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Protein

E3 ubiquitin-protein ligase TRIM36

Gene

TRIM36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 84RING-type; degeneratePROSITE-ProRule annotationAdd BLAST52
Zinc fingeri154 – 192B box-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri207 – 249B box-type 2PROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152503-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM36 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 98
Tripartite motif-containing protein 36
Zinc-binding protein Rbcc728
Gene namesi
Name:TRIM36
Synonyms:RBCC728, RNF98
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16280. TRIM36.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi55521.
OpenTargetsiENSG00000152503.
PharmGKBiPA38111.

Polymorphism and mutation databases

BioMutaiTRIM36.
DMDMi313104034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562521 – 728E3 ubiquitin-protein ligase TRIM36Add BLAST728

Proteomic databases

MaxQBiQ9NQ86.
PaxDbiQ9NQ86.
PeptideAtlasiQ9NQ86.
PRIDEiQ9NQ86.

PTM databases

iPTMnetiQ9NQ86.
PhosphoSitePlusiQ9NQ86.

Expressioni

Tissue specificityi

Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart.1 Publication

Gene expression databases

BgeeiENSG00000152503.
CleanExiHS_TRIM36.
ExpressionAtlasiQ9NQ86. baseline and differential.
GenevisibleiQ9NQ86. HS.

Organism-specific databases

HPAiHPA059000.

Interactioni

Subunit structurei

Interacts with CENPH.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4A2Q142403EBI-2341518,EBI-73473
EIF4A2Q14240-23EBI-2341518,EBI-10232522
GLRX3O760035EBI-2341518,EBI-374781
GRB7Q144513EBI-2341518,EBI-970191
TRAF3IP3Q9Y2283EBI-2341518,EBI-765817
ZMAT2Q96NC03EBI-2341518,EBI-2682299
ZNF417Q8TAU33EBI-2341518,EBI-740727
ZNF587Q96SQ53EBI-2341518,EBI-6427977

Protein-protein interaction databases

BioGridi120695. 18 interactors.
IntActiQ9NQ86. 13 interactors.
STRINGi9606.ENSP00000282369.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ86.
SMRiQ9NQ86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 413COSPROSITE-ProRule annotationAdd BLAST58
Domaini419 – 510Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92
Domaini508 – 720B30.2/SPRYPROSITE-ProRule annotationAdd BLAST213

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili271 – 345Sequence analysisAdd BLAST75

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 84RING-type; degeneratePROSITE-ProRule annotationAdd BLAST52
Zinc fingeri154 – 192B box-type 1PROSITE-ProRule annotationAdd BLAST39
Zinc fingeri207 – 249B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFI. Eukaryota.
ENOG410Z6W7. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049213.
HOVERGENiHBG059072.
InParanoidiQ9NQ86.
KOiK12013.
OMAiKILMCPE.
OrthoDBiEOG091G020H.
PhylomeDBiQ9NQ86.
TreeFamiTF315216.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027726. Trim36.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF29. PTHR24103:SF29. 3 hits.
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH
60 70 80 90 100
SICHKCVKEL LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG
110 120 130 140 150
WKRNSLTPRT TVFPCPGCEH DVDLGERGIN GLFRNFTLET IVERYRQAAR
160 170 180 190 200
AATAIMCDLC KPPPQESTKS CMDCSASYCN ECFKIHHPWG TIKAQHEYVG
210 220 230 240 250
PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN HANHRVTTMS
260 270 280 290 300
SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI
310 320 330 340 350
THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG
360 370 380 390 400
YAQEVLKETD QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT
410 420 430 440 450
SKQTELLGEL SFFSSGIDVP EINEEQSKVY NNALINWHHP EKDKADSYVL
460 470 480 490 500
EYRKINRDDE MSWNEIEVCG TSKIIQDLEN SSTYAFRVRA YKGSICSPCS
510 520 530 540 550
RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR AGFNLLLAAE
560 570 580 590 600
RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW
610 620 630 640 650
LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT
660 670 680 690 700
SSNEPENRVL PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY
710 720
PAFALMGSGG IQLEEPITAK YLEYQEDM
Length:728
Mass (Da):83,013
Last modified:November 30, 2010 - v2
Checksum:i1D1B4F98325BD73C
GO
Isoform 2 (identifier: Q9NQ86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-60: VTIKNIEREL...SICHKCVKEL → MPDWRRGYRC...GNKSGKHFKT
     61-728: Missing.

Note: No experimental confirmation available.
Show »
Length:60
Mass (Da):6,742
Checksum:i5F14D56947E8AB29
GO
Isoform 3 (identifier: Q9NQ86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-61: VTIKNIEREL...ICHKCVKELL → ASAMGLQQTH...VGKQSLPRRT
     62-728: Missing.

