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Protein

Cartilage acidic protein 1

Gene

CRTAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage acidic protein 1
Alternative name(s):
68 kDa chondrocyte-expressed protein
Short name:
CEP-68
ASPIC
Gene namesi
Name:CRTAC1
Synonyms:ASPIC1, CEP68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14882. CRTAC1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • growth cone Source: Ensembl
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55118.
OpenTargetsiENSG00000095713.
PharmGKBiPA26899.

Polymorphism and mutation databases

BioMutaiCRTAC1.
DMDMi50400672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000749728 – 661Cartilage acidic protein 1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi563 ↔ 577Sequence analysis
Disulfide bondi570 ↔ 586Sequence analysis
Disulfide bondi592 ↔ 605Sequence analysis
Glycosylationi608O-linked (GalNAc...)Sequence analysis1
Glycosylationi618O-linked (GalNAc...)Sequence analysis1
Glycosylationi619O-linked (GalNAc...)Sequence analysis1
Glycosylationi621O-linked (GalNAc...)Sequence analysis1
Glycosylationi626O-linked (GalNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NQ79.
PeptideAtlasiQ9NQ79.
PRIDEiQ9NQ79.

PTM databases

iPTMnetiQ9NQ79.
PhosphoSitePlusiQ9NQ79.

Expressioni

Tissue specificityi

Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.2 Publications

Inductioni

Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.1 Publication

Gene expression databases

BgeeiENSG00000095713.
CleanExiHS_CEP68.
HS_CRTAC1.
ExpressionAtlasiQ9NQ79. baseline and differential.
GenevisibleiQ9NQ79. HS.

Organism-specific databases

HPAiHPA008175.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AQP1P299723EBI-10205543,EBI-745213
MAPRE2Q155555EBI-10205543,EBI-739717
MORN4Q8NDC43EBI-10205543,EBI-10269566

Protein-protein interaction databases

BioGridi120427. 19 interactors.
IntActiQ9NQ79. 4 interactors.
STRINGi9606.ENSP00000359629.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 88FG-GAP 1; atypicalAdd BLAST43
Repeati105 – 147FG-GAP 2; atypicalAdd BLAST43
Repeati283 – 333FG-GAP 3; atypicalAdd BLAST51
Repeati395 – 437FG-GAP 4; atypicalAdd BLAST43
Domaini559 – 605EGF-likeAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi622 – 639Ala-richAdd BLAST18

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 4 FG-GAP repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHAW. Eukaryota.
ENOG410ZVH2. LUCA.
GeneTreeiENSGT00390000013726.
HOVERGENiHBG051111.
InParanoidiQ9NQ79.
OMAiNNNWLRV.
OrthoDBiEOG091G033Y.
PhylomeDBiQ9NQ79.
TreeFamiTF333171.

