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Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in gonadal development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi267 – 326HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-9010553. Regulation of expression of SLITs and ROBOs.

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143355.15.
HGNCiHGNC:14222. LHX9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56956.
OpenTargetsiENSG00000143355.
PharmGKBiPA30368.

Polymorphism and mutation databases

BioMutaiLHX9.
DMDMi224471883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757981 – 397LIM/homeobox protein Lhx9Add BLAST397

Proteomic databases

PaxDbiQ9NQ69.
PeptideAtlasiQ9NQ69.
PRIDEiQ9NQ69.

PTM databases

iPTMnetiQ9NQ69.
PhosphoSitePlusiQ9NQ69.

Expressioni

Gene expression databases

BgeeiENSG00000143355.
CleanExiHS_LHX9.
ExpressionAtlasiQ9NQ69. baseline and differential.
GenevisibleiQ9NQ69. HS.

Organism-specific databases

HPAiHPA009695.

Interactioni

Subunit structurei

Interacts with LDB1 and LDB2.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121280. 8 interactors.
IntActiQ9NQ69. 5 interactors.
STRINGi9606.ENSP00000356357.

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi276 – 288Combined sources13
Helixi294 – 303Combined sources10
Helixi308 – 327Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMQNMR-A268-334[»]
ProteinModelPortaliQ9NQ69.
SMRiQ9NQ69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQ69.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 130LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini131 – 193LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOVERGENiHBG006262.
InParanoidiQ9NQ69.
KOiK09373.
OMAiHGISGDH.
OrthoDBiEOG091G13BH.
PhylomeDBiQ9NQ69.
TreeFamiTF315442.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVGCRAED NSCPFRPPAM LFHGISGGHI QGIMEEMERR SKTEARLAKG
60 70 80 90 100
AQLNGRDAGM PPLSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL VYCRAHFETL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALTPPGTAT TLTDLTNPTI TVVTSVTSNM DSHESGSPSQ TTLTNLF
Length:397
Mass (Da):43,976
Last modified:March 3, 2009 - v3
Checksum:iFA8BBB550A5FCE03
GO
Isoform 2 (identifier: Q9NQ69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDNSCPFRPP → MLNGTTLEA

Show »
Length:388
Mass (Da):42,904
Checksum:iA4DC8B914D7C3B66
GO
Isoform 3 (identifier: Q9NQ69-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDNSCPFRPP → MLNGTTLEA
     313-397: VWFQNARAKF...PSQTTLTNLF → GEQILGHYSQTSRRLKIP

Show »
Length:321
Mass (Da):36,056
Checksum:iD26CE988920D6DC3
GO
Isoform 4 (identifier: Q9NQ69-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-397: VWFQNARAKF...PSQTTLTNLF → GEQILGHYSQTSRRLKIP

Show »
Length:330
Mass (Da):37,129
Checksum:i4A819459D3BB038B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364281 – 18MEIVG…PFRPP → MLNGTTLEA in isoform 2 and isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_036429313 – 397VWFQN…LTNLF → GEQILGHYSQTSRRLKIP in isoform 3 and isoform 4. CuratedAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277915 mRNA. Translation: CAB97493.1.
AJ277916
, AJ277917, AJ277918, AJ277919, AJ277920 Genomic DNA. Translation: CAB98128.1. Sequence problems.
AJ296272 mRNA. Translation: CAC33174.1.
AY273889 mRNA. Translation: AAP32471.2.
AL590115 Genomic DNA. Translation: CAH71760.1.
AL590115 Genomic DNA. Translation: CAH71761.1.
AL590115 Genomic DNA. Translation: CAH71763.1.
AL590115 Genomic DNA. Translation: CAH71764.1.
CH471067 Genomic DNA. Translation: EAW91290.1.
CH471067 Genomic DNA. Translation: EAW91292.1.
BC131622 mRNA. Translation: AAI31623.1.
CCDSiCCDS1393.1. [Q9NQ69-1]
CCDS30962.1. [Q9NQ69-2]
RefSeqiNP_001014434.1. NM_001014434.1. [Q9NQ69-2]
NP_064589.2. NM_020204.2. [Q9NQ69-1]
UniGeneiHs.442578.
Hs.706475.

Genome annotation databases

EnsembliENST00000367387; ENSP00000356357; ENSG00000143355. [Q9NQ69-1]
ENST00000367390; ENSP00000356360; ENSG00000143355. [Q9NQ69-2]
ENST00000367391; ENSP00000356361; ENSG00000143355. [Q9NQ69-3]
GeneIDi56956.
KEGGihsa:56956.
UCSCiuc001gui.2. human. [Q9NQ69-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLHX9_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ69
Secondary accession number(s): Q5VUE2
, Q5VUE3, Q5VUE6, Q86UH2, Q9BYU6, Q9NQ70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references