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Protein

A-kinase-interacting protein 1

Gene

AKIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.2 Publications

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase-interacting protein 1
Alternative name(s):
Breast cancer-associated gene 3 protein
PKA-interacting protein
Proline-rich protein BCA3
Gene namesi
Name:AKIP1
Synonyms:BCA3, C11orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1170. AKIP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi56672.
OpenTargetsiENSG00000166452.
PharmGKBiPA25484.

Polymorphism and mutation databases

BioMutaiAKIP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648571 – 210A-kinase-interacting protein 1Add BLAST210

Proteomic databases

MaxQBiQ9NQ31.
PaxDbiQ9NQ31.
PeptideAtlasiQ9NQ31.
PRIDEiQ9NQ31.

PTM databases

iPTMnetiQ9NQ31.
PhosphoSitePlusiQ9NQ31.

Expressioni

Tissue specificityi

Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.2 Publications

Gene expression databases

BgeeiENSG00000166452.
CleanExiHS_C11orf17.
ExpressionAtlasiQ9NQ31. baseline and differential.
GenevisibleiQ9NQ31. HS.

Organism-specific databases

HPAiHPA061391.

Interactioni

Subunit structurei

Interacts with PRKACA and RELA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKACAP176124EBI-517035,EBI-476586

Protein-protein interaction databases

BioGridi121180. 11 interactors.
IntActiQ9NQ31. 4 interactors.
STRINGi9606.ENSP00000310459.

Structurei

3D structure databases

ProteinModelPortaliQ9NQ31.
SMRiQ9NQ31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGJ9. Eukaryota.
ENOG41114P0. LUCA.
GeneTreeiENSGT00390000017064.
HOVERGENiHBG030457.
InParanoidiQ9NQ31.
OMAiPGGIYQI.
OrthoDBiEOG091G0W3L.
PhylomeDBiQ9NQ31.
TreeFamiTF337318.

Family and domain databases

InterProiIPR033214. AKIP1.
[Graphical view]
PANTHERiPTHR14330. PTHR14330. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NQ31-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNCLAAAAL NGVDRRSLQR SARLALEVLE RAKRRAVDWH ALERPKGCMG
60 70 80 90 100
VLAREAPHLE KQPAAGPQRV LPGEREERPP TLSASFRTMA EFMDYTSSQC
110 120 130 140 150
GKYYSSVPEE GGATHVYRYH RGESKLHMCL DIGNGQRKDR KKTSLGPGGS
160 170 180 190 200
YQISEHAPEA SQPAENISKD LYIEVYPGTY SVTVGSNDLT KKTHVVAVDS
210
GQSVDLVFPV
Length:210
Mass (Da):23,114
Last modified:October 23, 2007 - v2
Checksum:iF00AA1F166C37967
GO
Isoform 2 (identifier: Q9NQ31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-163: Missing.

Show »
Length:183
Mass (Da):20,207
Checksum:i872DD878B01C513B
GO
Isoform 3 (identifier: Q9NQ31-3) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:183
Mass (Da):20,034
Checksum:iCF22CF64A41F33DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41A → T in BAC11537 (PubMed:15489334).Curated1
Sequence conflicti92F → S in BAC11537 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02156523R → K.2 PublicationsCorresponds to variant rs1133833dbSNPEnsembl.1
Natural variantiVAR_050688132I → T.Corresponds to variant rs35131475dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01327575 – 101Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_013276137 – 163Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493783 mRNA. Translation: AAM12862.1.
AF493784 mRNA. Translation: AAM12863.1.
AF493785 mRNA. Translation: AAM12864.1.
AF493786 Genomic DNA. Translation: AAM12865.1.
AF493786 Genomic DNA. Translation: AAM12866.1.
AF493786 Genomic DNA. Translation: AAM12867.1.
AF512007 mRNA. Translation: AAM34785.1.
AJ400877 Genomic DNA. Translation: CAB92290.1.
AK075308 mRNA. Translation: BAC11537.1.
BC030996 mRNA. Translation: AAH30996.1.
CCDSiCCDS55743.1. [Q9NQ31-2]
CCDS55744.1. [Q9NQ31-3]
CCDS7793.1. [Q9NQ31-1]
RefSeqiNP_001193575.1. NM_001206646.1. [Q9NQ31-3]
NP_001193576.1. NM_001206647.1. [Q9NQ31-2]
NP_001193577.1. NM_001206648.1.
NP_065693.2. NM_020642.3. [Q9NQ31-1]
XP_016873500.1. XM_017018011.1. [Q9NQ31-1]
UniGeneiHs.131180.

Genome annotation databases

EnsembliENST00000299576; ENSP00000299576; ENSG00000166452. [Q9NQ31-3]
ENST00000309357; ENSP00000310644; ENSG00000166452. [Q9NQ31-2]
ENST00000309377; ENSP00000310459; ENSG00000166452. [Q9NQ31-1]
ENST00000396648; ENSP00000379885; ENSG00000166452. [Q9NQ31-3]
ENST00000534147; ENSP00000431331; ENSG00000166452. [Q9NQ31-1]
GeneIDi56672.
KEGGihsa:56672.
UCSCiuc001mgx.4. human. [Q9NQ31-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493783 mRNA. Translation: AAM12862.1.
AF493784 mRNA. Translation: AAM12863.1.
AF493785 mRNA. Translation: AAM12864.1.
AF493786 Genomic DNA. Translation: AAM12865.1.
AF493786 Genomic DNA. Translation: AAM12866.1.
AF493786 Genomic DNA. Translation: AAM12867.1.
AF512007 mRNA. Translation: AAM34785.1.
AJ400877 Genomic DNA. Translation: CAB92290.1.
AK075308 mRNA. Translation: BAC11537.1.
BC030996 mRNA. Translation: AAH30996.1.
CCDSiCCDS55743.1. [Q9NQ31-2]
CCDS55744.1. [Q9NQ31-3]
CCDS7793.1. [Q9NQ31-1]
RefSeqiNP_001193575.1. NM_001206646.1. [Q9NQ31-3]
NP_001193576.1. NM_001206647.1. [Q9NQ31-2]
NP_001193577.1. NM_001206648.1.
NP_065693.2. NM_020642.3. [Q9NQ31-1]
XP_016873500.1. XM_017018011.1. [Q9NQ31-1]
UniGeneiHs.131180.

3D structure databases

ProteinModelPortaliQ9NQ31.
SMRiQ9NQ31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121180. 11 interactors.
IntActiQ9NQ31. 4 interactors.
STRINGi9606.ENSP00000310459.

PTM databases

iPTMnetiQ9NQ31.
PhosphoSitePlusiQ9NQ31.

Polymorphism and mutation databases

BioMutaiAKIP1.

Proteomic databases

MaxQBiQ9NQ31.
PaxDbiQ9NQ31.
PeptideAtlasiQ9NQ31.
PRIDEiQ9NQ31.

Protocols and materials databases

DNASUi56672.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299576; ENSP00000299576; ENSG00000166452. [Q9NQ31-3]
ENST00000309357; ENSP00000310644; ENSG00000166452. [Q9NQ31-2]
ENST00000309377; ENSP00000310459; ENSG00000166452. [Q9NQ31-1]
ENST00000396648; ENSP00000379885; ENSG00000166452. [Q9NQ31-3]
ENST00000534147; ENSP00000431331; ENSG00000166452. [Q9NQ31-1]
GeneIDi56672.
KEGGihsa:56672.
UCSCiuc001mgx.4. human. [Q9NQ31-1]

Organism-specific databases

CTDi56672.
DisGeNETi56672.
GeneCardsiAKIP1.
H-InvDBHIX0009428.
HGNCiHGNC:1170. AKIP1.
HPAiHPA061391.
MIMi609191. gene.
neXtProtiNX_Q9NQ31.
OpenTargetsiENSG00000166452.
PharmGKBiPA25484.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJ9. Eukaryota.
ENOG41114P0. LUCA.
GeneTreeiENSGT00390000017064.
HOVERGENiHBG030457.
InParanoidiQ9NQ31.
OMAiPGGIYQI.
OrthoDBiEOG091G0W3L.
PhylomeDBiQ9NQ31.
TreeFamiTF337318.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166452-MONOMER.

Miscellaneous databases

ChiTaRSiAKIP1. human.
GenomeRNAii56672.
PROiQ9NQ31.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166452.
CleanExiHS_C11orf17.
ExpressionAtlasiQ9NQ31. baseline and differential.
GenevisibleiQ9NQ31. HS.

Family and domain databases

InterProiIPR033214. AKIP1.
[Graphical view]
PANTHERiPTHR14330. PTHR14330. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAKIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NQ31
Secondary accession number(s): Q8NBS2
, Q8TAC6, Q8TAD3, Q8TAE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.