Q9NQ34 (TMM9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 9B

Gene names

Name:	TMEM9B
Synonyms:	C11orf15
ORF Names:	UNQ712/PRO1375

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM9 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	signal transducer activity Inferred from mutant phenotype PubMed 12761501. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Ref.4
	Chain	34 – 198	165	Transmembrane protein 9B		PRO_0000034376
Regions
	Transmembrane	103 – 125	23	Helical; Potential
Amino acid modifications
	Modified residue	164	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NQ34 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 888E55365A01B44F	FASTA	198	22,531
	10 20 30 40 50 60 MATLWGGLLR LGSLLSLSCL ALSVLLLAQL SDAAKNFEDV RCKCICPPYK ENSGHIYNKN 70 80 90 100 110 120 ISQKDCDCLH VVEPMPVRGP DVEAYCLRCE CKYEERSSVT IKVTIIIYLS ILGLLLLYMV 130 140 150 160 170 180 YLTLVEPILK RRLFGHAQLI QSDDDIGDHQ PFANAHDVLA RSRSRANVLN KVEYAQQRWK 190 LQVQEQRKSV FDRHVVLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7." Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R. Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 34-48.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ400877 Genomic DNA. Translation: CAB92287.1. AY359069 mRNA. Translation: AAQ89428.1. BC040124 mRNA. Translation: AAH40124.1.
IPI	IPI00009880.
RefSeq	NP_065695.1. NM_020644.1.
UniGene	Hs.501853.
3D structure databases
ProteinModelPortal	Q9NQ34.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NQ34. 1 interaction.
MINT	MINT-1390777.
PTM databases
PhosphoSite	Q9NQ34.
Polymorphism databases
DMDM	20532029.
Proteomic databases
PaxDb	Q9NQ34.
PeptideAtlas	Q9NQ34.
PRIDE	Q9NQ34.
Protocols and materials databases
DNASU	56674.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000534025; ENSP00000433361; ENSG00000175348.
GeneID	56674.
KEGG	hsa:56674.
UCSC	uc001mhe.1. human.
Organism-specific databases
CTD	56674.
GeneCards	GC11M008969.
HGNC	HGNC:1168. TMEM9B.
HPA	HPA037784.
neXtProt	NX_Q9NQ34.
PharmGKB	PA25482.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289024.
HOGENOM	HOG000044306.
HOVERGEN	HBG050972.
InParanoid	Q9NQ34.
OMA	MLNKVEH.
OrthoDB	EOG45HRZP.
PhylomeDB	Q9NQ34.
Gene expression databases
ArrayExpress	Q9NQ34.
Bgee	Q9NQ34.
CleanEx	HS_TMEM9B.
Genevestigator	Q9NQ34.
GermOnline	ENSG00000175348. Homo sapiens.
Family and domain databases
InterPro	IPR008853. TMEM9. [Graphical view]
PANTHER	PTHR13064. PTHR13064. 1 hit.
Pfam	PF05434. Tmemb_9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM9B. human.
GenomeRNAi	56674.
NextBio	62173.

Entry information

Entry name

TMM9B_HUMAN

Accession

Primary (citable) accession number: Q9NQ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.