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Q9NQ75

- CASS4_HUMAN

UniProt

Q9NQ75 - CASS4_HUMAN

Protein

Cas scaffolding protein family member 4

Gene

CASS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.1 Publication

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cas scaffolding protein family member 4
    Alternative name(s):
    HEF-like protein
    HEF1-EFS-p130Cas-like protein
    Short name:
    HEPL
    Gene namesi
    Name:CASS4
    Synonyms:C20orf32, HEFL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15878. CASS4.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell junctionfocal adhesion 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. focal adhesion Source: UniProtKB-SubCell
    4. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162381095.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 786786Cas scaffolding protein family member 4PRO_0000079425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei200 – 2001Phosphoserine2 Publications
    Modified residuei249 – 2491Phosphoserine2 Publications
    Modified residuei305 – 3051Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated on tyrosines by SRC.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NQ75.
    PaxDbiQ9NQ75.
    PRIDEiQ9NQ75.

    PTM databases

    PhosphoSiteiQ9NQ75.

    Expressioni

    Tissue specificityi

    Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines.1 Publication

    Gene expression databases

    BgeeiQ9NQ75.
    CleanExiHS_CASS4.
    GenevestigatoriQ9NQ75.

    Organism-specific databases

    HPAiHPA012659.

    Interactioni

    Subunit structurei

    Interacts (via SH3 domain) with PTK2/FAK1 (via C-terminus).1 Publication

    Protein-protein interaction databases

    BioGridi121359. 1 interaction.
    IntActiQ9NQ75. 3 interactions.
    STRINGi9606.ENSP00000353462.

    Structurei

    Secondary structure

    1
    786
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 207
    Beta strandi25 – 295
    Beta strandi38 – 436
    Beta strandi51 – 588
    Beta strandi61 – 644
    Turni65 – 673
    Beta strandi68 – 703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CRENMR-A14-71[»]
    ProteinModelPortaliQ9NQ75.
    SMRiQ9NQ75. Positions 13-72, 431-589, 674-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NQ75.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 7363SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi274 – 2774Poly-Ser
    Compositional biasi373 – 42957Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CAS family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG72030.
    HOGENOMiHOG000111312.
    HOVERGENiHBG107575.
    InParanoidiQ9NQ75.
    OMAiCSDELAF.
    OrthoDBiEOG7QRQTD.
    PhylomeDBiQ9NQ75.
    TreeFamiTF328782.

    Family and domain databases

    InterProiIPR021901. CAS_DUF3513.
    IPR003661. EnvZ-like_dim/P.
    IPR014928. Serine_rich.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF12026. DUF3513. 1 hit.
    PF08824. Serine_rich. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00388. HisKA. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q9NQ75-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGTGIMDCA PKALLARALY DNCPDCSDEL AFSRGDILTI LEQHVPESEG    50
    WWKCLLHGRQ GLAPANRLQI LTEVAADRPC PPFLRGLEEA PASSEETYQV 100
    PTLPRPPTPG PVYEQMRSWA EGPQPPTAQV YEFPDPPTSA RIICEKTLSF 150
    PKQAILTLPR PVRASLPTLP SQVYDVPTQH RGPVVLKEPE KQQLYDIPAS 200
    PKKAGLHPPD SQASGQGVPL ISVTTLRRGG YSTLPNPQKS EWIYDTPVSP 250
    GKASVRNTPL TSFAEESRPH ALPSSSSTFY NPPSGRSRSL TPQLNNNVPM 300
    QKKLSLPEIP SYGFLVPRGT FPLDEDVSYK VPSSFLIPRV EQQNTKPNIY 350
    DIPKATSSVS QAGKELEKAK EVSENSAGHN SSWFSRRTTS PSPEPDRLSG 400
    SSSDSRASIV SSCSTTSTDD SSSSSSEESA KELSLDLDVA KETVMALQHK 450
    VVSSVAGLML FVSRKWRFRD YLEANIDAIH RSTDHIEESV REFLDFARGV 500
    HGTACNLTDS NLQNRIRDQM QTISNSYRIL LETKESLDNR NWPLEVLVTD 550
    SVQNSPDDLE RFVMVARMLP EDIKRFASIV IANGRLLFKR NCEKEETVQL 600
    TPNAEFKCEK YIQPPQRETE SHQKSTPSTK QREDEHSSEL LKKNRANICG 650
    QNPGPLIPQP SSQQTPERKP RLSEHCRLYF GALFKAISAF HGSLSSSQPA 700
    EIITQSKLVI MVGQKLVDTL CMETQERDVR NEILRGSSHL CSLLKDVALA 750
    TKNAVLTYPS PAALGHLQAE AEKLEQHTRQ FRGTLG 786
    Length:786
    Mass (Da):87,144
    Last modified:October 10, 2002 - v2
    Checksum:i0E84CD7F60A361DB
    GO
    Isoform 2 (identifier: Q9NQ75-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         652-786: NPGPLIPQPS...HTRQFRGTLG → VSSEFQVIEKGASIVTWSSGY

    Note: No experimental confirmation available.

    Show »
    Length:672
    Mass (Da):74,587
    Checksum:i9100A597C52C415F
    GO
    Isoform 3 (identifier: Q9NQ75-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-651: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:349
    Mass (Da):38,346
    Checksum:i0DC83EBD13CF6839
    GO

    Sequence cautioni

    The sequence CAC00655.1 differs from that shown. Reason: Frameshift at positions 336 and 342.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti329 – 3291Y → N in CAC00655. 1 PublicationCurated
    Sequence conflicti350 – 3501Missing in CAC00655. 1 PublicationCurated
    Sequence conflicti488 – 4881E → A in CAC00655. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti491 – 4911R → K.
    Corresponds to variant rs16979936 [ dbSNP | Ensembl ].
    VAR_054084
    Natural varianti629 – 6291T → N.
    Corresponds to variant rs6069755 [ dbSNP | Ensembl ].
    VAR_054085
    Natural varianti660 – 6601P → S.1 Publication
    Corresponds to variant rs35031530 [ dbSNP | Ensembl ].
    VAR_054086
    Natural varianti780 – 7801Q → H.
    Corresponds to variant rs7272702 [ dbSNP | Ensembl ].
    VAR_054087

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei215 – 651437Missing in isoform 3. 1 PublicationVSP_003806Add
    BLAST
    Alternative sequencei652 – 786135NPGPL…RGTLG → VSSEFQVIEKGASIVTWSSG Y in isoform 2. 1 PublicationVSP_003807Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276678 mRNA. Translation: CAC00655.1. Frameshift.
    AK027760 mRNA. Translation: BAB55351.1.
    AL121914 Genomic DNA. Translation: CAC12719.2.
    AL121914 Genomic DNA. Translation: CAI19330.1.
    CH471077 Genomic DNA. Translation: EAW75546.1.
    CH471077 Genomic DNA. Translation: EAW75547.1.
    BC027951 mRNA. Translation: AAH27951.1.
    CCDSiCCDS33492.1. [Q9NQ75-1]
    CCDS54475.1. [Q9NQ75-3]
    RefSeqiNP_001157586.1. NM_001164114.1.
    NP_001157587.1. NM_001164115.1. [Q9NQ75-3]
    NP_001157588.1. NM_001164116.1. [Q9NQ75-1]
    NP_065089.2. NM_020356.3. [Q9NQ75-1]
    UniGeneiHs.473144.

    Genome annotation databases

    EnsembliENST00000360314; ENSP00000353462; ENSG00000087589. [Q9NQ75-1]
    ENST00000434344; ENSP00000410027; ENSG00000087589. [Q9NQ75-3]
    GeneIDi57091.
    KEGGihsa:57091.
    UCSCiuc002xxp.2. human. [Q9NQ75-1]
    uc002xxq.4. human. [Q9NQ75-2]
    uc010gio.2. human. [Q9NQ75-3]

    Polymorphism databases

    DMDMi23813906.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ276678 mRNA. Translation: CAC00655.1 . Frameshift.
    AK027760 mRNA. Translation: BAB55351.1 .
    AL121914 Genomic DNA. Translation: CAC12719.2 .
    AL121914 Genomic DNA. Translation: CAI19330.1 .
    CH471077 Genomic DNA. Translation: EAW75546.1 .
    CH471077 Genomic DNA. Translation: EAW75547.1 .
    BC027951 mRNA. Translation: AAH27951.1 .
    CCDSi CCDS33492.1. [Q9NQ75-1 ]
    CCDS54475.1. [Q9NQ75-3 ]
    RefSeqi NP_001157586.1. NM_001164114.1.
    NP_001157587.1. NM_001164115.1. [Q9NQ75-3 ]
    NP_001157588.1. NM_001164116.1. [Q9NQ75-1 ]
    NP_065089.2. NM_020356.3. [Q9NQ75-1 ]
    UniGenei Hs.473144.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CRE NMR - A 14-71 [» ]
    ProteinModelPortali Q9NQ75.
    SMRi Q9NQ75. Positions 13-72, 431-589, 674-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121359. 1 interaction.
    IntActi Q9NQ75. 3 interactions.
    STRINGi 9606.ENSP00000353462.

    PTM databases

    PhosphoSitei Q9NQ75.

    Polymorphism databases

    DMDMi 23813906.

    Proteomic databases

    MaxQBi Q9NQ75.
    PaxDbi Q9NQ75.
    PRIDEi Q9NQ75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360314 ; ENSP00000353462 ; ENSG00000087589 . [Q9NQ75-1 ]
    ENST00000434344 ; ENSP00000410027 ; ENSG00000087589 . [Q9NQ75-3 ]
    GeneIDi 57091.
    KEGGi hsa:57091.
    UCSCi uc002xxp.2. human. [Q9NQ75-1 ]
    uc002xxq.4. human. [Q9NQ75-2 ]
    uc010gio.2. human. [Q9NQ75-3 ]

    Organism-specific databases

    CTDi 57091.
    GeneCardsi GC20P054987.
    H-InvDB HIX0015932.
    HGNCi HGNC:15878. CASS4.
    HPAi HPA012659.
    neXtProti NX_Q9NQ75.
    PharmGKBi PA162381095.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72030.
    HOGENOMi HOG000111312.
    HOVERGENi HBG107575.
    InParanoidi Q9NQ75.
    OMAi CSDELAF.
    OrthoDBi EOG7QRQTD.
    PhylomeDBi Q9NQ75.
    TreeFami TF328782.

    Miscellaneous databases

    EvolutionaryTracei Q9NQ75.
    GenomeRNAii 57091.
    NextBioi 62895.
    PROi Q9NQ75.

    Gene expression databases

    Bgeei Q9NQ75.
    CleanExi HS_CASS4.
    Genevestigatori Q9NQ75.

    Family and domain databases

    InterProi IPR021901. CAS_DUF3513.
    IPR003661. EnvZ-like_dim/P.
    IPR014928. Serine_rich.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF12026. DUF3513. 1 hit.
    PF08824. Serine_rich. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00388. HisKA. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HEF-like protein (HEFL) is involved in integrin signalling."
      Jahn T., Will T., Bresolin G., Coutinho S., Peschel C., Duyster J.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT SER-660.
      Tissue: Placenta.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-249 AND SER-305, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    7. Cited for: FUNCTION, INTERACTION WITH PTK2/FAK1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION BY SRC.
    8. "Solution structure of RSGI RUH-036, an SH3 domain from human."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 14-71.

    Entry informationi

    Entry nameiCASS4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ75
    Secondary accession number(s): E1P5Z8
    , Q5QPD6, Q96K09, Q9BYL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3