Family and domain databases

InterProiIPR027039. Crtac1.
IPR001881. EGF-like_Ca-bd_dom.
IPR018097. EGF_Ca-bd_CS.
IPR011519. UnbV_ASPIC.
[Graphical view]
PANTHERiPTHR16026. PTHR16026. 1 hit.
PfamiPF07645. EGF_CA. 1 hit.
PF07593. UnbV_ASPIC. 1 hit.
[Graphical view]
SMARTiSM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS01187. EGF_CA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ79-1) [UniParc]FASTAAdd to basket
Also known as: CRTAC1-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSADPGMS RMLPFLLLLW FLPITEGSQR AEPMFTAVTN SVLPPDYDSN
60 70 80 90 100
PTQLNYGVAV TDVDHDGDFE IVVAGYNGPN LVLKYDRAQK RLVNIAVDER
110 120 130 140 150
SSPYYALRDR QGNAIGVTAC DIDGDGREEI YFLNTNNAFS GVATYTDKLF
160 170 180 190 200
KFRNNRWEDI LSDEVNVARG VASLFAGRSV ACVDRKGSGR YSIYIANYAY
210 220 230 240 250
GNVGPDALIE MDPEASDLSR GILALRDVAA EAGVSKYTGG RGVSVGPILS
260 270 280 290 300
SSASDIFCDN ENGPNFLFHN RGDGTFVDAA ASAGVDDPHQ HGRGVALADF
310 320 330 340 350
NRDGKVDIVY GNWNGPHRLY LQMSTHGKVR FRDIASPKFS MPSPVRTVIT
360 370 380 390 400
ADFDNDQELE IFFNNIAYRS SSANRLFRVI RREHGDPLIE ELNPGDALEP
410 420 430 440 450
EGRGTGGVVT DFDGDGMLDL ILSHGESMAQ PLSVFRGNQG FNNNWLRVVP
460 470 480 490 500
RTRFGAFARG AKVVLYTKKS GAHLRIIDGG SGYLCEMEPV AHFGLGKDEA
510 520 530 540 550
SSVEVTWPDG KMVSRNVASG EMNSVLEILY PRDEDTLQDP APLECGQGFS
560 570 580 590 600
QQENGHCMDT NECIQFPFVC PRDKPVCVNT YGSYRCRTNK KCSRGYEPNE
610 620 630 640 650
DGTACVGTLG QSPGPRPTTP TAAAATAAAA AAAGAATAAP VLVDGDLNLG
660
SVVKESCEPS C
Note: Shares an exon with the neighboring tail-to-tail oriented gene GOLGA7B.
Length:661
Mass (Da):71,421
Last modified:July 19, 2004 - v2
Checksum:i2EF75321817F0D01
GO
Isoform 2 (identifier: Q9NQ79-2) [UniParc]FASTAAdd to basket
Also known as: CRTAC1-B

The sequence of this isoform differs from the canonical sequence as follows:
     607-645: GTLGQSPGPR...ATAAPVLVDG → AQVAFLGGYS...LGLCLQLYAL
     646-661: Missing.

Show »
Length:645
Mass (Da):70,434
Checksum:i815B2A4D3C5A321A
GO
Isoform 3 (identifier: Q9NQ79-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-661: CGQGFSQQEN...VVKESCEPSC → TPMNASSSHS...LELPLLHRSS

Note: No experimental confirmation available.
Show »
Length:628
Mass (Da):68,059
Checksum:i48AE68C4EB26DE40
GO

Sequence cautioni

The sequence AAH34245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB98268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB98269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI12584 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454F → V in BAA91540 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048972253A → T.Corresponds to variant rs35853031dbSNPEnsembl.1
Natural variantiVAR_048973569V → M.Corresponds to variant rs2297935dbSNPEnsembl.1
Natural variantiVAR_061152658E → K.Corresponds to variant rs56007204dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010893545 – 661CGQGF…CEPSC → TPMNASSSHSCALETSPYVS TPMEATGAGPTRSAVGATSP TRMAQPAWGLSASHRAPAPP PPPLLLPLPLLLPLLELPLL HRSS in isoform 3. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_010894607 – 645GTLGQ…VLVDG → AQVAFLGGYSSAASRISEPL SRASYLSLGLGLCLQLYAL in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_010895646 – 661Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276171 mRNA. Translation: CAB98267.1.
AJ276171 mRNA. Translation: CAB98268.1. Different initiation.
AJ276171 mRNA. Translation: CAB98269.1. Different initiation.
AK001182 mRNA. Translation: BAA91540.1. Different initiation.
AK292084 mRNA. Translation: BAF84773.1.
AL139239 Genomic DNA. Translation: CAI12584.1. Sequence problems.
AL139239, AL358938 Genomic DNA. Translation: CAI12585.1.
AL358938, AL139239 Genomic DNA. Translation: CAI14277.1.
AJ279016 mRNA. Translation: CAC08451.1.
AJ421515 mRNA. Translation: CAD13394.1.
BC034245 mRNA. Translation: AAH34245.1. Different initiation.
CCDSiCCDS31266.1. [Q9NQ79-1]
CCDS55723.1. [Q9NQ79-2]
RefSeqiNP_001193457.1. NM_001206528.2. [Q9NQ79-2]
NP_060528.3. NM_018058.6. [Q9NQ79-1]
UniGeneiHs.500736.

Genome annotation databases

EnsembliENST00000370591; ENSP00000359623; ENSG00000095713. [Q9NQ79-2]
ENST00000370597; ENSP00000359629; ENSG00000095713. [Q9NQ79-1]
GeneIDi55118.
KEGGihsa:55118.
UCSCiuc001kou.2. human. [Q9NQ79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276171 mRNA. Translation: CAB98267.1.
AJ276171 mRNA. Translation: CAB98268.1. Different initiation.
AJ276171 mRNA. Translation: CAB98269.1. Different initiation.
AK001182 mRNA. Translation: BAA91540.1. Different initiation.
AK292084 mRNA. Translation: BAF84773.1.
AL139239 Genomic DNA. Translation: CAI12584.1. Sequence problems.
AL139239, AL358938 Genomic DNA. Translation: CAI12585.1.
AL358938, AL139239 Genomic DNA. Translation: CAI14277.1.
AJ279016 mRNA. Translation: CAC08451.1.
AJ421515 mRNA. Translation: CAD13394.1.
BC034245 mRNA. Translation: AAH34245.1. Different initiation.
CCDSiCCDS31266.1. [Q9NQ79-1]
CCDS55723.1. [Q9NQ79-2]
RefSeqiNP_001193457.1. NM_001206528.2. [Q9NQ79-2]
NP_060528.3. NM_018058.6. [Q9NQ79-1]
UniGeneiHs.500736.

3D structure databases

ProteinModelPortaliQ9NQ79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120427. 19 interactors.
IntActiQ9NQ79. 4 interactors.
STRINGi9606.ENSP00000359629.

PTM databases

iPTMnetiQ9NQ79.
PhosphoSitePlusiQ9NQ79.

Polymorphism and mutation databases

BioMutaiCRTAC1.
DMDMi50400672.

Proteomic databases

PaxDbiQ9NQ79.
PeptideAtlasiQ9NQ79.
PRIDEiQ9NQ79.

Protocols and materials databases

DNASUi55118.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370591; ENSP00000359623; ENSG00000095713. [Q9NQ79-2]
ENST00000370597; ENSP00000359629; ENSG00000095713. [Q9NQ79-1]
GeneIDi55118.
KEGGihsa:55118.
UCSCiuc001kou.2. human. [Q9NQ79-1]

Organism-specific databases

CTDi55118.
DisGeNETi55118.
GeneCardsiCRTAC1.
H-InvDBHIX0035366.
HGNCiHGNC:14882. CRTAC1.
HPAiHPA008175.
MIMi606276. gene.
neXtProtiNX_Q9NQ79.
OpenTargetsiENSG00000095713.
PharmGKBiPA26899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHAW. Eukaryota.
ENOG410ZVH2. LUCA.
GeneTreeiENSGT00390000013726.
HOVERGENiHBG051111.
InParanoidiQ9NQ79.
OMAiNNNWLRV.
OrthoDBiEOG091G033Y.
PhylomeDBiQ9NQ79.
TreeFamiTF333171.

Miscellaneous databases

GenomeRNAii55118.
PROiQ9NQ79.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095713.
CleanExiHS_CEP68.
HS_CRTAC1.
ExpressionAtlasiQ9NQ79. baseline and differential.
GenevisibleiQ9NQ79. HS.

Family and domain databases

InterProiIPR027039. Crtac1.
IPR001881. EGF-like_Ca-bd_dom.
IPR018097. EGF_Ca-bd_CS.
IPR011519. UnbV_ASPIC.
[Graphical view]
PANTHERiPTHR16026. PTHR16026. 1 hit.
PfamiPF07645. EGF_CA. 1 hit.
PF07593. UnbV_ASPIC. 1 hit.
[Graphical view]
SMARTiSM00179. EGF_CA. 1 hit.
[Graphical view]
PROSITEiPS01187. EGF_CA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ79
Secondary accession number(s): B1ALN4
, Q5T4F8, Q8N4H6, Q8TE52, Q9NQ78, Q9NQ80, Q9NW46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.