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Protein

Serine protease inhibitor Kazal-type 5

Gene

SPINK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei46 – 47Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • anagen Source: UniProtKB
  • epidermal cell differentiation Source: UniProtKB
  • epithelial cell differentiation Source: UniProtKB
  • extracellular matrix organization Source: UniProtKB
  • hair cell differentiation Source: UniProtKB
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of antibacterial peptide production Source: Ensembl
  • negative regulation of immune response Source: UniProtKB
  • negative regulation of serine-type endopeptidase activity Source: Ensembl
  • regulation of T cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133710-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.
SABIO-RKQ9NQ38.

Protein family/group databases

MEROPSiI01.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 5
Alternative name(s):
Lympho-epithelial Kazal-type-related inhibitor
Short name:
LEKTI
Cleaved into the following 2 chains:
Gene namesi
Name:SPINK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15464. SPINK5.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB
  • epidermal lamellar body Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Netherton syndrome (NETH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration.
See also OMIM:256500

Keywords - Diseasei

Hypotrichosis, Ichthyosis

Organism-specific databases

DisGeNETi11005.
MalaCardsiSPINK5.
MIMi256500. phenotype.
OpenTargetsiENSG00000133710.
Orphaneti634. Netherton syndrome.
PharmGKBiPA37962.

Polymorphism and mutation databases

BioMutaiSPINK5.
DMDMi212276440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001657223 – 1064Serine protease inhibitor Kazal-type 5Add BLAST1042
PeptideiPRO_000001657323 – 77Hemofiltrate peptide HF6478Add BLAST55
PeptideiPRO_0000016574356 – 423Hemofiltrate peptide HF7665Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 66
Disulfide bondi44 ↔ 63
Disulfide bondi97 ↔ 133PROSITE-ProRule annotation
Disulfide bondi111 ↔ 130PROSITE-ProRule annotation
Disulfide bondi119 ↔ 151PROSITE-ProRule annotation
Disulfide bondi161 ↔ 197PROSITE-ProRule annotation
Disulfide bondi175 ↔ 194PROSITE-ProRule annotation
Disulfide bondi225 ↔ 261PROSITE-ProRule annotation
Disulfide bondi239 ↔ 258PROSITE-ProRule annotation
Disulfide bondi297 ↔ 333PROSITE-ProRule annotation
Disulfide bondi311 ↔ 330PROSITE-ProRule annotation
Disulfide bondi367 ↔ 403
Disulfide bondi381 ↔ 400
Disulfide bondi437 ↔ 473PROSITE-ProRule annotation
Disulfide bondi451 ↔ 470PROSITE-ProRule annotation
Disulfide bondi496 ↔ 532PROSITE-ProRule annotation
Disulfide bondi510 ↔ 529PROSITE-ProRule annotation
Disulfide bondi567 ↔ 603PROSITE-ProRule annotation
Disulfide bondi581 ↔ 600PROSITE-ProRule annotation
Disulfide bondi632 ↔ 668PROSITE-ProRule annotation
Disulfide bondi646 ↔ 665PROSITE-ProRule annotation
Disulfide bondi707 ↔ 743PROSITE-ProRule annotation
Disulfide bondi721 ↔ 740PROSITE-ProRule annotation
Disulfide bondi774 ↔ 810PROSITE-ProRule annotation
Disulfide bondi788 ↔ 807PROSITE-ProRule annotation
Disulfide bondi849 ↔ 885PROSITE-ProRule annotation
Disulfide bondi863 ↔ 882PROSITE-ProRule annotation
Disulfide bondi916 ↔ 952PROSITE-ProRule annotation
Disulfide bondi930 ↔ 949PROSITE-ProRule annotation
Disulfide bondi993 ↔ 1028
Disulfide bondi1006 ↔ 1025
Disulfide bondi1014 ↔ 1046

Post-translational modificationi

Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9NQ38.
PeptideAtlasiQ9NQ38.
PRIDEiQ9NQ38.

PTM databases

iPTMnetiQ9NQ38.
PhosphoSitePlusiQ9NQ38.

Miscellaneous databases

PMAP-CutDBQ9NQ38.

Expressioni

Tissue specificityi

Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.1 Publication

Gene expression databases

BgeeiENSG00000133710.
CleanExiHS_SPINK5.
ExpressionAtlasiQ9NQ38. baseline and differential.
GenevisibleiQ9NQ38. HS.

Organism-specific databases

HPAiCAB015347.
HPA009067.
HPA011351.

Interactioni

Protein-protein interaction databases

BioGridi116196. 1 interactor.
STRINGi9606.ENSP00000352936.

Structurei

Secondary structure

11064
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni25 – 27Combined sources3
Helixi33 – 36Combined sources4
Beta strandi37 – 40Combined sources4
Helixi48 – 52Combined sources5
Helixi54 – 76Combined sources23
Helixi363 – 366Combined sources4
Helixi367 – 370Combined sources4
Turni371 – 373Combined sources3
Beta strandi375 – 377Combined sources3
Helixi399 – 413Combined sources15
Helixi990 – 993Combined sources4
Turni1000 – 1002Combined sources3
Beta strandi1013 – 1015Combined sources3
Turni1016 – 1018Combined sources3
Beta strandi1019 – 1024Combined sources6
Helixi1025 – 1034Combined sources10
Beta strandi1040 – 1045Combined sources6
Helixi1047 – 1049Combined sources3
Helixi1055 – 1058Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0ZNMR-A356-423[»]
1HDLNMR-A23-77[»]
1UUCNMR-A23-77[»]
1UVFNMR-A989-1047[»]
1UVGNMR-A989-1064[»]
ProteinModelPortaliQ9NQ38.
SMRiQ9NQ38.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NQ38.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66Kazal-like 1; atypicalPROSITE-ProRule annotationAdd BLAST39
Domaini91 – 153Kazal-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini155 – 216Kazal-like 3PROSITE-ProRule annotationAdd BLAST62
Domaini219 – 285Kazal-like 4PROSITE-ProRule annotationAdd BLAST67
Domaini291 – 352Kazal-like 5PROSITE-ProRule annotationAdd BLAST62
Domaini361 – 423Kazal-like 6PROSITE-ProRule annotationAdd BLAST63
Domaini431 – 489Kazal-like 7PROSITE-ProRule annotationAdd BLAST59
Domaini490 – 551Kazal-like 8PROSITE-ProRule annotationAdd BLAST62
Domaini561 – 622Kazal-like 9PROSITE-ProRule annotationAdd BLAST62
Domaini626 – 688Kazal-like 10PROSITE-ProRule annotationAdd BLAST63
Domaini701 – 757Kazal-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini768 – 830Kazal-like 12PROSITE-ProRule annotationAdd BLAST63
Domaini843 – 905Kazal-like 13PROSITE-ProRule annotationAdd BLAST63
Domaini910 – 971Kazal-like 14PROSITE-ProRule annotationAdd BLAST62
Domaini987 – 1048Kazal-like 15PROSITE-ProRule annotationAdd BLAST62

Domaini

Contains at least one active inhibitory domain for trypsin (domain 6).

Sequence similaritiesi

Contains 15 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0D. Eukaryota.
ENOG4111TR7. LUCA.
GeneTreeiENSGT00510000048608.
HOVERGENiHBG006183.
InParanoidiQ9NQ38.
OMAiCHENLIR.
OrthoDBiEOG091G14HG.
PhylomeDBiQ9NQ38.
TreeFamiTF336724.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 12 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 14 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform f-l (identifier: Q9NQ38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIATVSVLL PLALCLIQDA ASKNEDQEMC HEFQAFMKNG KLFCPQDKKF
60 70 80 90 100
FQSLDGIMFI NKCATCKMIL EKEAKSQKRA RHLARAPKAT APTELNCDDF
110 120 130 140 150
KKGERDGDFI CPDYYEAVCG TDGKTYDNRC ALCAENAKTG SQIGVKSEGE
160 170 180 190 200
CKSSNPEQDV CSAFRPFVRD GRLGCTREND PVLGPDGKTH GNKCAMCAEL
210 220 230 240 250
FLKEAENAKR EGETRIRRNA EKDFCKEYEK QVRNGRLFCT RESDPVRGPD
260 270 280 290 300
GRMHGNKCAL CAEIFKQRFS EENSKTDQNL GKAEEKTKVK REIVKLCSQY
310 320 330 340 350
QNQAKNGILF CTRENDPIRG PDGKMHGNLC SMCQAYFQAE NEEKKKAEAR
360 370 380 390 400
ARNKRESGKA TSYAELCSEY RKLVRNGKLA CTRENDPIQG PDGKVHGNTC
410 420 430 440 450
SMCEVFFQAE EEEKKKKEGK SRNKRQSKST ASFEELCSEY RKSRKNGRLF
460 470 480 490 500
CTRENDPIQG PDGKMHGNTC SMCEAFFQQE ERARAKAKRE AAKEICSEFR
510 520 530 540 550
DQVRNGTLIC TREHNPVRGP DGKMHGNKCA MCASVFKLEE EEKKNDKEEK
560 570 580 590 600
GKVEAEKVKR EAVQELCSEY RHYVRNGRLP CTRENDPIEG LDGKIHGNTC
610 620 630 640 650
SMCEAFFQQE AKEKERAEPR AKVKREAEKE TCDEFRRLLQ NGKLFCTREN
660 670 680 690 700
DPVRGPDGKT HGNKCAMCKA VFQKENEERK RKEEEDQRNA AGHGSSGGGG
710 720 730 740 750
GNTQDECAEY REQMKNGRLS CTRESDPVRD ADGKSYNNQC TMCKAKLERE
760 770 780 790 800
AERKNEYSRS RSNGTGSESG KDTCDEFRSQ MKNGKLICTR ESDPVRGPDG
810 820 830 840 850
KTHGNKCTMC KEKLEREAAE KKKKEDEDRS NTGERSNTGE RSNDKEDLCR
860 870 880 890 900
EFRSMQRNGK LICTRENNPV RGPYGKMHIN KCAMCQSIFD REANERKKKD
910 920 930 940 950
EEKSSSKPSN NAKDECSEFR NYIRNNELIC PRENDPVHGA DGKFYTNKCY
960 970 980 990 1000
MCRAVFLTEA LERAKLQEKP SHVRASQEED SPDSFSSLDS EMCKDYRVLP
1010 1020 1030 1040 1050
RIGYLCPKDL KPVCGDDGQT YNNPCMLCHE NLIRQTNTHI RSTGKCEESS
1060
TPGTTAASMP PSDE
Length:1,064
Mass (Da):120,714
Last modified:November 4, 2008 - v2
Checksum:i6CBEF39BB9E6D75D
GO
Isoform short (identifier: Q9NQ38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     914-916: DEC → VIY
     917-1064: Missing.

Show »
Length:916
Mass (Da):104,017
Checksum:i82A029D102BD8C26
GO
Isoform long (identifier: Q9NQ38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     914-914: D → DQCRQVQNEAEDAKFRQPGRSLASVARMSTD

Show »
Length:1,094
Mass (Da):124,076
Checksum:i8EF0D8DE3A62227A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 27DAASKNEDQ → GQCEKDSLS in CAB96877 (PubMed:10835624).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047115267Q → R.3 PublicationsCorresponds to variant rs6892205dbSNPEnsembl.1
Natural variantiVAR_061337335A → V.2 PublicationsCorresponds to variant rs34482796dbSNPEnsembl.1
Natural variantiVAR_047116368S → N.3 PublicationsCorresponds to variant rs2303063dbSNPEnsembl.1
Natural variantiVAR_047117386D → N.Corresponds to variant rs2303064dbSNPEnsembl.1
Natural variantiVAR_047118395V → M.Corresponds to variant rs17775319dbSNPEnsembl.1
Natural variantiVAR_015537420K → E.3 PublicationsCorresponds to variant rs2303067dbSNPEnsembl.1
Natural variantiVAR_047119441R → H.Corresponds to variant rs34393923dbSNPEnsembl.1
Natural variantiVAR_047120588I → M.Corresponds to variant rs35877540dbSNPEnsembl.1
Natural variantiVAR_047121711R → Q.2 PublicationsCorresponds to variant rs3777134dbSNPEnsembl.1
Natural variantiVAR_047122825E → D.Corresponds to variant rs2303070dbSNPEnsembl.1
Natural variantiVAR_047123887S → R.Corresponds to variant rs28408445dbSNPEnsembl.1
Natural variantiVAR_047124969K → E.Corresponds to variant rs3188691dbSNPEnsembl.1
Natural variantiVAR_047125972H → R.Corresponds to variant rs17705005dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040019914 – 916DEC → VIY in isoform short. 1 Publication3
Alternative sequenceiVSP_040020914D → DQCRQVQNEAEDAKFRQPGR SLASVARMSTD in isoform long. 1 Publication1
Alternative sequenceiVSP_040021917 – 1064Missing in isoform short. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228139 mRNA. Translation: CAB40839.1.
AJ391230
, AJ270944, AJ391231, AJ391232, AJ391233, AJ391234, AJ391235, AJ276579, AJ391236, AJ276580, AJ391237, AJ391238, AJ391239, AJ391240, AJ391241, AJ276578, AJ391242, AJ391243, AJ391244, AJ391245, AJ391246, AJ391247, AJ391248, AJ391249, AJ391250, AJ391251, AJ391252, AJ391253, AJ391254, AJ276577 Genomic DNA. Translation: CAB96877.1.
DQ149927 mRNA. Translation: ABA06534.1.
DQ149928 mRNA. Translation: ABA06535.1.
DQ149929 mRNA. Translation: ABA06536.1.
AC008722 Genomic DNA. No translation available.
AC116334 Genomic DNA. No translation available.
AF295784 Genomic DNA. Translation: AAK97139.1.
AF295783 Genomic DNA. Translation: AAK97140.1.
CCDSiCCDS43382.1. [Q9NQ38-1]
CCDS47300.1. [Q9NQ38-3]
CCDS47301.1. [Q9NQ38-2]
RefSeqiNP_001121170.1. NM_001127698.1. [Q9NQ38-3]
NP_001121171.1. NM_001127699.1. [Q9NQ38-2]
NP_006837.2. NM_006846.3. [Q9NQ38-1]
UniGeneiHs.331555.

Genome annotation databases

EnsembliENST00000256084; ENSP00000256084; ENSG00000133710. [Q9NQ38-1]
ENST00000359874; ENSP00000352936; ENSG00000133710. [Q9NQ38-3]
ENST00000398454; ENSP00000381472; ENSG00000133710. [Q9NQ38-2]
GeneIDi11005.
KEGGihsa:11005.
UCSCiuc003low.2. human. [Q9NQ38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SPINK5base

SPINK5 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ228139 mRNA. Translation: CAB40839.1.
AJ391230
, AJ270944, AJ391231, AJ391232, AJ391233, AJ391234, AJ391235, AJ276579, AJ391236, AJ276580, AJ391237, AJ391238, AJ391239, AJ391240, AJ391241, AJ276578, AJ391242, AJ391243, AJ391244, AJ391245, AJ391246, AJ391247, AJ391248, AJ391249, AJ391250, AJ391251, AJ391252, AJ391253, AJ391254, AJ276577 Genomic DNA. Translation: CAB96877.1.
DQ149927 mRNA. Translation: ABA06534.1.
DQ149928 mRNA. Translation: ABA06535.1.
DQ149929 mRNA. Translation: ABA06536.1.
AC008722 Genomic DNA. No translation available.
AC116334 Genomic DNA. No translation available.
AF295784 Genomic DNA. Translation: AAK97139.1.
AF295783 Genomic DNA. Translation: AAK97140.1.
CCDSiCCDS43382.1. [Q9NQ38-1]
CCDS47300.1. [Q9NQ38-3]
CCDS47301.1. [Q9NQ38-2]
RefSeqiNP_001121170.1. NM_001127698.1. [Q9NQ38-3]
NP_001121171.1. NM_001127699.1. [Q9NQ38-2]
NP_006837.2. NM_006846.3. [Q9NQ38-1]
UniGeneiHs.331555.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0ZNMR-A356-423[»]
1HDLNMR-A23-77[»]
1UUCNMR-A23-77[»]
1UVFNMR-A989-1047[»]
1UVGNMR-A989-1064[»]
ProteinModelPortaliQ9NQ38.
SMRiQ9NQ38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116196. 1 interactor.
STRINGi9606.ENSP00000352936.

Protein family/group databases

MEROPSiI01.013.

PTM databases

iPTMnetiQ9NQ38.
PhosphoSitePlusiQ9NQ38.

Polymorphism and mutation databases

BioMutaiSPINK5.
DMDMi212276440.

Proteomic databases

PaxDbiQ9NQ38.
PeptideAtlasiQ9NQ38.
PRIDEiQ9NQ38.

Protocols and materials databases

DNASUi11005.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256084; ENSP00000256084; ENSG00000133710. [Q9NQ38-1]
ENST00000359874; ENSP00000352936; ENSG00000133710. [Q9NQ38-3]
ENST00000398454; ENSP00000381472; ENSG00000133710. [Q9NQ38-2]
GeneIDi11005.
KEGGihsa:11005.
UCSCiuc003low.2. human. [Q9NQ38-1]

Organism-specific databases

CTDi11005.
DisGeNETi11005.
GeneCardsiSPINK5.
H-InvDBHIX0005288.
HGNCiHGNC:15464. SPINK5.
HPAiCAB015347.
HPA009067.
HPA011351.
MalaCardsiSPINK5.
MIMi256500. phenotype.
605010. gene.
neXtProtiNX_Q9NQ38.
OpenTargetsiENSG00000133710.
Orphaneti634. Netherton syndrome.
PharmGKBiPA37962.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP0D. Eukaryota.
ENOG4111TR7. LUCA.
GeneTreeiENSGT00510000048608.
HOVERGENiHBG006183.
InParanoidiQ9NQ38.
OMAiCHENLIR.
OrthoDBiEOG091G14HG.
PhylomeDBiQ9NQ38.
TreeFamiTF336724.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133710-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.
SABIO-RKQ9NQ38.

Miscellaneous databases

ChiTaRSiSPINK5. human.
EvolutionaryTraceiQ9NQ38.
GeneWikiiLEKTI.
GenomeRNAii11005.
PMAP-CutDBQ9NQ38.
PROiQ9NQ38.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133710.
CleanExiHS_SPINK5.
ExpressionAtlasiQ9NQ38. baseline and differential.
GenevisibleiQ9NQ38. HS.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 2 hits.
PF07648. Kazal_2. 12 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 14 hits.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 2 hits.
PS51465. KAZAL_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISK5_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ38
Secondary accession number(s): A8MYE8
, B7WPB7, D6REN5, O75770, Q3LX95, Q3LX96, Q3LX97, Q96PP2, Q96PP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.