Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9NQ31 (BCA3_HUMAN)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Proline-rich protein BCA3
Alternative name(s):
    Breast cancer-associated gene 3 protein
    PKA-interacting protein
    AKIP1
Gene names
Name: BCA3
Synonyms: C11orf17
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Subunit structure

Interacts with PRKACA. Ref.5

Subcellular location

Nucleus. Note: Locates to punctate spots. Ref.5

Tissue specificity

Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. Ref.5 Ref.1

Hide | Top

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseProto-oncogene
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding Ref.5

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRKACAP176122EBI-517035,EBI-476586

Hide | Top

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NQ31-1)

Also known as: 1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NQ31-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-163: Missing.
Isoform 3 (identifier: Q9NQ31-3)

Also known as: 1b;

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Proline-rich protein BCA3
PRO_0000064857

Natural variations

Alternative sequence75 – 10127Missing in isoform 3.
VSP_013275
Alternative sequence137 – 16327Missing in isoform 2.
VSP_013276
Natural variant231R → K: dbSNP rs1133833. Ref.3 Ref.4
VAR_021565
Natural variant1321I → T: dbSNP rs35131475.
VAR_050688

Experimental info

Sequence conflict411A → T in BAC11537. Ref.4
Sequence conflict921F → S in BAC11537. Ref.4

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1a) [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: F00AA1F166C37967

FASTA21023,114
        10         20         30         40         50         60 
MDNCLAAAAL NGVDRRSLQR SARLALEVLE RAKRRAVDWH ALERPKGCMG VLAREAPHLE 

        70         80         90        100        110        120 
KQPAAGPQRV LPGEREERPP TLSASFRTMA EFMDYTSSQC GKYYSSVPEE GGATHVYRYH 

       130        140        150        160        170        180 
RGESKLHMCL DIGNGQRKDR KKTSLGPGGS YQISEHAPEA SQPAENISKD LYIEVYPGTY 

       190        200        210 
SVTVGSNDLT KKTHVVAVDS GQSVDLVFPV

« Hide

Isoform 2.

Checksum: 872DD878B01C513B
Show »

FASTA18320,207
Isoform 3 (1b).

Checksum: CF22CF64A41F33DF
Show »

FASTA18320,034

Hide | Top

References

« Hide 'large scale' references
[1]"Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein."
Kitching R., Li H., Wong M.J., Kanaganayakam S., Kahn H., Seth A.
Biochim. Biophys. Acta 1625:116-121(2003) [PubMed: 12527432] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
Tissue: Lymph node.
[2]"Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
Cytogenet. Cell Genet. 93:284-290(2001) [PubMed: 11528127] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-23.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-23.
Tissue: Kidney.
[5]"A-kinase-interacting protein localizes protein kinase A in the nucleus."
Sastri M., Barraclough D.M., Carmichael P.T., Taylor S.S.
Proc. Natl. Acad. Sci. U.S.A. 102:349-354(2005) [PubMed: 15630084] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH PRKACA.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF493783 mRNA. Translation: AAM12862.1.
AF493784 mRNA. Translation: AAM12863.1.
AF493785 mRNA. Translation: AAM12864.1.
AF493786 Genomic DNA. Translation: AAM12865.1.
AF493786 Genomic DNA. Translation: AAM12866.1.
AF493786 Genomic DNA. Translation: AAM12867.1.
AF512007 mRNA. Translation: AAM34785.1.
AJ400877 Genomic DNA. Translation: CAB92290.1.
AK075308 mRNA. Translation: BAC11537.1.
BC030996 mRNA. Translation: AAH30996.1.
IPIIPI00152039.
IPI00152045.
IPI00299443.
RefSeqNP_065693.2.
NP_878904.2.
UniGeneHs.131180

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9NQ31. 2 interactions.

Genome annotation databases

EnsemblENSG00000166452. Homo sapiens. [Contig view]
GeneID56672.
KEGGhsa:56672.

Organism-specific databases

GeneCardsGC11P008889.
H-InvDBHIX0009428.
HGNCHGNC:1170. C11orf17.
MIM609191. gene.
PharmGKBPA25484.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9NQ31.
HOVERGENQ9NQ31.
OMAQ9NQ31. RAVDWHS.

Gene expression databases

ArrayExpressQ9NQ31.
BgeeQ9NQ31.
CleanExHS_C11orf17.
GermOnlineENSG00000166452. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio62163.
SOURCESearch...

Hide | Top

Entry information

Entry nameBCA3_HUMAN
AccessionPrimary (citable) accession number: Q9NQ31
Secondary accession number(s): Q8NBS2 expand/collapse secondary AC list , Q8TAC6, Q8TAD3, Q8TAE0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 23, 2007
Last modified: June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents