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Protein

Suppressor of SWI4 1 homolog

Gene

PPAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in cell growth.

Miscellaneous

A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of SWI4 1 homolog
Short name:
Ssf-1
Alternative name(s):
Brix domain-containing protein 3
Peter Pan homolog
Gene namesi
Name:PPAN
Synonyms:BXDC3, SSF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130810.19
HGNCiHGNC:9227 PPAN
MIMi607793 gene
neXtProtiNX_Q9NQ55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56342
OpenTargetsiENSG00000130810
ENSG00000243207
PharmGKBiPA162399971

Polymorphism and mutation databases

BioMutaiPPAN
DMDMi21264056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202571 – 473Suppressor of SWI4 1 homologAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei438N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NQ55
MaxQBiQ9NQ55
PaxDbiQ9NQ55
PeptideAtlasiQ9NQ55
PRIDEiQ9NQ55

2D gel databases

SWISS-2DPAGEQ9NQ55

PTM databases

iPTMnetiQ9NQ55
PhosphoSitePlusiQ9NQ55
SwissPalmiQ9NQ55

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000130810
CleanExiHS_PPAN
ExpressionAtlasiQ9NQ55 baseline and differential
GenevisibleiQ9NQ55 HS

Organism-specific databases

HPAiHPA043265

Interactioni

Protein-protein interaction databases

BioGridi121141, 108 interactors
593098, 40 interactors
IntActiQ9NQ55, 16 interactors
MINTiQ9NQ55
STRINGi9606.ENSP00000450710

Structurei

3D structure databases

ProteinModelPortaliQ9NQ55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 292BrixPROSITE-ProRule annotationAdd BLAST264

Phylogenomic databases

eggNOGiKOG2963 Eukaryota
ENOG410XRP7 LUCA
GeneTreeiENSGT00530000064158
HOGENOMiHOG000210038
HOVERGENiHBG026954
InParanoidiQ9NQ55
KOiK14859
OMAiVTHLMLF
OrthoDBiEOG091G079K
PhylomeDBiQ9NQ55
TreeFamiTF318923

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQSGRSRHQ KRARAQAQLR NLEAYAANPH SFVFTRGCTG RNIRQLSLDV
60 70 80 90 100
RRVMEPLTAS RLQVRKKNSL KDCVAVAGPL GVTHFLILSK TETNVYFKLM
110 120 130 140 150
RLPGGPTLTF QVKKYSLVRD VVSSLRRHRM HEQQFAHPPL LVLNSFGPHG
160 170 180 190 200
MHVKLMATMF QNLFPSINVH KVNLNTIKRC LLIDYNPDSQ ELDFRHYSIK
210 220 230 240 250
VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGAGLSES EAEPDGDHNI
260 270 280 290 300
TELPQAVAGR GNMRAQQSAV RLTEIGPRMT LQLIKVQEGV GEGKVMFHSF
310 320 330 340 350
VSKTEEELQA ILEAKEKKLR LKAQRQAQQA QNVQRKQEQR EAHRKKSLEG
360 370 380 390 400
MKKARVGGSD EEASGIPSRT ASLELGEDDD EQEDDDIEYF CQAVGEAPSE
410 420 430 440 450
DLFPEAKQKR LAKSPGRKRK RWEMDRGRGR LCDQKFPKTK DKSQGAQARR
460 470
GPRGASRDGG RGRGRGRPGK RVA
Length:473
Mass (Da):53,194
Last modified:October 1, 2000 - v1
Checksum:i9FF7B7201BD37BEC
GO
Isoform 2 (identifier: Q9NQ55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-456: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):51,900
Checksum:iDEDA8FEF86C6575D
GO
Isoform 3 (identifier: Q9NQ55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-473: ARRGPRGASRDGGRGRGRGRPGKRVA → VPSPALPTSW...SWQSATCSAP

Note: No experimental confirmation available.Curated
Show »
Length:520
Mass (Da):58,199
Checksum:iB5EE1A65E9E13B5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q9NQ55-3)
Sequence conflicti520P → L in BC171852 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022157358G → V. Corresponds to variant dbSNP:rs2305793Ensembl.1
Natural variantiVAR_048422408Q → R. Corresponds to variant dbSNP:rs11559188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003973444 – 456Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_046377448 – 473ARRGP…GKRVA → VPSPALPTSWQLPTTNSVGS RGTSCGPYWWLSSWWPWPAM AWPCTASASGSSAHGTPPWS SLSSWQSATCSAP in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292529 mRNA Translation: CAB99252.1
AC020931 Genomic DNA No translation available.
BC000535 mRNA Translation: AAH00535.2
BC009833 mRNA Translation: AAH09833.1
BC033202 mRNA Translation: AAH33202.1
BC171852 mRNA No translation available.
AJ300588 mRNA Translation: CAC18877.1 Different termination.
CCDSiCCDS12225.1 [Q9NQ55-1]
PIRiJC7359
RefSeqiNP_001035754.1, NM_001040664.2
NP_064615.3, NM_020230.6 [Q9NQ55-1]
UniGeneiHs.14468

Genome annotation databases

EnsembliENST00000253107; ENSP00000253107; ENSG00000130810 [Q9NQ55-1]
GeneIDi56342
692312
KEGGihsa:56342
hsa:692312
UCSCiuc002mmz.3 human [Q9NQ55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSF1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ55
Secondary accession number(s): C9J3F9, Q9BW97, Q9H170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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