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Protein

G-protein coupled receptor family C group 5 member C

Gene

GPRC5C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170412-MONOMER.

Protein family/group databases

TCDBi9.A.14.11.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member C
Alternative name(s):
Retinoic acid-induced gene 3 protein
Short name:
RAIG-3
Gene namesi
Name:GPRC5C
Synonyms:RAIG3
ORF Names:PSEC0087
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:13309. GPRC5C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 50ExtracellularSequence analysisAdd BLAST27
Transmembranei51 – 71Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini107 – 120ExtracellularSequence analysisAdd BLAST14
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 155CytoplasmicSequence analysisAdd BLAST14
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 208ExtracellularSequence analysisAdd BLAST32
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 241CytoplasmicSequence analysisAdd BLAST12
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 300Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini301 – 441CytoplasmicSequence analysisAdd BLAST141

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • receptor complex Source: MGI
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55890.
OpenTargetsiENSG00000170412.
PharmGKBiPA28939.

Polymorphism and mutation databases

BioMutaiGPRC5C.
DMDMi46396014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001296724 – 441G-protein coupled receptor family C group 5 member CAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Modified residuei344PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei403PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei414PhosphotyrosineBy similarity1
Modified residuei423PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NQ84.
MaxQBiQ9NQ84.
PaxDbiQ9NQ84.
PeptideAtlasiQ9NQ84.
PRIDEiQ9NQ84.

PTM databases

iPTMnetiQ9NQ84.
PhosphoSitePlusiQ9NQ84.
SwissPalmiQ9NQ84.

Expressioni

Tissue specificityi

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).2 Publications

Inductioni

By all-trans retinoic acid (ATRA).2 Publications

Gene expression databases

BgeeiENSG00000170412.
CleanExiHS_GPRC5C.
ExpressionAtlasiQ9NQ84. baseline and differential.
GenevisibleiQ9NQ84. HS.

Organism-specific databases

HPAiHPA029776.

Interactioni

Protein-protein interaction databases

BioGridi120980. 31 interactors.
IntActiQ9NQ84. 1 interactor.
MINTiMINT-5006165.
STRINGi9606.ENSP00000376403.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
GeneTreeiENSGT00520000055551.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ9NQ84.
KOiK04620.
PhylomeDBiQ9NQ84.
TreeFamiTF321410.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG
60 70 80 90 100
IVLEAVAGAG IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL
110 120 130 140 150
FCLVFACVVK PDFSTCASRR FLFGVLFAIC FSCLAAHVFA LNFLARKNHG
160 170 180 190 200
PRGWVIFTVA LLLTLVEVII NTEWLIITLV RGSGEGGPQG NSSAGWAVAS
210 220 230 240 250
PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK HGVFVLLTTA
260 270 280 290 300
TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV
310 320 330 340 350
SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA
360 370 380 390 400
AKRPVSPYSG YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV
410 420 430 440
MGSANSTLRA EDMYSAQSHQ AATPPKDGKN SQVFRNPYVW D
Length:441
Mass (Da):48,193
Last modified:April 13, 2004 - v2
Checksum:iB255D9680328FE3D
GO
Isoform 2 (identifier: Q9NQ84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTQPEPGLGARM

Show »
Length:453
Mass (Da):49,389
Checksum:i232D2F2BCD64EE46
GO

Sequence cautioni

The sequence AAH16860 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI10849 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25081 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25082 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG54752 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC00633 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204I → V in CAC00633 (PubMed:10945465).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377251M → MGTQPEPGLGARM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276102 mRNA. Translation: CAC00633.1. Different initiation.
AF207989 mRNA. Translation: AAF72870.1.
BT007435 mRNA. Translation: AAP36103.1.
AK131210 mRNA. Translation: BAG54752.1. Different initiation.
AK075397 mRNA. Translation: BAC11595.1.
AB451470 mRNA. Translation: BAG70284.1.
AC079325 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89163.1.
BC016860 mRNA. Translation: AAH16860.2. Different initiation.
BC110848 mRNA. Translation: AAI10849.1. Different initiation.
BC125080 mRNA. Translation: AAI25081.1. Different initiation.
BC125081 mRNA. Translation: AAI25082.1. Different initiation.
CCDSiCCDS42378.1. [Q9NQ84-2]
RefSeqiNP_061123.3. NM_018653.3. [Q9NQ84-2]
NP_071319.2. NM_022036.2.
UniGeneiHs.446438.

Genome annotation databases

EnsembliENST00000392629; ENSP00000376405; ENSG00000170412. [Q9NQ84-2]
GeneIDi55890.
KEGGihsa:55890.
UCSCiuc002jkp.4. human. [Q9NQ84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276102 mRNA. Translation: CAC00633.1. Different initiation.
AF207989 mRNA. Translation: AAF72870.1.
BT007435 mRNA. Translation: AAP36103.1.
AK131210 mRNA. Translation: BAG54752.1. Different initiation.
AK075397 mRNA. Translation: BAC11595.1.
AB451470 mRNA. Translation: BAG70284.1.
AC079325 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89163.1.
BC016860 mRNA. Translation: AAH16860.2. Different initiation.
BC110848 mRNA. Translation: AAI10849.1. Different initiation.
BC125080 mRNA. Translation: AAI25081.1. Different initiation.
BC125081 mRNA. Translation: AAI25082.1. Different initiation.
CCDSiCCDS42378.1. [Q9NQ84-2]
RefSeqiNP_061123.3. NM_018653.3. [Q9NQ84-2]
NP_071319.2. NM_022036.2.
UniGeneiHs.446438.

3D structure databases

ProteinModelPortaliQ9NQ84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120980. 31 interactors.
IntActiQ9NQ84. 1 interactor.
MINTiMINT-5006165.
STRINGi9606.ENSP00000376403.

Protein family/group databases

TCDBi9.A.14.11.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9NQ84.
PhosphoSitePlusiQ9NQ84.
SwissPalmiQ9NQ84.

Polymorphism and mutation databases

BioMutaiGPRC5C.
DMDMi46396014.

Proteomic databases

EPDiQ9NQ84.
MaxQBiQ9NQ84.
PaxDbiQ9NQ84.
PeptideAtlasiQ9NQ84.
PRIDEiQ9NQ84.

Protocols and materials databases

DNASUi55890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392629; ENSP00000376405; ENSG00000170412. [Q9NQ84-2]
GeneIDi55890.
KEGGihsa:55890.
UCSCiuc002jkp.4. human. [Q9NQ84-1]

Organism-specific databases

CTDi55890.
DisGeNETi55890.
GeneCardsiGPRC5C.
HGNCiHGNC:13309. GPRC5C.
HPAiHPA029776.
MIMi605949. gene.
neXtProtiNX_Q9NQ84.
OpenTargetsiENSG00000170412.
PharmGKBiPA28939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI6. Eukaryota.
ENOG4110E9P. LUCA.
GeneTreeiENSGT00520000055551.
HOGENOMiHOG000116197.
HOVERGENiHBG051794.
InParanoidiQ9NQ84.
KOiK04620.
PhylomeDBiQ9NQ84.
TreeFamiTF321410.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170412-MONOMER.

Miscellaneous databases

ChiTaRSiGPRC5C. human.
GenomeRNAii55890.
PROiQ9NQ84.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170412.
CleanExiHS_GPRC5C.
ExpressionAtlasiQ9NQ84. baseline and differential.
GenevisibleiQ9NQ84. HS.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC5C_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ84
Secondary accession number(s): B5BUN4, Q2NL85, Q9NZG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.