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Protein

Signal peptide, CUB and EGF-like domain-containing protein 2

Gene

SCUBE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175356-MONOMER.
ReactomeiR-HSA-5362798. Release of Hh-Np from the secreting cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptide, CUB and EGF-like domain-containing protein 2
Alternative name(s):
Protein CEGP1
Gene namesi
Name:SCUBE2
Synonyms:CEGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30425. SCUBE2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi57758.
PharmGKBiPA134908812.

Polymorphism and mutation databases

BioMutaiSCUBE2.
DMDMi311033510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000025558032 – 999Signal peptide, CUB and EGF-like domain-containing protein 2Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 62By similarity
Disulfide bondi56 ↔ 71By similarity
Disulfide bondi73 ↔ 84By similarity
Disulfide bondi90 ↔ 102By similarity
Disulfide bondi98 ↔ 111By similarity
Disulfide bondi113 ↔ 126By similarity
Disulfide bondi368 ↔ 378By similarity
Disulfide bondi374 ↔ 387By similarity
Disulfide bondi389 ↔ 401By similarity
Disulfide bondi407 ↔ 418By similarity
Disulfide bondi414 ↔ 427By similarity
Disulfide bondi429 ↔ 442By similarity
Glycosylationi659N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi809 ↔ 835By similarity
Disulfide bondi862 ↔ 883By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ9NQ36.
PRIDEiQ9NQ36.

PTM databases

iPTMnetiQ9NQ36.
PhosphoSitePlusiQ9NQ36.

Expressioni

Tissue specificityi

Expressed in a broad spectrum of adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000175356.
CleanExiHS_SCUBE2.
ExpressionAtlasiQ9NQ36. baseline and differential.
GenevisibleiQ9NQ36. HS.

Organism-specific databases

HPAiHPA006353.
HPA029871.

Interactioni

Subunit structurei

Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9NQ36.
SMRiQ9NQ36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 85EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini86 – 127EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini128 – 168EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini177 – 213EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini217 – 252EGF-like 5PROSITE-ProRule annotationAdd BLAST36
Domaini286 – 321EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini323 – 363EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini364 – 402EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini403 – 443EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini809 – 921CUBPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000230943.
HOVERGENiHBG054902.
InParanoidiQ9NQ36.
OrthoDBiEOG091G00SV.
PhylomeDBiQ9NQ36.
TreeFamiTF351672.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR026823. cEGF.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF00431. CUB. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07699. Ephrin_rec_like. 3 hits.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00181. EGF. 10 hits.
SM00179. EGF_CA. 8 hits.
SM01411. Ephrin_rec_like. 3 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57184. SSF57184. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01180. CUB. 1 hit.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVAGRNRPG AAWAVLLLLL LLPPLLLLAG AVPPGRGRAA GPQEDVDECA
60 70 80 90 100
QGLDDCHADA LCQNTPTSYK CSCKPGYQGE GRQCEDIDEC GNELNGGCVH
110 120 130 140 150
DCLNIPGNYR CTCFDGFMLA HDGHNCLDVD ECLENNGGCQ HTCVNVMGSY
160 170 180 190 200
ECCCKEGFFL SDNQHTCIHR SEEGLSCMNK DHGCSHICKE APRGSVACEC
210 220 230 240 250
RPGFELAKNQ RDCILTCNHG NGGCQHSCDD TADGPECSCH PQYKMHTDGR
260 270 280 290 300
SCLEREDTVL EVTESNTTSV VDGDKRVKRR LLMETCAVNN GGCDRTCKDT
310 320 330 340 350
STGVHCSCPV GFTLQLDGKT CKDIDECQTR NGGCDHFCKN IVGSFDCGCK
360 370 380 390 400
KGFKLLTDEK SCQDVDECSL DRTCDHSCIN HPGTFACACN RGYTLYGFTH
410 420 430 440 450
CGDTNECSIN NGGCQQVCVN TVGSYECQCH PGYKLHWNKK DCVEVKGLLP
460 470 480 490 500
TSVSPRVSLH CGKSGGGDGC FLRCHSGIHL SSDVTTIRTS VTFKLNEGKC
510 520 530 540 550
SLKNAELFPE GLRPALPEKH SSVKESFRYV NLTCSSGKQV PGAPGRPSTP
560 570 580 590 600
KEMFITVEFE LETNQKEVTA SCDLSCIVKR TEKRLRKAIR TLRKAVHREQ
610 620 630 640 650
FHLQLSGMNL DVAKKPPRTS ERQAESCGVG QGHAENQCVS CRAGTYYDGA
660 670 680 690 700
RERCILCPNG TFQNEEGQMT CEPCPRPGNS GALKTPEAWN MSECGGLCQP
710 720 730 740 750
GEYSADGFAP CHLCALGTFQ PEAGRTSCFP CGGGLATKHQ GATSFQDCET
760 770 780 790 800
RVQCSPGHFY NTTTHRCIRC PVGTYQPEFG KNNCVSCPGN TTTDFDGSTN
810 820 830 840 850
ITQCKNRRCG GELGDFTGYI ESPNYPGNYP ANTECTWTIN PPPKRRILIV
860 870 880 890 900
VPEIFLPIED DCGDYLVMRK TSSSNSVTTY ETCQTYERPI AFTSRSKKLW
910 920 930 940 950
IQFKSNEGNS ARGFQVPYVT YDEDYQELIE DIVRDGRLYA SENHQEILKD
960 970 980 990
KKLIKALFDV LAHPQNYFKY TAQESREMFP RSFIRLLRSK VSRFLRPYK
Length:999
Mass (Da):109,966
Last modified:November 2, 2010 - v2
Checksum:i1EE1B0BC2D5DED93
GO
Isoform 2 (identifier: Q9NQ36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: S → SGLQGAYSVTCGSSSPLRNKQQKSNDSAFG
     639-695: Missing.

