ID LZTL1_HUMAN Reviewed; 299 AA. AC Q9NQ48; B3KSI9; B4E0K7; Q8TC61; Q9NQ56; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 157. DE RecName: Full=Leucine zipper transcription factor-like protein 1; GN Name=LZTFL1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY, RP DEVELOPMENTAL STAGE, AND VARIANT ASN-246. RC TISSUE=Testis; RX PubMed=11352561; DOI=10.1006/geno.2000.6498; RA Kiss H., Kedra D., Kiss C., Kost-Alimova M., Yang Y., Klein G., Imreh S., RA Dumanski J.P.; RT "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within RT the common eliminated region 1 (C3CER1) in 3p21.3."; RL Genomics 73:10-19(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Endometrial adenocarcinoma; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLU-152 RP AND ARG-251. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP FUNCTION AS TUMOR SUPPRESSOR, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=20233871; DOI=10.1158/0008-5472.can-09-3826; RA Wei Q., Zhou W., Wang W., Gao B., Wang L., Cao J., Liu Z.P.; RT "Tumor-suppressive functions of leucine zipper transcription factor-like RT 1."; RL Cancer Res. 70:2942-2950(2010). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP FUNCTION, SELF-ASSOCIATION, INTERACTION WITH BBS9, ASSOCIATION WITH THE RP BBSOME COMPLEX, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 24-LYS-ARG-25. RX PubMed=22072986; DOI=10.1371/journal.pgen.1002358; RA Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., RA Sheffield V.C.; RT "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and RT Smoothened."; RL PLoS Genet. 7:E1002358-E1002358(2011). RN [10] RP FUNCTION IN SONIC HEDGEHOG PATHWAY, AND INVOLVEMENT IN BBS17. RX PubMed=22510444; DOI=10.1136/jmedgenet-2012-100737; RA Marion V., Stutzmann F., Gerard M., De Melo C., Schaefer E., Claussmann A., RA Helle S., Delague V., Souied E., Barrey C., Verloes A., Stoetzel C., RA Dollfus H.; RT "Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened RT trafficking regulator, in a family with Bardet--Biedl syndrome with situs RT inversus and insertional polydactyly."; RL J. Med. Genet. 49:317-321(2012). RN [11] RP VARIANT BBS17 PRO-87. RX PubMed=23692385; DOI=10.1111/cge.12198; RA Schaefer E., Lauer J., Durand M., Pelletier V., Obringer C., Claussmann A., RA Braun J.J., Redin C., Mathis C., Muller J., Schmidt-Mutter C., Flori E., RA Marion V., Stoetzel C., Dollfus H.; RT "Mesoaxial polydactyly is a major feature in Bardet-Biedl syndrome patients RT with LZTFL1 (BBS17) mutations."; RL Clin. Genet. 85:476-481(2014). CC -!- FUNCTION: Regulates ciliary localization of the BBSome complex. CC Together with the BBSome complex, controls SMO ciliary trafficking and CC contributes to the sonic hedgehog (SHH) pathway regulation. May play a CC role in neurite outgrowth. May have tumor suppressor function. CC {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, CC ECO:0000269|PubMed:22510444}. CC -!- SUBUNIT: Self-associates. Interacts with BBS9; the interaction mediates CC the association of LZTL1 with the BBsome complex and regulates BBSome CC ciliary trafficking. {ECO:0000269|PubMed:22072986}. CC -!- INTERACTION: CC Q9NQ48; Q3SYG4: BBS9; NbExp=8; IntAct=EBI-2824799, EBI-2826852; CC Q9NQ48; Q08426: EHHADH; NbExp=3; IntAct=EBI-2824799, EBI-2339219; CC Q9NQ48; Q9NQ48: LZTFL1; NbExp=18; IntAct=EBI-2824799, EBI-2824799; CC Q9NQ48; Q9H8S9: MOB1A; NbExp=3; IntAct=EBI-2824799, EBI-748229; CC Q9NQ48; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-2824799, EBI-741158; CC Q9NQ48; Q9HAT8: PELI2; NbExp=3; IntAct=EBI-2824799, EBI-448407; CC Q9NQ48; Q9NRD5: PICK1; NbExp=5; IntAct=EBI-2824799, EBI-79165; CC Q9NQ48; P25786: PSMA1; NbExp=3; IntAct=EBI-2824799, EBI-359352; CC Q9NQ48; P20618: PSMB1; NbExp=3; IntAct=EBI-2824799, EBI-372273; CC Q9NQ48; O00560: SDCBP; NbExp=6; IntAct=EBI-2824799, EBI-727004; CC Q9NQ48; Q6AZZ1: TRIM68; NbExp=3; IntAct=EBI-2824799, EBI-2130449; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20233871, CC ECO:0000269|PubMed:22072986}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9NQ48-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9NQ48-2; Sequence=VSP_053429; CC Name=3; CC IsoId=Q9NQ48-3; Sequence=VSP_053428, VSP_053430; CC -!- TISSUE SPECIFICITY: Expressed in prostate, ovary, stomach, pancreas, CC esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at CC protein level). Down-regulated in multiple primary tumors (at protein CC level). Detected in testis, heart, skeletal muscle, thymus, spleen, CC small intestine, and peripheral blood leukocytes. CC {ECO:0000269|PubMed:11352561, ECO:0000269|PubMed:20233871}. CC -!- DEVELOPMENTAL STAGE: Expressed in brain, lung, liver, and kidney. CC {ECO:0000269|PubMed:11352561}. CC -!- DISEASE: Bardet-Biedl syndrome 17 (BBS17) [MIM:615994]: A syndrome CC characterized by usually severe pigmentary retinopathy, early-onset CC obesity, polydactyly, hypogenitalism, renal malformation and CC intellectual disability. Secondary features include diabetes mellitus, CC hypertension and congenital heart disease. Bardet-Biedl syndrome CC inheritance is autosomal recessive, but three mutated alleles (two at CC one locus, and a third at a second locus) may be required for clinical CC manifestation of some forms of the disease. CC {ECO:0000269|PubMed:22510444, ECO:0000269|PubMed:23692385}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. Patients carrying LZTFL1 mutations manifest mesoaxial CC polydactyly, a clinical feature very uncommon for Bardet-Biedl syndrome CC (PubMed:22510444, PubMed:23692385). Some patients manifest situs CC inversus (PubMed:22510444). {ECO:0000269|PubMed:22510444}. CC -!- SIMILARITY: Belongs to the LZTFL1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ289880; CAB96873.1; -; Genomic_DNA. DR EMBL; AJ297351; CAB95836.1; -; mRNA. DR EMBL; BX640604; CAE45710.1; -; mRNA. DR EMBL; AK093705; BAG52751.1; -; mRNA. DR EMBL; AK303416; BAG64469.1; -; mRNA. DR EMBL; AC098476; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC099782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW64749.1; -; Genomic_DNA. DR EMBL; CH471055; EAW64750.1; -; Genomic_DNA. DR EMBL; BC025988; AAH25988.1; -; mRNA. DR EMBL; BC042483; AAH42483.1; -; mRNA. DR CCDS; CCDS2731.1; -. [Q9NQ48-1] DR CCDS; CCDS63608.1; -. [Q9NQ48-2] DR CCDS; CCDS63609.1; -. [Q9NQ48-3] DR RefSeq; NP_001263307.1; NM_001276378.1. [Q9NQ48-2] DR RefSeq; NP_001263308.1; NM_001276379.1. [Q9NQ48-3] DR RefSeq; NP_065080.1; NM_020347.3. [Q9NQ48-1] DR RefSeq; XP_011532140.1; XM_011533838.2. DR RefSeq; XP_016862133.1; XM_017006644.1. DR AlphaFoldDB; Q9NQ48; -. DR SMR; Q9NQ48; -. DR BioGRID; 120062; 47. DR IntAct; Q9NQ48; 24. DR STRING; 9606.ENSP00000296135; -. DR iPTMnet; Q9NQ48; -. DR PhosphoSitePlus; Q9NQ48; -. DR BioMuta; LZTFL1; -. DR DMDM; 74734310; -. DR REPRODUCTION-2DPAGE; IPI00478250; -. DR EPD; Q9NQ48; -. DR jPOST; Q9NQ48; -. DR MassIVE; Q9NQ48; -. DR MaxQB; Q9NQ48; -. DR PaxDb; 9606-ENSP00000296135; -. DR PeptideAtlas; Q9NQ48; -. DR ProteomicsDB; 3643; -. DR ProteomicsDB; 82080; -. [Q9NQ48-1] DR Pumba; Q9NQ48; -. DR Antibodypedia; 29604; 291 antibodies from 28 providers. DR DNASU; 54585; -. DR Ensembl; ENST00000296135.11; ENSP00000296135.6; ENSG00000163818.20. [Q9NQ48-1] DR Ensembl; ENST00000539217.5; ENSP00000441784.1; ENSG00000163818.20. [Q9NQ48-3] DR Ensembl; ENST00000684620.1; ENSP00000506925.1; ENSG00000163818.20. [Q9NQ48-2] DR GeneID; 54585; -. DR KEGG; hsa:54585; -. DR MANE-Select; ENST00000296135.11; ENSP00000296135.6; NM_020347.4; NP_065080.1. DR UCSC; uc003cox.3; human. [Q9NQ48-1] DR AGR; HGNC:6741; -. DR CTD; 54585; -. DR DisGeNET; 54585; -. DR GeneCards; LZTFL1; -. DR