Note: No experimental confirmation available.
Show »
Length:61
Mass (Da):6,702
Checksum:i1326D724A01FC532
GO
Isoform 4 (identifier: Q9NQ86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSESGEMSEFGYIMELIAKGK → MEGDGSDSP

Note: No experimental confirmation available.
Show »
Length:716
Mass (Da):81,570
Checksum:iD07682496F9897BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313R → G in BAH12340 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023197428K → R.2 PublicationsCorresponds to variant rs79290430dbSNPEnsembl.1
Natural variantiVAR_023198456N → S.1 PublicationCorresponds to variant rs17137481dbSNPEnsembl.1
Natural variantiVAR_020490678D → N.4 PublicationsCorresponds to variant rs2974617dbSNPEnsembl.1
Natural variantiVAR_057221725Q → E.Corresponds to variant rs3749745dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538181 – 21MSESG…IAKGK → MEGDGSDSP in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_04579122 – 61VTIKN…VKELL → ASAMGLQQTHEHSRLTSKGG EARCPFEISEVGKQSLPRRT in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04351122 – 60VTIKN…CVKEL → MPDWRRGYRCRQGCGKTTEL ATATDFSQTGNKSGKHFKT in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_04351261 – 728Missing in isoform 2. 1 PublicationAdd BLAST668
Alternative sequenceiVSP_04579262 – 728Missing in isoform 3. 1 PublicationAdd BLAST667

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272269 mRNA. Translation: CAB94831.1.
BX460627 mRNA. No translation available.
AK316422 mRNA. Translation: BAH14793.1.
AK296389 mRNA. Translation: BAH12340.1.
AC008494 Genomic DNA. No translation available.
AC094104 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48972.1.
BC045164 mRNA. Translation: AAH45164.1.
BC046096 mRNA. Translation: AAH46096.1.
BC130334 mRNA. Translation: AAI30335.1.
CCDSiCCDS34211.1. [Q9NQ86-2]
CCDS34212.1. [Q9NQ86-3]
CCDS4115.1. [Q9NQ86-1]
CCDS75287.1. [Q9NQ86-4]
RefSeqiNP_001017397.1. NM_001017397.1. [Q9NQ86-2]
NP_001017398.1. NM_001017398.1. [Q9NQ86-3]
NP_001287681.1. NM_001300752.1.
NP_001287688.1. NM_001300759.1. [Q9NQ86-4]
NP_061170.2. NM_018700.3. [Q9NQ86-1]
UniGeneiHs.519514.
Hs.638953.

Genome annotation databases

EnsembliENST00000282369; ENSP00000282369; ENSG00000152503. [Q9NQ86-1]
ENST00000379617; ENSP00000368937; ENSG00000152503. [Q9NQ86-3]
ENST00000379618; ENSP00000368938; ENSG00000152503. [Q9NQ86-2]
ENST00000513154; ENSP00000423934; ENSG00000152503. [Q9NQ86-4]
GeneIDi55521.
KEGGihsa:55521.
UCSCiuc003kqs.4. human. [Q9NQ86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272269 mRNA. Translation: CAB94831.1.
BX460627 mRNA. No translation available.
AK316422 mRNA. Translation: BAH14793.1.
AK296389 mRNA. Translation: BAH12340.1.
AC008494 Genomic DNA. No translation available.
AC094104 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48972.1.
BC045164 mRNA. Translation: AAH45164.1.
BC046096 mRNA. Translation: AAH46096.1.
BC130334 mRNA. Translation: AAI30335.1.
CCDSiCCDS34211.1. [Q9NQ86-2]
CCDS34212.1. [Q9NQ86-3]
CCDS4115.1. [Q9NQ86-1]
CCDS75287.1. [Q9NQ86-4]
RefSeqiNP_001017397.1. NM_001017397.1. [Q9NQ86-2]
NP_001017398.1. NM_001017398.1. [Q9NQ86-3]
NP_001287681.1. NM_001300752.1.
NP_001287688.1. NM_001300759.1. [Q9NQ86-4]
NP_061170.2. NM_018700.3. [Q9NQ86-1]
UniGeneiHs.519514.
Hs.638953.

3D structure databases

ProteinModelPortaliQ9NQ86.
SMRiQ9NQ86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120695. 18 interactors.
IntActiQ9NQ86. 13 interactors.
STRINGi9606.ENSP00000282369.

PTM databases

iPTMnetiQ9NQ86.
PhosphoSitePlusiQ9NQ86.

Polymorphism and mutation databases

BioMutaiTRIM36.
DMDMi313104034.

Proteomic databases

MaxQBiQ9NQ86.
PaxDbiQ9NQ86.
PeptideAtlasiQ9NQ86.
PRIDEiQ9NQ86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282369; ENSP00000282369; ENSG00000152503. [Q9NQ86-1]
ENST00000379617; ENSP00000368937; ENSG00000152503. [Q9NQ86-3]
ENST00000379618; ENSP00000368938; ENSG00000152503. [Q9NQ86-2]
ENST00000513154; ENSP00000423934; ENSG00000152503. [Q9NQ86-4]
GeneIDi55521.
KEGGihsa:55521.
UCSCiuc003kqs.4. human. [Q9NQ86-1]

Organism-specific databases

CTDi55521.
DisGeNETi55521.
GeneCardsiTRIM36.
H-InvDBHIX0005100.
HIX0032376.
HGNCiHGNC:16280. TRIM36.
HPAiHPA059000.
MIMi609317. gene.
neXtProtiNX_Q9NQ86.
OpenTargetsiENSG00000152503.
PharmGKBiPA38111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFI. Eukaryota.
ENOG410Z6W7. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000049213.
HOVERGENiHBG059072.
InParanoidiQ9NQ86.
KOiK12013.
OMAiKILMCPE.
OrthoDBiEOG091G020H.
PhylomeDBiQ9NQ86.
TreeFamiTF315216.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152503-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii55521.
PROiQ9NQ86.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152503.
CleanExiHS_TRIM36.
ExpressionAtlasiQ9NQ86. baseline and differential.
GenevisibleiQ9NQ86. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR027726. Trim36.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR24103:SF29. PTHR24103:SF29. 3 hits.
PfamiPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI36_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ86
Secondary accession number(s): A1L3Z1
, A6NDD0, B7Z3V4, B7ZAV7, E9PFI8, Q0P5Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.