Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NQ84 (GPC5C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor family C group 5 member C
Alternative name(s):
Retinoic acid-induced gene 3 protein
Short name=RAIG-3
Gene names
Name:GPRC5C
Synonyms:RAIG3
ORF Names:PSEC0087
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note: Localized in the plasma membrane and perinuclear vesicles. Ref.1 Ref.2

Tissue specificity

Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG). Ref.1 Ref.2

Induction

By all-trans retinoic acid (ATRA). Ref.1 Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Sequence caution

The sequence AAH16860.2 differs from that shown. Reason: Erroneous initiation.

The sequence AAI10849.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI25081.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI25082.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAG54752.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC00633.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NQ84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NQ84-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTQPEPGLGARM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 441418G-protein coupled receptor family C group 5 member C
PRO_0000012967

Regions

Topological domain24 – 5027Extracellular Potential
Transmembrane51 – 7121Helical; Name=1; Potential
Topological domain72 – 8514Cytoplasmic Potential
Transmembrane86 – 10621Helical; Name=2; Potential
Topological domain107 – 12014Extracellular Potential
Transmembrane121 – 14121Helical; Name=3; Potential
Topological domain142 – 15514Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 20832Extracellular Potential
Transmembrane209 – 22921Helical; Name=5; Potential
Topological domain230 – 24112Cytoplasmic Potential
Transmembrane242 – 26221Helical; Name=6; Potential
Topological domain263 – 27917Extracellular Potential
Transmembrane280 – 30021Helical; Name=7; Potential
Topological domain301 – 441141Cytoplasmic Potential

Amino acid modifications

Glycosylation1911N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence11M → MGTQPEPGLGARM in isoform 2.
VSP_037725

Experimental info

Sequence conflict2041I → V in CAC00633. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: B255D9680328FE3D

FASTA44148,193
        10         20         30         40         50         60 
MAIHKALVMC LGLPLFLFPG AWAQGHVPPG CSQGLNPLYY NLCDRSGAWG IVLEAVAGAG 

        70         80         90        100        110        120 
IVTTFVLTII LVASLPFVQD TKKRSLLGTQ VFFLLGTLGL FCLVFACVVK PDFSTCASRR 

       130        140        150        160        170        180 
FLFGVLFAIC FSCLAAHVFA LNFLARKNHG PRGWVIFTVA LLLTLVEVII NTEWLIITLV 

       190        200        210        220        230        240 
RGSGEGGPQG NSSAGWAVAS PCAIANMDFV MALIYVMLLL LGAFLGAWPA LCGRYKRWRK 

       250        260        270        280        290        300 
HGVFVLLTTA TSVAIWVVWI VMYTYGNKQH NSPTWDDPTL AIALAANAWA FVLFYVIPEV 

       310        320        330        340        350        360 
SQVTKSSPEQ SYQGDMYPTR GVGYETILKE QKGQSMFVEN KAFSMDEPVA AKRPVSPYSG 

       370        380        390        400        410        420 
YNGQLLTSVY QPTEMALMHK VPSEGAYDII LPRATANSQV MGSANSTLRA EDMYSAQSHQ 

       430        440 
AATPPKDGKN SQVFRNPYVW D 

« Hide

Isoform 2 [UniParc].

Checksum: 232D2F2BCD64EE46
Show »

FASTA45349,389

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)."
Robbins M.J., Michalovich D., Hill J., Calver A.R., Medhurst A.D., Gloger I., Sims M.A., Middlemiss D.N., Pangalos M.N.
Genomics 67:8-18(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
[2]"Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D."
Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B., Krogsgaard-Larsen P., O'Hara P.
Biochim. Biophys. Acta 1518:237-248(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and Pancreas.
[10]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ276102 mRNA. Translation: CAC00633.1. Different initiation.
AF207989 mRNA. Translation: AAF72870.1.
BT007435 mRNA. Translation: AAP36103.1.
AK131210 mRNA. Translation: BAG54752.1. Different initiation.
AK075397 mRNA. Translation: BAC11595.1.
AB451470 mRNA. Translation: BAG70284.1.
AC079325 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89163.1.
BC016860 mRNA. Translation: AAH16860.2. Different initiation.
BC110848 mRNA. Translation: AAI10849.1. Different initiation.
BC125080 mRNA. Translation: AAI25081.1. Different initiation.
BC125081 mRNA. Translation: AAI25082.1. Different initiation.
CCDSCCDS42378.1. [Q9NQ84-2]
RefSeqNP_061123.3. NM_018653.3. [Q9NQ84-2]
NP_071319.2. NM_022036.2.
UniGeneHs.446438.

3D structure databases

ProteinModelPortalQ9NQ84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120980. 2 interactions.
IntActQ9NQ84. 1 interaction.
MINTMINT-5006165.
STRING9606.ENSP00000340595.

Protein family/group databases

TCDB9.A.14.11.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ9NQ84.

Polymorphism databases

DMDM46396014.

Proteomic databases

MaxQBQ9NQ84.
PaxDbQ9NQ84.
PRIDEQ9NQ84.

Protocols and materials databases

DNASU55890.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000392627; ENSP00000376403; ENSG00000170412.
ENST00000392629; ENSP00000376405; ENSG00000170412. [Q9NQ84-2]
GeneID55890.
KEGGhsa:55890.
UCSCuc002jkp.3. human. [Q9NQ84-2]
uc002jkt.3. human. [Q9NQ84-1]

Organism-specific databases

CTD55890.
GeneCardsGC17P072427.
HGNCHGNC:13309. GPRC5C.
HPAHPA029776.
MIM605949. gene.
neXtProtNX_Q9NQ84.
PharmGKBPA28939.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44972.
HOGENOMHOG000116197.
HOVERGENHBG051794.
InParanoidQ9NQ84.
KOK04620.
PhylomeDBQ9NQ84.
TreeFamTF321410.

Gene expression databases

ArrayExpressQ9NQ84.
BgeeQ9NQ84.
CleanExHS_GPRC5C.
GenevestigatorQ9NQ84.

Family and domain databases

InterProIPR017978. GPCR_3_C.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPRC5C. human.
GenomeRNAi55890.
NextBio61227.
PROQ9NQ84.
SOURCESearch...

Entry information

Entry nameGPC5C_HUMAN
AccessionPrimary (citable) accession number: Q9NQ84
Secondary accession number(s): B5BUN4, Q2NL85, Q9NZG5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries