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Q9NQ31

- AKIP1_HUMAN

UniProt

Q9NQ31 - AKIP1_HUMAN

Protein

A-kinase-interacting protein 1

Gene

AKIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. substrate adhesion-dependent cell spreading Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A-kinase-interacting protein 1
    Alternative name(s):
    Breast cancer-associated gene 3 protein
    PKA-interacting protein
    Proline-rich protein BCA3
    Gene namesi
    Name:AKIP1
    Synonyms:BCA3, C11orf17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1170. AKIP1.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Locates to punctate spots.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA25484.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210A-kinase-interacting protein 1PRO_0000064857Add
    BLAST

    Proteomic databases

    MaxQBiQ9NQ31.
    PaxDbiQ9NQ31.
    PRIDEiQ9NQ31.

    PTM databases

    PhosphoSiteiQ9NQ31.

    Expressioni

    Tissue specificityi

    Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.2 Publications

    Gene expression databases

    ArrayExpressiQ9NQ31.
    BgeeiQ9NQ31.
    CleanExiHS_C11orf17.
    GenevestigatoriQ9NQ31.

    Organism-specific databases

    HPAiHPA052455.

    Interactioni

    Subunit structurei

    Interacts with PRKACA and RELA.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKACAP176124EBI-517035,EBI-476586

    Protein-protein interaction databases

    BioGridi121180. 9 interactions.
    IntActiQ9NQ31. 2 interactions.
    STRINGi9606.ENSP00000310459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NQ31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40909.
    HOVERGENiHBG030457.
    InParanoidiQ9NQ31.
    OMAiHRGKSEL.
    OrthoDBiEOG712TZK.
    PhylomeDBiQ9NQ31.
    TreeFamiTF337318.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NQ31-1) [UniParc]FASTAAdd to Basket

    Also known as: 1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNCLAAAAL NGVDRRSLQR SARLALEVLE RAKRRAVDWH ALERPKGCMG    50
    VLAREAPHLE KQPAAGPQRV LPGEREERPP TLSASFRTMA EFMDYTSSQC 100
    GKYYSSVPEE GGATHVYRYH RGESKLHMCL DIGNGQRKDR KKTSLGPGGS 150
    YQISEHAPEA SQPAENISKD LYIEVYPGTY SVTVGSNDLT KKTHVVAVDS 200
    GQSVDLVFPV 210
    Length:210
    Mass (Da):23,114
    Last modified:October 23, 2007 - v2
    Checksum:iF00AA1F166C37967
    GO
    Isoform 2 (identifier: Q9NQ31-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         137-163: Missing.

    Show »
    Length:183
    Mass (Da):20,207
    Checksum:i872DD878B01C513B
    GO
    Isoform 3 (identifier: Q9NQ31-3) [UniParc]FASTAAdd to Basket

    Also known as: 1b

    The sequence of this isoform differs from the canonical sequence as follows:
         75-101: Missing.

    Show »
    Length:183
    Mass (Da):20,034
    Checksum:iCF22CF64A41F33DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411A → T in BAC11537. (PubMed:15489334)Curated
    Sequence conflicti92 – 921F → S in BAC11537. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231R → K.2 Publications
    Corresponds to variant rs1133833 [ dbSNP | Ensembl ].
    VAR_021565
    Natural varianti132 – 1321I → T.
    Corresponds to variant rs35131475 [ dbSNP | Ensembl ].
    VAR_050688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 10127Missing in isoform 3. 1 PublicationVSP_013275Add
    BLAST
    Alternative sequencei137 – 16327Missing in isoform 2. 1 PublicationVSP_013276Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493783 mRNA. Translation: AAM12862.1.
    AF493784 mRNA. Translation: AAM12863.1.
    AF493785 mRNA. Translation: AAM12864.1.
    AF493786 Genomic DNA. Translation: AAM12865.1.
    AF493786 Genomic DNA. Translation: AAM12866.1.
    AF493786 Genomic DNA. Translation: AAM12867.1.
    AF512007 mRNA. Translation: AAM34785.1.
    AJ400877 Genomic DNA. Translation: CAB92290.1.
    AK075308 mRNA. Translation: BAC11537.1.
    BC030996 mRNA. Translation: AAH30996.1.
    CCDSiCCDS55743.1. [Q9NQ31-2]
    CCDS55744.1. [Q9NQ31-3]
    CCDS7793.1. [Q9NQ31-1]
    RefSeqiNP_001193575.1. NM_001206646.1. [Q9NQ31-3]
    NP_001193576.1. NM_001206647.1. [Q9NQ31-2]
    NP_001193577.1. NM_001206648.1.
    NP_065693.2. NM_020642.3. [Q9NQ31-1]
    UniGeneiHs.131180.

    Genome annotation databases

    EnsembliENST00000299576; ENSP00000299576; ENSG00000166452. [Q9NQ31-3]
    ENST00000309357; ENSP00000310644; ENSG00000166452. [Q9NQ31-2]
    ENST00000309377; ENSP00000310459; ENSG00000166452. [Q9NQ31-1]
    ENST00000396648; ENSP00000379885; ENSG00000166452. [Q9NQ31-3]
    ENST00000534147; ENSP00000431331; ENSG00000166452. [Q9NQ31-1]
    GeneIDi56672.
    KEGGihsa:56672.
    UCSCiuc001mgx.3. human. [Q9NQ31-1]
    uc001mgy.3. human. [Q9NQ31-3]
    uc001mgz.3. human. [Q9NQ31-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493783 mRNA. Translation: AAM12862.1 .
    AF493784 mRNA. Translation: AAM12863.1 .
    AF493785 mRNA. Translation: AAM12864.1 .
    AF493786 Genomic DNA. Translation: AAM12865.1 .
    AF493786 Genomic DNA. Translation: AAM12866.1 .
    AF493786 Genomic DNA. Translation: AAM12867.1 .
    AF512007 mRNA. Translation: AAM34785.1 .
    AJ400877 Genomic DNA. Translation: CAB92290.1 .
    AK075308 mRNA. Translation: BAC11537.1 .
    BC030996 mRNA. Translation: AAH30996.1 .
    CCDSi CCDS55743.1. [Q9NQ31-2 ]
    CCDS55744.1. [Q9NQ31-3 ]
    CCDS7793.1. [Q9NQ31-1 ]
    RefSeqi NP_001193575.1. NM_001206646.1. [Q9NQ31-3 ]
    NP_001193576.1. NM_001206647.1. [Q9NQ31-2 ]
    NP_001193577.1. NM_001206648.1.
    NP_065693.2. NM_020642.3. [Q9NQ31-1 ]
    UniGenei Hs.131180.

    3D structure databases

    ProteinModelPortali Q9NQ31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121180. 9 interactions.
    IntActi Q9NQ31. 2 interactions.
    STRINGi 9606.ENSP00000310459.

    PTM databases

    PhosphoSitei Q9NQ31.

    Proteomic databases

    MaxQBi Q9NQ31.
    PaxDbi Q9NQ31.
    PRIDEi Q9NQ31.

    Protocols and materials databases

    DNASUi 56672.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299576 ; ENSP00000299576 ; ENSG00000166452 . [Q9NQ31-3 ]
    ENST00000309357 ; ENSP00000310644 ; ENSG00000166452 . [Q9NQ31-2 ]
    ENST00000309377 ; ENSP00000310459 ; ENSG00000166452 . [Q9NQ31-1 ]
    ENST00000396648 ; ENSP00000379885 ; ENSG00000166452 . [Q9NQ31-3 ]
    ENST00000534147 ; ENSP00000431331 ; ENSG00000166452 . [Q9NQ31-1 ]
    GeneIDi 56672.
    KEGGi hsa:56672.
    UCSCi uc001mgx.3. human. [Q9NQ31-1 ]
    uc001mgy.3. human. [Q9NQ31-3 ]
    uc001mgz.3. human. [Q9NQ31-2 ]

    Organism-specific databases

    CTDi 56672.
    GeneCardsi GC11P008932.
    H-InvDB HIX0009428.
    HGNCi HGNC:1170. AKIP1.
    HPAi HPA052455.
    MIMi 609191. gene.
    neXtProti NX_Q9NQ31.
    PharmGKBi PA25484.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40909.
    HOVERGENi HBG030457.
    InParanoidi Q9NQ31.
    OMAi HRGKSEL.
    OrthoDBi EOG712TZK.
    PhylomeDBi Q9NQ31.
    TreeFami TF337318.

    Miscellaneous databases

    ChiTaRSi AKIP1. human.
    GenomeRNAii 56672.
    NextBioi 62163.
    PROi Q9NQ31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NQ31.
    Bgeei Q9NQ31.
    CleanExi HS_C11orf17.
    Genevestigatori Q9NQ31.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein."
      Kitching R., Li H., Wong M.J., Kanaganayakam S., Kahn H., Seth A.
      Biochim. Biophys. Acta 1625:116-121(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
      Tissue: Lymph node.
    2. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
      Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
      Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-23.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-23.
      Tissue: Kidney.
    5. "A-kinase-interacting protein localizes protein kinase A in the nucleus."
      Sastri M., Barraclough D.M., Carmichael P.T., Taylor S.S.
      Proc. Natl. Acad. Sci. U.S.A. 102:349-354(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH PRKACA.
    6. "AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65."
      Gao N., Asamitsu K., Hibi Y., Ueno T., Okamoto T.
      J. Biol. Chem. 283:7834-7843(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RELA, SUBCELLULAR LOCATION.
    7. "A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling."
      Gao N., Hibi Y., Cueno M., Asamitsu K., Okamoto T.
      J. Biol. Chem. 285:28097-28104(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiAKIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NQ31
    Secondary accession number(s): Q8NBS2
    , Q8TAC6, Q8TAD3, Q8TAE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3