Show »
Length:971
Mass (Da):106,766
Checksum:iDF62C02052F0E0F0
GO
Isoform 3 (identifier: Q9NQ36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-569: Missing.
     806-872: NRRCGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTS → T

Show »
Length:807
Mass (Da):88,879
Checksum:i8D8CFF8E9D525120
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti916V → G in BAC85521 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028870591T → M.1 PublicationCorresponds to variant rs3751055dbSNPEnsembl.1
Natural variantiVAR_028871712H → Q.3 PublicationsCorresponds to variant rs7395988dbSNPEnsembl.1
Natural variantiVAR_028872752V → G.Corresponds to variant rs12419343dbSNPEnsembl.1
Natural variantiVAR_028873791T → S.Corresponds to variant rs3751057dbSNPEnsembl.1
Natural variantiVAR_028874843P → R.Corresponds to variant rs3751059dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021293444 – 569Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_021294482S → SGLQGAYSVTCGSSSPLRNK QQKSNDSAFG in isoform 2. 1 Publication1
Alternative sequenceiVSP_039955639 – 695Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_021295806 – 872NRRCG…MRKTS → T in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400877 Genomic DNA. Translation: CAB92285.1.
AK123039 mRNA. Translation: BAC85521.1.
AC079296 Genomic DNA. No translation available.
BC111690 mRNA. Translation: AAI11691.1.
CCDSiCCDS53599.1. [Q9NQ36-3]
CCDS7797.2. [Q9NQ36-2]
CCDS81553.1. [Q9NQ36-1]
RefSeqiNP_001164161.1. NM_001170690.1.
NP_001317128.1. NM_001330199.1.
NP_066025.2. NM_020974.2.
UniGeneiHs.523468.

Genome annotation databases

EnsembliENST00000309263; ENSP00000310658; ENSG00000175356.
ENST00000450649; ENSP00000415187; ENSG00000175356.
GeneIDi57758.
KEGGihsa:57758.
UCSCiuc001mhj.3. human. [Q9NQ36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400877 Genomic DNA. Translation: CAB92285.1.
AK123039 mRNA. Translation: BAC85521.1.
AC079296 Genomic DNA. No translation available.
BC111690 mRNA. Translation: AAI11691.1.
CCDSiCCDS53599.1. [Q9NQ36-3]
CCDS7797.2. [Q9NQ36-2]
CCDS81553.1. [Q9NQ36-1]
RefSeqiNP_001164161.1. NM_001170690.1.
NP_001317128.1. NM_001330199.1.
NP_066025.2. NM_020974.2.
UniGeneiHs.523468.

3D structure databases

ProteinModelPortaliQ9NQ36.
SMRiQ9NQ36.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9NQ36.
PhosphoSitePlusiQ9NQ36.

Polymorphism and mutation databases

BioMutaiSCUBE2.
DMDMi311033510.

Proteomic databases

PeptideAtlasiQ9NQ36.
PRIDEiQ9NQ36.

Protocols and materials databases

DNASUi57758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309263; ENSP00000310658; ENSG00000175356.
ENST00000450649; ENSP00000415187; ENSG00000175356.
GeneIDi57758.
KEGGihsa:57758.
UCSCiuc001mhj.3. human. [Q9NQ36-1]

Organism-specific databases

CTDi57758.
DisGeNETi57758.
GeneCardsiSCUBE2.
HGNCiHGNC:30425. SCUBE2.
HPAiHPA006353.
HPA029871.
MIMi611747. gene.
neXtProtiNX_Q9NQ36.
PharmGKBiPA134908812.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000230943.
HOVERGENiHBG054902.
InParanoidiQ9NQ36.
OrthoDBiEOG091G00SV.
PhylomeDBiQ9NQ36.
TreeFamiTF351672.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175356-MONOMER.
ReactomeiR-HSA-5362798. Release of Hh-Np from the secreting cell.

Miscellaneous databases

ChiTaRSiSCUBE2. human.
GenomeRNAii57758.
PROiQ9NQ36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175356.
CleanExiHS_SCUBE2.
ExpressionAtlasiQ9NQ36. baseline and differential.
GenevisibleiQ9NQ36. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR026823. cEGF.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR009030. Growth_fac_rcpt_.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF00431. CUB. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07699. Ephrin_rec_like. 3 hits.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00181. EGF. 10 hits.
SM00179. EGF_CA. 8 hits.
SM01411. Ephrin_rec_like. 3 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57184. SSF57184. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS01180. CUB. 1 hit.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCUB2_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ36
Secondary accession number(s): Q2NKQ8, Q6ZWI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.