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Reviewed, UniProtKB/Swiss-Prot Q9NQ34 (TMM9B_HUMAN)

Last modified January 19, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Transmembrane protein 9B
Gene names
Name: TMEM9B
Synonyms: C11orf15
ORF Names: UNQ712/PRO1375
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM9 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processpositive regulation of I-kappaB kinase/NF-kappaB cascade

Inferred from mutant phenotype. Source: UniProtKB

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsignal transducer activity

Inferred from mutant phenotype. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Ref.4
Chain34 – 198165Transmembrane protein 9B
PRO_0000034376

Regions

Transmembrane103 – 12523 Potential

Amino acid modifications

Modified residue1641Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9NQ34-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 888E55365A01B44F

FASTA19822,531
        10         20         30         40         50         60 
MATLWGGLLR LGSLLSLSCL ALSVLLLAQL SDAAKNFEDV RCKCICPPYK ENSGHIYNKN 

        70         80         90        100        110        120 
ISQKDCDCLH VVEPMPVRGP DVEAYCLRCE CKYEERSSVT IKVTIIIYLS ILGLLLLYMV 

       130        140        150        160        170        180 
YLTLVEPILK RRLFGHAQLI QSDDDIGDHQ PFANAHDVLA RSRSRANVLN KVEYAQQRWK 

       190 
LQVQEQRKSV FDRHVVLS 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
Cytogenet. Cell Genet. 93:284-290(2001) [PubMed: 11528127] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 34-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ400877 Genomic DNA. Translation: CAB92287.1.
AY359069 mRNA. Translation: AAQ89428.1.
BC040124 mRNA. Translation: AAH40124.1.
IPIIPI00009880.
RefSeqNP_065695.1.
UniGeneHs.501853

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9NQ34. 1 interaction.

PTM databases

PhosphoSiteQ9NQ34.

Proteomic databases

PeptideAtlasQ9NQ34.
PRIDEQ9NQ34.

Genome annotation databases

EnsemblENST00000309134; ENSP00000311842; ENSG00000175348; Homo sapiens. [Genome view]
GeneID56674.
KEGGhsa:56674.
UCSCuc001mhe.1. human.

Organism-specific databases

CTD56674.
GeneCardsGC11M008926.
H-InvDBHIX0026147.
HGNCHGNC:1168. TMEM9B.
PharmGKBPA25482.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG506119.
HOVERGENQ9NQ34.
InParanoidQ9NQ34.
OMANMLNKVE.
OrthoDBEOG94BDMQ.
PhylomeDBQ9NQ34.

Gene expression databases

ArrayExpressQ9NQ34.
BgeeQ9NQ34.
CleanExHS_TMEM9B.
GenevestigatorQ9NQ34.
GermOnlineENSG00000175348. Homo sapiens.

Family and domain databases

InterProIPR008853. TMEM9.
[Graphical view]
PANTHERPTHR13064. TMEM9. 1 hit.
PfamPF05434. Tmemb_9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio62173.

Entry information

Entry nameTMM9B_HUMAN
AccessionPrimary (citable) accession number: Q9NQ34
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: January 19, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents