Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Achaete-scute homolog 3

Gene

ASCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Inhibits myogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 3
Short name:
ASH-3
Short name:
hASH3
Alternative name(s):
Class A basic helix-loop-helix protein 42
Short name:
bHLHa42
bHLH transcriptional regulator Sgn-1
Gene namesi
Name:ASCL3
Synonyms:BHLHA42, HASH3, SGN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176009.3.
HGNCiHGNC:740. ASCL3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25040.

Polymorphism and mutation databases

BioMutaiASCL3.
DMDMi20454833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271331 – 180Achaete-scute homolog 3Add BLAST180

Proteomic databases

PaxDbiQ9NQ33.
PRIDEiQ9NQ33.

PTM databases

iPTMnetiQ9NQ33.
PhosphoSitePlusiQ9NQ33.

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000176009.
CleanExiHS_ASCL3.
GenevisibleiQ9NQ33. HS.

Organism-specific databases

HPAiHPA027032.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121184. 6 interactors.
IntActiQ9NQ33. 6 interactors.
STRINGi9606.ENSP00000318846.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ33.
SMRiQ9NQ33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 144bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
HOGENOMiHOG000034089.
HOVERGENiHBG050591.
InParanoidiQ9NQ33.
KOiK09067.
OMAiGYAQLRH.
OrthoDBiEOG091G0OGL.
PhylomeDBiQ9NQ33.
TreeFamiTF322889.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR015660. MASH1/Ascl1a-like.
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NQ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRGNSSLP DKLPIFPDSA RLPLTRSFYL EPMVTFHVHP EAPVSSPYSE
60 70 80 90 100
ELPRLPFPSD SLILGNYSEP CPFSFPMPYP NYRGCEYSYG PAFTRKRNER
110 120 130 140 150
ERQRVKCVNE GYAQLRHHLP EEYLEKRLSK VETLRAAIKY INYLQSLLYP
160 170 180
DKAETKNNPG KVSSMIATTS HHADPMFRIV
Length:180
Mass (Da):20,797
Last modified:May 2, 2002 - v2
Checksum:iC9B90C885DE94F81
GO

Sequence cautioni

The sequence CAB92288 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05594854R → L1 PublicationCorresponds to variant dbSNP:rs4909951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046450 Genomic DNA. Translation: BAB83913.1.
AJ400877 Genomic DNA. Translation: CAB92288.1. Different initiation.
RefSeqiNP_065697.1. NM_020646.2.
UniGeneiHs.501852.

Genome annotation databases

EnsembliENST00000531618; ENSP00000435770; ENSG00000176009.
GeneIDi56676.
KEGGihsa:56676.
UCSCiuc057yvn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiASCL3_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ33
Secondary accession number(s): Q8WYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: September 27, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot