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Protein

39S ribosomal protein L40, mitochondrial

Gene

MRPL40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:G66-33484-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L40, mitochondrial
Short name:
L40mt
Short name:
MRP-L40
Alternative name(s):
Nuclear localization signal-containing protein deleted in velocardiofacial syndrome
Up-regulated in metastasis
Gene namesi
Name:MRPL40
Synonyms:NLVCF, URIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14491. MRPL40.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64976.
OpenTargetsiENSG00000185608.
PharmGKBiPA30972.

Polymorphism and mutation databases

BioMutaiMRPL40.
DMDMi21263795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000003055847 – 20639S ribosomal protein L40, mitochondrialAdd BLAST160

Proteomic databases

EPDiQ9NQ50.
MaxQBiQ9NQ50.
PaxDbiQ9NQ50.
PeptideAtlasiQ9NQ50.
PRIDEiQ9NQ50.
TopDownProteomicsiQ9NQ50.

PTM databases

iPTMnetiQ9NQ50.
PhosphoSitePlusiQ9NQ50.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000185608.
CleanExiHS_MRPL40.
GenevisibleiQ9NQ50. HS.

Organism-specific databases

HPAiHPA006181.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-1053902,EBI-948001
NOTCH2NLQ7Z3S95EBI-1053902,EBI-945833
TFCP2Q128003EBI-1053902,EBI-717422
TRIM27P143733EBI-1053902,EBI-719493

Protein-protein interaction databases

BioGridi122364. 69 interactors.
IntActiQ9NQ50. 15 interactors.
MINTiMINT-6782189.
STRINGi9606.ENSP00000333401.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4081-206[»]
3J9Melectron microscopy3.5081-206[»]
ProteinModelPortaliQ9NQ50.
SMRiQ9NQ50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4778. Eukaryota.
ENOG4111PQW. LUCA.
GeneTreeiENSGT00390000010239.
HOGENOMiHOG000015976.
HOVERGENiHBG044505.
InParanoidiQ9NQ50.
KOiK17421.
OMAiRCLHTTP.
OrthoDBiEOG091G0RI9.
PhylomeDBiQ9NQ50.
TreeFamiTF105982.

Family and domain databases

InterProiIPR019192. Ribosomal_L28/L40_mit.
[Graphical view]
PfamiPF09812. MRP-L28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NQ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL
60 70 80 90 100
RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFIT PLKFLDKARE
110 120 130 140 150
RPQVELTFEE TERRALLLKK WSLYKQQERK MERDTIRAML EAQQEALEEL
160 170 180 190 200
QLESPKLHAE AIKRDPNLFP FEKEGPHYTP PIPNYQPPEG RYNDITKVYT

QVEFKR
Length:206
Mass (Da):24,490
Last modified:October 1, 2000 - v1
Checksum:iAE6262A9A94B05FD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06180911L → P.1 PublicationCorresponds to variant rs1128399dbSNPEnsembl.1
Natural variantiVAR_016088129R → H.1 PublicationCorresponds to variant rs7575dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034091 mRNA. Translation: AAC70904.1.
AJ295637 mRNA. Translation: CAC00535.1.
CR456532 mRNA. Translation: CAG30418.1.
AK123768 mRNA. Translation: BAG53959.1.
CH471176 Genomic DNA. Translation: EAX03042.1.
BC009707 mRNA. Translation: AAH09707.1.
CCDSiCCDS13760.1.
RefSeqiNP_003767.2. NM_003776.3.
UniGeneiHs.431307.

Genome annotation databases

EnsembliENST00000333130; ENSP00000333401; ENSG00000185608.
GeneIDi64976.
KEGGihsa:64976.
UCSCiuc002zpg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034091 mRNA. Translation: AAC70904.1.
AJ295637 mRNA. Translation: CAC00535.1.
CR456532 mRNA. Translation: CAG30418.1.
AK123768 mRNA. Translation: BAG53959.1.
CH471176 Genomic DNA. Translation: EAX03042.1.
BC009707 mRNA. Translation: AAH09707.1.
CCDSiCCDS13760.1.
RefSeqiNP_003767.2. NM_003776.3.
UniGeneiHs.431307.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4081-206[»]
3J9Melectron microscopy3.5081-206[»]
ProteinModelPortaliQ9NQ50.
SMRiQ9NQ50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122364. 69 interactors.
IntActiQ9NQ50. 15 interactors.
MINTiMINT-6782189.
STRINGi9606.ENSP00000333401.

PTM databases

iPTMnetiQ9NQ50.
PhosphoSitePlusiQ9NQ50.

Polymorphism and mutation databases

BioMutaiMRPL40.
DMDMi21263795.

Proteomic databases

EPDiQ9NQ50.
MaxQBiQ9NQ50.
PaxDbiQ9NQ50.
PeptideAtlasiQ9NQ50.
PRIDEiQ9NQ50.
TopDownProteomicsiQ9NQ50.

Protocols and materials databases

DNASUi64976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333130; ENSP00000333401; ENSG00000185608.
GeneIDi64976.
KEGGihsa:64976.
UCSCiuc002zpg.4. human.

Organism-specific databases

CTDi64976.
DisGeNETi64976.
GeneCardsiMRPL40.
HGNCiHGNC:14491. MRPL40.
HPAiHPA006181.
MIMi605089. gene.
neXtProtiNX_Q9NQ50.
OpenTargetsiENSG00000185608.
PharmGKBiPA30972.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4778. Eukaryota.
ENOG4111PQW. LUCA.
GeneTreeiENSGT00390000010239.
HOGENOMiHOG000015976.
HOVERGENiHBG044505.
InParanoidiQ9NQ50.
KOiK17421.
OMAiRCLHTTP.
OrthoDBiEOG091G0RI9.
PhylomeDBiQ9NQ50.
TreeFamiTF105982.

Enzyme and pathway databases

BioCyciZFISH:G66-33484-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMRPL40.
GenomeRNAii64976.
PROiQ9NQ50.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185608.
CleanExiHS_MRPL40.
GenevisibleiQ9NQ50. HS.

Family and domain databases

InterProiIPR019192. Ribosomal_L28/L40_mit.
[Graphical view]
PfamiPF09812. MRP-L28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM40_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ50
Secondary accession number(s): B3KVZ7, O95134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.