Q9NQ55 (SSF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Suppressor of SWI4 1 homolog
Short name=Ssf-1

Alternative name(s):
Brix domain-containing protein 3
Peter Pan homolog

Gene names

Name:	PPAN
Synonyms:	BXDC3, SSF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in cell growth.
Subcellular location	Nucleus › nucleolus Ref.5.
Tissue specificity	Widely expressed. Ref.1 Ref.4
Miscellaneous	A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (Ref.4).
Sequence similarities	Contains 1 Brix domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NQ55-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NQ55-2)

The sequence of this isoform differs from the canonical sequence as follows:
     444-456: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NQ55-3)

The sequence of this isoform differs from the canonical sequence as follows:
     448-473: ARRGPRGASRDGGRGRGRGRPGKRVA → VPSPALPTSW...SWQSATCSAP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Suppressor of SWI4 1 homolog		PRO_0000120257
Regions
	Domain	29 – 292	264	Brix
Natural variations
	Alternative sequence	444 – 456	13	Missing in isoform 2.		VSP_003973
	Alternative sequence	448 – 473	26	ARRGP…GKRVA → VPSPALPTSWQLPTTNSVGS RGTSCGPYWWLSSWWPWPAM AWPCTASASGSSAHGTPPWS SLSSWQSATCSAP in isoform 3.		VSP_046377
	Natural variant	358	1	G → V. Corresponds to variant rs2305793 [ dbSNP | Ensembl ].		VAR_022157
	Natural variant	408	1	Q → R. Corresponds to variant rs11559188 [ dbSNP | Ensembl ].		VAR_048422
Experimental info
Isoform 3:
	Sequence conflict	520	1	P → L in BC171852. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9FF7B7201BD37BEC	FASTA	473	53,194
	10 20 30 40 50 60 MGQSGRSRHQ KRARAQAQLR NLEAYAANPH SFVFTRGCTG RNIRQLSLDV RRVMEPLTAS 70 80 90 100 110 120 RLQVRKKNSL KDCVAVAGPL GVTHFLILSK TETNVYFKLM RLPGGPTLTF QVKKYSLVRD 130 140 150 160 170 180 VVSSLRRHRM HEQQFAHPPL LVLNSFGPHG MHVKLMATMF QNLFPSINVH KVNLNTIKRC 190 200 210 220 230 240 LLIDYNPDSQ ELDFRHYSIK VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGAGLSES 250 260 270 280 290 300 EAEPDGDHNI TELPQAVAGR GNMRAQQSAV RLTEIGPRMT LQLIKVQEGV GEGKVMFHSF 310 320 330 340 350 360 VSKTEEELQA ILEAKEKKLR LKAQRQAQQA QNVQRKQEQR EAHRKKSLEG MKKARVGGSD 370 380 390 400 410 420 EEASGIPSRT ASLELGEDDD EQEDDDIEYF CQAVGEAPSE DLFPEAKQKR LAKSPGRKRK 430 440 450 460 470 RWEMDRGRGR LCDQKFPKTK DKSQGAQARR GPRGASRDGG RGRGRGRPGK RVA
	Isoform 2 [UniParc]. Checksum: DEDA8FEF86C6575D	FASTA	460	51,900
	10 20 30 40 50 60 MGQSGRSRHQ KRARAQAQLR NLEAYAANPH SFVFTRGCTG RNIRQLSLDV RRVMEPLTAS 70 80 90 100 110 120 RLQVRKKNSL KDCVAVAGPL GVTHFLILSK TETNVYFKLM RLPGGPTLTF QVKKYSLVRD 130 140 150 160 170 180 VVSSLRRHRM HEQQFAHPPL LVLNSFGPHG MHVKLMATMF QNLFPSINVH KVNLNTIKRC 190 200 210 220 230 240 LLIDYNPDSQ ELDFRHYSIK VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGAGLSES 250 260 270 280 290 300 EAEPDGDHNI TELPQAVAGR GNMRAQQSAV RLTEIGPRMT LQLIKVQEGV GEGKVMFHSF 310 320 330 340 350 360 VSKTEEELQA ILEAKEKKLR LKAQRQAQQA QNVQRKQEQR EAHRKKSLEG MKKARVGGSD 370 380 390 400 410 420 EEASGIPSRT ASLELGEDDD EQEDDDIEYF CQAVGEAPSE DLFPEAKQKR LAKSPGRKRK 430 440 450 460 RWEMDRGRGR LCDQKFPKTK DKSRDGGRGR GRGRPGKRVA
	Isoform 3 [UniParc]. Checksum: B5EE1A65E9E13B5E	FASTA	520	58,199
	10 20 30 40 50 60 MGQSGRSRHQ KRARAQAQLR NLEAYAANPH SFVFTRGCTG RNIRQLSLDV RRVMEPLTAS 70 80 90 100 110 120 RLQVRKKNSL KDCVAVAGPL GVTHFLILSK TETNVYFKLM RLPGGPTLTF QVKKYSLVRD 130 140 150 160 170 180 VVSSLRRHRM HEQQFAHPPL LVLNSFGPHG MHVKLMATMF QNLFPSINVH KVNLNTIKRC 190 200 210 220 230 240 LLIDYNPDSQ ELDFRHYSIK VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGAGLSES 250 260 270 280 290 300 EAEPDGDHNI TELPQAVAGR GNMRAQQSAV RLTEIGPRMT LQLIKVQEGV GEGKVMFHSF 310 320 330 340 350 360 VSKTEEELQA ILEAKEKKLR LKAQRQAQQA QNVQRKQEQR EAHRKKSLEG MKKARVGGSD 370 380 390 400 410 420 EEASGIPSRT ASLELGEDDD EQEDDDIEYF CQAVGEAPSE DLFPEAKQKR LAKSPGRKRK 430 440 450 460 470 480 RWEMDRGRGR LCDQKFPKTK DKSQGAQVPS PALPTSWQLP TTNSVGSRGT SCGPYWWLSS 490 500 510 520 WWPWPAMAWP CTASASGSSA HGTPPWSSLS SWQSATCSAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, genomic organization, and tissue distribution of human Ssf-1." Suarez-Huerta N., Boeynaems J.-M., Communi D. Biochem. Biophys. Res. Commun. 275:37-42(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain, Placenta and Skin.
[4]	"Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes." Communi D., Suarez-Huerta N., Dussossoy D., Savi P., Boeynaems J.-M. J. Biol. Chem. 276:16561-16566(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-427, TISSUE SPECIFICITY, TRANS-SPLICING. Tissue: Placenta.
[5]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ292529 mRNA. Translation: CAB99252.1. AC020931 Genomic DNA. No translation available. BC000535 mRNA. Translation: AAH00535.2. BC009833 mRNA. Translation: AAH09833.1. BC033202 mRNA. Translation: AAH33202.1. BC171852 mRNA. No translation available. AJ300588 mRNA. Translation: CAC18877.1. Different termination.
IPI	IPI00219793. IPI00329590. IPI00926444.
PIR	JC7359.
RefSeq	NP_001035754.1. NM_001040664.2. NP_001185619.1. NM_001198690.1. NP_064615.3. NM_020230.5.
UniGene	Hs.14468.
3D structure databases
ProteinModelPortal	Q9NQ55.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NQ55. 5 interactions.
MINT	MINT-3072003.
STRING	9606.ENSP00000253107.
PTM databases
PhosphoSite	Q9NQ55.
Polymorphism databases
DMDM	21264056.
2D gel databases
SWISS-2DPAGE	Q9NQ55.
Proteomic databases
PaxDb	Q9NQ55.
PRIDE	Q9NQ55.
Protocols and materials databases
DNASU	56342. 692312.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253107; ENSP00000253107; ENSG00000130810. ENST00000428358; ENSP00000411918; ENSG00000243207. ENST00000556468; ENSP00000450710; ENSG00000130810.
GeneID	56342. 692312.
KEGG	hsa:56342. hsa:692312.
UCSC	uc002mmz.2. human. uc010xla.2. human.
Organism-specific databases
CTD	56342. 692312.
GeneCards	GC19P010216.
HGNC	HGNC:9227. PPAN.
HPA	HPA043265.
MIM	607793. gene.
neXtProt	NX_Q9NQ55.
PharmGKB	PA162399971.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272199.
HOGENOM	HOG000210038.
HOVERGEN	HBG026954.
InParanoid	Q9NQ55.
KO	K14859.
OMA	RRVMEPF.
PhylomeDB	Q9NQ55.
Gene expression databases
ArrayExpress	Q9NQ55.
Bgee	Q9NQ55.
CleanEx	HS_PPAN.
Genevestigator	Q9NQ55.
GermOnline	ENSG00000130810. Homo sapiens.
Family and domain databases
InterPro	IPR007109. Brix. [Graphical view]
Pfam	PF04427. Brix. 1 hit. [Graphical view]
SMART	SM00879. Brix. 1 hit. [Graphical view]
PROSITE	PS50833. BRIX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPAN. human.
NextBio	124574.
SOURCE	Search...

Entry information

Entry name

SSF1_HUMAN

Accession

Primary (citable) accession number: Q9NQ55
Secondary accession number(s): C9J3F9, Q9BW97, Q9H170

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.