GeneReviews; LZTFL1; -. DR HGNC; HGNC:6741; LZTFL1. DR HPA; ENSG00000163818; Low tissue specificity. DR MalaCards; LZTFL1; -. DR MIM; 606568; gene. DR MIM; 615994; phenotype. DR neXtProt; NX_Q9NQ48; -. DR OpenTargets; ENSG00000163818; -. DR Orphanet; 110; Bardet-Biedl syndrome. DR PharmGKB; PA30505; -. DR VEuPathDB; HostDB:ENSG00000163818; -. DR eggNOG; ENOG502QRGB; Eukaryota. DR GeneTree; ENSGT00390000016415; -. DR HOGENOM; CLU_083519_0_0_1; -. DR InParanoid; Q9NQ48; -. DR OMA; QMEGTTA; -. DR OrthoDB; 3031373at2759; -. DR PhylomeDB; Q9NQ48; -. DR TreeFam; TF329023; -. DR PathwayCommons; Q9NQ48; -. DR Reactome; R-HSA-5620922; BBSome-mediated cargo-targeting to cilium. DR SignaLink; Q9NQ48; -. DR BioGRID-ORCS; 54585; 6 hits in 1157 CRISPR screens. DR ChiTaRS; LZTFL1; human. DR GenomeRNAi; 54585; -. DR Pharos; Q9NQ48; Tbio. DR PRO; PR:Q9NQ48; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q9NQ48; Protein. DR Bgee; ENSG00000163818; Expressed in bronchial epithelial cell and 199 other cell types or tissues. DR ExpressionAtlas; Q9NQ48; baseline and differential. DR GO; GO:0005929; C:cilium; IEA:Ensembl. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0002177; C:manchette; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB. DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl. DR GO; GO:1903568; P:negative regulation of protein localization to ciliary membrane; IMP:GO_Central. DR GO; GO:1903565; P:negative regulation of protein localization to cilium; IMP:GO_Central. DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl. DR InterPro; IPR026157; LZTFL1. DR PANTHER; PTHR21635; LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE; 1. DR PANTHER; PTHR21635:SF0; LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1; 1. DR Pfam; PF15294; Leu_zip; 1. DR Genevisible; Q9NQ48; HS. PE 1: Evidence at protein level; KW Alternative splicing; Bardet-Biedl syndrome; Ciliopathy; Coiled coil; KW Cytoplasm; Disease variant; Obesity; Reference proteome. FT CHAIN 1..299 FT /note="Leucine zipper transcription factor-like protein 1" FT /id="PRO_0000318757" FT REGION 145..299 FT /note="Interaction with BSS9" FT COILED 96..296 FT /evidence="ECO:0000255" FT VAR_SEQ 1..43 FT /note="MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESR -> MRNQD FT PGKMGRQRKSIKLYPTHPLVTFPRSWAKFQEKAL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_053428" FT VAR_SEQ 1..17 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_053429" FT VAR_SEQ 260..299 FT /note="ELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAQYEPED -> I (in FT isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_053430" FT VARIANT 87 FT /note="L -> P (in BBS17; dbSNP:rs515726135)" FT /evidence="ECO:0000269|PubMed:23692385" FT /id="VAR_070104" FT VARIANT 152 FT /note="K -> E (in dbSNP:rs17855512)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_038877" FT VARIANT 246 FT /note="D -> N (in dbSNP:rs1129183)" FT /evidence="ECO:0000269|PubMed:11352561" FT /id="VAR_038878" FT VARIANT 251 FT /note="Q -> R (in dbSNP:rs17852322)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_038879" FT MUTAGEN 24..25 FT /note="KR->AS: Increases BBS4, BBS8 and BBS9 ciliary FT localization." FT /evidence="ECO:0000269|PubMed:22072986" FT CONFLICT 108 FT /note="R -> Q (in Ref. 6; AAH25988)" FT /evidence="ECO:0000305" FT CONFLICT 224 FT /note="K -> R (in Ref. 3; BAG64469)" FT /evidence="ECO:0000305" SQ SEQUENCE 299 AA; 34592 MW; DCCD59AB98ED2C8A CRC64; MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEDTFT IDEVSEVLNG LQAVVHSEVE SELINTAYTN VLLLRQLFAQ AEKWYLKLQT DISELENREL LEQVAEFEKA EITSSNKKPI LDVTKPKLAP LNEGGTAELL NKEILRLQEE NEKLKSRLKT IEIQATNALD EKSKLEKALQ DLQLDQGNQK DFIKAQDLSN LENTVAALKS EFQKTLNDKT ENQKSLEENL ATAKHDLLRV QEQLHMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAQYEPED //