPAiHPA037871.

Interactioni

Protein-protein interaction databases

BioGridi121368. 5 interactors.
IntActiQ9NQ89. 3 interactors.
STRINGi9606.ENSP00000261250.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ89.
SMRiQ9NQ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4506. Eukaryota.
ENOG410XS4V. LUCA.
GeneTreeiENSGT00390000010229.
HOGENOMiHOG000233884.
HOVERGENiHBG057511.
InParanoidiQ9NQ89.
OMAiEMEKVMQ.
OrthoDBiEOG091G077P.
PhylomeDBiQ9NQ89.
TreeFamiTF314243.

Family and domain databases

InterProiView protein in InterPro
IPR019311. DUF2362.
PANTHERiPTHR16525. PTHR16525. 1 hit.
PfamiView protein in Pfam
PF10154. DUF2362. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NQ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNRERFCN REREFVYKFK VGSQCLELRV PLKFPVQENA SHLHGRLMLL
60 70 80 90 100
HSLPCFIEKD LKEALTQFIE EESLSDYDRD AEASLAAVKS GEVDLHQLAS
110 120 130 140 150
TWAKAYAETT LEHARPEEPS WDEDFADVYH DLIHSPASET LLNLEHNYFV
160 170 180 190 200
SISELIGERD VELKKLRERQ GIEMEKVMQE LGKSLTDQDV NSLAAQHFES
210 220 230 240 250
QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS SLSEEIKVQP
260 270 280 290 300
SQFRESVEAI GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
310 320 330 340 350
HKRNHRSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC
360 370 380 390 400
QECTDFHFPR IEEQLEVVQQ VVLYARTQRR SKLKESLDSG NQNGGNDDKT
410 420 430 440 450
KNAERNYLNV LPGEFYITRH SNLSEIHVAF HLCVDDHVKS GNITARDPAI
460 470 480 490 500
MGLRNILKVC CTHDITTISI PLLLVHDMSE EMTIPWCLRR AELVFKCVKG
510 520 530 540 550
FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF RVSSTLTLTS

KH
Length:552
Mass (Da):63,801
Last modified:October 1, 2000 - v1
Checksum:iE183A979E3BA0F5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Q → R in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti156I → V in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti165K → E in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti245E → G in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti377T → P in CAE46058 (PubMed:17974005).Curated1
Sequence conflicti465I → V in CAE46058 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272205 mRNA. Translation: CAC01126.1.
AL834377 mRNA. Translation: CAD39040.1.
BX641128 mRNA. Translation: CAE46058.1.
CH471116 Genomic DNA. Translation: EAW88845.1.
CH471116 Genomic DNA. Translation: EAW88846.1.
BC016908 mRNA. Translation: AAH16908.1.
CCDSiCCDS8528.1.
RefSeqiNP_001291740.1. NM_001304811.1.
NP_065107.1. NM_020374.3.
UniGeneiHs.302977.

Genome annotation databases

EnsembliENST00000261250; ENSP00000261250; ENSG00000047621.
ENST00000545746; ENSP00000439996; ENSG00000047621.
GeneIDi57102.
KEGGihsa:57102.
UCSCiuc001qms.4. human.

Similar proteinsi

Entry informationi

Entry nameiCL004_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ89
Secondary accession number(s): D3DUQ8, Q6MZH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot